Hypereosinophilic syndrome
View article: PO:22:033 | Unraveling VEXAS syndrome: when skin manifestations and monoclonal gammopathy precede hematological myeloid alterations
PO:22:033 | Unraveling VEXAS syndrome: when skin manifestations and monoclonal gammopathy precede hematological myeloid alterations Open
Background. VEXAS (Vacuoles, Enzyme E1, X-linked, Autoinflammatory, Somatic) syndrome is a rare adult disease caused by somatic mutations in the UBA1 gene within hematopoietic stem cells (1). These mutations compromise the ubiquitin-activa…
View article: Bullous Wells’ Syndrome: Case Report and Systematic Review
Bullous Wells’ Syndrome: Case Report and Systematic Review Open
Background/Objectives: Wells’ syndrome (WS) is an uncommon cutaneous disease with unknown etiology. Itchy bullous lesions and erythematous plaques characterize the bullous WS (BWS), a rare subtype of the syndrome. We describe the case of a…
View article: New issues in the focus of biological therapy in the treatment of rhinosinusitis with nasal polyps and T2-associated inflammatory diseases: A review
New issues in the focus of biological therapy in the treatment of rhinosinusitis with nasal polyps and T2-associated inflammatory diseases: A review Open
Peripheral blood eosinophils are now seen as an important marker in determining the leading endotype of the inflammatory response in patients with severe uncontrolled rhinosinusitis polyposa. The T2-endotype of inflammation is dominant in …
View article: Mepolizumab for hypereosinophilic syndrome: effectiveness and safety from real-world evidence
Mepolizumab for hypereosinophilic syndrome: effectiveness and safety from real-world evidence Open
Hypereosinophilic syndrome (HES) is a rare condition characterized by elevated eosinophil levels and related symptoms of eosinophil-mediated organ damage. We reviewed the effectiveness and safety of mepolizumab for the treatment of HES. A …
View article: Non-atherosclerotic myocardial infarction in hypereosinophilic syndrome: emerging insights and therapeutic approaches
Non-atherosclerotic myocardial infarction in hypereosinophilic syndrome: emerging insights and therapeutic approaches Open
Hypereosinophilic syndrome (HES) is a heterogeneous disorder characterised by persistent, abnormal eosinophil elevation in blood and tissues, with multisystem involvement. Cardiac manifestations are frequent in HES and significantly worsen…
View article: Brief report: Assessing content validity of the PROMIS Short Form v1.0 - Fatigue 7a in adults with hypereosinophilic syndrome
Brief report: Assessing content validity of the PROMIS Short Form v1.0 - Fatigue 7a in adults with hypereosinophilic syndrome Open
View article: Hypereosinophilic Syndrome Masquerading as a Dialyzer Reaction: A Great Mimicker
Hypereosinophilic Syndrome Masquerading as a Dialyzer Reaction: A Great Mimicker Open
View article: Idiopathic hypereosinophilic syndrome: Potential pathologic somatic gene variants identified by exome sequencing
Idiopathic hypereosinophilic syndrome: Potential pathologic somatic gene variants identified by exome sequencing Open
Several somatic mutations were identified in our cohort of patients with idiopathic HES. Increasing the number of patients through collaborative efforts and pursuing functional testing of these variants will help elucidate the importance o…
View article: P93 | Hypereosinophilic syndrome and novel eosinophil-depleting therapies
P93 | Hypereosinophilic syndrome and novel eosinophil-depleting therapies Open
Premises: Hypereosinophilic syndrome (HES) is a rare systemic inflammatory disorder characterized by an elevated eosinophil count and a heterogeneous clinical presentation. Conventional treatments may have significant dose-limiting side ef…
View article: Idiopathic Hypereosinophilic Syndrome Presenting As Eosinophilic Ascites and Pleural Effusion in an Elderly Male: A Rare Clinical Manifestation
Idiopathic Hypereosinophilic Syndrome Presenting As Eosinophilic Ascites and Pleural Effusion in an Elderly Male: A Rare Clinical Manifestation Open
Hypereosinophilic syndrome (HES) is a rare disorder marked by sustained blood eosinophilia and associated tissue or organ damage in the absence of a secondary identifiable cause. Eosinophilic ascites and pleural effusion are extremely rare…
View article: Hypereosinophilic syndrome associated with idiopathic eosinophilic vasculitis
Hypereosinophilic syndrome associated with idiopathic eosinophilic vasculitis Open
Hypereosinophilic syndrome (HES) is a complex heterogenous syndrome associated with hypereosinophilia and end organ involvement. A 46-year-old woman presented with swelling of the upper and lower limbs, neck and face, with shortness of bre…
View article: Case Report: Idiopathic hypereosinophilic syndrome presenting with gastrointestinal involvement mimicking IBD: a diagnostic challenge
Case Report: Idiopathic hypereosinophilic syndrome presenting with gastrointestinal involvement mimicking IBD: a diagnostic challenge Open
Background Idiopathic hypereosinophilic syndrome (iHES) is a rare hematologic condition characterized by persistent, unexplained eosinophilia and organ involvement. Its diagnosis is challenging due to overlapping features with other eosino…
View article: A Case Report on Eosinophilic Hepatitis with Hypereosinophilic Syndrome
A Case Report on Eosinophilic Hepatitis with Hypereosinophilic Syndrome Open
Eosinophilic hepatitis could be labelled as one of the rarest cause of acute hepatitis. It is itself a part of another rare disorder called hypereosinophilic syndrome (HES), which constitute a hetergenous group of disorders, defined as per…
View article: Loeffler’s endocarditis with hypereosinophilic syndrome – a rare case study report
Loeffler’s endocarditis with hypereosinophilic syndrome – a rare case study report Open
This case report describes the clinical presentation of Loeffler’s syndrome in a 50-year-old male non-diabetic and non-hypertensive who presented with complaints of pedal edema and breathlessness, signifying New York Heart Association III …
View article: Development and implementation of Phleos, a web-based tool for the data collection on Hypereosinophilic syndrome: the Italian Network on HES (INHES) study protocol
Development and implementation of Phleos, a web-based tool for the data collection on Hypereosinophilic syndrome: the Italian Network on HES (INHES) study protocol Open
Hypereosinophilic syndrome (HES) is a heterogeneous group of disorders characterised by persistent hypereosinophilia associated with organ damage. Due to its rarity and heterogeneity in its clinical presentation, HES remains underdiagnosed…
View article: [Efficacy and survival outcomes of patients with lymphocytic variant hypereosinophilic syndrome].
[Efficacy and survival outcomes of patients with lymphocytic variant hypereosinophilic syndrome]. Open
Objective: To analyze the clinical characteristics, therapeutic responses, and survival outcomes of patients with lymphocytic variant hypereosinophilic syndrome (L-HES) . Methods: We retrospectively reviewed clinical data fro…
View article: Hypereosinophilic Syndrome in a Patient With Cystic Fibrosis: A Rare Case of Cardiac Involvement and Response to Mepolizumab
Hypereosinophilic Syndrome in a Patient With Cystic Fibrosis: A Rare Case of Cardiac Involvement and Response to Mepolizumab Open
Hypereosinophilic syndrome (HES) is a rare condition characterized by persistent eosinophilia (eosinophil count ≥1.5 × 109/L) and end-organ damage in the absence of an identifiable cause. Cardiac involvement is common and may le…
View article: Clinical and immunological biomarkers in hypereosinophilic syndrome: the second step after diagnostic algorithms
Clinical and immunological biomarkers in hypereosinophilic syndrome: the second step after diagnostic algorithms Open
Background Idiopathic hypereosinophilic syndrome currently represents a major unmet need for all medical specialties dealing with this disease. Markers capable of characterising the wide variability of its clinical presentation are current…
View article: Hypereosinophilic Syndrome With Sialadenitis and Orbital Inflammation: A Case Report
Hypereosinophilic Syndrome With Sialadenitis and Orbital Inflammation: A Case Report Open
View article: An Uncommon Case of Non‐Specific Interstitial Pneumonia (<scp>NSIP</scp>) Associated With Idiopathic Hypereosinophilic Syndrome (<scp>HES</scp>) Reversed by Mepolizumab
An Uncommon Case of Non‐Specific Interstitial Pneumonia (<span>NSIP</span>) Associated With Idiopathic Hypereosinophilic Syndrome (<span>HES</span>) Reversed by Mepolizumab Open
Hypereosinophilic Syndrome ( HES ) represents a heterogeneous and complex group of disorders characterised by persistent blood and tissue eosinophilia, leading to progressive tissue damage and organ dysfunction. This spectrum includes both…
View article: BI36 A case study of hypereosinophilic syndrome in a patient with atopic dermatitis on dupilumab therapy and <i>Strongyloides</i> infection
BI36 A case study of hypereosinophilic syndrome in a patient with atopic dermatitis on dupilumab therapy and <i>Strongyloides</i> infection Open
A 33-year-old British Bangladeshi man with a lifelong history of moderate-to-severe atopic dermatitis presented to a dermatology clinic. He had an Eczema Area and Severity Index score of 17.6 and a Dermatology Life Quality Index score of 1…
View article: Primary care physicians play a crucial role in diagnosing and managing rare eosinophilic diseases: HES and EGPA
Primary care physicians play a crucial role in diagnosing and managing rare eosinophilic diseases: HES and EGPA Open
Hypereosinophilic syndrome (HES) and eosinophilic granulomatosis with polyangiitis (EGPA) are chronic eosinophilic diseases with serious multisystem manifestations. Patients with HES or EGPA often fail to receive a timely diagnosis, and wh…
View article: Idiopathic hypereosinophilic syndrome presenting with eosinophilic pleural and pericardial effusions: A case report
Idiopathic hypereosinophilic syndrome presenting with eosinophilic pleural and pericardial effusions: A case report Open
View article: High Disease Burden and Oral Corticosteroid Use in Patients with Hypereosinophilic Syndrome and Eosinophilic Granulomatosis with Polyangiitis: Country-Level Insights into Real-World Management in Europe
High Disease Burden and Oral Corticosteroid Use in Patients with Hypereosinophilic Syndrome and Eosinophilic Granulomatosis with Polyangiitis: Country-Level Insights into Real-World Management in Europe Open
Objectives: To analyze variations in patient characteristics, treatment patterns, clinical manifestations, clinical outcomes (i.e., response, flares and flare-free survival in HES; remission, relapses and relapse-free survival in EGPA; and…
View article: The Hypereosinophilic Syndrome: About 2 Cases
The Hypereosinophilic Syndrome: About 2 Cases Open
Hypereosinophilia syndrome is a group of rare diseases characterized by persistent blood eosinophilia (eosinophil count > 1.5 G/L for more than 6 months) associated with organ damage due to infiltration or degranulation of eosinophils. The…
View article: Coronary Artery Spasm as a Rare Manifestation of Hypereosinophilic Syndrome: A Case Report
Coronary Artery Spasm as a Rare Manifestation of Hypereosinophilic Syndrome: A Case Report Open
Hypereosinophilic syndrome (HES) is a rare hematologic disorder characterized by persistently elevated eosinophil counts, leading to organ involvement. While eosinophilic myocarditis and endocarditis are common manifestations, coronary art…
View article: Considerations for enhancing dupilumab research in hypereosinophilic syndromes
Considerations for enhancing dupilumab research in hypereosinophilic syndromes Open
View article: Reply to “Considerations for enhancing dupilumab research in hypereosinophilic syndromes”
Reply to “Considerations for enhancing dupilumab research in hypereosinophilic syndromes” Open
View article: Type 2 Autoimmune Hepatitis in an Older Man Receiving Steroid Therapy for Hypereosinophilic Syndrome
Type 2 Autoimmune Hepatitis in an Older Man Receiving Steroid Therapy for Hypereosinophilic Syndrome Open
View article: Native Aortic Valve Thrombosis: A Rare Presentation in Idiopathic Hypereosinophilic Syndrome
Native Aortic Valve Thrombosis: A Rare Presentation in Idiopathic Hypereosinophilic Syndrome Open
Persistently high-raised eosinophils are the hallmark of the rare heterogeneous group of illnesses known as idiopathic hypereosinophilic syndrome (HES). Eosinophil-mediated multiorgan damage is often the result of chronic illness. Although…