Interstitial lung disease
View article: PO:14:207 | Nailfold capillaroscopy in systemic lupus erythematosus: microvascular alterations and their clinical relevance
PO:14:207 | Nailfold capillaroscopy in systemic lupus erythematosus: microvascular alterations and their clinical relevance Open
Background. Nailfold videocapillaroscopy (NVC) is a valuable tool for assessing microvascular abnormalities in connective tissue diseases. While well established in systemic sclerosis, its role in systemic lupus erythematosus (SLE) remains…
View article: Combining Pirfenidone With Mycophenolate Mofetil for Systemic Sclerosis–Related Interstitial Lung Disease (Scleroderma Lung Study <scp>III</scp> ): An Investigator‐Initiated, Multicenter, Randomized, Double‐Blind, Placebo‐Controlled Phase 2 Trial
Combining Pirfenidone With Mycophenolate Mofetil for Systemic Sclerosis–Related Interstitial Lung Disease (Scleroderma Lung Study <span>III</span> ): An Investigator‐Initiated, Multicenter, Randomized, Double‐Blind, Placebo‐Controlled Phase 2 Trial Open
Objective Mycophenolate mofetil (MMF) can stabilize or improve lung function in systemic sclerosis–related interstitial lung disease (SSc‐ILD). We hypothesized that combining MMF with pirfenidone (PFD) would produce a significantly more ra…
View article: Comparison of 1.7 mm and 1.9 mm Cryoprobes in Specimen Quality for Fibrotic Interstitial Lung Disease
Comparison of 1.7 mm and 1.9 mm Cryoprobes in Specimen Quality for Fibrotic Interstitial Lung Disease Open
View article: Rituximab-Induced Interstitial Lung Disease: A Possible Underestimated Complication—A Systematic Review
Rituximab-Induced Interstitial Lung Disease: A Possible Underestimated Complication—A Systematic Review Open
Background: Rituximab, a monoclonal antibody targeting CD20, has revolutionized the management of B-cell lymphoproliferative disorders and some immune conditions, significantly improving disease control and patient survival. Beyond its ind…
View article: PO:24:057 | Qualitative and quantitative analysis of nailfold videocapillaroscopy in patients with idiopathic inflammatory myopathies: focus on muscle histology
PO:24:057 | Qualitative and quantitative analysis of nailfold videocapillaroscopy in patients with idiopathic inflammatory myopathies: focus on muscle histology Open
Background. Idiopathic inflammatory myopathies (IIM) are a group of autoimmune diseases characterized by inflammation of the muscle with clinical manifestations such as skin rash, interstitial lung disease, heart involvement or arthritis. …
View article: Angioedema as a Presenting Feature of Systemic Lupus Erythematosus With Myositis and Vasculitis—Successfully Treated With Mycophenolate and Prednisolone
Angioedema as a Presenting Feature of Systemic Lupus Erythematosus With Myositis and Vasculitis—Successfully Treated With Mycophenolate and Prednisolone Open
Introduction Angioedema is a rare manifestation of systemic lupus erythematosus (SLE). Myositis and vasculitis are uncommon manifestations of SLE. The former being a harbinger and feature of the latter has not been reported. Method A case …
View article: PO:17:254 | Systemic lupus erythematosus with pulmonary involvement: clinical insights from an Albanian cohort
PO:17:254 | Systemic lupus erythematosus with pulmonary involvement: clinical insights from an Albanian cohort Open
Background. Systemic Lupus Erythematosus (SLE) is a chronic autoimmune disease that can significantly affect the lungs leading to irreversible damage, resulting in reduced life quality and varied mortality rates. It can impact all parts of…
View article: The benefits of a rapid diagnostic primary care circuit for interstitial lung disease
The benefits of a rapid diagnostic primary care circuit for interstitial lung disease Open
View article: Azacitidine in VEXAS: Up-Front Multidisciplinary Treatment or a Last Resort?
Azacitidine in VEXAS: Up-Front Multidisciplinary Treatment or a Last Resort? Open
VEXAS (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic) syndrome is a recently characterised adult-onset autoinflammatory disorder driven by acquired mutations in UBA1. We present the diagnostic and therapeutic journey of a 64-yea…
View article: Anti-CENP-A/B reactivity in samples exhibiting the centromere HEp-2 pattern is associated with a lower frequency of interstitial lung disease in limited cutaneous systemic sclerosis patients
Anti-CENP-A/B reactivity in samples exhibiting the centromere HEp-2 pattern is associated with a lower frequency of interstitial lung disease in limited cutaneous systemic sclerosis patients Open
Introduction: Anti-centromere antibodies are associated with limited cutaneous systemic sclerosis (lcSSc) anda more favorable prognosis. The centromere HEp-2 pattern (AC-3) suggests the presence of antibodies againstCENP antigens, mainly C…
View article: PO:25:073 | Pulmonary involvement and progressive interstitial lung disease in anti-synthetase syndrome: a single-center retrospective study
PO:25:073 | Pulmonary involvement and progressive interstitial lung disease in anti-synthetase syndrome: a single-center retrospective study Open
Background. Anti-synthetase syndrome (ASS) is a systemic autoimmune disease frequently associated with lung involvement. This single-center retrospective study aimed to longitudinally assess the clinical and instrumental evolution of patie…
View article: PO:22:039 | A rare form of interstitial lung disease: granulomatous and lymphocytic interstitial lung disease
PO:22:039 | A rare form of interstitial lung disease: granulomatous and lymphocytic interstitial lung disease Open
Background. In August 2024, a 48-year-old man presented to the emergency department with worsening dyspnea and oxygen desaturation. His medical history was remarkable only for IgA deficiency, but he reported recurrent episodes of pneumonia…
View article: Rheumatoid arthritis-associated interstitial lung disease: clinical predictive model and external validation
Rheumatoid arthritis-associated interstitial lung disease: clinical predictive model and external validation Open
View article: PO:33:197 | Systemic sclerosis and endothelial dysfunction: the passive leg movement technique in the assessment of no-mediated vascular impairment
PO:33:197 | Systemic sclerosis and endothelial dysfunction: the passive leg movement technique in the assessment of no-mediated vascular impairment Open
Objectives: To evaluate nitric oxide (NO)-mediated vascular dysfunction in patients with Systemic Sclerosis (SSc) compared to age- and sex-matched healthy controls through passive leg movement (PLM). Materials and Methods: Twenty-one patie…
View article: PO:24:066 | Antibody profile in myositis and early risk of interstitial lung disease: clinical and laboratory correlations in patients with suspected rheumatologic disease
PO:24:066 | Antibody profile in myositis and early risk of interstitial lung disease: clinical and laboratory correlations in patients with suspected rheumatologic disease Open
Background. Interstitial lung disease (ILD) is a frequent comorbidity not only in idiopathic inflammatory myopathies (IIM) but also in other rheumatologic disorders such as Sjögren’s syndrome, systemic sclerosis, and rheumatoid arthritis. …
View article: Incidental pulmonary findings on CT in daily practice: the nodule and the interstitial lung abnormalities - what’s old, what’s new
Incidental pulmonary findings on CT in daily practice: the nodule and the interstitial lung abnormalities - what’s old, what’s new Open
The growing use of computed tomography (CT) in clinical practice has led to an increase in incidental pulmonary findings, with nodules being among the most commonly encountered. Managing these nodules remains a significant challenge in cli…
View article: Resveratrol attenuates pulmonary fibrosis by inhibiting alveolar epithelial senescence via targeting SASP-related proteins: an integrated bioinformatics-experimental study
Resveratrol attenuates pulmonary fibrosis by inhibiting alveolar epithelial senescence via targeting SASP-related proteins: an integrated bioinformatics-experimental study Open
Background Pulmonary fibrosis (PF) is a progressive and fatal interstitial lung disease with limited treatment options. Premature senescence of alveolar epithelial type II cells (AT2 cells) plays a critical role in PF pathogenesis. This st…
View article: Die Inkontinenz-assoziierte Dermatitis (IAD) als pflegesensitives Patientenergebnis am Universitätsklinikum Freiburg – aktueller Stand
Die Inkontinenz-assoziierte Dermatitis (IAD) als pflegesensitives Patientenergebnis am Universitätsklinikum Freiburg – aktueller Stand Open
View article: PO:25:082 | Progressive interstitial lung disease secondary to Sjögren's disease in a patient with inclusion body myositis complicated by dysphagia: a multidisciplinary approach and therapeutic challenges
PO:25:082 | Progressive interstitial lung disease secondary to Sjögren's disease in a patient with inclusion body myositis complicated by dysphagia: a multidisciplinary approach and therapeutic challenges Open
Background. Inclusion Body Myositis (IBM) is a rare idiopathic inflammatory myopathy, characterized by an insidious onset with progressive muscle weakness and dysphagia. While its association with Sjögren’s syndrome (pSS) has been reported…
View article: ANTI-RO ANTIBODY POSITIVITY AND ITS RELATIONSHIP WITH PULMONARY INVOLVEMENT IN SYSTEMIC SCLEROSIS
ANTI-RO ANTIBODY POSITIVITY AND ITS RELATIONSHIP WITH PULMONARY INVOLVEMENT IN SYSTEMIC SCLEROSIS Open
View article: Acute Exacerbation of Interstitial Lung Disease: Early Diagnosis and Treatment
Acute Exacerbation of Interstitial Lung Disease: Early Diagnosis and Treatment Open
Diagnosis and treatment of acute exacerbation of interstitial lung disease (AE-ILD) continue to be challenging. The annual incidence of AE in idiopathic pulmonary fibrosis (IPF) is 5% to 15%, with an in-hospital mortality exceeding 50%. Si…
View article: Genetic susceptibility to interstitial lung disease: a case of ABCA3 gene mutation and multi-pathogen infection
Genetic susceptibility to interstitial lung disease: a case of ABCA3 gene mutation and multi-pathogen infection Open
View article: DiseaseOntology/HumanDiseaseOntology: DO November 2025 Release
DiseaseOntology/HumanDiseaseOntology: DO November 2025 Release Open
This release of the Human Disease Ontology includes 11,997 disease classes, 9,713 with textual definitions (81.0%). Translation files now include 11,824 labels (98.6%), 11,483 synonyms (59.1%), and 6,409 definitions (66.0%) in Spanish. New…
View article: Supplementary Table S1 from Phase II Study of Docetaxel and Trametinib in Patients with <i>KRAS</i> Mutation Positive Recurrent Non–Small Cell Lung Cancer (NSCLC; SWOG S1507, NCT-02642042)
Supplementary Table S1 from Phase II Study of Docetaxel and Trametinib in Patients with <i>KRAS</i> Mutation Positive Recurrent Non–Small Cell Lung Cancer (NSCLC; SWOG S1507, NCT-02642042) Open
Supplementary Table 1. Dose Modifications for Docetaxel and Trametinib
View article: Comparison of sedated respiratory-gated computed tomography to anesthetized inspiratory-expiratory breath-hold computed tomography in dogs with respiratory disease
Comparison of sedated respiratory-gated computed tomography to anesthetized inspiratory-expiratory breath-hold computed tomography in dogs with respiratory disease Open
Objective To determine the diagnostic accuracy of sedated respiratory-gated (RG) CT as a minimally invasive surrogate for anesthetized, ventilator-assisted inspiratory-expiratory breath-hold (I:E-BH) CT scans by being able to identify CT l…
View article: Hemophagocytic Lymphohistiocytosis in a Pediatric Lung Transplant Recipient
Hemophagocytic Lymphohistiocytosis in a Pediatric Lung Transplant Recipient Open
Background Hemophagocytic lymphohistiocytosis (HLH) is a rare complication of solid organ transplantation and is a syndrome of systemic hyperinflammation secondary to dysregulation of the inflammatory response, primarily involving lymphocy…
View article: CT Imaging Features of Pulmonary Sarcoidosis: Typical and Atypical Radiological Features and Their Differential Diagnosis
CT Imaging Features of Pulmonary Sarcoidosis: Typical and Atypical Radiological Features and Their Differential Diagnosis Open
Sarcoidosis is a chronic, idiopathic, multisystemic inflammatory disease characterized by non-caseating granulomas, most commonly affecting the lungs and mediastinal lymph nodes. Radiological imaging plays a fundamental role in the diagnos…
View article: Relationship between anxiety and depression, dyspnea severity, and pulmonary function in connective tissue disease-associated interstitial lung disease
Relationship between anxiety and depression, dyspnea severity, and pulmonary function in connective tissue disease-associated interstitial lung disease Open
BACKGROUND Patients with connective tissue disease-associated interstitial lung disease (CTD-ILD) experience not only progressive respiratory impairment but also a significant psychological burden. The prevalence and impact of anxiety and …
View article: Medication-induced lung disease in children
Medication-induced lung disease in children Open
Medication-induced lung disease is rare in children but can be associated with considerable morbidity and mortality and can alter treatment regimens for children with a variety of conditions. Medication-induced lung disease tends to occur …
View article: When Dyspnea Is More Than Pneumonia: Interwoven Mechanisms Of Autoimmune Multiorgan Disease In An Adolescent—A Case Report
When Dyspnea Is More Than Pneumonia: Interwoven Mechanisms Of Autoimmune Multiorgan Disease In An Adolescent—A Case Report Open
Dyspnea in adolescents is often underestimated as a simple respiratory infection, yet it may represent the fairst sign of complex autoimmune multiorgan disease. This report highlights the autoimmune mechanisms underlying dyspnea to promote…