Hypercapnia
View article: High-flow nasal oxygenation versus standard oxygenation for gastrointestinal endoscopy with sedation in obese patients
High-flow nasal oxygenation versus standard oxygenation for gastrointestinal endoscopy with sedation in obese patients Open
Background: During the GIE procedure performed under sedation, various complications can occur, with hypoxia being the most frequent, significantly impacting mortality and morbidity. Methodology: A total of 60 cases were included in the re…
View article: What is the treatment for hypercapnic respiratory failure in an obese patient?
What is the treatment for hypercapnic respiratory failure in an obese patient? Open
Non-invasive ventilation (NIV) and bilevel positive airway pressure (BiPAP) are effective in treating hypercapnic respiratory failure in obese patients, primarily by improving ventilation and reducing complications.
View article: What is the treatment for hypercapnic respiratory failure in an obese patient?
What is the treatment for hypercapnic respiratory failure in an obese patient? Open
Non-invasive ventilation (NIV) and bilevel positive airway pressure (BiPAP) are effective in treating hypercapnic respiratory failure in obese patients, primarily by improving ventilation and reducing complications.
View article: The influence of intermittent hypercapnia on cerebrospinal fluid flow and clearance in Parkinson’s disease and healthy older adults
The influence of intermittent hypercapnia on cerebrospinal fluid flow and clearance in Parkinson’s disease and healthy older adults Open
A failure of the glymphatic pathway to clear brain byproducts implicated in neurodegeneration may contribute to the pathophysiology of Parkinson's disease. The glymphatic pathway relies on vasomotion (rhythmic constriction and dilation of …
View article: Time-Based Capnography to Diagnose Airway Obstruction During Lung Lobectomy in a Dog
Time-Based Capnography to Diagnose Airway Obstruction During Lung Lobectomy in a Dog Open
A 10-year-old, 7.0 kg, female spayed mixed-breed dog presented for a second opinion regarding lobectomy for a lung mass. Mechanical ventilation was initiated due to hypercapnia (ETCO2 of 61 mmHg) with PIP of 8 cmH2O. The PIP was gradually …
View article: Development of periodic breathing in awake healthy individuals under controlled progressive hypoxia
Development of periodic breathing in awake healthy individuals under controlled progressive hypoxia Open
The aim of this study was to better understand the ventilatory response to controlled progressive hypoxia in healthy individuals and identify factors influencing the development of periodic breathing under hypoxic conditions. The study was…
View article: Normobaric Hypoxic Cardiac Rehabilitation: Comparative Effects of Training at 2000 m and 3000 m Simulated Altitude in Post-Myocardial Infarction Patients
Normobaric Hypoxic Cardiac Rehabilitation: Comparative Effects of Training at 2000 m and 3000 m Simulated Altitude in Post-Myocardial Infarction Patients Open
Background: Coronary artery disease remains the leading cause of morbidity and mortality in developed countries. Despite advances in treatment and standard rehabilitation, conventional programs may be monotonous and insufficiently engaging…
View article: A clinical guide to non-invasive respiratory support in acute respiratory failure: ventilation settings, technical optimization and clinical indications
A clinical guide to non-invasive respiratory support in acute respiratory failure: ventilation settings, technical optimization and clinical indications Open
View article: Phrenic Long-Term Facilitation Following Acute Intermittent Hypercapnic-Hypoxia in Rats
Phrenic Long-Term Facilitation Following Acute Intermittent Hypercapnic-Hypoxia in Rats Open
Phrenic long-term facilitation (pLTF) is a form of respiratory motor plasticity, expressed as a lasting increase in phrenic nerve activity following acute intermittent hypoxia (AIH). Whereas AIH also elicits ventilatory LTF (vLTF) in unane…
View article: Physiological comparison of noninvasive ventilation and CPAP on inspiratory efforts after extubation in critically ill patients with morbid obesity: a post-hoc analysis
Physiological comparison of noninvasive ventilation and CPAP on inspiratory efforts after extubation in critically ill patients with morbid obesity: a post-hoc analysis Open
Background No study has evaluated the inspiratory effort in patients with obesity immediately after extubation according to the noninvasive ventilatory support used. We aimed to determine, in critically ill patients with morbid obesity, wh…
View article: The role of non-invasive respiratory support at different stages of acute hypoxemic respiratory failure treatment. Part I
The role of non-invasive respiratory support at different stages of acute hypoxemic respiratory failure treatment. Part I Open
Treatment of hypoxemic acute respiratory failure remains one of the urgent and applied problems of modern intensive care, as it is the leading cause of critical conditions and high mortality in patients in intensive care units. Patient sel…
View article: Unmasking Cyanide Toxicity: A Case of Encephalopathy and Ventilatory Support Following Smoke Inhalation
Unmasking Cyanide Toxicity: A Case of Encephalopathy and Ventilatory Support Following Smoke Inhalation Open
View article: Effects of extracorporeal carbon dioxide removal in facilitating ultra-protective ventilation strategies for patients with acute respiratory distress syndrome: a systematic review and meta-analysis
Effects of extracorporeal carbon dioxide removal in facilitating ultra-protective ventilation strategies for patients with acute respiratory distress syndrome: a systematic review and meta-analysis Open
Background Although low tidal volume ventilation has been shown to reduce mortality in patients with acute respiratory distress syndrome (ARDS), overall mortality remains high (30%−40%). Ultra-protective ventilation (≤4 mL/kg predicted bod…
View article: Successful Non-Invasive Management of Near-Fatal Asthma with Severe Hypercapnic Respiratory Failure: A Case Report
Successful Non-Invasive Management of Near-Fatal Asthma with Severe Hypercapnic Respiratory Failure: A Case Report Open
View article: The effects of targeted mild hypercapnia on right ventricular function after out-of-hospital cardiac arrest. A sub-study of the TAME cardiac arrest trial.
The effects of targeted mild hypercapnia on right ventricular function after out-of-hospital cardiac arrest. A sub-study of the TAME cardiac arrest trial. Open
View article: ROLE OF NIV IN ACUTE EXACERBATION OF COPD
ROLE OF NIV IN ACUTE EXACERBATION OF COPD Open
Introduction: A globally increasing trend and prevalence with increasing mortality from COPD cases due to acute exacerbation is now a well known and established fact. The infection/ inflammation due to the environmental factors are the tri…
View article: What are the potential benefits and risks associated with using high flow nasal oxygen in asthma patients experiencing acute respiratory failure?
What are the potential benefits and risks associated with using high flow nasal oxygen in asthma patients experiencing acute respiratory failure? Open
High-flow nasal oxygen (HFNO) shows promise for managing acute respiratory failure in asthma patients, improving oxygenation and reducing respiratory distress, although further studies are needed to assess its safety and effectiveness.
View article: What are the potential benefits and risks associated with using high flow nasal oxygen in asthma patients experiencing acute respiratory failure?
What are the potential benefits and risks associated with using high flow nasal oxygen in asthma patients experiencing acute respiratory failure? Open
High-flow nasal oxygen (HFNO) shows promise for managing acute respiratory failure in asthma patients, improving oxygenation and reducing respiratory distress, although further studies are needed to assess its safety and effectiveness.
View article: What is the utility of high-flow oxygen therapy devices?
What is the utility of high-flow oxygen therapy devices? Open
High-flow oxygen therapy devices show promise in reducing intubation rates and improving oxygenation across various respiratory conditions, though variability in outcomes suggests a need for more standardized research.
View article: What is the utility of high-flow oxygen therapy devices?
What is the utility of high-flow oxygen therapy devices? Open
High-flow oxygen therapy devices show promise in reducing intubation rates and improving oxygenation across various respiratory conditions, though variability in outcomes suggests a need for more standardized research.
View article: What is the utility of high-flow oxygen therapy devices?
What is the utility of high-flow oxygen therapy devices? Open
High-flow oxygen therapy devices show promise in reducing intubation rates and improving oxygenation across various respiratory conditions, though variability in outcomes suggests a need for more standardized research.
View article: What is the utility of high-flow oxygen therapy devices?
What is the utility of high-flow oxygen therapy devices? Open
High-flow oxygen therapy devices show promise in reducing intubation rates and improving oxygenation across various respiratory conditions, though variability in outcomes suggests a need for more standardized research.
View article: Aminophylline in acute exacerbation of COPD: Utility and treatment effects in hypercapnic respiratory failure (ACUTE): A pilot observational study
Aminophylline in acute exacerbation of COPD: Utility and treatment effects in hypercapnic respiratory failure (ACUTE): A pilot observational study Open
Background and Objective: Aminophylline may play a role in managing both stable and exacerbating COPD, but its use is controversial due to its narrow therapeutic window. We aimed to evaluate the role of aminophylline in acute exacerbations…
View article: Full-Face Snorkeling Masks Carry a Risk of Hypercapnia and Drowning in Younger Children: A Case Series
Full-Face Snorkeling Masks Carry a Risk of Hypercapnia and Drowning in Younger Children: A Case Series Open
Background: Recently, a new type of full-face snorkeling mask (FFSM), called “Easy-breath” masks, has become extremely popular both in adults and children due to their effective marketing and relative comfort. However, these masks are comp…
View article: Hypercapnia promotes maladaptive airway and vascular remodeling in mice
Hypercapnia promotes maladaptive airway and vascular remodeling in mice Open
CO2 isn't just a gas-it can remodel lungs and worsen COPD, but may be reversible with CO2-lowering therapies.
View article: Early acclimatization to high altitude: Acid–base and fluid balance dynamics during the first 2 days at 3100 m
Early acclimatization to high altitude: Acid–base and fluid balance dynamics during the first 2 days at 3100 m Open
Immediate responses to hypoxia at high altitude are hyperventilation and successive respiratory alkalosis. Alkalosis, in turn, can affect cerebrospinal fluid pH and ventilatory control. The kidneys compensate metabolically for respiratory …
View article: Hypercapnia-Induced Noncirrhotic Hyperammonemia (HIH): Unveiling an Unrecognized Association
Hypercapnia-Induced Noncirrhotic Hyperammonemia (HIH): Unveiling an Unrecognized Association Open
View article: Deconvolved Widefield Fluorescence Microscopy Image Dataset of Carotid Body Chemoreceptors in Wistar and Spontaneously Hypertensive Rats. Part B
Deconvolved Widefield Fluorescence Microscopy Image Dataset of Carotid Body Chemoreceptors in Wistar and Spontaneously Hypertensive Rats. Part B Open
PART A of the dataset is available via doi: 10.5281/zenodo.15353631 Image dataset of the neurovascular interface of the carotid body (CB) arterial chemoreceptors. CB from normotensive (Wistar) and Spontaneously Hypertensive rats (SHR) of m…
View article: Deconvolved Widefield Fluorescence Microscopy Image Dataset of Carotid Body Chemoreceptors in Wistar and Spontaneously Hypertensive Rats. Part B
Deconvolved Widefield Fluorescence Microscopy Image Dataset of Carotid Body Chemoreceptors in Wistar and Spontaneously Hypertensive Rats. Part B Open
PART A of the dataset is available via doi: 10.5281/zenodo.15353631 Image dataset of the neurovascular interface of the carotid body (CB) arterial chemoreceptors. CB from normotensive (Wistar) and Spontaneously Hypertensive rats (SHR) of m…
View article: Chemoreflex function in pulmonary diseases – A review
Chemoreflex function in pulmonary diseases – A review Open
The chemoreflex is a vital protective reflex that is crucial in restoring normal blood gas and pH levels. The carotid bodies are peripheral chemoreceptors activated by hypoxia (primarily), hypercapnia, acidaemia, temperature, lactate and p…