Golden hamster ≈ Golden hamster
View article
Sex Differences in Lung Imaging and SARS-CoV-2 Antibody Responses in a COVID-19 Golden Syrian Hamster Model Open
Men experience more severe outcomes from coronavirus disease 2019 (COVID-19) than women. Golden Syrian hamsters were used to explore sex differences in the pathogenesis of a human clinical isolate of severe acute respiratory syndrome coron…
View article
Decreases in body temperature and body mass constitute pre-hibernation remodelling in the Syrian golden hamster, a facultative mammalian hibernator Open
Hibernation is an adaptive strategy for surviving during periods with little or no food availability, by profoundly reducing the metabolic rate and the core body temperature ( T b ). Obligate hibernators (e.g. bears, ground squirrels, etc.…
View article
Tissue Distribution of ACE2 Protein in Syrian Golden Hamster (Mesocricetus auratus) and Its Possible Implications in SARS-CoV-2 Related Studies Open
The Syrian golden hamster ( Mesocricetus auratus ) has recently been demonstrated as a clinically relevant animal model for SARS-CoV-2 infection. However, lack of knowledge about the tissue-specific expression pattern of various proteins i…
View article
The golden (Syrian) hamster as a model for the study of reproductive biology: Past, present, and future Open
Background The golden (Syrian) hamster ( Mesocricetus auratus ) is a small rodent that belongs to the Cricetidae family. It has several unique features that are advantageous for the study of reproductive and developmental biology, includin…
View article
Comparison of the pathogenesis of SARS-CoV-2 infection in K18-hACE2 mouse and Syrian golden hamster models Open
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the etiological agent of COVID-19, causes life-threatening disease. This novel coronavirus enters host cells via the respiratory tract, promoting the formation of severe pulmona…
View article
Comparison of the therapeutic effects of the dietary and topical forms of Zizyphus jujuba extract on oral mucositis induced by 5-fluorouracil: A golden hamster model Open
The use of Z. jujuba hydroalcoholic extract in systemic and topical forms may be associated with reduced intensity of OM, diminished concentration of MDA, and increased activity of MPO and SOD on induced OM in golden hamster undergoing 5-F…
View article
Circadian variations of clock gene Per2 and cell cycle genes in different stages of carcinogenesis in golden hamster buccal mucosa Open
Previous studies have suggested that the expression of clock genes have circadian rhythms and many cell cycle genes are regulated by clock genes. The disruption of circadian rhythms appears to be associated with the acceleration of cancer …
View article
Zika Virus Infection in Syrian Golden Hamsters and Strain 13 Guinea Pigs Open
To evaluate potential immunocompetent small animal models of Zika virus (ZIKV) infection, we inoculated Syrian golden hamsters (subcutaneously or intraperitoneally) and strain 13 guinea pigs (intraperitoneally) with Senegalese ZIKV strain …
View article
Male-Specific Submaxillary Gland Protein, a Lipocalin Allergen of the Golden Hamster, Differs from the Lipocalin Allergens of Siberian and Roborovski Dwarf Hamsters Open
Background: An increasing number of asthma cases upon exposure to hamsters and anaphylactic reactions following hamster bites are being reported, but the allergens responsible are still poorly characterized. In the Golden hamster, male-spe…
View article
Golden Syrian Hamster Models for Cancer Research Open
The golden Syrian hamster (Mesocricetus auratus) has long been a valuable rodent model of human diseases, especially infectious and metabolic diseases. Hamsters have also been valuable models of several chemically induced cancers such as t…
View article
Plasma metabolomics of the time resolved response to Opisthorchis felineus infection in an animal model (golden hamster, Mesocricetus auratus) Open
The time resolved metabolic signature of Opisthorchis infection in the hamster's plasma shows a coherent shift in amino acids and lipid metabolism. Our work provides insight into the metabolic basis of the host response on the helminth inf…
View article
Photoperiod regulates the differential expression of KiSS-1 and GPR54 in various tissues and sexes of striped hamster Open
In order to investigate how photoperiod affects the expression of KiSS-1/G-protein-coupled receptor 54 (GPR54), the hypothalamus, the ovaries and testicles of the striped hamster were studied following photoperiod treatment and melatonin i…
View article
The Microvillar and Solitary Chemosensory Cells as the Novel Targets of Infection of SARS-CoV-2 in Syrian Golden Hamsters Open
Patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of coronavirus disease 2019, suffer from respiratory and non-respiratory symptoms. Among these symptoms, the loss of smell has attract…
View article
SARS-CoV-2 Disease Severity in the Golden Syrian Hamster Model of Infection Is Related to the Volume of Intranasal Inoculum Open
The golden Syrian hamster (Mesocricetus auratus) is now commonly used in preclinical research for the study of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and the assessment of vaccines, drugs and therapeutics. H…
View article
What can seasonal models teach us about energy balance? Open
Torpid states are used by many endotherms to save energy during winter. During torpor, metabolic rate is downregulated to fractions of resting metabolic rate and often associated with a severe drop in body temperature that challenges mamma…
View article
The influence of sex and diet on the characteristics of hibernation in Syrian hamsters Open
Research on deep hibernators almost exclusively uses species captured from the wild or from local breeding. An exception is Syrian hamster (Mesocricetus auratus), the only standard laboratory animal showing deep hibernation. In deep hibern…
View article
A novel cancer syndrome caused by<i>KCNQ1</i>-deficiency in the golden Syrian hamster Open
None of the hamsters in our colony that were wild-type or heterozygous for KCNQ1 mutations developed cancers indicating that the cancer phenotype is linked to KCNQ1-deficiency. This study is also the first evidence linking KCNQ1-deficiency…
View article
Limits to sustained energy intake XXIX: the case of the golden hamster (<i>Mesocricetus auratus</i>) Open
Golden hamster females have the shortest known gestation period among placental mammals and at the same time raise very large litters of up to 16 offspring, which are born in a naked and blind state and are able to pick up food from days 1…
View article
Age of Laboratory Hamster and Human: Drawing the Connexion Open
Hamsters have unique physiological characteristics rendering them well-suited for biomedical research as experimental model. They match beneficial traits of both smaller rodents and larger mammals that make them suitable for laboratory use…
View article
Prevention of pancreatic cancer in a hamster model by cAMP decrease Open
Smoking and alcoholism are risk factors for the development of pancreatitis-associated pancreatic ductal adenocarcinoma (PDAC). We have previously shown that these cancers overexpressed stress neurotransmitters and cyclic adenosine monopho…
View article
Molecular Characterization of Hamster-Adapted Yellow Fever Virus Open
We previously reported two hamster models for viscerotropic yellow fever virus (YFV) infection: one using a YFV strain (Jiménez), isolated from a fatal human case in Panama in 1974, and the other using the prototype YFV strain (Asibi). Asi…
View article
Granulin Expression in Hamsters during Opisthorchis viverrini Infection-Induced Cholangiocarcinogenesis Open
The secreted growth factor granulin (GRN) is upregulated during diverse epithelial cancers. GRN stimulates cell growth and development while inhibiting apoptosis. Orthologues of vertebrate granulins evolved in other animals including the l…
View article
Food-Anticipatory Activity in Syrian Hamsters: Behavioral and Molecular Responses in the Hypothalamus According to Photoperiodic Conditions Open
When food availability is restricted, animals adjust their behavior according to the timing of food access. Most rodents, such as rats and mice, and a wide number of other animals express before timed food access a bout of activity, define…
View article
The Syrian Golden Hamster Estrous Cycle Open
The Syrian hamster, Mesocricetus auratus, is a suitable rodent species for standard regulatory toxicity studies. However, little is published about the female Syrian hamster reproductive system. It has unique anatomic features that differ …
View article
Characterizations of Hamster Retina as a Model for Studies of Retinal Cholesterol Homeostasis Open
Cholesterol homeostasis in the retina, a sensory organ in the back of the eye, has been studied in mice but not hamsters, despite the latter being more similar to humans than mice with respect to their whole-body cholesterol maintenance. T…
View article
Acute hepatologic and nephrologic effects of calcitriol in Syrian golden hamster (Mesocricetus auratus) Open
Although vitamin D is included in the group of fat-soluble vitamins, it must be considered as a prohormone. Its active forms including calcitriol have pleiotropic effects and play an important role in the regulation of cell proliferation, …
View article
Anti-Atherosclerotic Effect of a Polyphenol-Rich Ingredient, Oleactiv®, in a Hypercholesterolemia-Induced Golden Syrian Hamster Model Open
The development of nutraceutical ingredients has risen as a nutritional solution for health prevention. This study evaluated the effects of Oleactiv®, an ingredient developed for the prevention of atherogenesis, in hypercholesterolemic ham…
View article
EMODIN EFFICACY ON THE AKT, MAPK, ERK AND DNMT EXPRESSION PATTERN DURING DMBA-INDUCED ORAL CARCINOMA IN GOLDEN SYRIAN HAMSTERS Open
Background: The present study has evaluated the Emodin efficacy on the Akt, MAPK, ERK and DNMT expression pattern during
7,12-dimethylbenz[a]anthracene (DMBA)-induced oral carcinoma in golden Syrian hamsters, in order to explore its antit…
View article
Expressions of Gonadotropin Subunit Genes in the Reproductively Inactive Golden Hamsters Open
Photoperiod has well been established to regulate testicular activities in golden hamsters. These animals breed actively around summer but become infertile in winter. In males, testicles are full of multistep germ cells including spermatoz…
View article
A New Target Organ of Leishmania (Viannia) braziliensis Chronic Infection: The Intestine Open
Leishmania (Viannia) braziliensis is one of the main causes of cutaneous leishmaniasis in the Americas. This species presents genetic polymorphism that can cause destructive lesions in oral, nasal, and oropharyngeal tracts. In a previous s…