Plasmodium berghei
View article: Evaluation of the Effect of Combining Artemether Lumefantrine with Hippocratea africana and Eremomastax speciosa Extracts on Malaria Parasite Using Infected Adult Mice
Evaluation of the Effect of Combining Artemether Lumefantrine with Hippocratea africana and Eremomastax speciosa Extracts on Malaria Parasite Using Infected Adult Mice Open
The high burden of malaria in most parts of the world led to the recommended use of Artemisinin-based combination therapy (ACT) by WHO, with varying degree of success. The effect of combining Artemether Lumefantrine with Hippocratea africa…
View article: PfPI3K inhibition reversed artemisinin resistance by increasing ROS and ubiquitinated protein levels in Plasmodium falciparum
PfPI3K inhibition reversed artemisinin resistance by increasing ROS and ubiquitinated protein levels in Plasmodium falciparum Open
Phosphatidylinositol-3-phosphate (PI3P) is the key mediator of resistance to artemisinin drugs (ARTs) and that phosphatidylinositol 3-kinase (PfPI3K) is a promising target for eliminating ARTs resistance. However, few studies investigated …
View article: Antiplasmodial and Hematolipid Restorative Effects of Azadiracta indica Leaf Extract in Plasmodium berghei-Infected Swiss Albino Mice
Antiplasmodial and Hematolipid Restorative Effects of Azadiracta indica Leaf Extract in Plasmodium berghei-Infected Swiss Albino Mice Open
Malaria remains a major public health burden in tropical and subtropical regions, with persistent challenges of drug resistance and associated hematological and metabolic complications. This study investigated the antiplasmodial and hemato…
View article: PREreview of "Single cell transcriptomics and development of gametocyte-specific molecular markers for avian malaria parasites"
PREreview of "Single cell transcriptomics and development of gametocyte-specific molecular markers for avian malaria parasites" Open
This Zenodo record is a permanently preserved version of a PREreview. You can view the complete PREreview at https://prereview.org/reviews/17636234. Manuscript SummaryBerthomieu et al. address a critical gap in avian malar…
View article: PREreview of "Single cell transcriptomics and development of gametocyte-specific molecular markers for avian malaria parasites"
PREreview of "Single cell transcriptomics and development of gametocyte-specific molecular markers for avian malaria parasites" Open
This Zenodo record is a permanently preserved version of a PREreview. You can view the complete PREreview at https://prereview.org/reviews/17636234. Manuscript Summary Berthomieu et al. address a critical gap in avian malaria research by d…
View article: SEQUESTRATION OF ERYTHROCYTE INFECTED BY Plasmodium berghei ANKA IN MICE LIVER TREATED WITH ETHANOL EXTRACT OF PEARL GRASS (Hedyotis corymbosa (L.) Lamk)
SEQUESTRATION OF ERYTHROCYTE INFECTED BY Plasmodium berghei ANKA IN MICE LIVER TREATED WITH ETHANOL EXTRACT OF PEARL GRASS (Hedyotis corymbosa (L.) Lamk) Open
Background: Malaria is a parasitic infection caused by the Plasmodium genus. Certain Plasmodium species can evade the immune system by sequestering internal organs, including the liver. The ethanolic extract of pearl grass (Hedyotis corymb…
View article: Cerebral malaria: of mice and men
Cerebral malaria: of mice and men Open
Background Cerebral malaria is a major cause of death in endemic areas. An animal model of cerebral malaria has been studied widely in which C57BL/6 mice are infected with the Plasmodium berghei ANKA strain. The histopathology and the resp…
View article: Antimalarial effects of ethanolic extracts of Andrographis paniculata leaves and Allium sativum bulbs on Plasmodium berghei (NK65)-induced Parasitemia in Albino mice
Antimalarial effects of ethanolic extracts of Andrographis paniculata leaves and Allium sativum bulbs on Plasmodium berghei (NK65)-induced Parasitemia in Albino mice Open
Malaria remains a major cause of morbidity and mortality in sub-Saharan Africa, disproportionately affecting children and pregnant women. The increasing resistance to conventional antimalarial drugs underscores the urgent need for alternat…
View article: Evaluation of Trace Elements and Antioxidant Vitamins Effect following Palm Oil Supplemented Diet on Plasmodium berghei Infected Mice.
Evaluation of Trace Elements and Antioxidant Vitamins Effect following Palm Oil Supplemented Diet on Plasmodium berghei Infected Mice. Open
Malaria infection induces a cascade of secondary pathological events, among which oxidative stress and inflammation are interconnected. This interaction often exacerbates tissue damage and significantly contributes to disease progression. …
View article: Plasmodium actin-like proteins are essential for DNA segregation during male gametogenesis and malaria transmission
Plasmodium actin-like proteins are essential for DNA segregation during male gametogenesis and malaria transmission Open
Protozoan parasites of the genus Plasmodium cause malaria and involve infection of multiple hosts and cell types during the life cycle. Producing sexually fit gametocytes is essential for transmitting the Plasmodium parasite into an anophe…
View article: Multi-epitope mRNA Malaria Vaccine for Liver-Stage Specific CD8+ T Cells 3136
Multi-epitope mRNA Malaria Vaccine for Liver-Stage Specific CD8+ T Cells 3136 Open
Description Plasmodium sporozoites progress through a short obligate liver-stage, representing a critical period for vaccine targeting, prior to blood-stage infection. Malaria-specific liver tissue resident memory CD8 T cells (Trm) are cri…
View article: Type-I IFNs induce GBPs and lysosomal defense in hepatocytes to control malaria 2178
Type-I IFNs induce GBPs and lysosomal defense in hepatocytes to control malaria 2178 Open
Description Plasmodium parasites develop and replicate within the hepatocytes before infecting the erythrocytes and initiating clinical malaria. Although type-I interferons (IFNs) can hinder Plasmodium infection within the liver, the under…
View article: IL-15 enhances T resident memory formation and function following genetically attenuated Plasmodium vaccination in mice 3232
IL-15 enhances T resident memory formation and function following genetically attenuated Plasmodium vaccination in mice 3232 Open
Description Tissue resident memory T (Trm) cells are critical for local protection against invading pathogens and are being targeted for vaccination strategies. Malaria is a major public health threat in need of durable vaccines, as it cau…
View article: Effects of Moderate Malnutrition during Pregnancy on Neonatal Immunity to Malaria 2369
Effects of Moderate Malnutrition during Pregnancy on Neonatal Immunity to Malaria 2369 Open
Description High mortality rates due to malnutrition and malaria are reported in children under five years. Surprisingly, there is limited knowledge on neonatal immunity to the Plasmodium infection in relation to malnutrition, in part due …
View article: Microbiome-mediated modulation of immune memory to P. yoelii affects the resistance to secondary cerebral malaria challenge 2521
Microbiome-mediated modulation of immune memory to P. yoelii affects the resistance to secondary cerebral malaria challenge 2521 Open
Description Malaria is caused by protozoan parasites in the genus Plasmodium. Over time individuals slowly develop clinical immunity to malaria, but this process occurs at variable rates, and the mechanism of protection is not fully unders…
View article: Influenza-induced suppressive alveolar macrophages protect against malarial immunopathology during coinfection 3547
Influenza-induced suppressive alveolar macrophages protect against malarial immunopathology during coinfection 3547 Open
Description Severe cerebral and pulmonary vascular damage by CD8 T cells remains a major challenge in malaria, which kills >600,000 people annually. Coinfections can significantly alter disease progression by changing the immune kinetic…
View article: Bond lifetime under force as a potential mechanism underlying the pathogenicity of low affinity CD8 T cells in experimental cerebral malaria 3182
Bond lifetime under force as a potential mechanism underlying the pathogenicity of low affinity CD8 T cells in experimental cerebral malaria 3182 Open
Description Despite the presence of anti-malarial treatments, cerebral malaria persists as one of the most lethal malaria complications. CD8 T cells mediate the development of experimental cerebral malaria (ECM), which is characterized by …
View article: Hemozoin persistence after Plasmodium infection diminishes protective whole-parasite induced CD8+ T cell responses that can be overcome by mRNA vaccination 2096
Hemozoin persistence after Plasmodium infection diminishes protective whole-parasite induced CD8+ T cell responses that can be overcome by mRNA vaccination 2096 Open
Description Several malaria vaccine candidates, including radiation attenuated sporozoites (RAS), show disappointing performance when tested in malaria endemic regions, compared to their strong performance in malaria-naïve individuals. One…
View article: A Modular Chromosomal Passenger Complex Rewires Chromosome Segregation in <i>Plasmodium berghei</i>
A Modular Chromosomal Passenger Complex Rewires Chromosome Segregation in <i>Plasmodium berghei</i> Open
Summary Faithful chromosome segregation relies on precise kinetochore–microtubule interactions and checkpoint surveillance, yet the molecular basis of these processes varies widely across eukaryotes and is only beginning to be defined in a…
View article: Non-conventional B cells dynamics during the Plasmodium berghei infection of BALB/c mice
Non-conventional B cells dynamics during the Plasmodium berghei infection of BALB/c mice Open
View article: Antimalarial and neuroprotective effects of ethanolic extracts of the five-flower remedy in an experimental cerebral malaria model
Antimalarial and neuroprotective effects of ethanolic extracts of the five-flower remedy in an experimental cerebral malaria model Open
Cerebral malaria (CM), a life-threatening consequence of Plasmodium falciparum infection, is associated with a high fatality rate and long-term brain impairment in survivors. Despite advances in malaria treatment, effective therapies to mi…
View article: Comparative Impacts of Alternating Magnetic Field and Crude Extract of Tithonia diversifolia Leaf on Hematological Indices of Plasmodium berghei-Infected Mice
Comparative Impacts of Alternating Magnetic Field and Crude Extract of Tithonia diversifolia Leaf on Hematological Indices of Plasmodium berghei-Infected Mice Open
The present study investigated the comparative effects of varying intensities of alternating magnetic field and Tithionia diversifolia crude extract on hematological parameters of mice infected with Plasmodium berghei. Experimental solenoi…
View article: Novel Inhibitors of <i>Plasmodium</i> Phosphatidylinositol 4-kinase IIIβ with Low Propensity for Resistance: Life Cycle Stage Activity and <i>In Vivo</i> Efficacy in a Humanized Mouse Malaria Infection Model
Novel Inhibitors of <i>Plasmodium</i> Phosphatidylinositol 4-kinase IIIβ with Low Propensity for Resistance: Life Cycle Stage Activity and <i>In Vivo</i> Efficacy in a Humanized Mouse Malaria Infection Model Open
Anticancer ATP-competitive inhibitors are a promising source of new starting points for antimalarial drug discovery. Herein, we present a novel antimalarial chemotype based on the anticancer human ataxia-telangiectasia-mutated (ATM) kinase…
View article: Herbal Triad Therapy: Antiplasmodial, Immunomodulatory and Antioxidant Effects in Plasmodium berghei-Infected Mice
Herbal Triad Therapy: Antiplasmodial, Immunomodulatory and Antioxidant Effects in Plasmodium berghei-Infected Mice Open
Background: Malaria is responsible for significant morbidity and mortality, especially in sub-Saharan Africa. Malaria can lead to complications involving vital organs such as the liver and spleen, intensifying the need for new therapeutic …
View article: WITHDRAWN
WITHDRAWN Open
View article: Hepatoprotective and Antiplasmodial Effects of Ethanolic Leaf Extracts of Azadirachta indica and Cymbopogon citratus in Plasmodium berghei-Infected Mice
Hepatoprotective and Antiplasmodial Effects of Ethanolic Leaf Extracts of Azadirachta indica and Cymbopogon citratus in Plasmodium berghei-Infected Mice Open
Malaria remains a major public health concern in sub-Saharan Africa, with Nigeria among the most affected countries. This study evaluated the hepatoprotective and antiplasmodial effects of ethanolic leaf extracts of Azadirachta indica (EAI…
View article: Time-of-day of infection: impact on liver stage malaria parasites in untreated and drug-treated hosts
Time-of-day of infection: impact on liver stage malaria parasites in untreated and drug-treated hosts Open
Background Circadian clocks are thought to have evolved owing to the benefits of anticipating daily environmental rhythms. Daily environmental rhythms that impact on fitness include interactions between organisms, such as host–pathogen int…
View article: Comparative Activities of Stem Bark Extracts of Anthocleista vogelii, Bligha sapida, Voacanga africana and Momordica charantia Leaf against Plasmodium berghei- berghei in Mice
Comparative Activities of Stem Bark Extracts of Anthocleista vogelii, Bligha sapida, Voacanga africana and Momordica charantia Leaf against Plasmodium berghei- berghei in Mice Open
Background: The search for antimalarial molecules from plants necessitates comparative studies of ethnomedicinal antimalarial plants to quickly identify those that may be used in further search. Therefore, the median lethal dose, LD50, and…
View article: Exploration of Fluorinated Peptoid‐Based Histone Deacetylase Inhibitors as Dual‐Stage Antiplasmodial Agents
Exploration of Fluorinated Peptoid‐Based Histone Deacetylase Inhibitors as Dual‐Stage Antiplasmodial Agents Open
The antiplasmodial properties of a series of fluorinated peptoid‐capped histone deacetylase inhibitors (HDACi) were investigated against asexual blood stages of the drug‐sensitive 3D7 and drug‐resistant Dd2 strains of Plasmodium falciparum…
View article: Lycopene Mitigates Malaria‐Induced Reactive Oxygen and Nitrogen Species and Oxidative Damage in Mice Brain and Lungs
Lycopene Mitigates Malaria‐Induced Reactive Oxygen and Nitrogen Species and Oxidative Damage in Mice Brain and Lungs Open
The severity of malaria is associated with low antioxidant availability and elevated free radical production, which induces oxidative damage in cerebral and pulmonary microcirculation. This can be mitigated by dietary antioxidants. We inve…