Functional gastrointestinal disorder
View article: The Gut – Brain Axis in Autism: Pediatric Perspectives
The Gut – Brain Axis in Autism: Pediatric Perspectives Open
Introduction: Autism spectrum disorder (ASD) is a neurodevelopmental condition frequently associated with gastrointestinal comorbidities such as constipation, diarrhea, abdominal pain, and feeding difficulties. Emerging evidence implicates…
View article: Integrated effects of Kampo treatment on gastrointestinal symptoms and stress in patients with functional dyspepsia: a preliminary prospective observational study
Integrated effects of Kampo treatment on gastrointestinal symptoms and stress in patients with functional dyspepsia: a preliminary prospective observational study Open
Aim This preliminary, single-center prospective observational study aimed to investigate the effects of Kampo treatment on improving gastrointestinal symptoms and reducing stress levels in patients with Functional Dyspepsia (FD). Methods A…
View article: Altered gut microbial functional pathways in people with irritable bowel syndrome enable precision health insights
Altered gut microbial functional pathways in people with irritable bowel syndrome enable precision health insights Open
Rather than waiting to diagnose IBS after symptoms appear, these functional pathway scores can help to provide early health insights into molecular pathways that may contribute to IBS. These molecular endpoints could also assist with measu…
View article: Comparative Study on the Impact of Different Dietary Interventions on Symptoms and Quality of Life in Patients with Irritable Bowel Syndrome
Comparative Study on the Impact of Different Dietary Interventions on Symptoms and Quality of Life in Patients with Irritable Bowel Syndrome Open
Background: Irritable Bowel Syndrome (IBS) is a functional gastrointestinal disorder characterized by abdominal pain and altered bowel habits. Dietary manipulation is a primary therapeutic modality. While the low Fermentable Oligosaccharid…
View article: Comparative Study on the Impact of Different Dietary Interventions on Symptoms and Quality of Life in Patients with Irritable Bowel Syndrome
Comparative Study on the Impact of Different Dietary Interventions on Symptoms and Quality of Life in Patients with Irritable Bowel Syndrome Open
Background: Irritable Bowel Syndrome (IBS) is a functional gastrointestinal disorder characterized by abdominal pain and altered bowel habits. Dietary manipulation is a primary therapeutic modality. While the low Fermentable Oligosaccharid…
View article: Long-Term Outcomes After Therapeutic Induction in Patients with Functional Dyspepsia
Long-Term Outcomes After Therapeutic Induction in Patients with Functional Dyspepsia Open
Background: This multicenter retrospective study evaluated the long-term outcomes of functional dyspepsia (FD) and factors associated with treatment resistance over a 3-year period after treatment initiation. Methods: A total of 111 patien…
View article: Non-Coeliac Wheat Sensitivity: Symptoms in Search of a Mechanism, or a Distinct Well-Defined Clinical Entity? A Narrative Review
Non-Coeliac Wheat Sensitivity: Symptoms in Search of a Mechanism, or a Distinct Well-Defined Clinical Entity? A Narrative Review Open
Non-coeliac wheat sensitivity (NCWS) is characterised by gastrointestinal and extra-intestinal symptoms following gluten/wheat ingestion in individuals without coeliac disease or wheat allergy but remains controversial due to symptom overl…
View article: Targeting Irritable Bowel Syndrome Through Diet and Mechanism-Based Therapies: A Pathophysiological Approach
Targeting Irritable Bowel Syndrome Through Diet and Mechanism-Based Therapies: A Pathophysiological Approach Open
Irritable Bowel Syndrome (IBS) is a prevalent and heterogeneous functional gastrointestinal disorder with a complex and multifactorial pathophysiology. Traditional treatment approaches have focused on symptom relief, often overlooking the …
View article: A Re-evaluation of the Association Between Helicobacter pylori Infection and Pediatric Recurrent Abdominal Pain: A Systematic Review of Organic Versus Functional Etiologies
A Re-evaluation of the Association Between Helicobacter pylori Infection and Pediatric Recurrent Abdominal Pain: A Systematic Review of Organic Versus Functional Etiologies Open
Introduction: The association between Helicobacter pylori infection and Recurrent Abdominal Pain (RAP) in children is a subject of long-standing, significant controversy. While numerous studies in hospital-based settings report a significa…
View article: Melatonin Improves Intestinal Barrier Impairment in a Mouse Model of Autism Spectrum Disorder
Melatonin Improves Intestinal Barrier Impairment in a Mouse Model of Autism Spectrum Disorder Open
Autism spectrum disorder (ASD) is a neurodevelopmental condition mainly characterized by social impairments and repetitive behaviors. An altered intestinal barrier morphology and increased transmucosal leaks have also been implicated in AS…
View article: Intermittent Fasting as a Potential Therapeutic Approach for Irritable Bowel Syndrome: A Mechanistic Perspective
Intermittent Fasting as a Potential Therapeutic Approach for Irritable Bowel Syndrome: A Mechanistic Perspective Open
Irritable bowel syndrome (IBS) is a common gastrointestinal disorder marked by abdominal discomfort, altered bowel habits, and comorbidities like anxiety, fatigue, and poor sleep. Existing treatments often fall short of long-term relief an…
View article: Randomised, placebo-controlled study to assess the safety and efficacy of Enterosgel® in the treatment of functional abdominal pain in children and young people (ENTOPIC): study protocol for a clinical trial
Randomised, placebo-controlled study to assess the safety and efficacy of Enterosgel® in the treatment of functional abdominal pain in children and young people (ENTOPIC): study protocol for a clinical trial Open
Background : Functional abdominal pain disorders (FAPDs) comprise of irritable bowel syndrome, functional dyspepsia, abdominal migraine and functional abdominal pain not otherwise specified. FAPDs are common in children worldwide, decrease…
View article: CORRELATION BETWEEN CLINICAL MANIFESTATIONS OF GUT DYSBIOSIS AND BEHAVIORAL CHANGES IN CHILDREN WITH AUTISM SPECTRUM DISORDER
CORRELATION BETWEEN CLINICAL MANIFESTATIONS OF GUT DYSBIOSIS AND BEHAVIORAL CHANGES IN CHILDREN WITH AUTISM SPECTRUM DISORDER Open
Introduction: Autism Spectrum Disorder (ASD) is a neurodevelopmental condition frequently associated with gastrointestinal symptoms, which may influence behavior and quality of life. Objective: This study aimed to investigate the presence …
View article: CORRELATION BETWEEN CLINICAL MANIFESTATIONS OF GUT DYSBIOSIS AND BEHAVIORAL CHANGES IN CHILDREN WITH AUTISM SPECTRUM DISORDER
CORRELATION BETWEEN CLINICAL MANIFESTATIONS OF GUT DYSBIOSIS AND BEHAVIORAL CHANGES IN CHILDREN WITH AUTISM SPECTRUM DISORDER Open
Introduction: Autism Spectrum Disorder (ASD) is a neurodevelopmental condition frequently associated with gastrointestinal symptoms, which may influence behavior and quality of life. Objective: This study aimed to investigate the presence …
View article: Pathophysiological mechanisms of functional dyspepsia: a narrative review
Pathophysiological mechanisms of functional dyspepsia: a narrative review Open
Background Functional dyspepsia (FD) is a common gastrointestinal disorder with a global prevalence of about 40%. Its pathogenesis is multifactorial and not fully understood, which complicates diagnosis and treatment. Advances in research …
View article: Knowledge, attitude and practice of patients with functional gastrointestinal disorders toward their diseases: a web-based cross-sectional study in a Chinese outpatient setting
Knowledge, attitude and practice of patients with functional gastrointestinal disorders toward their diseases: a web-based cross-sectional study in a Chinese outpatient setting Open
Objectives This study aimed to investigate the knowledge, attitude and practice (KAP) of patients living with functional gastrointestinal disorders (FGIDs) toward their diseases. Design A web-based cross-sectional study was conducted. Sett…
View article: Microbial Influences on Neurodevelopment: Implications for Autism Spectrum Disorders and Attention Deficit Hyperactivity Disorder
Microbial Influences on Neurodevelopment: Implications for Autism Spectrum Disorders and Attention Deficit Hyperactivity Disorder Open
The intricate interplay between the gut microbiome and neurodevelopment has unveiled a transformative perspective on the etiology and management of autism spectrum disorders (ASD) and attention deficit hyperactivity disorder (ADHD), two pr…
View article: Risk factors for the formation of the irritable bowel syndrome in children
Risk factors for the formation of the irritable bowel syndrome in children Open
Aim. To evaluate the association of the irritable bowel syndrome (IBS) with risk factors in school-aged children.Materials and methods. A cross-sectional study included 1,296 schoolchildren aged of 7–17 years. IBS was diagnosed according t…
View article: Psychological characteristics of patients with irritable bowel syndrome and their dynamics against the background of cytoprotective therapy
Psychological characteristics of patients with irritable bowel syndrome and their dynamics against the background of cytoprotective therapy Open
BACKGROUND: Irritable bowel syndrome (IBS) is a common functional bowel disorder caused by disruption of the bidirectional brain-gut signaling pathways. While psychological disorders are considered a predisposing factor for the development…
View article: Current status of functional testing for upper gastrointestinal disorders: state-of-the-art review
Current status of functional testing for upper gastrointestinal disorders: state-of-the-art review Open
Neurogastroenterology and motility disorders of the upper gastrointestinal (GI) tract represent a complex and heterogeneous group of conditions that involve the interaction between the GI tract and the central nervous system. They constitu…
View article: Disorders of Gut−Brain Interaction in a Pediatric Cystic Fibrosis Cohort
Disorders of Gut−Brain Interaction in a Pediatric Cystic Fibrosis Cohort Open
Introduction Disorders of gut−brain interaction (DGBI), such as irritable bowel syndrome, occur at a higher prevalence in adults with cystic fibrosis (CF), compared to the general population. DGBI are associated with impaired quality of li…
View article: Why are disorders of gut–brain interaction (DGBI) often food-related? Duodenal eosinophils and mast cells, small intestinal bacteria, food allergy and altered food intake in functional dyspepsia and the irritable bowel syndrome: a new paradigm
Why are disorders of gut–brain interaction (DGBI) often food-related? Duodenal eosinophils and mast cells, small intestinal bacteria, food allergy and altered food intake in functional dyspepsia and the irritable bowel syndrome: a new paradigm Open
The underlying causes of irritable bowel syndrome (IBS) and functional dyspepsia (FD) have remained largely elusive, but emerging data suggest immune activation and loss of small intestinal homeostasis may explain a major subgroup. FD and …
View article: Validating a novel scoring system for the assessment and treatment of functional gastrointestinal disorders in children
Validating a novel scoring system for the assessment and treatment of functional gastrointestinal disorders in children Open
BACKGROUND Functional gastrointestinal disorders (FGIDs), defined as ‘Disorders of Gut-Brain Interaction’, are now considered a global health problem. There is a dearth of concepts and scales to assess the severity of the different symptom…
View article: Alternative Gastrointestinal Conditions Identified in Patients Meeting Rome IV Criteria for Irritable Bowel Syndrome or Functional Diarrhea Referred to Secondary Care: A Prospective Study
Alternative Gastrointestinal Conditions Identified in Patients Meeting Rome IV Criteria for Irritable Bowel Syndrome or Functional Diarrhea Referred to Secondary Care: A Prospective Study Open
Introduction: Organic gastrointestinal (GI) disorders can be missed in individuals with irritable bowel syndrome (IBS). This study investigated the frequency of organic disorders in patients with diarrhea-predominant IBS or functional diar…
View article: Functional Bowel Disorder Management in Routine Practice with Tips for Hot Topics: Expert Opinion Review
Functional Bowel Disorder Management in Routine Practice with Tips for Hot Topics: Expert Opinion Review Open
Functional gastrointestinal system disorders are common problems in practice. The most common symptoms are abdominal pain, gas, bloating, diarrhea, constipation, and a mixture of these, and similar symptoms can be seen in conditions such a…
View article: Vitamin D Deficiency and Its Correction in IBS Subtypes: Gender Differences and Biochemical Correlates
Vitamin D Deficiency and Its Correction in IBS Subtypes: Gender Differences and Biochemical Correlates Open
Background: Irritable Bowel Syndrome (IBS) is a prevalent functional gastrointestinal disorder with diverse subtypes. Recent evidence suggests a link between vitamin D deficiency and IBS; however, the association between vitamin D levels, …
View article: Investigating the Health Potential of Mentha Species Against Gastrointestinal Disorders—A Systematic Review of Clinical Evidence
Investigating the Health Potential of Mentha Species Against Gastrointestinal Disorders—A Systematic Review of Clinical Evidence Open
Background/Objectives: Gastrointestinal disorders include a broad spectrum of clinical conditions due to various symptoms. Abdominal pain claims attention as it can be associated with multiple diseases, and some of them can lead to chronic…
View article: Therapeutic effect of peppermint oil application in patients with irritable bowel syndrome and metabolic syndrome
Therapeutic effect of peppermint oil application in patients with irritable bowel syndrome and metabolic syndrome Open
Irritable bowel syndrome (IBS) is one of the most common functional gastrointestinal disorders, affecting almost 20% of the population, causing significant functional and socioeconomic burden. An existing association between functional bow…
View article: Decoding Abdominal Pain in Constipation-predominant Irritable Bowel Syndrome and Functional Constipation: Mechanisms and Managements
Decoding Abdominal Pain in Constipation-predominant Irritable Bowel Syndrome and Functional Constipation: Mechanisms and Managements Open
View article: Vitamin D in Irritable Bowel Syndrome: Exploring Its Role in Symptom Relief and Pathophysiology
Vitamin D in Irritable Bowel Syndrome: Exploring Its Role in Symptom Relief and Pathophysiology Open
Irritable Bowel Syndrome (IBS) is a chronic functional gastrointestinal disorder. Despite its common occurrence, the pathophysiology of IBS remains not fully understood. Emerging evidence suggests that IBS is a multifactorial condition cha…