Chlamydiales
View article: Epidemiological characteristics of Ureaplasma urealyticum, Chlamydia trachomatis, Neisseria gonorrhoeae, and herpes simplex virus among 5,577 gynecological outpatients in the Xihu district of Hangzhou, China
Epidemiological characteristics of Ureaplasma urealyticum, Chlamydia trachomatis, Neisseria gonorrhoeae, and herpes simplex virus among 5,577 gynecological outpatients in the Xihu district of Hangzhou, China Open
This study characterizes the epidemiology of UU, CT, NG, and HSV in real-world obstetrics and gynecology outpatient settings in Xihu District, Hangzhou. Given the elevated positivity among younger women, targeted health education and manag…
View article: A pilot study of re-purposing drugs to treat koalas with chlamydia
A pilot study of re-purposing drugs to treat koalas with chlamydia Open
The koala (Phascolarctos cinereus) is an endangered species in parts of Australia, in part due to chlamydial infections. Treatment is difficult due to the hepatic metabolism of the koala, and the critical reliance on a gut microbiota for s…
View article: Prevalence of Ureaplasma urealyticum, Chlamydia trachomatis, Neisseria gonorrhoeae and Herpes simplex virus in Hangzhou, China
Prevalence of Ureaplasma urealyticum, Chlamydia trachomatis, Neisseria gonorrhoeae and Herpes simplex virus in Hangzhou, China Open
View article: Chlamydia trachomatis Infection and Its Association with Human Papillomavirus Among Adolescent Girls and Young Women of Eastern Cape, South Africa
Chlamydia trachomatis Infection and Its Association with Human Papillomavirus Among Adolescent Girls and Young Women of Eastern Cape, South Africa Open
Background/Objectives: Adolescent girls and young women (AGYW) have a high burden of sexually transmitted infections (STIs). This study examined the prevalence of Chlamydia trachomatis, its association with human papillomavirus (HPV), and …
View article: RELATIONSHIP BETWEEN REACTIVE OXYGEN SPECIES, VITAMIN E, CATALASE AND CHLAMYDIA TRACHOMATIS IN SERUM OF INFERTILE FEMALE
RELATIONSHIP BETWEEN REACTIVE OXYGEN SPECIES, VITAMIN E, CATALASE AND CHLAMYDIA TRACHOMATIS IN SERUM OF INFERTILE FEMALE Open
Background: The failure in female reproductive system could be cause infertility according to different factors such as sperm isoantobody, zona pellucid antibody, ovarian antibody, Chlamydia trachomatis infection, hormonal imbalance and ev…
View article: Insights into chlamydial infection at the sub-cellular level using label-free Raman spectroscopy in comparison to electron microscopy
Insights into chlamydial infection at the sub-cellular level using label-free Raman spectroscopy in comparison to electron microscopy Open
Intracellular infections are difficult to study as the host cell protects the pathogen from direct observation from the outside. Transmission electron microscopy (TEM) is the most commonly used method for subcellular analysis. However, sam…
View article: Evaluation of Mycoplasma genitalium positivity and co-infection with Chlamydia trachomatis and/or Neisseria gonorrhoeae at various care sites across the United States
Evaluation of Mycoplasma genitalium positivity and co-infection with Chlamydia trachomatis and/or Neisseria gonorrhoeae at various care sites across the United States Open
MG positivity was high and MG co-infection with CT was common. These findings improve understanding of MG prevalence and may help inform the targeting of MG screening to specific patient populations. Co-infection data support using multipl…
View article: RELATIONSHIP BETWEEN REACTIVE OXYGEN SPECIES, VITAMIN E, CATALASE AND CHLAMYDIA TRACHOMATIS IN SERUM OF INFERTILE FEMALE
RELATIONSHIP BETWEEN REACTIVE OXYGEN SPECIES, VITAMIN E, CATALASE AND CHLAMYDIA TRACHOMATIS IN SERUM OF INFERTILE FEMALE Open
Background: The failure in female reproductive system could be cause infertility according to different factors such as sperm isoantobody, zona pellucid antibody, ovarian antibody, Chlamydia trachomatis infection, hormonal imbalance and ev…
View article: Back to normality? Respiratory viruses, Mycoplasma pneumoniae, Chlamydophila pneumoniae, and Bordetella pertussis trends: local epidemiological update after the COVID-19 storm
Back to normality? Respiratory viruses, Mycoplasma pneumoniae, Chlamydophila pneumoniae, and Bordetella pertussis trends: local epidemiological update after the COVID-19 storm Open
This retrospective study assessed the circulation of respiratory viruses, MP, CP and BP in our geographical area, observing their gradual and asynchronous re-emergence following the COVID-19 pandemic. Strengthening advanced molecular micro…
View article: Sharp increase in Chlamydia pneumoniae infections in 2024 in Germany
Sharp increase in Chlamydia pneumoniae infections in 2024 in Germany Open
View article: Clinical Validation of Loop‐Mediated Isothermal Amplification Assays for the Rapid Detection of <i>Neisseria gonorrhoeae</i> and <i>Chlamydia trachomatis</i>
Clinical Validation of Loop‐Mediated Isothermal Amplification Assays for the Rapid Detection of <i>Neisseria gonorrhoeae</i> and <i>Chlamydia trachomatis</i> Open
Neisseria gonorrhoeae (GC) and Chlamydia trachomatis (CT) are the predominant causes of bacterial sexually transmitted diseases. While nucleic acid amplification testing (NAATs), primarily polymerase chain reaction (PCR), is regarded as th…
View article: Comparative and phylogenomic analysis of Chlamydia pneumoniae reveals unique carbohydrate active enzyme family (GT5) among respiratory isolates
Comparative and phylogenomic analysis of Chlamydia pneumoniae reveals unique carbohydrate active enzyme family (GT5) among respiratory isolates Open
Chlamydia pneumoniae is an obligatory intracellular pathogen found in humans and animals. Understanding the genomic diversity is crucial for unravelling its pathogenic mechanisms and transmission dynamics. In this study, 14 complete genome…
View article: HIV-1 and <i>Chlamydia trachomatis</i> restrict their respective growth but promote their survival in co-infected human macrophages
HIV-1 and <i>Chlamydia trachomatis</i> restrict their respective growth but promote their survival in co-infected human macrophages Open
HIV-1 and Chlamydia trachomatis (CT) are two significant sexually transmitted pathogens that frequently co-infect individuals. However, the mechanisms by which these two obligate intracellular pathogens interact at the cellular level remai…
View article: <i>Chlamydia trachomatis</i> and <i>Neisseria gonorrhoeae</i> bacterial loads in men who have sex with men on pre-exposure prophylaxis: a cross-sectional study
<i>Chlamydia trachomatis</i> and <i>Neisseria gonorrhoeae</i> bacterial loads in men who have sex with men on pre-exposure prophylaxis: a cross-sectional study Open
Objective Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (NG) are the most commonly reported sexually transmitted infections globally. Anorectal CT/NG detection among men who have sex with men (MSM) and coinfections is common. Epidem…
View article: Genome-wide identification of modulators of Chlamydia trachomatis parasitophorous vacuole stability highlights an important role for sphingolipid supply
Genome-wide identification of modulators of Chlamydia trachomatis parasitophorous vacuole stability highlights an important role for sphingolipid supply Open
A mechanistic understanding of how intracellular pathogens evade the intrinsic defenses of their host cells could open up intriguing therapeutic opportunities. Here, we applied a genome-wide genetic screening approach to investigate the na…
View article: Molecular Detection of <i>Chlamydia trachomatis</i> in Infertile Syrian Women: A Comparative Analysis of <i>ompA</i> and Cryptic Plasmid PCR Assays
Molecular Detection of <i>Chlamydia trachomatis</i> in Infertile Syrian Women: A Comparative Analysis of <i>ompA</i> and Cryptic Plasmid PCR Assays Open
Background Chlamydia trachomatis is a highly prevalent sexually transmitted infection (STI) strongly associated with female infertility. Polymerase Chain Reaction (PCR) is considered the gold standard for diagnosis, utilizing primers desig…
View article: Respiratory microbiome and metabolome features associate disease severity and the need for doxycycline treatment in children with macrolide-resistant Mycoplasma pneumoniae-mediated pneumonia
Respiratory microbiome and metabolome features associate disease severity and the need for doxycycline treatment in children with macrolide-resistant Mycoplasma pneumoniae-mediated pneumonia Open
Introduction Commensal bacterial community along the upper respiratory tract functions against pathogens. The host determinants of Mycoplasma pneumoniae severity should be identified against the increasing threat of macrolide-resistant M. …
View article: Dual Isotopologue Profiling of Bacterial Pathogens and their Host Cells: Metabolic Adaptation of Human Macrophages and Fallopian Tube Cells to Intracellular <i>Chlamydia trachomatis</i>
Dual Isotopologue Profiling of Bacterial Pathogens and their Host Cells: Metabolic Adaptation of Human Macrophages and Fallopian Tube Cells to Intracellular <i>Chlamydia trachomatis</i> Open
Chlamydia trachomatis is a Gram-negative bacterium that utilizes multiple host-derived substrates to ensure its intracellular survival. In this study, human fallopian tube (HFT) cells, and human macrophages polarized toward a pro-in…
View article: Comparative Evaluation of Recombinant Chlamydia abortus and Chlamydia trachomatis Major Outer Membrane Proteins for Diagnosing Human Chlamydial Infection
Comparative Evaluation of Recombinant Chlamydia abortus and Chlamydia trachomatis Major Outer Membrane Proteins for Diagnosing Human Chlamydial Infection Open
Chlamydia trachomatis infection is a public health problem. Serological tests can determine the disease burden and serve as a biomarker for identifying patients with infertility due to tubal obstruction. However, cross-reactions between ch…
View article: Chlamydia vaughanii sp. nov., a novel Chlamydia isolated from a tropical fish (bushymouth catfish)
Chlamydia vaughanii sp. nov., a novel Chlamydia isolated from a tropical fish (bushymouth catfish) Open
The Chlamydiaceae is a family of strict, intracellular bacteria which include human and animal pathogens such as Chlamydia trachomatis and Chlamydia psittaci . Following the death of multiple Ancistrus dolichopterus fish (bushymouth catfis…
View article: Chlamydia trachomatis Infections: A Rapid Decrease in Denmark from 2022 to 2024 is Driven by the Young Population
Chlamydia trachomatis Infections: A Rapid Decrease in Denmark from 2022 to 2024 is Driven by the Young Population Open
View article: Assessment of <i>Chlamydia trachomatis</i> testing in Sweden 2016–2023 and the incidence of associated complications
Assessment of <i>Chlamydia trachomatis</i> testing in Sweden 2016–2023 and the incidence of associated complications Open
IBSS has become the most important CT case detector in Sweden. Primary care and gynaecology clinics have low positivity rates. The decrease in PID rates may be due to generous CT testing, although other explanations are possible. Consideri…
View article: Chlamydia trachomatis pgp3 ELISA
Chlamydia trachomatis pgp3 ELISA Open
Chlamydia trachomatis (Ct) serology is an important tool to support infection and disease surveillance of the population but there are currently no formal reference reagents and few commercial assays available. Our objective was to develop…
View article: Prevalence of Chlamydia trachomatis, Neisseria gonorrhoeae, and Ureaplasma urealyticum infections in males and females of childbearing age in Chengdu, China
Prevalence of Chlamydia trachomatis, Neisseria gonorrhoeae, and Ureaplasma urealyticum infections in males and females of childbearing age in Chengdu, China Open
Background Sexually transmitted infections (STIs) are a global public health issue, due to their high prevalence and potential impact on pregnancy outcome and fetal health. The objective of this study is to investigate the prevalence of ST…
View article: Detection of human IgG antibodies against <i>Mycoplasma genitalium</i> using a recombinant MG075 antigen
Detection of human IgG antibodies against <i>Mycoplasma genitalium</i> using a recombinant MG075 antigen Open
Mycoplasma genitalium is a sexually transmitted pathogen that can cause a range of reproductive tract diseases in both men and women. To disentangle the relationship between M. genitalium infection(s) and subsequent reproductive health com…
View article: Chlamydia pneumoniae relies on host glutathione for its growth and induces integrated stress response-mediated changes in macrophage glutathione metabolism
Chlamydia pneumoniae relies on host glutathione for its growth and induces integrated stress response-mediated changes in macrophage glutathione metabolism Open
The obligate intracellular bacterium Chlamydia pneumoniae can enter into persistent phenotype, which is refractory to antibiotics and causes prolonged inflammatory state in the host. Molecular mechanisms enabling C. pneumoniae intracellula…
View article: Parachlamydia acanthamoebae: disease-causing pathogen or opportunistic bystander?
Parachlamydia acanthamoebae: disease-causing pathogen or opportunistic bystander? Open
Graphical abstract Parachlamydia acanthamoebae is an obligate intracellular bacterium found in free-living Acanthamoeba amoebae. As with other Chlamydiales, P. acanthamoebae has a biphasic lifecycle with an infectious elementary body and a…
View article: Adoption of an in-silico analysis approach to assess the functional and structural impacts of rpoB-encoded protein mutations on Chlamydia pneumoniae sensitivity to antibiotics
Adoption of an in-silico analysis approach to assess the functional and structural impacts of rpoB-encoded protein mutations on Chlamydia pneumoniae sensitivity to antibiotics Open
View article: Noninvasive Monitoring of Humoral Immune Responses in Men With Acute <i>Chlamydia trachomatis</i> Urethral Infection Using First-Catch Urine
Noninvasive Monitoring of Humoral Immune Responses in Men With Acute <i>Chlamydia trachomatis</i> Urethral Infection Using First-Catch Urine Open
We investigated the relationship between Chlamydia trachomatis load and anti-chlamydial antibody using first-catch urine from 108 men with nongonococcal urethritis. Men who reported prior chlamydia had elevated anti-chlamydial IgA and lowe…
View article: Serum IgG1 and IgG3 Antibody Responses to <i>Chlamydia trachomatis</i> Pgp3 and Hsp60 in Tubal Factor Infertility
Serum IgG1 and IgG3 Antibody Responses to <i>Chlamydia trachomatis</i> Pgp3 and Hsp60 in Tubal Factor Infertility Open
Background Our goal was to investigate IgG1 and IgG3 antibody responses to Chlamydia trachomatis proteins Pgp3 and Hsp60 in women with tubal factor infertility (TFI). Our goal was to determine the role of these biomarkers in the diagnosis …