Motor cortex
View article: Contralesional activity reflects compensation, while brainstem detour pathways support skilled motor recovery after stroke
Contralesional activity reflects compensation, while brainstem detour pathways support skilled motor recovery after stroke Open
Large strokes frequently result in lasting motor deficits and trigger extensive reorganization within the brain and spinal cord. Altered neuronal activity in the contralesional hemisphere has been documented in both humans and rodent model…
View article: Multidimensional analysis of brain activation patterns in different motor therapies using functional near-infrared spectroscopy
Multidimensional analysis of brain activation patterns in different motor therapies using functional near-infrared spectroscopy Open
Objective This study employed functional near-infrared spectroscopy (fNIRS) to systematically compare the effects of active movement (AM), passive movement (PM), and motor imagery (MI) on sensorimotor cortex excitability across three dimen…
View article: Rehabilitation of Post-Traumatic Epilepsy Through Neurofeedback and Motor Therapy: A 6-Month Follow-Up Case Study
Rehabilitation of Post-Traumatic Epilepsy Through Neurofeedback and Motor Therapy: A 6-Month Follow-Up Case Study Open
Background/Objectives: Post-traumatic epilepsy (PTE) is a frequent complication of Traumatic Brain Injury (TBI), often contributing to exacerbate functional and neurological impairment. Since PTE is difficult to treat with traditional anti…
View article: Subcortical control of reaching in humans
Subcortical control of reaching in humans Open
Accurate visually guided reaching requires transformation of target-related photoreceptor responses into precisely coordinated activation of trunk and arm muscles. The cerebral cortex is widely believed to compute the requisite kinematic a…
View article: Computational Modeling of Transcranial Electric Stimulation in Anemic Conditions: A Hodgkin-Huxley and Finite Element Analysis
Computational Modeling of Transcranial Electric Stimulation in Anemic Conditions: A Hodgkin-Huxley and Finite Element Analysis Open
Computational models of tES typically assume normal physiological conditions. The effect of systemic metabolic disorders like anemia on tES efficacy remains unexplored. This study investigates the effects of transcranial electric stimulati…
View article: Transcranial static magnetic field stimulation of the primary motor cortex in essential tremor: a randomized pilot study
Transcranial static magnetic field stimulation of the primary motor cortex in essential tremor: a randomized pilot study Open
Alterations in the motor cortex may contribute to essential tremor (ET) pathophysiology. Transcranial static magnetic field stimulation (tSMS), a non-invasive and portable technique, reduces corticospinal excitability, but its therapeutic …
View article: Concurrent Bilateral M1 and Anodal Cerebellar tDCS Effects on Learning of a Bimanual Video Game Task
Concurrent Bilateral M1 and Anodal Cerebellar tDCS Effects on Learning of a Bimanual Video Game Task Open
Purpose The primary motor cortex (M1) and the cerebellum are important sites of processing for motor learning of complex, bimanual tasks. However, little is known about the current and polarity effects of transcranial direct current stimul…
View article: The Association of EEG μ Rhythm Phase and Power with TMS-Assessed Cortical Excitability States
The Association of EEG μ Rhythm Phase and Power with TMS-Assessed Cortical Excitability States Open
The efficacy of transcranial magnetic stimulation (TMS) is influenced by the brain’s real-time activity state. This study aimed to investigate the correlation between cortical excitability states and EEG features, specifically the phase an…
View article: Increased layer 5 Martinotti cell excitation reduces pyramidal cell population plasticity and improves learned motor execution
Increased layer 5 Martinotti cell excitation reduces pyramidal cell population plasticity and improves learned motor execution Open
During motor activity and motor learning, pyramidal cells in the motor cortex receive inputs from local interneurons as well as deeper structures. Layer 5 pyramidal cells in the primary motor cortex then feed commands to spinal circuits fo…
View article: Developmental Dysregulation of Synaptic and Myelin-Related Genes in Frontal Cortex and Serum Infrared Spectroscopy Signature in the Valproic Acid Model of Autism
Developmental Dysregulation of Synaptic and Myelin-Related Genes in Frontal Cortex and Serum Infrared Spectroscopy Signature in the Valproic Acid Model of Autism Open
Neural circuits emerge during development through dynamic interactions between genetic instructions and environmental cues that shape cell fate, connectivity, and the timing of myelination. In developmental disorders such as autism, abnorm…
View article: Enhancing corticospinal facilitation from sEMG-triggered paired intermittent theta burst stimulation and neuromuscular electrical stimulation in young and older adults
Enhancing corticospinal facilitation from sEMG-triggered paired intermittent theta burst stimulation and neuromuscular electrical stimulation in young and older adults Open
Background Pairing intermittent theta burst stimulation (iTBS) with neuromuscular electrical stimulation (NMES) can increase corticospinal excitability (CSE) of a relaxed muscle. Whether initiating stimulation with surface electromyographi…
View article: Increased layer 5 Martinotti cell excitation reduces pyramidal cell population plasticity and improves learned motor execution
Increased layer 5 Martinotti cell excitation reduces pyramidal cell population plasticity and improves learned motor execution Open
During motor activity and motor learning, pyramidal cells in the motor cortex receive inputs from local interneurons as well as deeper structures. Layer 5 pyramidal cells in the primary motor cortex then feed commands to spinal circuits fo…
View article: Reviewer #1 (Public review): Visuomotor mismatch EEG responses in occipital cortex of freely moving human subjects
Reviewer #1 (Public review): Visuomotor mismatch EEG responses in occipital cortex of freely moving human subjects Open
View article: Reviewer #3 (Public review): Visuomotor mismatch EEG responses in occipital cortex of freely moving human subjects
Reviewer #3 (Public review): Visuomotor mismatch EEG responses in occipital cortex of freely moving human subjects Open
View article: Functional specialization of the human posterior parietal cortex in visually and proprioceptively driven reaching corrections
Functional specialization of the human posterior parietal cortex in visually and proprioceptively driven reaching corrections Open
While online adjustments during reaching are essential for interacting with our dynamic environment, the specialized contributions of subregions of the posterior parietal cortex (PPC) remain unclear. In this study, we investigate the disti…
View article: Patient-Centered Chronic Spinal Pain Management Using Exercise and Neuromodulation: Study Protocol for a Randomized Controlled Trial
Patient-Centered Chronic Spinal Pain Management Using Exercise and Neuromodulation: Study Protocol for a Randomized Controlled Trial Open
Introduction: Persistent Spinal Pain Syndrome Type 2 (PSPS-T2) is associated with changes in the brain’s pain processing. This is often due to problems with the body’s natural way of handling the pain management system. Exercise therapy, s…
View article: Reviewer #2 (Public review): Visuomotor mismatch EEG responses in occipital cortex of freely moving human subjects
Reviewer #2 (Public review): Visuomotor mismatch EEG responses in occipital cortex of freely moving human subjects Open
View article: Upregulation of sphingomyelin and <scp>ABCA8</scp> in response to <scp>TDP</scp> ‐43 pathology in amyotrophic lateral sclerosis brain
Upregulation of sphingomyelin and <span>ABCA8</span> in response to <span>TDP</span> ‐43 pathology in amyotrophic lateral sclerosis brain Open
Amyotrophic lateral sclerosis (ALS) is a rapidly progressing neurodegenerative disease characterized by the degeneration of motor neurons and the presence of TAR DNA‐binding protein 43 (TDP‐43) aggregation in the brain. Dyslipidemia is a c…
View article: Altered motor coordination, vocal communication, and cerebellar circuit connectivity in mice carrying a near-complete human chromosome 21
Altered motor coordination, vocal communication, and cerebellar circuit connectivity in mice carrying a near-complete human chromosome 21 Open
Individuals with Down syndrome (DS) frequently face challenges with motor control and coordination, affecting their daily physical movements. The neural mechanism underlying motor coordination deficits in DS remains poorly understood. Usin…
View article: The unexpected dual role of S100A9 amyloid protein on neurodegeneration in progressive multiple sclerosis motor cortex
The unexpected dual role of S100A9 amyloid protein on neurodegeneration in progressive multiple sclerosis motor cortex Open
Motor cortical inflammation and neurodegeneration are key features of progressive multiple sclerosis (MS), contributing to irreversible motor disability. However, the precise mechanisms leading to neuronal loss remain poorly understood. Wh…
View article: Effect of low-frequency repetitive transcranial magnetic stimulation combined with motor imagery training on upper limb motor recovery and primary motor cortex activation in stroke patients: A randomized controlled trial
Effect of low-frequency repetitive transcranial magnetic stimulation combined with motor imagery training on upper limb motor recovery and primary motor cortex activation in stroke patients: A randomized controlled trial Open
Background: We aimed to investigate the effects of low-frequency repetitive transcranial magnetic stimulation (LF-rTMS) combined with motor imagery training (MIT) on upper limb function recovery and primary motor cortex (M1) activation in …
View article: Bilateral intermittent theta-burst stimulation as a priming strategy to enhance action observation and imitation training in early parkinson’s disease: a proof-of-concept study
Bilateral intermittent theta-burst stimulation as a priming strategy to enhance action observation and imitation training in early parkinson’s disease: a proof-of-concept study Open
Bilateral iTBS targeting the leg representation of the primary motor cortex can potentiate AOIT effects in early-stage PIGD by enhancing cortical plasticity and motor learning. These findings support the integration of iTBS as a priming st…
View article: Dataset - Motor System Oligodendroglia Atlas Reveals Activation States Associated with Region-Specific Vulnerability in ALS.
Dataset - Motor System Oligodendroglia Atlas Reveals Activation States Associated with Region-Specific Vulnerability in ALS. Open
h5ad file with internal gzip compression. This is a repository for the data generated and used for the manuscript "Georgopoulou et. al., Motor System Oligodendroglia Atlas Reveals Activation States Associated with Re…
View article: Sustained shoulder elevation posture: an under-recognized functional movement disorder phenotype
Sustained shoulder elevation posture: an under-recognized functional movement disorder phenotype Open
Patients with sustained shoulder elevation postures were observed over time in our movement disorders clinic and occasionally reported in literature as variants of dystonia or post-traumatic movement disorders. We retrospectively assessed …
View article: Dataset - Motor System Oligodendroglia Atlas Reveals Activation States Associated with Region-Specific Vulnerability in ALS.
Dataset - Motor System Oligodendroglia Atlas Reveals Activation States Associated with Region-Specific Vulnerability in ALS. Open
h5ad file with internal gzip compression. This is a repository for the data generated and used for the manuscript "Georgopoulou et. al., Motor System Oligodendroglia Atlas Reveals Activation States Associated with Region-Specific Vulnerabi…
View article: Functional connectivity between non-motor and motor networks predicts motor recovery changes after stroke
Functional connectivity between non-motor and motor networks predicts motor recovery changes after stroke Open
Stroke impairs limb motor function, which affects patients' quality of life and imposes economic burdens. Early prediction of motor recovery is essential for guiding treatment and rehabilitation. While the corticospinal tract is a known bi…
View article: Revisiting the purpose of the thalamus: anatomically sub-cortical but functionally supra-cortical?
Revisiting the purpose of the thalamus: anatomically sub-cortical but functionally supra-cortical? Open
The largely accepted view of the brain function is corticocentric: the cerebral cortex monitors the world to provide optimal behavioural decisions given current external and internal demands. However, this overlooks a crucial fact: the cer…
View article: Imagining the beat: causal evidence for dorsal premotor cortex (dPMC) role in beat imagery via transcranial magnetic stimulation (TMS)
Imagining the beat: causal evidence for dorsal premotor cortex (dPMC) role in beat imagery via transcranial magnetic stimulation (TMS) Open
The ability to internally generate and maintain a rhythmic pulse, i.e., beat imagery, is a fundamental aspect of musical cognition. While recent theories propose that premotor regions support internal temporal predictions during rhythm per…
View article: Evaluation of cortical excitability patterns in patients undergoing glioblastoma resection in the motor area
Evaluation of cortical excitability patterns in patients undergoing glioblastoma resection in the motor area Open
Background: Brain tumors adjacent to the primary motor cortex may alter corticospinal physiology through mass effects, pathway disruption and maladaptive plasticity. Preoperative transcranial magnetic stimulation (TMS) maps cortical excita…
View article: Effects of concurrent transcranial direct and alternating current stimulation on human motor skill learning: a systematic review and Bayesian meta-analysis
Effects of concurrent transcranial direct and alternating current stimulation on human motor skill learning: a systematic review and Bayesian meta-analysis Open
Motor learning is important throughout human lifespan for acquisition, refinement and preservation of motor skills and for regaining functional abilities through rehabilitation training. Therefore, it is essential to develop strategies and…