Histiocytic sarcoma
View article: Primary pulmonary histiocytic sarcoma with nodal and esophageal metastasis in a dog—imaging and anatomopathological aspects
Primary pulmonary histiocytic sarcoma with nodal and esophageal metastasis in a dog—imaging and anatomopathological aspects Open
The involvement of cranial mediastinal and tracheobronchial lymph nodes, as well as the presence of pleural effusion, are common features associated with HS. However, the occurrence of esophageal metastases is considered uncommon, highligh…
View article: Characterization of host immune cell infiltrate in human CAR T cell-mediated xenogeneic graft versus host disease in NSG mice
Characterization of host immune cell infiltrate in human CAR T cell-mediated xenogeneic graft versus host disease in NSG mice Open
Chimeric antigen receptor (CAR) T cells are revolutionary cancer therapies that are Food and Drug Administration-approved for hematologic malignancies and under investigation for solid tumors. The use of allogeneic over autologous CAR T ce…
View article: Primary central nervous system histiocytic sarcoma: a systematic review of clinical presentations, radiologic findings, treatment strategies, and prognostic outcomes
Primary central nervous system histiocytic sarcoma: a systematic review of clinical presentations, radiologic findings, treatment strategies, and prognostic outcomes Open
Background Primary central nervous system histiocytic sarcoma (PCNSHS) is a rare malignant neoplasm of histiocytic origin. Its clinical features, optimal management, and outcomes remain poorly defined. Methods We systematically reviewed Pu…
View article: 341 Case Report: Clonally Related Non-Langerhans Cell Histiocytic Neoplasm arising post-allogeneic transplant in a patient with acute myeloid leukemia
341 Case Report: Clonally Related Non-Langerhans Cell Histiocytic Neoplasm arising post-allogeneic transplant in a patient with acute myeloid leukemia Open
Introduction/Objective Extramedullary involvement by myeloid precursor cells - known as myeloid sarcoma -is a well-recognized manifestation of myeloid neoplasms, typically resulting from leukemic cells migrating through circulation and inf…
View article: 509 Histiocytic Sarcoma with IGH::BCL2 Fusion: A Rare Case of Transdifferentiation from Follicular Lymphoma
509 Histiocytic Sarcoma with IGH::BCL2 Fusion: A Rare Case of Transdifferentiation from Follicular Lymphoma Open
Introduction/Objective Histiocytic sarcoma (HS) is a rare hematolymphoid malignancy, accounting for less than 1% of all hematologic neoplasms. While most cases arise de novo, rare instances of HS have been reported as transformations from …
View article: 202 Cutaneous Histiocytic Sarcoma with Predominant Spindle Cell Morphology
202 Cutaneous Histiocytic Sarcoma with Predominant Spindle Cell Morphology Open
Introduction/Objective Extra-nodal histiocytic sarcoma is an extremely rare neoplasm that has mostly polygonal cell morphology. It can remain localized to a single organ or become disseminated. Histiocytic sarcoma is not a true mesenchymal…
View article: Histiocytic Sarcoma: A Review and Update
Histiocytic Sarcoma: A Review and Update Open
Histiocytic sarcoma (HS) is an ultra-rare hematopoietic neoplasm that frequently occurs in extranodal sites of adults. Clinically, HS demonstrates aggressive behavior and can arise de novo or in association with other hematological neoplas…
View article: An intestinal histiocytic sarcoma in a collared peccary (Pecari tajacu): a case report
An intestinal histiocytic sarcoma in a collared peccary (Pecari tajacu): a case report Open
Background Research on cancer in wild animals provides important insights into the mechanisms of carcinogenesis. Histiocytic sarcomas comprise a rare malignant macrophage-dendritic cell lineage neoplasm in wildlife. This study reports a ca…
View article: A rare case of adolescent Histiocytic Sarcoma
A rare case of adolescent Histiocytic Sarcoma Open
Histiocytic sarcoma is a rare haematopoietic malignancy with an aggressive nature and poor prognosis. It occurs infrequently in children and adolescents, with only a few cases reported worldwide.A well 14-year-old male patient presented wi…
View article: Pulmonary Mass as the First Clinical Manifestation of Histiocytic Sarcoma with Multi-Organ Involvement: A Case Report and Review of the Literature
Pulmonary Mass as the First Clinical Manifestation of Histiocytic Sarcoma with Multi-Organ Involvement: A Case Report and Review of the Literature Open
Histiocytic sarcoma is a malignant neoplasm with cells showing morphologic and immunohistochemical features of histiocytes. The lung and stomach are rare sites of involvement, and few have been reported in the existing literature. We repor…
View article: Splenic histiocytic sarcoma: Disease progression from the perspective of pathophysiology
Splenic histiocytic sarcoma: Disease progression from the perspective of pathophysiology Open
Splenic histiocytic sarcoma (SHS) is a rare, aggressive hematological malignancy with unclear progression and management. Our case illustrates the progression and pathophysiological processes of SHS and provides key data for the diagnosis,…
View article: Co-occurrence of clonally related follicular lymphoma and histiocytic sarcoma
Co-occurrence of clonally related follicular lymphoma and histiocytic sarcoma Open
View article: Primary Cutaneous Histiocytic Sarcoma: A Rare Case
Primary Cutaneous Histiocytic Sarcoma: A Rare Case Open
Histiocytic sarcoma is a rare malignancy composed of neoplastic cells that resemble macrophages in morphology and immunoprofile. It manifests in lymph nodes or extranodal sites, with the majority occurring in the gastrointestinal tract, ce…
View article: Disseminated Histiocytic Sarcoma in a Japanese Macaque (<scp><i>Macaca fuscata</i></scp>)
Disseminated Histiocytic Sarcoma in a Japanese Macaque (<span><i>Macaca fuscata</i></span>) Open
Histiocytic sarcomas are rare in humans and primates. Particularly, only a few examples in nonhuman primates have been reported. This is the first report of histiocytic sarcoma in Macaca fuscata . The final diagnosis was made using immunoh…
View article: Nodal histiocytic sarcoma mimicking metastatic carcinoma, a challenging diagnosis – Case report of an extremely rare hematolymphoid neoplasm with recent updates
Nodal histiocytic sarcoma mimicking metastatic carcinoma, a challenging diagnosis – Case report of an extremely rare hematolymphoid neoplasm with recent updates Open
Histiocytic sarcoma (HS), a rare malignant neoplasm of hematolymphoid origin, belongs to the World Health Organization (WHO) classification of histiocytic and dendritic cell neoplasms. This rare aggressive malignancy occurs predominantly i…
View article: Rnaseq transcriptome analysis in response to different stressors in canine histiocytic sarcoma cells
Rnaseq transcriptome analysis in response to different stressors in canine histiocytic sarcoma cells Open
View article: Difficulties of Differentiating Primary Histiocytic Sarcoma of the Central Nervous System from Glioblastoma in Older Patients: Methylation Analysis and Review of the Literature
Difficulties of Differentiating Primary Histiocytic Sarcoma of the Central Nervous System from Glioblastoma in Older Patients: Methylation Analysis and Review of the Literature Open
Primary histiocytic sarcoma of the central nervous system is an extremely rare malignancy, with only 43 cases reported to date. It often presents diagnostic challenges due to its rarity and similarities with other central nervous system tu…
View article: Current Perspectives on Mesenchymal Dendritic Cell Neoplasms of Lymphoid Tissue: Insights into Ontogeny, Updates on Classification, and Clinicopathologic Characteristics
Current Perspectives on Mesenchymal Dendritic Cell Neoplasms of Lymphoid Tissue: Insights into Ontogeny, Updates on Classification, and Clinicopathologic Characteristics Open
Mesenchymal dendritic cell neoplasms represent a distinct category of hematologic malignancies that challenge traditional classifications of histiocytic and classical dendritic/Langerhans cell neoplasms. Historically grouped under the broa…
View article: Molecular Classification Based on the Gene Expression Profiles in Canine Histiocytic Sarcoma Cells
Molecular Classification Based on the Gene Expression Profiles in Canine Histiocytic Sarcoma Cells Open
The molecular abnormalities of canine histiocytic sarcoma (CHS) remain to be elucidated. We previously revealed that the sensitivities to dasatinib and trametinib were significantly various among CHS cell lines, indicating the differences …
View article: Transdifferentiation of Multiple Myeloma into Histiocytic Sarcoma: Case report of a highly unusual phenomenon
Transdifferentiation of Multiple Myeloma into Histiocytic Sarcoma: Case report of a highly unusual phenomenon Open
Introduction Transdifferentiation of multiple myeloma (MM) into histiocytic sarcoma (HS) is exceptionally rare. We report a unique case, confirming this phenomenon through cytogenetics and molecular analyses. Case Presentation A 46-year-ol…
View article: Suspected calcitriol‐mediated hypercalcaemia and postmortem diagnosis of histiocytic sarcoma in a dog
Suspected calcitriol‐mediated hypercalcaemia and postmortem diagnosis of histiocytic sarcoma in a dog Open
This report describes a case of refractory ionised hypercalcaemia, of 12 months duration, in an 11‐year‐old, male, neutered beagle diagnosed with metastatic histiocytic sarcoma at postmortem examination. In this case, the parathyroid hormo…
View article: Extensive Bone Marrow Involvement by BRAF<sup>V660E</sup>-Mutated Bi-Phenotypic Erdheim-Chester Neoplasm/Rosai-Dorfman Disease (Mixed Histiocytic Neoplasm) with Atypical Histological Features and Fulminant Hemophagocytosis
Extensive Bone Marrow Involvement by BRAF<sup>V660E</sup>-Mutated Bi-Phenotypic Erdheim-Chester Neoplasm/Rosai-Dorfman Disease (Mixed Histiocytic Neoplasm) with Atypical Histological Features and Fulminant Hemophagocytosis Open
Background: Erdheim-Chester disease (ECD) is a recently recognized clonal hematopoietic neoplasm characterized by activating alterations in the MAPK pathway. It involves multi-organ accumulation of abnormal histiocytes, leading to nonspeci…
View article: Uncommon but intriguing: A pediatric primary histiocytic sarcoma case—Clinical insights and literature review
Uncommon but intriguing: A pediatric primary histiocytic sarcoma case—Clinical insights and literature review Open
Histiocytic sarcoma (HS) is a rare and aggressive malignancy derived from histiocytes, accounting for less than 1% of hematopoietic neoplasms. Pediatric soft tissue involvement is exceptionally rare, with limited data to guide management. …
View article: Histiocytic sarcoma involving multiple abdominal sites: A rare case with KRAS mutation and response to ICE chemotherapy
Histiocytic sarcoma involving multiple abdominal sites: A rare case with KRAS mutation and response to ICE chemotherapy Open
Histiocytic sarcoma (HS) is a rare and aggressive malignant neoplasm from histiocytic cells. This case report describes a 52-year-old male with HS involving multiple abdominal sites, diagnosed through imaging, histopathology, and immunohis…
View article: CD86 is linked to apoptosis in canine histiocytic sarcoma
CD86 is linked to apoptosis in canine histiocytic sarcoma Open
Immune checkpoints are critical for the regulation of tumor growth and regression. Recently an effect of CD80 and CD86 on tumor regression in canine cutaneous histiocytoma has been described. Further, the expression of MX dynamin like GTPa…
View article: Pulmonary histiocytic sarcoma in an Indian crested porcupine ( <i>Hystrix indica</i> ) with suspected dissemination
Pulmonary histiocytic sarcoma in an Indian crested porcupine ( <i>Hystrix indica</i> ) with suspected dissemination Open
An 11‐year‐old female Indian crested porcupine ( Hystrix indica ) presented with cough in December 2022. Initial diagnostic testing revealed neutrophilia, and radiographs revealed a bronchial pattern as well as significant enlargement of t…
View article: Histiocytic Sarcoma: An Unusual Tumor Posing Diagnostic Challenge
Histiocytic Sarcoma: An Unusual Tumor Posing Diagnostic Challenge Open
Histiocytic sarcoma (HS) is an unusual but aggressive tumor arising from non-Langerhans histiocytic cells of the immune system. It shows highly pleomorphic spindle-shaped cells resembling other sarcomas, posing the diagnostic difficulty. T…
View article: Diagnostic challenges of primary central nervous system histiocytic sarcoma: case report and literature review
Diagnostic challenges of primary central nervous system histiocytic sarcoma: case report and literature review Open
Histiocytic sarcoma (HS) is a rare malignant tumor that primarily affects the lymph nodes, intestines, skin, and soft tissues. Primary central nervous system histiocytic sarcoma (PCNSHS) is even rarer. We present the case of a 50-year-old …
View article: Cutaneous histiocytic sarcoma arising from soft tissue filler injections: a case report
Cutaneous histiocytic sarcoma arising from soft tissue filler injections: a case report Open
Background The administration of soft-tissue fillers is a popular aesthetic procedure. Nonetheless, it can result in complications such as foreign-body reactions, infections, skin necrosis, granulomas, and even malignant transformation. Th…
View article: Histiocytic sarcoma of the suprasellar region: illustrative case
Histiocytic sarcoma of the suprasellar region: illustrative case Open
BACKGROUND Histiocytic sarcoma (HS) is a rare malignant tumor of histiocytic origin, both morphologically and immunohistologically. Herein, the authors report the case of a suprasellar tumor confirmed as HS after craniotomy, which presente…