Corticotropin-releasing hormone
View article: Chronic Stress Segregates Mice into Distinct Behavioral Phenotypes Based on Glucocorticoid Sensitivity
Chronic Stress Segregates Mice into Distinct Behavioral Phenotypes Based on Glucocorticoid Sensitivity Open
Chronic stress alters hypothalamic–pituitary–adrenal (HPA) axis function, affecting corticosterone regulation and adaptive responses. Understanding individual variability in stress adaptation requires identifying distinct HPA axis response…
View article: An interneuronal CRH and CRHBP circuit stabilizes birdsong performance
An interneuronal CRH and CRHBP circuit stabilizes birdsong performance Open
The performance of skilled behaviors requires a balance between consistency and adaptability. Although the neural mechanisms that regulate this balance have been extensively studied at systems and physiological levels, relatively little is…
View article: An interneuronal CRH and CRHBP circuit stabilizes birdsong performance
An interneuronal CRH and CRHBP circuit stabilizes birdsong performance Open
The performance of skilled behaviors requires a balance between consistency and adaptability. Although the neural mechanisms that regulate this balance have been extensively studied at systems and physiological levels, relatively little is…
View article: Previous exposure to traumatic brain injury alters acute stress responses in mice
Previous exposure to traumatic brain injury alters acute stress responses in mice Open
Acute stress (AS) exposure and traumatic brain injury (TBI) have a high prevalence and result in emotional and behavioral impairments. In fact, TBI is a leading cause of mortality in young adults and survivors cope with neuropsychological …
View article: Impact of Sex, Gonadectomy, and Repeated Restraint Stress on Gut Microbiome in Mice
Impact of Sex, Gonadectomy, and Repeated Restraint Stress on Gut Microbiome in Mice Open
Recently, the bidirectional connection between the gastrointestinal microbiota and the brain has gained interest in many research studies. Findings have highlighted the potential role of stress and sex hormones in modulating the gut microb…
View article: Corticotripin releasing hormone neurons in paraventricular hypothalamic nucleus participated in the modulation of gastric motility by electro-acupuncture
Corticotripin releasing hormone neurons in paraventricular hypothalamic nucleus participated in the modulation of gastric motility by electro-acupuncture Open
Objectives Acute gastric distension (GD) impairs gastric motility and engages central stress circuits. We tested whether electroacupuncture (EA) at RN12/BL21 restores motility and probed mechanisms in the paraventricular nucleus (PVN), foc…
View article: Hormonal and Behavioral Consequences of Social Isolation and Loneliness: Neuroendocrine Mechanisms and Clinical Implications
Hormonal and Behavioral Consequences of Social Isolation and Loneliness: Neuroendocrine Mechanisms and Clinical Implications Open
Social isolation and loneliness represent critical psychosocial stressors associated with profound hormonal dysregulation and adverse behavioral outcomes. This review synthesizes current evidence on the neuroendocrine mechanisms linking pe…
View article: Chronic Stress Leads to Differentiation of Mice by Glucocorticoid Sensitivity into Groups Characterized by Specific Behavioral Phenotype
Chronic Stress Leads to Differentiation of Mice by Glucocorticoid Sensitivity into Groups Characterized by Specific Behavioral Phenotype Open
Chronic stress alters hypothalamic-pituitary-adrenal (HPA) axis function, influencing corticosterone regulation and adaptive responses. Identifying distinct response patterns can provide insight into individual variability in stress adapta…
View article: Dynamic interaction between stress hormones and neutrophils promotes neutrophil extracellular trap formation with behavioral consequences
Dynamic interaction between stress hormones and neutrophils promotes neutrophil extracellular trap formation with behavioral consequences Open
Recent studies have highlighted the crosstalk between neuroendocrine responses and the immune system but the mechanisms underlying this cooperation are still not well understood. The stress response is associated with peripheral inflammati…
View article: Gestational kynurenine metabolites mediate effects of pregnancy adiposity on child negative affect
Gestational kynurenine metabolites mediate effects of pregnancy adiposity on child negative affect Open
Background Mounting evidence links increased adiposity during pregnancy and offspring risk for mental health disorders. Yet the mechanisms underlying this association remain poorly understood, limiting our ability to design effective inter…
View article: Imbalanced innervation of the hypothalamic paraventricular nucleus by the AgRP and α-MSH axonal projections in germ-free mice
Imbalanced innervation of the hypothalamic paraventricular nucleus by the AgRP and α-MSH axonal projections in germ-free mice Open
Introduction. Innervation of the paraventricular nucleus of the hypothalamus (PVN) by the orexigenic agouti-related protein (AgRP) and anorexigenic α-melanocyte-stimulating hormone (α-MSH) neurons of the arcuate nucleus (ARC) is a key elem…
View article: Chronic stress and the IL-10-mediated immunoregulatory loop in the pathogenesis of periodontitis
Chronic stress and the IL-10-mediated immunoregulatory loop in the pathogenesis of periodontitis Open
Periodontitis is a chronic inflammatory condition that gradually destroys the tissues supporting the teeth, including the gingiva, periodontal ligament, and alveolar bone. Emerging evidence suggests that psychological stress plays a signif…
View article: CNSC-61. NEURAL SIGNATURE DISTINGUISHES SILENT FROM OVERT PHENOTYPE IN CORTICOTROPIC PITNETS
CNSC-61. NEURAL SIGNATURE DISTINGUISHES SILENT FROM OVERT PHENOTYPE IN CORTICOTROPIC PITNETS Open
Corticotroph pituitary neuroendocrine tumors (PitNETs) expressing adrenocorticotropic hormone (ACTH) can lead to Cushing’s disease (CD). In contrast, silent corticotroph PitNETs also produce ACTH but lack clinical or biochemical signs of h…
View article: Corticotropin‐releasing factor type 1 receptors in the rat nodose ganglion are involved in the transduction of stress‐induced visceral sensory signals to the brain
Corticotropin‐releasing factor type 1 receptors in the rat nodose ganglion are involved in the transduction of stress‐induced visceral sensory signals to the brain Open
Corticotropin‐releasing factor (CRF) plays roles in stress‐related responses through its type 1 (CRF 1 ) and type 2 receptors. Both CRF and CRF 1 are expressed in the rat colon. Peripheral CRF administration and various stressors increase …
View article: Corticotropin-releasing hormone modulates NREM sleep consolidation through the thalamic reticular nucleus
Corticotropin-releasing hormone modulates NREM sleep consolidation through the thalamic reticular nucleus Open
View article: Dataset: Activity of corticotropin-releasing factor neurons in the bed nucleus of the stria terminalis reduces anxiety-potentiated startle in female rats in an estrous phase-dependent manner
Dataset: Activity of corticotropin-releasing factor neurons in the bed nucleus of the stria terminalis reduces anxiety-potentiated startle in female rats in an estrous phase-dependent manner Open
View article: Electroacupuncture ameliorates visceral hypersensitivity and negative emotions by regulating paraventricular hypothalamic nucleus and colonic corticotropin-releasing factor signaling
Electroacupuncture ameliorates visceral hypersensitivity and negative emotions by regulating paraventricular hypothalamic nucleus and colonic corticotropin-releasing factor signaling Open
BACKGROUND Visceral hypersensitivity is the core pathogenesis of irritable bowel syndrome (IBS) and is often accompanied by negative emotions such as anxiety or depression. Paraventricular hypothalamic nucleus (PVN) corticotropin-releasing…
View article: Ultradian rhythms of CRH <sup>PVN</sup> neuron activity, behavior, and stress hormone secretion
Ultradian rhythms of CRH <sup>PVN</sup> neuron activity, behavior, and stress hormone secretion Open
The stress axis is always active, even in the absence of any threat. This manifests as hourly pulses of corticosteroid stress hormone secretion over the day. Corticotropin-releasing hormone (CRH) neurons in the paraventricular nucleus of t…
View article: Dynamic expression and regulation of corticotropin-releasing hormone and urotensin I during metamorphosis of olive flounder Paralichthys olivaceus
Dynamic expression and regulation of corticotropin-releasing hormone and urotensin I during metamorphosis of olive flounder Paralichthys olivaceus Open
View article: The effect of two types of exercise conditioning on hypothalamic corticotropin-releasing hormone (CRH) and gonadotropin-releasing hormone (GNRH) gene expression response to acute noise stress in rats
The effect of two types of exercise conditioning on hypothalamic corticotropin-releasing hormone (CRH) and gonadotropin-releasing hormone (GNRH) gene expression response to acute noise stress in rats Open
This study investigated the effect of two types of exercise on the hypothalamic expression of CRH and GnRH genes in response to acute noise stress in young rats. 42 male Wistar rats were divided into 7 groups including control (Con), Contr…
View article: Crosstalk between thyroid hormones and the central corticotropin‐releasing factor system in Atlantic salmon
Crosstalk between thyroid hormones and the central corticotropin‐releasing factor system in Atlantic salmon Open
The corticotropin‐releasing factor (CRF) system is primarily known for its conserved role in regulating pituitary corticotrope activity, but it can also influence thyroid hormone (TH) production by stimulating thyroid‐stimulating hormone (…
View article: Probiotics restore impaired spatial cognition and synaptic plasticity of prenatally-stressed male rats: focus on hippocampal and intestinal tight junctions
Probiotics restore impaired spatial cognition and synaptic plasticity of prenatally-stressed male rats: focus on hippocampal and intestinal tight junctions Open
View article: Translating stress systems: corticotropin releasing factor, its receptors, and the dopamine system in nonhuman primate models
Translating stress systems: corticotropin releasing factor, its receptors, and the dopamine system in nonhuman primate models Open
Stress is a fact of life, affecting organisms from the smallest invertebrates to humans. Mediating the stress system is the ancient neuropeptide, corticotropin releasing factor (CRF), which works as a neuromodulator to alter brain systems …
View article: Neuroanatomical and behavioral characterization of corticotropin releasing factor-expressing lateral Habenula neurons in mice
Neuroanatomical and behavioral characterization of corticotropin releasing factor-expressing lateral Habenula neurons in mice Open
The lateral habenula (LHb), which plays a critical role in value-based decision-making and in stress responses, is linked to drug addiction and mood disorders. Prior research from our lab demonstrated the LHb’s responsiveness to corticotro…
View article: Disruption of <scp><i>Ephb1</i></scp> causes reduced hypothalamic <scp>CRH</scp> and <scp>TRH</scp> expression and obesity in mice
Disruption of <span><i>Ephb1</i></span> causes reduced hypothalamic <span>CRH</span> and <span>TRH</span> expression and obesity in mice Open
Objective Ephrin type‐B receptor 1 (EphB1) is a receptor tyrosine kinase involved in axon guidance, synaptic plasticity, and tumorigenesis. However, the role of EphB1 in metabolic regulation and obesity remains poorly understood. This stud…
View article: The effect of corticotropin-release hormone on duodenal permeability and immune activation in healthy volunteers in a double-blind placebo-controlled study
The effect of corticotropin-release hormone on duodenal permeability and immune activation in healthy volunteers in a double-blind placebo-controlled study Open
Our investigation breaks new ground by directly examining the effects of corticotropin-release hormone (CRH) on duodenal alterations, including permeability and immune activation, in healthy subjects. Intriguingly, our findings highlight d…
View article: Early-life adversity alters adult nucleus incertus neurons: implications for neuronal mechanisms of increased stress and compulsive behavior vulnerability
Early-life adversity alters adult nucleus incertus neurons: implications for neuronal mechanisms of increased stress and compulsive behavior vulnerability Open
View article: Androgen receptors in corticotropin-releasing hormone neurons mediate the sexual dimorphism in restraint-induced thymic atrophy
Androgen receptors in corticotropin-releasing hormone neurons mediate the sexual dimorphism in restraint-induced thymic atrophy Open
Sexual dimorphism in immune responses is well documented, but the underlying mechanisms remain incompletely understood. Here, we identified a subset of corticotropin-releasing hormone (CRH) neurons that express androgen receptors (ARs) as …
View article: Lack of maternal exposure to somatostatin leads to diet-induced insulin and leptin resistance in mouse male offspring
Lack of maternal exposure to somatostatin leads to diet-induced insulin and leptin resistance in mouse male offspring Open
Somatostatin (Sst) is an inhibitory regulator of many hormones. The prenatal environment impacts an offspring’s risk to type 2 diabetes in adulthood. However, the effect of maternal Sst deficiency on glucose and insulin metabolism in offsp…
View article: Mast cells and corticotropin‐releasing hormone receptors in duodenal tissue of children with functional dyspepsia
Mast cells and corticotropin‐releasing hormone receptors in duodenal tissue of children with functional dyspepsia Open
Objectives Functional dyspepsia (FD) is a disorder of the gut–brain interaction characterized by epigastric pain, nausea, and/or early satiety. Existing literature suggests a physical link between psychiatric diagnoses and disorders of the…