Simian immunodeficiency virus
View article: RhCMV Expands CCR5 Memory T Cells and promotes SIV reservoir seeding in the Gut Mucosa
RhCMV Expands CCR5 Memory T Cells and promotes SIV reservoir seeding in the Gut Mucosa Open
Cytomegalovirus (CMV) is a prevalent β-herpesvirus that persists asymptomatically in immunocompetent hosts. In people with HIV-1 (PWH), CMV is associated with HIV-1 persistence and particular inflammatory-related co-morbidities. The true c…
View article: HIV Virion Capturing Liposomes for Therapeutic Vaccination
HIV Virion Capturing Liposomes for Therapeutic Vaccination Open
HIV infection currently has no effective cures and requires lifelong antiretroviral treatments. Cures have failed due to HIV’s immune evasion and rapid mutation rate. Here we present a first in class HIV therapeutic vaccine, termed nanotra…
View article: Depletion and recovery of IgG following treatment with Rozanoliximab and Imlifidase in pigtail macaques
Depletion and recovery of IgG following treatment with Rozanoliximab and Imlifidase in pigtail macaques Open
Antibodies are central players in adaptive immunity, providing protection against a wide array of pathogens through mechanisms such as neutralization, opsonization, recruitment of effector immune cells, complement activation and engagement…
View article: Development of recombinant BCG vaccine that can be used in individuals infected with the AIDS virus 2873
Development of recombinant BCG vaccine that can be used in individuals infected with the AIDS virus 2873 Open
Description It cannot be used for HIV-infected children in the setting of BCGosis such as disseminated BCG. On the other hand, it has been reported that BCG is effective against TB in simian AIDS virus infection. We attempted to develop an…
View article: Protecting simian immunodeficiency virus-infected macaques from Mycobacterium tuberculosis by intravenous Bacillus Calmette-Guérin vaccination requires viral control 2308
Protecting simian immunodeficiency virus-infected macaques from Mycobacterium tuberculosis by intravenous Bacillus Calmette-Guérin vaccination requires viral control 2308 Open
Description Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), is a major global health challenge, especially for people living with HIV (PLWH) not on antiretroviral therapy (ART). We previously showed that intravenous Bacillus…
View article: Strong SIV-specific memory NK cell responses formed in acute infection persist during chronic SIV infection 3354
Strong SIV-specific memory NK cell responses formed in acute infection persist during chronic SIV infection 3354 Open
Description Natural killer (NK) cells provide rapid and robust innate responses against viral infections. Multiple studies have shown that NK cells also mount antigen-specific recall responses. In nonhuman primates (NHP), antigen-specific …
View article: Indole-AhR-IL-22 pathway strengthens gut barrier in simian HIV infection 4482
Indole-AhR-IL-22 pathway strengthens gut barrier in simian HIV infection 4482 Open
Description Despite effective antiretroviral therapy (ART), HIV disrupts the intestinal barrier early on, causing mucosal immune dysfunction, microbial translocation, and chronic immune activation. Using the nonhuman primate model of treat…
View article: Immunometabolic reprogramming by caloric restriction leads to protection from SIV in rhesus macaques 3052
Immunometabolic reprogramming by caloric restriction leads to protection from SIV in rhesus macaques 3052 Open
Description Nutrient metabolism influences HIV-1 replication, immunity, and chronic inflammation, yet it is challenging to target therapeutically. We hypothesized that modulating metabolism via caloric restriction (CR), a safe, anti-aging …
View article: Origin and Correlates of Viral Rebound in SIV-Infected Rhesus Macaques Following ART Discontinuation
Origin and Correlates of Viral Rebound in SIV-Infected Rhesus Macaques Following ART Discontinuation Open
Summary The vast majority of persons living with HIV-1 who discontinue antiretroviral therapy (ART) demonstrate viral rebound, but the tissue-level events that lead to rebound viremia are poorly understood. Here we report the origin, dynam…
View article: Antiretroviral treatment does not prevent extrapulmonary tuberculosis during SIV/Mtb co-infection in macaques
Antiretroviral treatment does not prevent extrapulmonary tuberculosis during SIV/Mtb co-infection in macaques Open
Co-infection with both HIV and M. tuberculosis (Mtb) results in disseminated tuberculosis (TB) and accelerated progression of HIV. Despite greater access to antiretroviral treatment (ART), it remains unclear whether suppression of HIV repl…
View article: The pathogenicity and multi-organ proteomic profiles of Mpox virus infection in SIVmac239-infected rhesus macaques
The pathogenicity and multi-organ proteomic profiles of Mpox virus infection in SIVmac239-infected rhesus macaques Open
Mpox poses a heightened risk of severe disease and mortality among individuals with HIV, yet the molecular mechanisms and immunopathology underlying multi-organ damage caused by the mpox virus (MPXV), particularly in the context of HIV co-…
View article: Immune Control of AIDS Progression by an Adenovirus‐Based Therapeutic Vaccination in Acute Simian Immunodeficiency Virus‐Infected Macaques
Immune Control of AIDS Progression by an Adenovirus‐Based Therapeutic Vaccination in Acute Simian Immunodeficiency Virus‐Infected Macaques Open
Therapeutic vaccinations that enhance human immunodeficiency virus (HIV)‐specific immunity hold promise for reducing reliance on antiretroviral therapy (ART). We previously developed an adenovirus vector‐infected peripheral blood mononucle…
View article: BCL-2 Inhibition via Venetoclax at ART Initiation Induces Long-Term Reduction of the Intact SIV Reservoir
BCL-2 Inhibition via Venetoclax at ART Initiation Induces Long-Term Reduction of the Intact SIV Reservoir Open
View article: Identification of initial sites of SIV rebound after treatment cessation
Identification of initial sites of SIV rebound after treatment cessation Open
Antiretroviral therapy (ART) suspends HIV replication, but virus persists and rebounds after ART discontinuation. Although much is known about the persistent viral population, the tissue origin(s) and the earliest viral dynamics of post-AR…
View article: Inflammatory neutrophil responses and T cell activation in ART-treated SIVmac239-infected rhesus macaques
Inflammatory neutrophil responses and T cell activation in ART-treated SIVmac239-infected rhesus macaques Open
Modern antiretroviral therapy (ART) regimens have revolutionized the management of human immunodeficiency virus (HIV) and transformed it from a life-threatening disease to a manageable chronic condition. Despite the durable viral suppressi…
View article: Combining a rhesus cytomegalovirus/SIV vaccine with a neutralizing antibody to protect against SIV challenges in rhesus macaques
Combining a rhesus cytomegalovirus/SIV vaccine with a neutralizing antibody to protect against SIV challenges in rhesus macaques Open
A vaccine is considered essential for controlling the HIV pandemic and ultimately eradicating AIDS. Neutralizing antibodies and MHC-E-restricted CD8+ T cells have shown the ability to protect against the simian counterpart of HIV, SIV, in …
View article: Effectiveness of islatravir post‐exposure prophylaxis after intravenous challenge with simian immunodeficiency virus in rhesus macaques
Effectiveness of islatravir post‐exposure prophylaxis after intravenous challenge with simian immunodeficiency virus in rhesus macaques Open
Introduction Islatravir (ISL) is a nucleoside reverse transcriptase translocation inhibitor (NRTTI) with robust antiretroviral activity. The efficacy of ISL administered for post‐exposure prophylaxis (PEP) was evaluated in a simian immunod…
View article: Glycoprotein L–deleted single-cycle rhesus cytomegalovirus vectors elicit MHC-E–restricted CD8+ T cells that protect against SIV
Glycoprotein L–deleted single-cycle rhesus cytomegalovirus vectors elicit MHC-E–restricted CD8+ T cells that protect against SIV Open
Strain 68-1 rhesus CMV (RhCMV) vectors induce immune responses that mediate early, complete replication arrest of SIV infection in ∼60% of vaccinated rhesus macaques (RMs). This unique efficacy depends on the ability of these vectors to el…
View article: SIV/SARS-CoV-2 coinfection in rhesus macaques impacts viral shedding, host immunity, the microbiome, and viral evolution
SIV/SARS-CoV-2 coinfection in rhesus macaques impacts viral shedding, host immunity, the microbiome, and viral evolution Open
People living with HIV (PLWH) have an increased risk of severe COVID-19, including prolonged viral shedding and emergence of mutations. To investigate the simian immunodeficiency virus (SIV) macaque model for HIV/SARS-CoV-2 coinfection, se…
View article: Simian Immunodeficiency Virus-Infected Macrophage Traffic Out of the Central Nervous System
Simian Immunodeficiency Virus-Infected Macrophage Traffic Out of the Central Nervous System Open
We use intracisternal (i.c.) injection of fluorescent-superparamagnetic iron oxide nanoparticles (SPION) in SIV-infected monkeys that labeled CNS CD68-CD163-CD206 perivascular, meningeal, and choroid plexus (CP) macrophages. SPION + CD163 …
View article: Reviewer #2 (Public Review): Adaptation of CD4 in gorillas and chimpanzees conveyed resistance to simian immunodeficiency viruses
Reviewer #2 (Public Review): Adaptation of CD4 in gorillas and chimpanzees conveyed resistance to simian immunodeficiency viruses Open
View article: Reviewer #1 (Public Review): Adaptation of CD4 in gorillas and chimpanzees conveyed resistance to simian immunodeficiency viruses
Reviewer #1 (Public Review): Adaptation of CD4 in gorillas and chimpanzees conveyed resistance to simian immunodeficiency viruses Open
View article: eLife Assessment: Adaptation of CD4 in gorillas and chimpanzees conveyed resistance to simian immunodeficiency viruses
eLife Assessment: Adaptation of CD4 in gorillas and chimpanzees conveyed resistance to simian immunodeficiency viruses Open
View article: Author response: Adaptation of CD4 in gorillas and chimpanzees conveyed resistance to simian immunodeficiency viruses
Author response: Adaptation of CD4 in gorillas and chimpanzees conveyed resistance to simian immunodeficiency viruses Open
View article: Modeling simian immunodeficiency virus (SIV) latency in primary rhesus macaque CD4<sup>+</sup>T cells
Modeling simian immunodeficiency virus (SIV) latency in primary rhesus macaque CD4<sup>+</sup>T cells Open
Simian immunodeficiency virus (SIV)-infected rhesus macaques are valuable models for HIV cure research, offering insights into tissue reservoirs and enabling the evaluation of reservoir-reduction strategies. However, low frequencies of lat…
View article: Purging viral latency by a bifunctional HSV-vectored therapeutic vaccine in chronically SIV-infected macaques
Purging viral latency by a bifunctional HSV-vectored therapeutic vaccine in chronically SIV-infected macaques Open
The persistence of latent viral reservoirs remains the major obstacle to eradicating human immunodeficiency virus (HIV). We herein found that ICP34.5 can act as an antagonistic factor for the reactivation of HIV latency by herpes simplex v…
View article: eLife Assessment: Purging viral latency by a bifunctional HSV-vectored therapeutic vaccine in chronically SIV-infected macaques
eLife Assessment: Purging viral latency by a bifunctional HSV-vectored therapeutic vaccine in chronically SIV-infected macaques Open
View article: Persistence of CMV-specific anti-HIV CAR T cells after adoptive immunotherapy
Persistence of CMV-specific anti-HIV CAR T cells after adoptive immunotherapy Open
The success of chimeric antigen receptor (CAR)-T cell (Tc) immunotherapy in refractory B-cell acute lymphoblastic leukemia (B-ALL) suggests adaptation of this strategy toward HIV. Because cytomegalovirus (CMV) vaccine vectors generated Tc …
View article: Adaptation of CD4 in gorillas and chimpanzees conveyed resistance to simian immunodeficiency viruses
Adaptation of CD4 in gorillas and chimpanzees conveyed resistance to simian immunodeficiency viruses Open
Simian immunodeficiency viruses (SIVs) comprise a large group of primate lentiviruses that endemically infect African monkeys. HIV-1 spilled over to humans from this viral reservoir, but the spillover did not occur directly from monkeys to…
View article: Dissecting the steps in early Simian Immunodeficiency Virus dissemination following mucosal and intravenous infection of rhesus macaques
Dissecting the steps in early Simian Immunodeficiency Virus dissemination following mucosal and intravenous infection of rhesus macaques Open
In cases of HIV transmission, the typical delay from exposure to detectable viremia is approximately one week. This delay from exposure to viremia suggests that during initial expansion of virus from a limited number of founder lineages, t…