Aminoglycoside
View article: What is the evidence supporting the use of intratympanic gentamicin for treating Meniere's disease?
What is the evidence supporting the use of intratympanic gentamicin for treating Meniere's disease? Open
Intratympanic gentamicin is supported by limited evidence for controlling vertigo in Meniere's disease, with considerations required for potential ototoxicity and the need for further research to strengthen the evidence.
View article: What is the evidence supporting the use of intratympanic gentamicin for treating Meniere's disease?
What is the evidence supporting the use of intratympanic gentamicin for treating Meniere's disease? Open
Intratympanic gentamicin is supported by limited evidence for controlling vertigo in Meniere's disease, with considerations required for potential ototoxicity and the need for further research to strengthen the evidence.
View article: Detection of aac3IIc, aac(6)Ib and armA gene encoding aminoglycoside resistance in Klebsiella pneumoniae in Burkina Faso.
Detection of aac3IIc, aac(6)Ib and armA gene encoding aminoglycoside resistance in Klebsiella pneumoniae in Burkina Faso. Open
Background: Klebsiella pneumoniae is the second most frequently isolated bacterium in medical bacteriology laboratory after Escherichia coli. It can be responsible for many infections including urinary tract infections and pneumonia. The t…
View article: Recent advances in the biosynthetic pathway and structural modification of gentamicin
Recent advances in the biosynthetic pathway and structural modification of gentamicin Open
As a member of the first-generation aminoglycoside antibiotics, gentamicin was once widely used in clinical practice. However, due to its drug resistance, toxicity, and side effects and the development of novel antibiotics, gentamicin has …
View article: Transcriptional regulatory factor AHA_4052 regulates aminoglycoside resistance in Aeromonas hydrophila
Transcriptional regulatory factor AHA_4052 regulates aminoglycoside resistance in Aeromonas hydrophila Open
Introduction With the increasing identification of multidrug resistance in Aeromonas hydrophila isolated from diverse food sources, there is an urgent need to investigate its resistance mechanism. Previous studies have demonstrated that Om…
View article: Association of the existence of CRISPR-Cas system and antimicrobial resistance in multi-drug resistant Klebsiella pneumoniae in Egypt
Association of the existence of CRISPR-Cas system and antimicrobial resistance in multi-drug resistant Klebsiella pneumoniae in Egypt Open
The CRISPR-Cas systems are supposed to be associated with antibiotic susceptibility. Klebsiella pneumoniae ( K. pneumoniae ) is a major multidrug-resistant (MDR) pathogen that may cause severe infections. This study aimed to detect the ant…
View article: Pharmacodynamic interactions among meropenem ciprofloxacin and gentamicin in an in-vitro model
Pharmacodynamic interactions among meropenem ciprofloxacin and gentamicin in an in-vitro model Open
Meropenem, gentamicin and ciprofloxacin are often used together as empiric broad-spectrum therapy in different combinations. Recent regulations regarding the use of quinolones mean that greater justification is required when using this com…
View article: Safety, tolerability, and pharmacokinetics of a 2 g subcutaneous dose of ceftriaxone as an alternative to intravenous delivery
Safety, tolerability, and pharmacokinetics of a 2 g subcutaneous dose of ceftriaxone as an alternative to intravenous delivery Open
Subcutaneous delivery of antibiotics is a practical alternative to intravenous administration. Ceftriaxone is commonly used for a variety of infections with limited data on the safety and pharmacokinetics of a 2 g subcutaneous dose. This w…
View article: Đặc điểm dịch tễ, lâm sàng và kết quả điều trị bệnh nhân nhiễm Brucella melitensis tại Bệnh viện Bệnh Nhiệt đới
Đặc điểm dịch tễ, lâm sàng và kết quả điều trị bệnh nhân nhiễm Brucella melitensis tại Bệnh viện Bệnh Nhiệt đới Open
Đặt vấn đề: Brucellosis là bệnh lây truyền từ động vật sang người do Brucella spp. gây ra, trong đó B. melitensis là tác nhân thường gặp nhất. Brucellosis dễ bị chẩn đoán nhầm với các bệnh nhiễm trùng khác và dữ liệu còn hạn chế tại Việt N…
View article: Investigating the impact of type I-E CRISPR-Cas systems and acrEI10 on multidrug-resistance in clinical isolates of Klebsiella pneumoniae
Investigating the impact of type I-E CRISPR-Cas systems and acrEI10 on multidrug-resistance in clinical isolates of Klebsiella pneumoniae Open
Klebsiella pneumoniae is a pathogen related to nosocomial infections with a high rate of antibiotic resistance. The aim of this study was to understand the impact of the presence of CRISPR-Cas systems and an anti-CRISPR gene on multidrug-r…
View article: First report of a DIM-1-producing <i>Pseudomonas aeruginosa</i> in Spain: genomic characterization and resistance determinants
First report of a DIM-1-producing <i>Pseudomonas aeruginosa</i> in Spain: genomic characterization and resistance determinants Open
This study reports the first DIM-1-producing Pseudomonas aeruginosa identified in Spain. The multidrug-resistant ST233 clone harbored the bla DIM-1 gene within the class 1 integron In1592, together with aminoglycoside resistance genes aph(…
View article: Candesartan Cilexetil Disrupts Membrane Homeostasis of Methicillin-Resistant Staphylococcus aureus and Potentiates the Anti-bacterial Activity of Gentamicin and Polymyxin B
Candesartan Cilexetil Disrupts Membrane Homeostasis of Methicillin-Resistant Staphylococcus aureus and Potentiates the Anti-bacterial Activity of Gentamicin and Polymyxin B Open
Transcriptome raw files: RNA sequencing was performed on MRSA-MW2 bacteria treated with Candesartan Cilexetil (CC), using two biological replicates.
View article: Candesartan Cilexetil Disrupts Membrane Homeostasis of Methicillin-Resistant Staphylococcus aureus and Potentiates the Anti-bacterial Activity of Gentamicin and Polymyxin B
Candesartan Cilexetil Disrupts Membrane Homeostasis of Methicillin-Resistant Staphylococcus aureus and Potentiates the Anti-bacterial Activity of Gentamicin and Polymyxin B Open
Transcriptome raw files: RNA sequencing was performed on MRSA-MW2 bacteria treated with Candesartan Cilexetil (CC), using two biological replicates.
View article: Repurposed membrane-targeting RS17053 eradicates MRSA persisters and enhances aminoglycoside killing
Repurposed membrane-targeting RS17053 eradicates MRSA persisters and enhances aminoglycoside killing Open
The rapid rise of methicillin-resistant Staphylococcus aureus (MRSA) and its ability to form antibiotic-tolerant persisters pose a major challenge to antimicrobial therapy. These metabolically dormant cells survive antibiotic exposure with…
View article: Influence of heparin-based anticoagulants on antibiotic therapy
Influence of heparin-based anticoagulants on antibiotic therapy Open
Background A world without antibiotics is hard to conceive. They have revolutionized the treatment landscape for bacterial infections, reducing mortality rates and enabling complex medical procedures. However, their widespread use has fuel…
View article: Nephroprotective Effects of Ipomoea Aquatica (Kalmi shak) And Ramipril in Gentamicin Induced Nephrotoxic Rats - A Comparative Experimental Study
Nephroprotective Effects of Ipomoea Aquatica (Kalmi shak) And Ramipril in Gentamicin Induced Nephrotoxic Rats - A Comparative Experimental Study Open
Introduction: Acute kidney injury is an important public health problem in patients treated with gentamicin. Kalmi shak and ramipril have nephroprotective effects that can alleviate gentamicin induced nephrotoxicity. A study was carried ou…
View article: (ID: 54) Transforming gentamicin prescribing: an audit on safety and compliance
(ID: 54) Transforming gentamicin prescribing: an audit on safety and compliance Open
Introduction Gentamicin is an aminoglycoside antibiotic used as first-line treatment of various gastrointestinal and urinary tract infections. Because of its oto- and nephrotoxicity, dosing is weight-based and requires therapeutic drug mon…
View article: The Impact of an Ex Vivo Pediatric Extracorporeal Membrane Oxygenation Circuit on Sequestration of Antimicrobials
The Impact of an Ex Vivo Pediatric Extracorporeal Membrane Oxygenation Circuit on Sequestration of Antimicrobials Open
OBJECTIVES: To determine if common antimicrobials ( n = 11) are sequestered or degraded during a pediatric extracorporeal membrane oxygenation (ECMO) simulation. DESIGN: An ex vivo model of a closed ECMO circuit was established to simulate…
View article: CH3COOAg with Laccase-like Activity for Differentiation and Detection of Aminoglycoside Antibiotics
CH3COOAg with Laccase-like Activity for Differentiation and Detection of Aminoglycoside Antibiotics Open
Aminoglycoside antibiotics (AGs) are widely used in medicine and animal husbandry, but they pose significant risks due to residual toxicity and antibiotic resistance. In this study, a novel chemical sensor based on the laccase-like activit…
View article: Inhaled antibiotics and non-cystic fibrosis bronchiectasis: Trying to solve the puzzle
Inhaled antibiotics and non-cystic fibrosis bronchiectasis: Trying to solve the puzzle Open
Bronchiectasis is a chronic airway disease with recurrent exacerbations and hospitalisations. No inhaled antibiotic has shown consistently beneficial effects in trials. This review analyses the evidence on inhaled antibiotics in non-cystic…
View article: Basis for selective drug evasion of an aminoglycoside-resistance ribosomal RNA modification
Basis for selective drug evasion of an aminoglycoside-resistance ribosomal RNA modification Open
Aminoglycosides disrupt the fidelity of bacterial protein synthesis, but their potent antibacterial activity is threatened by multiple resistance mechanisms, including methylation of their ribosomal RNA (rRNA) binding site. However, the im…
View article: Enzyme-mediated aminoglycoside resistance without target mimicry
Enzyme-mediated aminoglycoside resistance without target mimicry Open
View article: Identification of a novel aminoglycoside nucleotidyltransferase ANT(3″)-Ic from Citrobacter telavivum S24
Identification of a novel aminoglycoside nucleotidyltransferase ANT(3″)-Ic from Citrobacter telavivum S24 Open
Understanding the antibiotic resistance profile of the emerging pathogen Citrobacter telavivum S24 is important for clinical care, surveillance, and research. C. telavivum S24, a strain that exhibits resistance to both streptomycin and spe…
View article: Detection of aminoglycoside-modifying enzyme genes in Pseudomonas aeruginosa clinical isolates
Detection of aminoglycoside-modifying enzyme genes in Pseudomonas aeruginosa clinical isolates Open
Pseudomonas aeruginosa is an opportunistic pathogen that frequently causes infections in immunocompromised patients and is involved in outbreaks of hospital-acquired infections with a high mortality rate. Aminoglycosides are a large catego…
View article: Screening Actinomycetes extracts for antimicrobial compounds against methicillin-resistant Staphylococcus aureus and helper-compounds against aminoglycoside-resistant E. coli
Screening Actinomycetes extracts for antimicrobial compounds against methicillin-resistant Staphylococcus aureus and helper-compounds against aminoglycoside-resistant E. coli Open
Background Innovative antibiotic discovery strategies are urgently needed to successfully combat infections caused by multi-drug-resistant bacteria. Methods We employed a direct screening approach to identify compounds with antimicrobial a…
View article: Synergistic action between peptide-neomycin conjugates and polymyxin B against multidrug-resistant gram-negative pathogens
Synergistic action between peptide-neomycin conjugates and polymyxin B against multidrug-resistant gram-negative pathogens Open
Globally, it is predicted that by 2050, 10 million people will die annually because of infections with drug-resistant bacteria. Since antibacterial agents with novel mechanisms of action have not been developed in the past 30 years, there …
View article: Resistance Mechanisms Of Acinetobacter Baumannii In North Indian Clinical Isolates: A Molecular Study Of Β-Lactam, Carbapenem, Cephalosporin, Fluoroquinolone, And Aminoglycoside Genes
Resistance Mechanisms Of Acinetobacter Baumannii In North Indian Clinical Isolates: A Molecular Study Of Β-Lactam, Carbapenem, Cephalosporin, Fluoroquinolone, And Aminoglycoside Genes Open
Background- The WHO recently added to priority list Carbapenem-resistant Acinetobacter baumannii (CRAB) major infection cause death throughout the developing world. With time the bacteria have become smarter so antimicrobial resistance is …
View article: Optimization of selection agent concentrations and expanding G418 utility for gentamicin resistance in Marchantia polymorpha
Optimization of selection agent concentrations and expanding G418 utility for gentamicin resistance in Marchantia polymorpha Open
Genetic transformation of plants is pivotal for advancing biotechnology, with success depending largely on effective selection methods. Marchantia polymorpha has emerged as a model plant due to its evolutionary importance, ease of manipula…
View article: TunR2, a novel mode-of-action tunicamycin-type antibiotic: Pharmacokinetics in C57BL/6 mouse and Holstein cattle
TunR2, a novel mode-of-action tunicamycin-type antibiotic: Pharmacokinetics in C57BL/6 mouse and Holstein cattle Open
We have investigated the pharmacokinetics of TunR2, a modified tunicamycin-type antibiotic, in mice and cattle. TunR2 has previously been shown to be effective in a mycobacterial disease model using zebrafish, with a minimal activation of …
View article: Correction: “Simultaneous Pharmacokinetic Modeling of Gentamicin, Tobramycin and Vancomycin Clearance From Neonates to Adults: Towards a Semi-physiological Function for Maturation in Glomerular Filtration”
Correction: “Simultaneous Pharmacokinetic Modeling of Gentamicin, Tobramycin and Vancomycin Clearance From Neonates to Adults: Towards a Semi-physiological Function for Maturation in Glomerular Filtration” Open