Anxiolytic
View article: "ROLE OF BIOACTIVE COMPOUNDS IN REGULATING SLEEP": MECHANISM AND CLINICAL EVIDANCE
"ROLE OF BIOACTIVE COMPOUNDS IN REGULATING SLEEP": MECHANISM AND CLINICAL EVIDANCE Open
Sleep is a vital physiological process essential for cognitive performance, metabolic regulation, and overall health. Increasing evidence indicates that various bioactive compounds—including polyphenols, alkaloids, terpenes, amino acid der…
View article: "ROLE OF BIOACTIVE COMPOUNDS IN REGULATING SLEEP": MECHANISM AND CLINICAL EVIDANCE
"ROLE OF BIOACTIVE COMPOUNDS IN REGULATING SLEEP": MECHANISM AND CLINICAL EVIDANCE Open
Sleep is a vital physiological process essential for cognitive performance, metabolic regulation, and overall health. Increasing evidence indicates that various bioactive compounds—including polyphenols, alkaloids, terpenes, amino ac…
View article: EXTRACTION, PHYTOCHEMICAL SCREENING AND ANTI-ANXIETY ACTIVITY OF HABENARIA LONGICORNICULATA EXTRACT
EXTRACTION, PHYTOCHEMICAL SCREENING AND ANTI-ANXIETY ACTIVITY OF HABENARIA LONGICORNICULATA EXTRACT Open
The present study aimed to evaluate the phytochemical composition and anxiolytic antidepressant potential of the hydroalcoholic extract of Habenaria longicorniculata. The plant extract was prepared using a hydroalcoholic solvent system, yi…
View article: EXTRACTION, PHYTOCHEMICAL SCREENING AND ANTI-ANXIETY ACTIVITY OF HABENARIA LONGICORNICULATA EXTRACT
EXTRACTION, PHYTOCHEMICAL SCREENING AND ANTI-ANXIETY ACTIVITY OF HABENARIA LONGICORNICULATA EXTRACT Open
The present study aimed to evaluate the phytochemical composition and anxiolytic antidepressant potential of the hydroalcoholic extract of Habenaria longicorniculata. The plant extract was prepared using a hydroalcoholic solvent system, yi…
View article: Comparative Study on Extracts from Traditional Medicinal Plants Echinacea purpurea (L.) Moench and Onopordum acanthium (L.): Antioxidant Activity In Vitro and Anxiolytic Effect In Vivo
Comparative Study on Extracts from Traditional Medicinal Plants Echinacea purpurea (L.) Moench and Onopordum acanthium (L.): Antioxidant Activity In Vitro and Anxiolytic Effect In Vivo Open
Background: Echinacea purpurea (L.) Moench (EP) and Onopordum acanthium (L.) (OA) are promising medicinal plants with diverse biological activities but there is no information on the effects of their combinations. To harness the therapeuti…
View article: Phytotherapy for Anxiety: A Narrative Review of Efficacy, Mechanisms and Clinical Considerations
Phytotherapy for Anxiety: A Narrative Review of Efficacy, Mechanisms and Clinical Considerations Open
Background: Anxiety disorders are among the most prevalent mental health conditions world-wide, and current pharmacological treatments, although effective, are often associated with ad-verse effects and incomplete symptom remission. These …
View article: Phytotherapy for Anxiety: A Narrative Review of Efficacy, Mechanisms and Clinical Considerations
Phytotherapy for Anxiety: A Narrative Review of Efficacy, Mechanisms and Clinical Considerations Open
Background: Anxiety disorders are among the most prevalent mental health conditions world-wide, and current pharmacological treatments, although effective, are often associated with ad-verse effects and incomplete symptom remission. These …
View article: Psychocardiological impact of depression on medication adherence, ventricular function, and readmission in heart failure: A retrospective cohort study
Psychocardiological impact of depression on medication adherence, ventricular function, and readmission in heart failure: A retrospective cohort study Open
BACKGROUND Depression is a highly prevalent and clinically significant psychiatric comorbidity in patients with heart failure (HF), exerting multidimensional effects that extend beyond emotional symptoms to influence physiological outcomes…
View article: Maternal mood disorders are associated with increased proportion of placental immune cell types driving gene expression differences
Maternal mood disorders are associated with increased proportion of placental immune cell types driving gene expression differences Open
Maternal mood disorders during pregnancy increase the risk of neurodevelopmental adversities in children. Alterations in placental function may play a role but remain largely unexplored. In the InTraUterine Sampling in Early Pregnancy stud…
View article: Cannabis-enriched oral <i>Actinomyces</i> induces anxiety-like behavior via impairing mitochondria and GABA signaling
Cannabis-enriched oral <i>Actinomyces</i> induces anxiety-like behavior via impairing mitochondria and GABA signaling Open
The human oral microbiome is increasingly recognized as a contributor to brain health, yet its mechanisms remain unclear. Our previous work revealed that oral Actinomyces species was enriched in chronic cannabis smokers. Here, we show oral…
View article: Tramadol as a potent anxiolytic agent in patients with mild brain damage
Tramadol as a potent anxiolytic agent in patients with mild brain damage Open
View article: Serotonergic Neuromodulation of Natural Products Isoreserpine and Isoreserpiline in Adult Zebrafish: An in Silico and In Vivo Investigation
Serotonergic Neuromodulation of Natural Products Isoreserpine and Isoreserpiline in Adult Zebrafish: An in Silico and In Vivo Investigation Open
Anxiety is a multidimensional behavioral disorder widely studied in neuroscience due to the involvement of specific neural circuits. Although benzodiazepines are commonly used, their side effects drive the search for new therapeutic altern…
View article: The alternative: Dimetindene maleate as a tranquilizer and anxiolytic
The alternative: Dimetindene maleate as a tranquilizer and anxiolytic Open
View article: Acute stress suppresses hunger-driven food seeking through PVN activation: Reversal by anxiolytic drug and ghrelin receptor agonist, with anxiolytic-like effects of refeeding
Acute stress suppresses hunger-driven food seeking through PVN activation: Reversal by anxiolytic drug and ghrelin receptor agonist, with anxiolytic-like effects of refeeding Open
Feeding behavior is influenced by both metabolic drive and emotional context, yet how acute stress interferes with hunger-driven motivation remains poorly understood. Using a conflict-based open-field feeding paradigm, we examined how 30-m…
View article: Psilocybin and Chronic Pain: A New Perspective for Future Pain Therapists?
Psilocybin and Chronic Pain: A New Perspective for Future Pain Therapists? Open
Background: Chronic pain affects nearly one in five adults worldwide and remains a major healthcare burden due to its persistence, multidimensional impact, and resistance to conventional therapies. The opioid crisis has further highlighted…
View article: Fluoxetine modulates both endocannabinoid and lysophosphatidic acid pathways in a region-specific Manner during alcohol withdrawal in male rats
Fluoxetine modulates both endocannabinoid and lysophosphatidic acid pathways in a region-specific Manner during alcohol withdrawal in male rats Open
Anxiety is a major symptom associated with alcohol withdrawal and a major factor increasing the risk of relapse. Although fluoxetine, a selective serotonin reuptake inhibitor, is used to alleviate these symptoms, its effects on brain lipid…
View article: Influence of Hypnosis and Acupuncture on Perioperative Complications
Influence of Hypnosis and Acupuncture on Perioperative Complications Open
Background: This randomised, single-centre study and original research manuscript aimed to evaluate whether perioperative hypnosis and acupuncture can reduce postoperative nausea and vomiting (PONV), opioid use, and other complications in …
View article: Stress-induced brain extracellular vesicles ameliorate anxiety behavior
Stress-induced brain extracellular vesicles ameliorate anxiety behavior Open
Extracellular vesicles (EVs), nanovesicles secreted by all types of cells, serve as a communication network, carrying information through the bloodstream to distant cells [1, 2]. Notably, brain cells secrete EVs that play a crucial role in…
View article: Suppression of Fear Memory Reinstatement by 3,6′-Disinapoyl Sucrose
Suppression of Fear Memory Reinstatement by 3,6′-Disinapoyl Sucrose Open
Fear memories are easily formed but very difficult to erase, and even after extinction, they easily relapse. Post-traumatic stress disorder(PTSD) is a disorder characterized by persistent and excessive symptoms triggered by traumatic fear …
View article: O PAPEL DO FARMACÊUTICO NO ACOMPANHAMENTO DE PACIENTES OBESOS EM TERAPIA COM AGONISTAS DE GLP-1
O PAPEL DO FARMACÊUTICO NO ACOMPANHAMENTO DE PACIENTES OBESOS EM TERAPIA COM AGONISTAS DE GLP-1 Open
A obesidade é uma doença crônica multifatorial caracterizada pelo acúmulo excessivo de gordura corporal, associada a um conjunto de fatores genéticos, metabólicos, ambientais e comportamentais. Nos últimos anos, observa-se um aumento progr…
View article: GLP-1 Receptor Agonists in Alcohol Use Disorder: Neurobiological Mechanisms and Therapeutic Potential
GLP-1 Receptor Agonists in Alcohol Use Disorder: Neurobiological Mechanisms and Therapeutic Potential Open
Alcohol use disorder (AUD) remains a significant global health challenge, characterized by compulsive alcohol intake, impaired control over consumption, and a high risk of relapse. Despite its widespread impact, pharmacological treatment o…
View article: On the use of psychobiotics in gastroenterology and clinical medicine (scientific review)
On the use of psychobiotics in gastroenterology and clinical medicine (scientific review) Open
Introduction . Currently, considerable attention of researchers is attracted to the study of the state and therapeutic significance of the human gut microbiota (GM), the imbalance of which can lead to the occurrence or aggravation of exist…
View article: ASSESSMENT OF MULTIPLE EUROPSYCHOPHARMACOLOGICAL ACTIVITIES AND ANTI-INFLAMMATORY ACTIVITY OF ETHANOLIC EXTRACT OF CALOTROPIS PROCERA
ASSESSMENT OF MULTIPLE EUROPSYCHOPHARMACOLOGICAL ACTIVITIES AND ANTI-INFLAMMATORY ACTIVITY OF ETHANOLIC EXTRACT OF CALOTROPIS PROCERA Open
Calotropis procera (Ait.) R.Br., also referred to as milkweed or ak, is a medicinalplant belonging to the Apocynaceae family, known for its medicinal properties against inflammation, pain, and neurological disorders. In this paper, t…
View article: ASSESSMENT OF MULTIPLE EUROPSYCHOPHARMACOLOGICAL ACTIVITIES AND ANTI-INFLAMMATORY ACTIVITY OF ETHANOLIC EXTRACT OF CALOTROPIS PROCERA
ASSESSMENT OF MULTIPLE EUROPSYCHOPHARMACOLOGICAL ACTIVITIES AND ANTI-INFLAMMATORY ACTIVITY OF ETHANOLIC EXTRACT OF CALOTROPIS PROCERA Open
Calotropis procera (Ait.) R.Br., also referred to as milkweed or ak, is a medicinalplant belonging to the Apocynaceae family, known for its medicinal properties against inflammation, pain, and neurological disorders. In this paper, the neu…
View article: Role of Medicinal Chemistry in Modulating GPCR Targets for Neurological Disorders
Role of Medicinal Chemistry in Modulating GPCR Targets for Neurological Disorders Open
This review analyses the application of medicinal chemistry in the modulation of G-protein-coupled receptor (GPCR) targets in the treatment of neurological disorders based on the presentation of preclinical evidence provided solely by anim…
View article: Exploring the anxiolytic effects of valproic acid: A systematic review
Exploring the anxiolytic effects of valproic acid: A systematic review Open
View article: Androgen Receptor Mediated Anxiolytic effect of Testosterone in Wistar Albino Rats
Androgen Receptor Mediated Anxiolytic effect of Testosterone in Wistar Albino Rats Open
The study aims to determine if a single testosterone injection, mediated by the androgen receptor, affects anxiety. The methods involve dividing male Wistar albino rats into four groups: a control group, a castrated group, a castrated grou…
View article: Androgen Receptor Mediated Anxiolytic effect of Testosterone in Wistar Albino Rats
Androgen Receptor Mediated Anxiolytic effect of Testosterone in Wistar Albino Rats Open
The study aims to determine if a single testosterone injection, mediated by the androgen receptor, affects anxiety. The methods involve dividing male Wistar albino rats into four groups: a control group, a castrated group, a castrate…
View article: Dexmedetomidine regulates sleep rhythm and alleviates neuroinflammation in rats under high-altitude hypoxia
Dexmedetomidine regulates sleep rhythm and alleviates neuroinflammation in rats under high-altitude hypoxia Open
High-altitude hypoxia (HH) significantly affects mammalian physiological functions, especially sleep rhythms, anxiety-like behavior, and neuroinflammation. In this study, adult male Sprague-Dawley rats were randomly assigned to five groups…
View article: Dexmedetomidine’s Role in Adult ICU After 20 Years of Experience—A Narrative Review
Dexmedetomidine’s Role in Adult ICU After 20 Years of Experience—A Narrative Review Open
Background: Dexmedetomidine (Dex) is a well-known a2-adrenoceptor agonist with sedative, anxiolytic, sympatholytic, and analgesic effects that has been used principally as adjuvant sedation in the ICU. The enhanced clinical experience of D…