Actinic keratosis ≈ Actinic keratosis
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Non Melanoma Skin Cancer Pathogenesis Overview Open
(1) Background: Non-melanoma skin cancer is the most frequently diagnosed cancer in humans. The process of skin carcinogenesis is still not fully understood. However, several studies have been conducted to better explain the mechanisms tha…
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Randomized Trial of Four Treatment Approaches for Actinic Keratosis Open
At 12 months after the end of treatment in patients with multiple actinic keratosis lesions on the head, 5% fluorouracil cream was the most effective of four field-directed treatments. (Funded by the Netherlands Organization for Health Res…
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Bioactive Compounds Isolated from Microalgae in Chronic Inflammation and Cancer Open
The risk of onset of cancer is influenced by poorly controlled chronic inflammatory processes. Inflammatory diseases related to cancer development include inflammatory bowel disease, which can lead to colon cancer, or actinic keratosis, as…
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Cutaneous Squamous Cell Carcinoma: From Pathophysiology to Novel Therapeutic Approaches Open
Cutaneous squamous cell carcinoma (cSCC), a non-melanoma skin cancer, is a keratinocyte carcinoma representing one of the most common cancers with an increasing incidence. cSCC could be in situ (e.g., Bowen’s disease) or an invasive form. …
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Review of applications of microneedling in dermatology Open
Microneedling (MN) is a novel therapeutic modality in dermatology. Through physical trauma from needle penetration, MN induces a wound healing cascade with minimal damage to the epidermis. This allows for enhancement in the absorption of m…
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A machine learning approach for skin disease detection and classification using image segmentation Open
Skin diseases are common health problems around the world. The perils of the infections are invisible, which cause physical health distress as well as initiate mental depression. In addition, it sometimes leads to skin cancer in severe cas…
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Randomized trial of calcipotriol combined with 5-fluorouracil for skin cancer precursor immunotherapy Open
Not applicable (investigator-initiated clinical trial).
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From actinic keratosis to squamous cell carcinoma: pathophysiology revisited Open
The precursor of most cutaneous invasive squamous cell carcinomas ( iSCC s) is intraepithelial UV ‐induced damage, known as field cancerization, which can eventually transform into actinic keratosis ( AK ). Although AK is the most common p…
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Cross-species identification of genomic drivers of squamous cell carcinoma development across preneoplastic intermediates Open
Cutaneous squamous cell carcinoma (cuSCC) comprises 15–20% of all skin cancers, accounting for over 700,000 cases in USA annually. Most cuSCC arise in association with a distinct precancerous lesion, the actinic keratosis (AK). To identify…
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Combined Treatments with Photodynamic Therapy for Non-Melanoma Skin Cancer Open
Non-melanoma skin cancer (NMSC) is the most common form of cancer in the Caucasian population. Among NMSC types, basal cell carcinoma (BCC) has the highest incidence and squamous cell carcinoma (SCC) is less common although it can metastas…
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Image Classification of Melanoma, Nevus and Seborrheic Keratosis by Deep Neural Network Ensemble Open
This short paper reports the method and the evaluation results of Casio and Shinshu University joint team for the ISBI Challenge 2017 - Skin Lesion Analysis Towards Melanoma Detection - Part 3: Lesion Classification hosted by ISIC. Our onl…
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Daylight Photodynamic Therapy: An Update Open
Daylight photodynamic therapy (dPDT) uses sunlight as a light source to treat superficial skin cancer. Using sunlight as a therapeutic device has been present for centuries, forming the basis of photodynamic therapy in the 20th century. Co…
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Topical PDT in the Treatment of Benign Skin Diseases: Principles and New Applications Open
Photodynamic therapy (PDT) uses a photosensitizer, light energy, and molecular oxygen to cause cell damage. Cells exposed to the photosensitizer are susceptible to destruction upon light absorption because excitation of the photosensitizin…
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Real-world approach to actinic keratosis management: practical treatment algorithm for office-based dermatology Open
Actinic keratosis (AK) is a chronic skin disease in which multiple clinical and subclinical lesions co-exist across large areas of sun-exposed skin, resulting in field cancerisation. Lesions require treatment because of their potential to …
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Detection of Skin Diseases from Dermoscopy Image Using the combination of Convolutional Neural Network and One-versus-All Open
The use of deep learning in the field of image processing is increasing. In this study, a new method based on Convolutional Neural Network is proposed to detect skin diseases automatically from Dermoscopy images. Skin cancer is one of the …
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A Deep Learning Approach Based on Explainable Artificial Intelligence for Skin Lesion Classification Open
The skin lesion types result in delayed diagnosis due to high similarity in early stages of the skin cancer. In this regard, deep learning algorithms are well-recognized solutions; however, these black box approaches result in lack of trus…
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Dermoscopy of Melanoma and Non-melanoma Skin Cancers Open
Dermoscopy is a widely used non-invasive technique for diagnosing skin tumors. In melanocytic tumors, e.g., melanoma and basal cell carcinoma (BCC), the effectiveness of dermoscopic examination has been fully established over the past two …
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Line‐field confocal optical coherence tomography—Practical applications in dermatology and comparison with established imaging methods Open
Background Non‐invasive diagnostic techniques in dermatology gained increasing popularity in the last decade. Reflectance confocal microscopy (RCM) and optical coherence tomography (OCT) are meanwhile established in research and clinical r…
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Current therapies for actinic keratosis Open
Actinic keratosis (AK) is a very common skin disease caused by chronic sun damage, which in 75% of cases arises on chronically sun‐exposed areas, such as face, scalp, neck, hands, and forearms. AKs must be considered an early squamous cell…
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S3 guideline for actinic keratosis and cutaneous squamous cell carcinoma – short version, part 1: diagnosis, interventions for actinic keratoses, care structures and quality‐of‐care indicators Open
Summary Actinic keratoses (AK) are common lesions in light‐skinned individuals that can potentially progress to cutaneous squamous cell carcinoma (cSCC). Both conditions may be associated with significant morbidity and constitute a major d…
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Skin Cancer Diagnosis With Reflectance Confocal Microscopy Open
The study highlights key RCM diagnostic criteria for melanoma and basal cell carcinoma that are reproducibly recognized among RCM users. Diagnostic accuracy increases with experience. The higher accuracy of majority diagnosis suggests that…
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Trial Watch: experimental TLR7/TLR8 agonists for oncological indications Open
Resiquimod (R848) and motolimod (VTX-2337) are second-generation experimental derivatives of imiquimod, an imidazoquinoline with immunostimulatory properties originally approved by the US Food and Drug Administration for the topical treatm…
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A proposed scoring system for assessing the severity of actinic keratosis on the head: actinic keratosis area and severity index Open
Background Actinic keratosis ( AK ) severity is currently evaluated by subjective assessment of patients. Objectives To develop and perform an initial pilot validation of a new easy‐to‐use quantitative tool for assessing AK severity on the…
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Defining the actinic keratosis field: a literature review and discussion Open
Despite the chronic and increasingly prevalent nature of actinic keratosis ( AK ) and existing evidence supporting assessment of the entire cancerization field during clinical management, a standardized definition of the AK field to aid in…
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Actinic keratosis – review for clinical practice Open
Actinic keratosis ( AK ) is a lesion that arises as a result of excessive exposure to solar radiation and appearing predominantly on Fitzpatrick phototype I and II skin. Given that some AK s evolve into squamous cell carcinoma, these lesio…
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A randomized, double‐blind, phase <span>III</span> , multicentre study to evaluate the safety and efficacy of <span>BF</span> ‐200 <span>ALA</span> (Ameluz <sup>®</sup> ) vs. placebo in the field‐directed treatment of mild‐to‐moderate actinic keratosis with photodynamic therapy (PDT) when using the <span>BF</span> ‐Rhodo <span>LED</span> <sup>®</sup> lamp Open
Field-directed therapy with BF-200 ALA and BF-RhodoLED lamp is highly effective and well tolerated for multiple mild-to-moderate AK lesions, providing greatly improved skin quality.
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Detection and Classification of Skin Cancer by Using a Parallel CNN Model Open
Skin cancer is one of the most lethal of all cancers. When it is not diagnosed and handled at the beginning, it is supposed to extend to other areas of the body.It also occurs while the tissue is revealed to light from the sun, mainly due …
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The importance of treating the field in actinic keratosis Open
Actinic keratoses (AKs) are intraepithelial atypical proliferations of keratinocytes that develop in skin that has undergone long‐term exposure to ultraviolet radiation. Given the ageing population and an increasing prevalence of AK, the s…
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CONSENSUS REPORT: Recognizing non‐melanoma skin cancer, including actinic keratosis, as an occupational disease – A Call to Action Open
1. Non-melanoma skin cancer (NMSC) is by far the most common cancer diagnosed in westernized countries, and one of the few almost preventable cancers if detected and treated early as up to 90% of NMSC may be attributed to excessive exposur…
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Photodynamic Therapy and Non-Melanoma Skin Cancer Open
Non-melanoma skin cancer (NMSC) is the most common malignancy among the Caucasian population. Photodynamic therapy (PDT) is gaining popularity for the treatment of basal cell carcinoma (BCC), Bowen’s disease (BD) and actinic keratosis (AK)…