Inositol
View article: The expanding landscape of inositol phosphate signaling network in land plants
The expanding landscape of inositol phosphate signaling network in land plants Open
The emergence of land plants from aquatic habitat over half a billion years ago marked a pivotal moment in Earth's history, profoundly altering both soil composition and atmospheric chemistry. This remarkable evolutionary transition was ac…
View article: The Ionic and Metabolic Response Mechanisms of Kochia scoparia in Response to Saline–Alkaline Stress
The Ionic and Metabolic Response Mechanisms of Kochia scoparia in Response to Saline–Alkaline Stress Open
Saline–alkaline stress is a critical environmental issue that limits plant growth and crop production. With the expansion of salinized land, investigating the response mechanisms of plants to salt–alkali stress is crucial. Integrated ionom…
View article: Hepatocyte‐Derived Extracellular Vesicles Deliver miR‐328‐3p to Trigger PP2A‐B56δ–Mediated p‐NLRP3 <sup>S295</sup> ‐Dependent Metaflammation in Macrophages upon Microcystin‐LR Exposure
Hepatocyte‐Derived Extracellular Vesicles Deliver miR‐328‐3p to Trigger PP2A‐B56δ–Mediated p‐NLRP3 <sup>S295</sup> ‐Dependent Metaflammation in Macrophages upon Microcystin‐LR Exposure Open
Microcystin‐LR (MC‐LR) exacerbates metabolic dysfunction‐associated steatotic liver disease (MASLD) by inducing histopathological damage and lipid metabolism disorders. Inducible hepatocyte‐derived extracellular vesicles (iHD‐EVs) released…
View article: Therapeutic targeting of endothelial calcium signaling accelerates the resolution of lung injury
Therapeutic targeting of endothelial calcium signaling accelerates the resolution of lung injury Open
Acute respiratory distress syndrome (ARDS) is a severe pulmonary disease characterized by acute, noncardiogenic pulmonary edema and hypoxemia leading to respiratory failure. It is induced by a diverse array of etiologies, including recent …
View article: Evaluating the Effects of Strategic Use of High Phytase Levels on Growth Performance and Carcass Characteristics of Late-Finishing Pigs Exposed to Limited Floor Space
Evaluating the Effects of Strategic Use of High Phytase Levels on Growth Performance and Carcass Characteristics of Late-Finishing Pigs Exposed to Limited Floor Space Open
This study evaluated the effects of high doses of phytase on the growth performance, carcass characteristics, and serum chemistry of late-finishing pigs housed under space-restricted conditions. Pigs (n = 375; 94.63 ± 0.61 kg) were randoml…
View article: JPT2/HN1L functions as an NAADP-binding protein in a cell type-specific manner
JPT2/HN1L functions as an NAADP-binding protein in a cell type-specific manner Open
Nicotinic acid adenine dinucleotide phosphate (NAADP) is a second messenger evoking Ca 2+ release from intracellular Ca 2+ stores by targeting several Ca 2+ release channels, including two-pore channels (TPC1/2), transient receptor potenti…
View article: Production of Archaeal Inositol Phospholipids in Engineered Saccharomyces cerevisiae
Production of Archaeal Inositol Phospholipids in Engineered Saccharomyces cerevisiae Open
Despite phospholipid backbone divergence between Archaea (ether-isoprenoid/glycerol-1-phosphate membranes) and Bacteria/Eukarya (ester-fatty acid/glycerol-3-phosphate membranes), known as the ‘lipid divide’, inositol headgroups are conserv…
View article: Acidocalcisome-like vacuoles constitute a feedback-controlled phosphate buffering system for the cytosol
Acidocalcisome-like vacuoles constitute a feedback-controlled phosphate buffering system for the cytosol Open
Cells experience strong variations in the consumption and availability of inorganic phosphate (Pi). Since Pi is an essential macronutrient but excess Pi has negative impacts on nucleotide hydrolysis and metabolism, its concentration must b…
View article: A minimum catalytic unit for synthesis of InsP6 and 5-PP-InsP5 in Arabidopsis
A minimum catalytic unit for synthesis of InsP6 and 5-PP-InsP5 in Arabidopsis Open
Inositol pyrophosphates, diphosphoinositol phosphates, are reported agents of phosphate homeostasis, disease resistance and hormone action in plants. Of the enzymes that have been shown to synthesize inositol pyrophophosphates, ITPK1 and V…
View article: A linear pathway for inositol pyrophosphate metabolism revealed by 18O labeling and model reduction
A linear pathway for inositol pyrophosphate metabolism revealed by 18O labeling and model reduction Open
The homeostasis of intracellular inorganic phosphate is essential for eukaryotic metabolism and is regulated by the INPHORS signalling pathway, which employs inositol pyrophosphates (IPPs) as key intermediary messengers. This study investi…
View article: FCRL1-mediated ERK inhibition through adapter functions of SHIP-1 2935
FCRL1-mediated ERK inhibition through adapter functions of SHIP-1 2935 Open
Description FCRL1 is a tyrosine-phosphorylated receptor expressed on B cells beginning at the immature phase. FCRL1 has been shown to potentiate B cell receptor-driven calcium signaling and is important for thymus-independent B cell respon…
View article: Complex sphingolipid metabolism impacts cell division and plasmodesmal development in the moss <i>Physcomitrium patens</i>
Complex sphingolipid metabolism impacts cell division and plasmodesmal development in the moss <i>Physcomitrium patens</i> Open
Developmental patterning and organ structure are elegantly simple in the moss Physcomitrium patens, which facilitates the cultivation and phenotypic characterization of severe mutant alleles. Essential membrane lipids, such as complex phos…
View article: Myo-inositol is a key regulator of avian metabolism: From mechanisms to seasonal behavior
Myo-inositol is a key regulator of avian metabolism: From mechanisms to seasonal behavior Open
Being naturally hyperglycemic and insulin insensitive, birds maintain plasma glucose levels twice as high as mammals of similar size. Recent evidence suggests that perturbation of myo-inositol (MI) plays a role in mammalian hyperglycemic r…
View article: SH2-mediated steric occlusion of the C2 domain regulates autoinhibition of SHIP1 inositol 5-phosphatase
SH2-mediated steric occlusion of the C2 domain regulates autoinhibition of SHIP1 inositol 5-phosphatase Open
The Src homology 2 (SH2) domain containing inositol polyphosphate 5-phosphatase 1 (SHIP1) is an immune cell specific enzyme that regulates phosphatidylinositol-(3,4,5)-trisphosphate signaling at the plasma membrane following receptor activ…
View article: Inositol metabolism as a broad-spectrum antiviral target
Inositol metabolism as a broad-spectrum antiviral target Open
Inositol plays many important roles in cellular processes through its various derivatives including phosphatidylinositol phosphates. Viruses use phosphatidylinositol phosphates for their replication in multiple processes including entry, f…
View article: The Use of Synaptic Extracellular Myo‐Inositol to Treat Developmental and Epileptic Encephalopathy
The Use of Synaptic Extracellular Myo‐Inositol to Treat Developmental and Epileptic Encephalopathy Open
Objective The developmental and epileptic encephalopathies (DEE) are associated with serious and lifelong neurological conditions and risk of early mortality. Here, we describe the chronic treatment of a boy with PLCB1 ‐related DEE with en…
View article: Milk phospholipids in correction of liver lipid profile in rats with tetracycline-induced fatty hepatosis
Milk phospholipids in correction of liver lipid profile in rats with tetracycline-induced fatty hepatosis Open
The research relevance is determined by the limited information on the molecular mechanisms of fatty hepatosis development in mammals and the identification of effective markers for the diagnosis of this pathology. Timely diagnosis of fatt…
View article: Formulation and Nutritional Evaluation of a Chickpea-based Functional Snack Enriched with Inositol for Diabetes Management
Formulation and Nutritional Evaluation of a Chickpea-based Functional Snack Enriched with Inositol for Diabetes Management Open
Background: Diabetes mellitus (DM) is a global health concern, making it necessary to develop functional foods to support blood sugar control. This study formulates and evaluates a chickpea-based functional snack enriched with myo-inositol…
View article: Inositol role in polycystic ovary syndrome (PCOS) and the awareness of Iraqi doctors regarding this role
Inositol role in polycystic ovary syndrome (PCOS) and the awareness of Iraqi doctors regarding this role Open
Polycystic ovary syndrome (PCOS) is a common endocrine disorder affecting females of reproductive age. The study aimed to evaluate the level of knowledge and awareness among Iraqi doctors regarding the potential role of inositol as a treat…
View article: Docosahexaenoic Acid Modulates Myo-Inositol and Myo-Inositol Biosynthetic Genes Expression: Implications for Bipolar Disorder
Docosahexaenoic Acid Modulates Myo-Inositol and Myo-Inositol Biosynthetic Genes Expression: Implications for Bipolar Disorder Open
Background: Bipolar disorder is a serious and recurrent mood disorder marked by alternating episodes of mania and depression, affecting an estimated 2.6% of the adult population and 3.9% across the lifetime. Although pharmacological mood s…
View article: Inositol (1,4,5)-trisphosphate 5-phosphatase promotes survival of uveal melanoma by regulating oncogenic G protein–driven calcium oscillations
Inositol (1,4,5)-trisphosphate 5-phosphatase promotes survival of uveal melanoma by regulating oncogenic G protein–driven calcium oscillations Open
Mutant constitutively active (CA) G protein α-subunits encoded by GNAQ or GNA11 (CA-GNAQ/11) drive uveal melanoma (UM), occur in uncommon subtypes of other cancers, and cause Sturge-Weber syndrome and other capillary malformations. CA-GNAQ…
View article: 2-aminoethoxydiphenylborane intervenes intracellular calcium signaling and attenuates myocardial ischemia-reperfusion injury in mice through ITPR1/MCU pathway
2-aminoethoxydiphenylborane intervenes intracellular calcium signaling and attenuates myocardial ischemia-reperfusion injury in mice through ITPR1/MCU pathway Open
View article: Dietary arginine silicate inositol supplementation supports egg quality and bone metabolism in late phase laying hens
Dietary arginine silicate inositol supplementation supports egg quality and bone metabolism in late phase laying hens Open
Dietary Arginine Silicate Inositol (ASI) was investigated as a nutritional intervention to enhance performance, egg characteristics, and bone quality of hens in late lay through mechanisms related to calcium metabolism. Lohmann LSL-Lite la…
View article: Anticancer evaluation of Myo-inositol through carbonic anhydrase IV inhibition activity: A spectroscopic, quantum computational, topological, drug-likeness and in-silico molecular docking studies
Anticancer evaluation of Myo-inositol through carbonic anhydrase IV inhibition activity: A spectroscopic, quantum computational, topological, drug-likeness and in-silico molecular docking studies Open
Numerous inositol isomers, particularly myo-inositol, are beneficial in the treatment of polycystic ovary syndrome, diabetes, anxiety, and depression. This study established that myo-inositol has the potential to be utilized as a carbonic …
View article: Correction to “the Role of Hsa‐miR‐193a‐5p as an Important Factor for Control of Inositol in Alopecia Areata”
Correction to “the Role of Hsa‐miR‐193a‐5p as an Important Factor for Control of Inositol in Alopecia Areata” Open
View article: TgA86 mouse model demonstrated potential markers for Bone Formation in Spondyloarthritis through ROS Detoxification, Folate Metabolism, and Inositol Phosphate Metabolism
TgA86 mouse model demonstrated potential markers for Bone Formation in Spondyloarthritis through ROS Detoxification, Folate Metabolism, and Inositol Phosphate Metabolism Open
Background Spondyloarthritis (SpA) represents a collection of inflammatory conditions distinguished by abnormal bone formation within the axial skeleton, ultimately resulting in ankylosis. The precise mechanisms responsible for this pathol…
View article: Soybean Inositol Polyphosphate 5‐Phosphatase 8 Confers Salt Tolerance by Reducing Sodium Influx Through Inositol 1,4,5‐Trisphosphate Signalling
Soybean Inositol Polyphosphate 5‐Phosphatase 8 Confers Salt Tolerance by Reducing Sodium Influx Through Inositol 1,4,5‐Trisphosphate Signalling Open
Evidence suggests that the metabolism of inositol and its derivatives may be involved in various biological processes including salt tolerance, but there has been limited understanding. Ectopic expression of Gs5PTase8 , an inositol polypho…
View article: STIM-IP3R crosstalk regulates migration of breast cancer cells
STIM-IP3R crosstalk regulates migration of breast cancer cells Open
Calcium ions (Ca2+) are crucial second messengers involved in numerous processes including tumorigenesis and cancer cell migration. Previous studies have shown that the endoplasmic reticulum (ER) Ca2+ sensors, stromal interaction molecules…
View article: Postharvest Application of Myo-Inositol Extends the Shelf-Life of Banana Fruit by Delaying Ethylene Biosynthesis and Improving Antioxidant Activity
Postharvest Application of Myo-Inositol Extends the Shelf-Life of Banana Fruit by Delaying Ethylene Biosynthesis and Improving Antioxidant Activity Open
Banana fruits are harvested and then undergo rapid ripening and senescence, sharply limiting their shelf-life and marketability. Myo-inositol (MI) is an important regulator in ethylene production and reactive oxygen species (ROS) accumulat…
View article: Chemical Synthesis and Structural Determination of the Inositol Glycan Head of Plant Sphingolipid GIPC in Brassicaceae
Chemical Synthesis and Structural Determination of the Inositol Glycan Head of Plant Sphingolipid GIPC in Brassicaceae Open
Glycosylinositol phosphoceramides (GIPCs), a major class of plant sphingolipids, are key components of the plasma membrane and play important roles in plants. These molecules consist of a ceramide 1‐phosphate tail attached to an inositol g…