Activated clotting time
View article: Heparin Resistance in Cardiac Surgery with Cardiopulmonary Bypass: Mechanisms, Clinical Implications, and Evidence-Based Management
Heparin Resistance in Cardiac Surgery with Cardiopulmonary Bypass: Mechanisms, Clinical Implications, and Evidence-Based Management Open
Background: Unfractionated heparin (UFH) is the standard anticoagulant during cardiopulmonary bypass (CPB). A clinically relevant subset develops heparin resistance (HR)—failure to reach adequate anticoagulation with usual UFH—raising thro…
View article: Multicenter Evaluation of Different Anti-Xa Assays and Diluted Russell’s Viper Venom Time in Ex Vivo Plasma Samples from Patients Treated with Rivaroxaban or Apixaban
Multicenter Evaluation of Different Anti-Xa Assays and Diluted Russell’s Viper Venom Time in Ex Vivo Plasma Samples from Patients Treated with Rivaroxaban or Apixaban Open
Background/Objectives: Different anti-Xa assays are routinely used to evaluate the plasma concentrations of direct factor X inhibitors (DXIs) rivaroxaban and apixaban, despite a lack of data on assay equivalence. Information on assay perfo…
View article: Exploring predictors of activated clotting time after unfractionated heparin administration in elective interventional neuroradiology
Exploring predictors of activated clotting time after unfractionated heparin administration in elective interventional neuroradiology Open
Background: Thromboembolic complications are the most frequent risk in endovascular treatment of intracranial pathology. To prevent this, unfractionated heparin (UFH) is used. The effect of heparin is difficult to predict. Therefore, bedsi…
View article: Editor's Choice – Activated Clotting Time Guided Heparinisation during Open Abdominal Aortic Aneurysm Repair (ACTION-1): A Randomised, Multicentre, Single Blind, Superiority Trial
Editor's Choice – Activated Clotting Time Guided Heparinisation during Open Abdominal Aortic Aneurysm Repair (ACTION-1): A Randomised, Multicentre, Single Blind, Superiority Trial Open
View article: Comparison of Regional Citrate Anticoagulation (RCA) with Heparin (HA) or No (NA) anticoagulation strategy in paediatric intensive care patients receiving continuous renal replacement therapy: A 9-year single centre tertiary cohort study
Comparison of Regional Citrate Anticoagulation (RCA) with Heparin (HA) or No (NA) anticoagulation strategy in paediatric intensive care patients receiving continuous renal replacement therapy: A 9-year single centre tertiary cohort study Open
Background & Objective: This is a single centre retrospective cohort study over period of 9 years of comparing regional citrate anticoagulation (RCA) vs heparin (HA) or no anticoagulation (NA) strategy in a paediatric intensive care patien…
View article: RBCs promote VWF tension-dependent activation and hemostatic clot formation under hemodilution: A combined in silico and ex vivo study
RBCs promote VWF tension-dependent activation and hemostatic clot formation under hemodilution: A combined in silico and ex vivo study Open
Introduction: Dilutional coagulopathy remains a major challenge in trauma and transfusion medicine, yet the mechanistic basis of impaired hemostasis under hemodilution is not fully understood. While red blood cells (RBCs) are traditionally…
View article: Heparin-induced thrombocytopenia after percutaneous coronary intervention complicated by hemothorax and pulmonary thromboembolism: The scylla and charybdis of hematology
Heparin-induced thrombocytopenia after percutaneous coronary intervention complicated by hemothorax and pulmonary thromboembolism: The scylla and charybdis of hematology Open
Introduction: Heparin-induced thrombocytopenia (HIT) is an immune-mediated reaction to heparin caused by antibodies directed against heparin and platelet factor 4 (PF4) complexes. Despite thrombocytopenia, HIT causes a paradoxical prothrom…
View article: 60 Data-Driven Optimization of Tube Fill Requirements for PT and PTT on the Automated CS-5100 Coagulation Analyzer
60 Data-Driven Optimization of Tube Fill Requirements for PT and PTT on the Automated CS-5100 Coagulation Analyzer Open
Underfilled blood tubes are a primary source of sample rejection in the clinical coagulation laboratory, leading to patient harm through unnecessary rejections that require additional blood draws and delay test results. The CS-5100 analyze…
View article: Advanced polyelectrolyte complexes for ultrafast hemostasis and blood superabsorption
Advanced polyelectrolyte complexes for ultrafast hemostasis and blood superabsorption Open
Blood clotting is the natural response of the human body to hemorrhage - one of the leading causes of death worldwide. Hemostatic sponges are used to physically block the bleeding site, reduce blood clotting time, and increase the chance o…
View article: Activated Clotting Time Analysis in Elective Percutaneous Coronary Intervention Using Bolus and Continous Heparin at Dr. Saiful Anwar Hospital Malang
Activated Clotting Time Analysis in Elective Percutaneous Coronary Intervention Using Bolus and Continous Heparin at Dr. Saiful Anwar Hospital Malang Open
BACKGROUND: Unfractionated heparin effectively prevents thrombosis during percutaneous coronary intervention (IKP). Analysis between sex, age, BMI, diabetes, smoking, CHF, hypertension, stroke, lesion characteristics, CHA2DS2-VASc score, p…
View article: Regional citrate anticoagulation for intermittent renal replacement therapy in critically ill patients: a retrospective case-control study
Regional citrate anticoagulation for intermittent renal replacement therapy in critically ill patients: a retrospective case-control study Open
View article: Management of cardiac surgery in a patient with antiphospholipid syndrome using the heparin-activated clotting time titration curve and thromboelastography: A case report
Management of cardiac surgery in a patient with antiphospholipid syndrome using the heparin-activated clotting time titration curve and thromboelastography: A case report Open
Patients with antiphospholipid syndrome undergoing cardiac surgery are at increased risk for thrombotic and hemorrhagic complications. We present here the management of a 68-year-old man with antiphospholipid syndrome who was scheduled for…
View article: Impact of Pre-PCI Activated Clotting Time on Outcomes of Bivalirudin Versus Heparin During Primary PCI
Impact of Pre-PCI Activated Clotting Time on Outcomes of Bivalirudin Versus Heparin During Primary PCI Open
Among patients with ST-segment elevation myocardial infarction undergoing PCI with radial artery access, procedural anticoagulation with bivalirudin was associated with lower 30-day rates of mortality, BARC types 3 to 5 bleeding, and stent…
View article: Editor's Choice – Activated Clotting Time Guided Heparinisation during Open Abdominal Aortic Aneurysm Repair (ACTION-1): A Randomised, Multicentre, Single Blind, Superiority Trial
Editor's Choice – Activated Clotting Time Guided Heparinisation during Open Abdominal Aortic Aneurysm Repair (ACTION-1): A Randomised, Multicentre, Single Blind, Superiority Trial Open
In patients undergoing open AAA repair, heparinisation with 100 IU/kg and ACT monitoring at a target of 200 seconds did not reduce the primary efficacy outcome and increased the risk of peri-operative bleeding compared with a single bolus …
View article: Comparison of Two Activated Clotting Time Targets During Cardiac Surgery With Cardiopulmonary Bypass: A Prospective Multicenter Randomized Controlled Trial
Comparison of Two Activated Clotting Time Targets During Cardiac Surgery With Cardiopulmonary Bypass: A Prospective Multicenter Randomized Controlled Trial Open
This study showed that a target ACT of ≥400 seconds is equivalent to a target ACT of ≥480 seconds in terms of intraoperative and postoperative PRBC transfusion rates in the modern cardiac surgery setting. This target range is considered co…
View article: Activated Clotting Time and Haemostatic Complications in Patients Receiving ECMO Support: A Systematic Review
Activated Clotting Time and Haemostatic Complications in Patients Receiving ECMO Support: A Systematic Review Open
Background: Extracorporeal membrane oxygenation (ECMO) requires systemic anticoagulation to prevent clotting, typically using unfractionated heparin (UFH). However, anticoagulation carries a bleeding risk, necessitating monitoring. Activat…
View article: Activated Clotting Time Measurement in Cardiac Surgery: An Infinite Game
Activated Clotting Time Measurement in Cardiac Surgery: An Infinite Game Open
View article: Unfractionated Heparin Therapy During Elective Percutaneous Coronary Intervention
Unfractionated Heparin Therapy During Elective Percutaneous Coronary Intervention Open
Coronary artery Disease (CAD) occurs due to an imbalance between myocardial oxygen demand and supply due to total or partial blockage of the coronary artery. Occlusion of coronary artery blood vessels in CAD patients requires revasculariza…
View article: Escalating doses of intravenous APAC demonstrate antithrombotic effect in pigs
Escalating doses of intravenous APAC demonstrate antithrombotic effect in pigs Open
Background Locally acting antiplatelet and anticoagulant (APAC) is developed as an antithrombotic agent for administration during vascular interventions and in thrombo-inflammatory conditions. APAC has entered human studies as a dual inhib…
View article: Coagulopathy as a Complication of Cardiopulmonary Arrest Following Balloon Valvuloplasty in a Dog
Coagulopathy as a Complication of Cardiopulmonary Arrest Following Balloon Valvuloplasty in a Dog Open
Objective To describe successful management of a coagulopathy secondary to cardiopulmonary arrest (CPA) associated with pulmonary balloon valvuloplasty. Case Summary An 8‐month‐old male intact Chihuahua mix presented for a pulmonary balloo…
View article: Characterizing the Effect of Heparin Dose and Monitoring Activated Clotting Time on Postoperative Lower Extremity Bypass Outcomes
Characterizing the Effect of Heparin Dose and Monitoring Activated Clotting Time on Postoperative Lower Extremity Bypass Outcomes Open
View article: Measuring activated clotting time (ACT) from the left atrium versus venous femoral sheath during cryo-balloon ablation - does the sampling site matter
Measuring activated clotting time (ACT) from the left atrium versus venous femoral sheath during cryo-balloon ablation - does the sampling site matter Open
Background The activated clotting time(ACT) is used routinely to monitor and titrate anticoagulation therapy with unfractionated heparin(UFH) during ablation procedures in the left atrium(LA). Inadequate anticoagulation during LA ablation …
View article: Significant differences between "high range" and "low range" point of care activated clotting time (ACT) assays during atrial fibrillation cryoablation
Significant differences between "high range" and "low range" point of care activated clotting time (ACT) assays during atrial fibrillation cryoablation Open
Introduction Anticoagulation with unfractionated heparin (UFH) is recommended during atrial fibrillation ablation (AFAbl) to maintain an activated clotting time (ACT) greater than 300 seconds. However, significant variability in the UFH do…
View article: Analysis of activated clotting time in patients receiving unfractionated heparin with and without continuous infusion during elective percutaneous coronary intervention
Analysis of activated clotting time in patients receiving unfractionated heparin with and without continuous infusion during elective percutaneous coronary intervention Open
Background: Percutaneous coronary intervention (PCI) involves a risk of thrombotic events. Unfractionated heparin (UFH) remains a preferred antithrombotic agent during PCI, though the optimal administration method is still under debate. Gi…
View article: Assessing direct transfusion feasibility with syringe‐based collection of whole blood from universal donors
Assessing direct transfusion feasibility with syringe‐based collection of whole blood from universal donors Open
Background The anticipated multidomain operations of future battlefields necessitates minimalistic medical strategies for treatment of combat wounded. Direct transfusion, involving the administration of blood directly from a donor to a rec…
View article: Investigation of a point-of-care viscoelastic coagulation monitor and its comparison to thromboelastography in 9 female southern white rhinoceros (Ceratotherium simum simum)
Investigation of a point-of-care viscoelastic coagulation monitor and its comparison to thromboelastography in 9 female southern white rhinoceros (Ceratotherium simum simum) Open
Objective To investigate a point-of-care viscoelastic coagulation monitor (VCM Vet; Entegrion Inc), compare the results to thromboelastography (TEG), and quantify traditional hemostatic analytes in southern white rhinoceros ( Ceratotherium…
View article: Activated Partial Thromboplastin Time and Anti-IIa Monitoring in Argatroban Anticoagulation in COVID-19 Patients on Venovenous Extracorporeal Membrane Oxygenation
Activated Partial Thromboplastin Time and Anti-IIa Monitoring in Argatroban Anticoagulation in COVID-19 Patients on Venovenous Extracorporeal Membrane Oxygenation Open
Unfractionated heparin has long been considered the standard anticoagulation in ECMO, despite some pitfalls such as heparin resistance, heparin induced thrombocytopenia (HIT), etc Recently, some centres started to increasingly use argatrob…
View article: Activated clotting time for anticoagulation management during catheter ablation of left atrial arrhythmias: Comparison of point-of-care devices in clinical routine
Activated clotting time for anticoagulation management during catheter ablation of left atrial arrhythmias: Comparison of point-of-care devices in clinical routine Open
View article: Effect of regional citrate anticoagulation vs. low molecular weight heparin anticoagulation in continuous renal replacement therapy for critically ill patients: A retrospective cohort study
Effect of regional citrate anticoagulation vs. low molecular weight heparin anticoagulation in continuous renal replacement therapy for critically ill patients: A retrospective cohort study Open
Introduction This study aimed to assess the efficacy and safety of regional citrate anticoagulation (RCA) and low molecular weight heparin anticoagulation (LMHA) in critically ill patients undergoing continuous renal replacement therapy (C…
View article: Clinical Evaluation of the Heparin Therapeutic Window Using Activated Clotting Time in Neurological Interventional Radiology at an Academic Medical Center
Clinical Evaluation of the Heparin Therapeutic Window Using Activated Clotting Time in Neurological Interventional Radiology at an Academic Medical Center Open
Context.— Activated clotting time (ACT) is useful for monitoring heparin therapy in neurointerventional radiology (NIR). We previously used the Hemochron Signature Elite instrument for measuring ACT in NIR. Objective.— To evaluate the suit…