Carcinoembryonic antigen
View article: Development of a Logistic Regression Model for Colorectal Cancer Relapse Prediction in Sabah, Malaysia
Development of a Logistic Regression Model for Colorectal Cancer Relapse Prediction in Sabah, Malaysia Open
Colorectal cancer (CRC) remains one of the leading causes of cancer-related deaths in Malaysia, with relapse contributing substantially to poor survival outcomes. Despite advances in treatment, relapse surveillance continues to rely on non…
View article: Impact of primary colorectal cancer site on surgical outcomes for liver metastases: A retrospective study
Impact of primary colorectal cancer site on surgical outcomes for liver metastases: A retrospective study Open
BACKGROUND Colorectal cancer is a common malignancy with increasing incidence, and 15%-25% of patients develop liver metastases with poor prognosis. Recent evidence suggests that primary tumor location significantly influences embryologica…
View article: Serum CEA, CA19-9, and AFP as Biomarkers for Gastric Cancer
Serum CEA, CA19-9, and AFP as Biomarkers for Gastric Cancer Open
Background: The diagnostic value of AFP, CA19-9 and CEA as biomarkers in gastric carcinoma remains uncertain. This research explores their role in forecasting patient survival and disease progression. Methods: A total of 630 early-stage ga…
View article: A high-affinity CEA-targeted nanobody for 68Ga PET imaging and 177Lu-based radioisotope therapy: preclinical and first-in-human evaluation
A high-affinity CEA-targeted nanobody for 68Ga PET imaging and 177Lu-based radioisotope therapy: preclinical and first-in-human evaluation Open
Carcinoembryonic antigen (CEA) is a clinically validated biomarker and therapeutic target in colorectal and other epithelial malignancies, yet current antibody-based approaches are hindered by poor pharmacokinetics, limited tumor penetrati…
View article: Clinical outcomes of ultrasound-guided mammotome vacuum-assisted excision for benign breast tumors and its impact on serum tumor markers
Clinical outcomes of ultrasound-guided mammotome vacuum-assisted excision for benign breast tumors and its impact on serum tumor markers Open
Background Ultrasound-guided vacuum-assisted excision (VAE) is widely used for benign breast lesions, but its systemic impact is unclear. We tested whether VAE increases serum CA15-3 at 3 months and described clinical outcomes. Methods In …
View article: Modelling Disease Trajectories in Colorectal Cancer with Longitudinal Carcinoembryonic Antigen (CEA) using Joint Multi-State Model
Modelling Disease Trajectories in Colorectal Cancer with Longitudinal Carcinoembryonic Antigen (CEA) using Joint Multi-State Model Open
In colorectal cancer (CRC), Carcinoembryonic Antigen (CEA) is a widely recognized biomarker for monitoring disease progression. However, its dynamic nature is often neglected in conventional survival analyses. Patients with CRC may experie…
View article: Cergutuzumab Amunaleukin in Combination with Atezolizumab in Patients with Carcinoembryonic Antigen-Positive Advanced/Metastatic Solid Tumors
Cergutuzumab Amunaleukin in Combination with Atezolizumab in Patients with Carcinoembryonic Antigen-Positive Advanced/Metastatic Solid Tumors Open
Purpose: Cergutuzumab amunaleukin (CA) is an immunocytokine comprising a variant form of interleukin-2 (constructed to avoid CD25 binding and Treg stimulation) fused to a carcinoembryonic antigen (CEA)-targeted antibody. This phase Ib open…
View article: Non-functional, non-mutated multifocal neuroendocrine neoplasms in a postpartum female: a Case Report of an infrequent disease
Non-functional, non-mutated multifocal neuroendocrine neoplasms in a postpartum female: a Case Report of an infrequent disease Open
Background Neuroendocrine neoplasms (NENs) represent a relatively rare yet heterogeneous group of neoplasms arising from diverse anatomical origins. The inherent variability in clinical manifestations and gradations of biological aggressiv…
View article: Bone metastasis in colorectal cancer: Pathophysiology, prognostic factors, survival outcomes, and treatment strategies – A comprehensive review
Bone metastasis in colorectal cancer: Pathophysiology, prognostic factors, survival outcomes, and treatment strategies – A comprehensive review Open
Background: Colorectal cancer ranks as the third most prevalent cancer globally, with over 1.9 million new cases and 930,000 deaths in 2020. While the liver and lungs are the most common site of colorectal cancer metastases, bone metastasi…
View article: How are elevated CEA levels used in monitoring the detection of colorectal cancer recurrence?
How are elevated CEA levels used in monitoring the detection of colorectal cancer recurrence? Open
CEA levels are commonly used in the follow-up of colorectal cancer patients to monitor for recurrence, although their limited sensitivity means they are most effective when used alongside other diagnostic modalities.
View article: Allergic Bronchopulmonary Aspergillosis Presenting with Pulmonary Solid Lesions and Elevated Serum Carcinoembryonic Antigen Mimicking Lung Cancer
Allergic Bronchopulmonary Aspergillosis Presenting with Pulmonary Solid Lesions and Elevated Serum Carcinoembryonic Antigen Mimicking Lung Cancer Open
View article: How are elevated CEA levels used in monitoring the detection of colorectal cancer recurrence?
How are elevated CEA levels used in monitoring the detection of colorectal cancer recurrence? Open
CEA levels are commonly used in the follow-up of colorectal cancer patients to monitor for recurrence, although their limited sensitivity means they are most effective when used alongside other diagnostic modalities.
View article: Fusobacterium nucleatum in colorectal cancer
Fusobacterium nucleatum in colorectal cancer Open
Background: Colorectal cancer is one of the most significant oncological diseases in the world due to its high morbidity and mortality. Fusobacterium nucleatum is an anaerobic bacterium that is actively studied in the context of colon carc…
View article: Perineural invasion as both a prognostic factor for stage II rectal cancer and an indicator for adjuvant chemotherapy
Perineural invasion as both a prognostic factor for stage II rectal cancer and an indicator for adjuvant chemotherapy Open
Perineural invasion (PNI) is widely recognized as a significant indicator of tumor aggressiveness and poor prognosis. In patients with stage II colorectal cancer, the presence of PNI may suggest a higher risk of disease recurrence. Therefo…
View article: Immunohistochemical markers in colorectal adenocarcinoma
Immunohistochemical markers in colorectal adenocarcinoma Open
Background: The caudal type homeobox 2 transcription factor (CDX2) is an emerging biomarker in CRC and is currently used in the clinic for diagnosis of intestinal adenocarcinomas as it is a relatively sensitive and specific intestinal mark…
View article: Semi-distributed interferometers for early detection of lung cancer biomarkers
Semi-distributed interferometers for early detection of lung cancer biomarkers Open
Background: Lung cancer is the second most common type of cancer around the globe and in Kazakhstan. Elevated concentrations of Carcinoembryonic antigen (CEA) and Anterior gradient protein 2 (AGR-2) in serum are associated with Non-Small C…
View article: Case Report: A rare case of mixed medullary-papillary thyroid carcinoma with mixed lymph node metastasis
Case Report: A rare case of mixed medullary-papillary thyroid carcinoma with mixed lymph node metastasis Open
Introduction By reviewing the diagnosis and treatment process of a rare case of mixed medullary-papillary thyroid carcinoma (MMPTC) in the right lobe, medullary thyroid carcinoma (MTC) combined with papillary thyroid carcinoma (PTC) in the…
View article: Parotid Gland Mass as the First Manifestation of Recurrent Metastatic Breast Carcinoma: Diagnostic Pitfalls and Therapeutic Considerations in Oral-Maxillofacial Care
Parotid Gland Mass as the First Manifestation of Recurrent Metastatic Breast Carcinoma: Diagnostic Pitfalls and Therapeutic Considerations in Oral-Maxillofacial Care Open
Breast cancer rarely metastasizes to the parotid gland. Early recognition in patients with a history of malignancy is critical for timely diagnosis and treatment. We report the case of a 60-year-old female who presented with a two-month hi…
View article: <i>RSPO3</i> rearrangements in advanced colorectal cancer patients and their relationship with disease characteristics
<i>RSPO3</i> rearrangements in advanced colorectal cancer patients and their relationship with disease characteristics Open
BACKGROUND Colorectal cancer (CRC) is the second leading cause of cancer-related death, largely due to limited treatment options in advanced stages. Genomic alterations in advanced CRC (aCRC) are complex and not fully characterized, with o…
View article: Colorectal clear cell carcinoma: a literature review
Colorectal clear cell carcinoma: a literature review Open
View article: Multi-Marker Model Enhances Diagnostic Accuracy in Biliary Stricture Determination: Meta-Analysis Validation
Multi-Marker Model Enhances Diagnostic Accuracy in Biliary Stricture Determination: Meta-Analysis Validation Open
Introduction: Biliary strictures present diagnostic challenges, necessitating early differentiation between benign and malignant cases. This study evaluates the diagnostic value of biliary and serum carcinoembryonic antigen (SCEA, BCEA) an…
View article: Sandwich-type amperometric aptasensor for carcinoembryonic antigen based on Janus colloids as enzyme-free labeling elements
Sandwich-type amperometric aptasensor for carcinoembryonic antigen based on Janus colloids as enzyme-free labeling elements Open
A masking/toposelective modification approach was employed to prepare novel Janus colloids based on Au nanoparticles anisotropically-modified with polyamidoamine dendrons. Catalytic Pt nanoparticles were further grown into the dendritic st…
View article: The sensitive and selective electrochemical detection of carcinoembryonic antigen using a nanoMIPs-aptamer sandwich assay
The sensitive and selective electrochemical detection of carcinoembryonic antigen using a nanoMIPs-aptamer sandwich assay Open
View article: Performance Evaluation of Black Phosphorus and Graphene Layers Using Surface Plasmon Resonance Biosensor for the Detection of CEA Antigens
Performance Evaluation of Black Phosphorus and Graphene Layers Using Surface Plasmon Resonance Biosensor for the Detection of CEA Antigens Open
The biomarker carcinoembryonic antigen (CEA) plays an important role in the diagnosis and monitoring of cancer, like breast, surveillance, colon, and liver cancer. The highly sensitive surface plasmon resonance (SPR) sensor presented in th…
View article: Development and validation of IgG N-glycosylation-based nomograms for early diagnosis and postoperative recurrence risk prediction of colorectal cancer in Chinese Han population
Development and validation of IgG N-glycosylation-based nomograms for early diagnosis and postoperative recurrence risk prediction of colorectal cancer in Chinese Han population Open
Background: Colorectal cancer (CRC) is among the leading causes of cancer morbidity and mortality worldwide, with prognosis heavily determined by stage at the diagnosis and risk of postoperative recurrence. Immunoglobulin G (IgG) N-glycosy…
View article: Evaluation of radiolabeled antibody targeting oncofetal antigen 5T4 in syngeneic tumor model
Evaluation of radiolabeled antibody targeting oncofetal antigen 5T4 in syngeneic tumor model Open
View article: Pathological Complete Response in a Rare Case of Rectal Small Cell Neuroendocrine Carcinoma Following Neoadjuvant Radiochemotherapy: A Case Report
Pathological Complete Response in a Rare Case of Rectal Small Cell Neuroendocrine Carcinoma Following Neoadjuvant Radiochemotherapy: A Case Report Open
Rectal neuroendocrine neoplasms are rare, aggressive tumors comprising a small fraction of rectal malignancies but with increasing incidence due to improved endoscopic detection. Small cell neuroendocrine carcinoma, a high‐grade variant, p…
View article: Peritoneal Tuberculosis Mimicking Cancerous Peritonitis With Elevated Serum Cancer Antigen 125 and Carbohydrate Antigen 19‐9 Levels: A Case Report
Peritoneal Tuberculosis Mimicking Cancerous Peritonitis With Elevated Serum Cancer Antigen 125 and Carbohydrate Antigen 19‐9 Levels: A Case Report Open
Peritoneal tuberculosis (PTB) is a rare extrapulmonary manifestation that poses diagnostic challenges due to nonspecific clinical features and can mimic carcinomatous peritonitis, particularly in patients with ascites and elevated serum ca…
View article: 58 Intrahepatic cholangiocarcinoma arising within a bile duct hamartoma, A rare case report
58 Intrahepatic cholangiocarcinoma arising within a bile duct hamartoma, A rare case report Open
Introduction/Objective Malignancies arising from the Von Meyenburg Complex/bile duct hamartomas in liver are exceedingly rare with very few cases reported in the literature. Multiple bile duct hamartomas are thought to arise as a consequen…
View article: Advanced Lung Adenocarcinoma in Non-Smoker: Unraveling Diagnostic Challenges with Immunohistochemistry and Atypical Marker Profiles
Advanced Lung Adenocarcinoma in Non-Smoker: Unraveling Diagnostic Challenges with Immunohistochemistry and Atypical Marker Profiles Open
Title Advanced Lung Adenocarcinoma in a Non-Smoker: Unravelling Diagnostic Challenges with Immunohistochemistry and Atypical Marker Profiles Introduction Lung adenocarcinoma is the most common subtype of non-small cell lung cancer (NSCLC),…