Thrombotic thrombocytopenic purpura
View article: Caplacizumab in Lupus-Associated Thrombotic Thrombocytopenic Purpura (TTP): Navigating Autoimmunity and Microangiopathy
Caplacizumab in Lupus-Associated Thrombotic Thrombocytopenic Purpura (TTP): Navigating Autoimmunity and Microangiopathy Open
View article: Long-Term Thrombotic Events in Patients with Myocardial Infarction: Proteomic Analysis of Platelets and Plasma Combined with Hemostasis Assessment
Long-Term Thrombotic Events in Patients with Myocardial Infarction: Proteomic Analysis of Platelets and Plasma Combined with Hemostasis Assessment Open
Aim To determine factors associated with an increased risk of thrombotic complications during antiplatelet therapy in patients with acute myocardial infarction (AMI) based on a study of the parameters of hemostasis functional activity, as …
View article: Genotype–Phenotype Variability in Congenital Thrombotic Thrombocytopenic Purpura (TTP): Two Novel ADAMTS13 Variants
Genotype–Phenotype Variability in Congenital Thrombotic Thrombocytopenic Purpura (TTP): Two Novel ADAMTS13 Variants Open
View article: Novel cryptic ADAMTS13 epitopes uncover a distinct open ADAMTS13 conformation in immune-mediated TTP
Novel cryptic ADAMTS13 epitopes uncover a distinct open ADAMTS13 conformation in immune-mediated TTP Open
Open ADAMTS13 conformation is gaining clinical interest as a biomarker for diagnosing immune-mediated thrombotic thrombocytopenic purpura (iTTP) and monitoring remission patients for increased relapse risks. Yet, little is known on how ope…
View article: Predicting Outcomes and Optimizing Therapy in Thrombotic Thrombocytopenic Purpura: Insights on Caplacizumab Use from a Romanian Hematology Center
Predicting Outcomes and Optimizing Therapy in Thrombotic Thrombocytopenic Purpura: Insights on Caplacizumab Use from a Romanian Hematology Center Open
Background: Thrombotic thrombocytopenic purpura (TTP) is a rare and life-threatening thrombotic microangiopathy requiring prompt diagnosis and treatment. This retrospective single-center study analyzed 31 adult patients diagnosed between 2…
View article: EASIX, a new tool to predict response and refractoriness in immune-mediated thrombotic thrombocytopenic purpura
EASIX, a new tool to predict response and refractoriness in immune-mediated thrombotic thrombocytopenic purpura Open
Introduction Immune-mediated thrombotic thrombocytopenic purpura (iTTP) is a life-threatening thrombotic microangiopathy resulting from severe ADAMTS13 deficiency. Caplacizumab accelerates platelet recovery, but ~15% of patients remain ref…
View article: Severe Octreotide-Induced Immune Thrombocytopenia With Bone Marrow Findings Suggestive of Acquired Amegakaryocytic Thrombocytopenic Purpura in a Cirrhotic Woman: An Unusual Case Report
Severe Octreotide-Induced Immune Thrombocytopenia With Bone Marrow Findings Suggestive of Acquired Amegakaryocytic Thrombocytopenic Purpura in a Cirrhotic Woman: An Unusual Case Report Open
View article: Recurrent Thrombocytopenia During Caplacizumab Therapy in Acute Immune‐Mediated Thrombotic Thrombocytopenic Purpura
Recurrent Thrombocytopenia During Caplacizumab Therapy in Acute Immune‐Mediated Thrombotic Thrombocytopenic Purpura Open
View article: von Willebrand factor and fibrin monomer - induced septic shock coagulation typing: Clinical comparison between thrombotic thrombocytopenic purpura - like syndrome and sepsis - induced coagulopathy with prognostic implications
von Willebrand factor and fibrin monomer - induced septic shock coagulation typing: Clinical comparison between thrombotic thrombocytopenic purpura - like syndrome and sepsis - induced coagulopathy with prognostic implications Open
TTP-like syndrome and SIC represent heterogeneous coagulation phenotypes in septic shock, with differences in biomarkers, organ injury, and prognosis. A vWF- and FM-guided subtype classification may improve individualized treatment strateg…
View article: Clinical Case Report: A 65-Year-Old Presenting with Disseminated Intravascular Coagulation as a Rituximab Infusional Reaction
Clinical Case Report: A 65-Year-Old Presenting with Disseminated Intravascular Coagulation as a Rituximab Infusional Reaction Open
View article: Postoperative thrombotic thrombocytopenic purpura following cervical posterior single open-door laminoplasty: A case report and literature review
Postoperative thrombotic thrombocytopenic purpura following cervical posterior single open-door laminoplasty: A case report and literature review Open
View article: Malignant Hypertension–Induced Thrombotic Microangiopathy Mimicking Atypical Hemolytic Uremic Syndrome and Thrombotic Thrombocytopenic Purpura
Malignant Hypertension–Induced Thrombotic Microangiopathy Mimicking Atypical Hemolytic Uremic Syndrome and Thrombotic Thrombocytopenic Purpura Open
Malignant hypertension is an important cause of secondary TMA. Controlled blood pressure reduction is the cornerstone of therapy. Multidisciplinary collaboration with nephrology helps confirm the diagnosis and guide plasma exchange decisio…
View article: 256 Microangiopathic Hemolytic Anemia Following Liver Transplantation: An Overlooked Complication Triggered by Sepsis
256 Microangiopathic Hemolytic Anemia Following Liver Transplantation: An Overlooked Complication Triggered by Sepsis Open
Introduction/Objective Microangiopathic hemolytic anemia (MAHA) is an uncommon but critical complication in solid organ transplant recipients. Its recognition is often delayed due to overlapping symptoms with other post-transplant conditio…
View article: Thrombotic Thrombocytopenic Purpura During Anti-Tuberculosis Therapy: A Case Report and Literature Review
Thrombotic Thrombocytopenic Purpura During Anti-Tuberculosis Therapy: A Case Report and Literature Review Open
View article: 71 Immune Thrombocytopenia and Thrombotic Thrombocytopenic Purpura: A Case of Overlapping Diagnoses in a Single Patient with Literature Review
71 Immune Thrombocytopenia and Thrombotic Thrombocytopenic Purpura: A Case of Overlapping Diagnoses in a Single Patient with Literature Review Open
Introduction/Objective Immune thrombocytopenia (ITP) and thrombotic thrombocytopenic purpura (TTP) are distinct disorders involving autoimmune platelet destruction and ADAMTS13 deficiency, respectively. Overlap of ITP and TTP diagnoses is …
View article: 12 Validation of a new semi-automated ADAMTS13 activity assay for prompt evaluation of presumptive thrombotic thrombocytopenic patients
12 Validation of a new semi-automated ADAMTS13 activity assay for prompt evaluation of presumptive thrombotic thrombocytopenic patients Open
The ADAMTS13 activity assay is considered a diagnostic test for confirmation of clinical diagnosis of thrombotic thrombocytopenia purpura (TTP). Nonetheless, most common methodologies involve ELISA-based assays that are manual and time con…
View article: Caplacizumab therapy for relapsed immune thrombotic thrombocytopenic purpura
Caplacizumab therapy for relapsed immune thrombotic thrombocytopenic purpura Open
View article: Antiphospholipid Syndrome and the Kidney
Antiphospholipid Syndrome and the Kidney Open
Antiphospholipid syndrome (APS) is a rare autoimmune disorder characterized by the persistent positivity of antiphospholipid antibodies (aPLs) along with thrombotic manifestations, obstetrical complications, or nonthrombotic manifestations…
View article: Prognostic value of laboratory biomarkers for mortality risk stratification in thrombotic thrombocytopenic purpura
Prognostic value of laboratory biomarkers for mortality risk stratification in thrombotic thrombocytopenic purpura Open
View article: Personalised treatment of patients with immune thrombotic thrombocytopenic purpura
Personalised treatment of patients with immune thrombotic thrombocytopenic purpura Open
Background. Treatment of immune thrombotic thrombocytopenic purpura (iTTP) includes plasma exchange (PEX) and immunosuppression (glucocorticoids and rituximab). The addition of caplacizumab to therapy has improved treatment outcomes in iTT…
View article: Optimizing ADAMTS13 prophylaxis to reduce relapse and organ failure in congenital thrombotic thrombocytopenic purpura
Optimizing ADAMTS13 prophylaxis to reduce relapse and organ failure in congenital thrombotic thrombocytopenic purpura Open
Congenital thrombotic thrombocytopenic purpura (cTTP) is caused by a severe inherited ADAMTS13 deficiency. While acute episodes are life-threatening, long-term burden of ischemic complications and effectiveness of prophylactic strategies r…
View article: P129 | Diagnostic pathway for thrombotic thrombocytopenic purpura: Case study
P129 | Diagnostic pathway for thrombotic thrombocytopenic purpura: Case study Open
Premises: TTP is characterized by MAHA with thrombocytopenia and organ ischemia. The diagnosis is confirmed by a severe deficiency in ADAMTS 13 activity, either congenital or immune-mediated.Case study: A 51-year-old woman with a medical h…
View article: Thrombotic thrombocytopenic purpura as a complication of pembrolizumab: a case report and literature review
Thrombotic thrombocytopenic purpura as a complication of pembrolizumab: a case report and literature review Open
The success of immune checkpoint inhibitors (ICIs) has revolutionized oncology, with an increasing number of patients receiving treatment every year. However, this progress has been accompanied by a rise in immune-related adverse events (i…
View article: High anti-ADAMTS13 IgG Levels after Plasma Exchange Predict Delayed ADAMTS13 Normalization in Immune-mediated Thrombotic Thrombocytopenic Purpura
High anti-ADAMTS13 IgG Levels after Plasma Exchange Predict Delayed ADAMTS13 Normalization in Immune-mediated Thrombotic Thrombocytopenic Purpura Open
In acute immune-mediated TTP (iTTP) caplacizumab therapy has proved to be effective in achieving an early clinical response. However, the discontinuation of caplacizumab therapy before ADAMTS13 activity has at least partially recovered can…
View article: Pregnancy-Induced Thrombotic Thrombocytopenic Purpura Complicated by Atypical Posterior Reversible Encephalopathy Syndrome and Acute Pancreatitis: A Rare Presentation
Pregnancy-Induced Thrombotic Thrombocytopenic Purpura Complicated by Atypical Posterior Reversible Encephalopathy Syndrome and Acute Pancreatitis: A Rare Presentation Open
View article: Rare onset of congenital thrombotic thrombocytopenic purpura during pregnancy: A novel ADAMTS13 gene variant
Rare onset of congenital thrombotic thrombocytopenic purpura during pregnancy: A novel ADAMTS13 gene variant Open
Background Congenital thrombotic thrombocytopenic purpura ( cTTP ) is a rare autosomal recessive thrombotic microangiopathy caused by biallelic mutations in ADAMTS13 , leading to severe enzyme deficiency. The absence of ADAMTS13 prevents c…
View article: Top of the Basilar Syndrome Following Carbon Monoxide Poisoning in a Patient with Idiopathic Thrombocytopenic Purpura
Top of the Basilar Syndrome Following Carbon Monoxide Poisoning in a Patient with Idiopathic Thrombocytopenic Purpura Open
View article: Successful treatment of transplant-associated thrombotic microangiopathy with iptacopan: a non-adult case study
Successful treatment of transplant-associated thrombotic microangiopathy with iptacopan: a non-adult case study Open
Transplant-associated thrombotic microangiopathy (TA-TMA) is a severe complication of hematopoietic stem cell transplantation (HSCT), characterized by microangiopathic hemolytic anemia, thrombocytopenia, microthrombosis, and multi-organ dy…
View article: Bone marrow metastasis of gastric signet ring cell carcinoma complicated by thrombotic microangiopathy: A case report
Bone marrow metastasis of gastric signet ring cell carcinoma complicated by thrombotic microangiopathy: A case report Open
BACKGROUND Thrombotic microangiopathy (TMA) is an acute syndrome characterized by microangiopathic hemolytic anemia, thrombocytopenia, and multi-organ dysfunction due to the microcirculation of platelet thrombi. Cancer-associated TMA is a …
View article: Suspected Sildenafil-Induced Immune Hemolytic Anemia Precipitating Acute Kidney Injury Requiring Hemodialysis
Suspected Sildenafil-Induced Immune Hemolytic Anemia Precipitating Acute Kidney Injury Requiring Hemodialysis Open
Drug-induced immune hemolytic anemia (DIIHA) is a rare secondary cause of autoimmune hemolytic anemia (AIHA), more frequently associated with drugs such as cephalosporins, penicillin, non-steroidal anti-inflammatory drugs (NSAIDs), and cer…