Explanipedia

Emphysematous Gastritis in a Patient with Concomitant COVID-19 Infection and Celiac Trunk Stenosis: A Case Report Open

Hira Khan, Anjali Rajagopal, Murali Dharan, Hira Khan, Anjali Rajagopal , et al. · 2025

This case report reviews a 75-year-old male with several comorbidities who presented with acute encephalopathy and sepsis in the setting of COVID-19 pneumonia, who was noted to have significant gaseous distention of the stomach, emphysemat…

Characteristics of Patients with Liver Cirrhosis Attending Azadi Center of Gastroenterology and Hepatology-Duhok Kurdistan Region Open

Mustafa Qasim Abdullah, Ali Abdulghani Ramathan, Azad Salih Muhammed · 2025

Background and objectives: Diagnosis of liver cirrhosis is made histologically, yet patients can present with clinical and laboratory features suggestive of end-stage liver disease and cirrhosis. The aim was to identify the causes, severit…

Gastric mucosal change after the eradication of Helicobacter pylori in patients at high risk for gastric cancers Open

Na Rae Lim, Woo Chul Chung · 2025

Background Eradication of Helicobacter pylori alone will not eliminate the risk of gastric cancer. There was no conclusive evidence that eradication therapy reduced the incidence of gastric cancer in patients with atrophic gastritis or int…

The Impact of Helicobacter pylori Eradication on the Outcomes of Gastric Mucosal Lesions Open

Yanjie Shen, Lu Sun, Liang Huang, Yanlin Zhou, Bin Lu · 2025

Background The eradication of Helicobacter pylori ( H. pylori ) has been shown to reduce the risk of progression of precancerous lesions to gastric cancer. However, whether H. pylori eradication can improve or even reverse atrophy and inte…

Case Report: Severe gastric atrophy associated with a novel homozygous variant in LRBA Open

Shilin Yuan, Ting Li, Tong Yu, Zhiling Wang · 2025

Background The prevalence of atrophic gastritis is challenging to determine, considering that it is typically asymptomatic and that its definition and diagnosis vary among studies. Furthermore, gastric atrophy is underreported and is often…

Inflammatory factors collaboratively link Helicobacter pylori-induced gastritis to gastric cancer Open

Mingze Zhang, Ade Su, Houji Song, Siyu Zhang, Yuan Deng , et al. · 2025

Long-term inflammatory reaction may promote gastric cancer initiation and development through multiple mechanisms. Recent studies have demonstrated that inflammatory mediators play a crucial role in the transition from gastritis to gastric…

Utilization of Hematological Markers to Distinguish Bile Reflux Gastritis From Helicobacter pylori-Associated Gastritis in Pediatric Patients Open

Shehanshah Muhammad Arqam, Maliha Mahmood, Labiqa Khowaja, Naveed Ul Haq, Farhan Ullah , et al. · 2025

Risk factors and serological diagnosis of Helicobacter pylori infection in children with abdominal pain and vomiting Open

Ranjit K. Chourashia, Farhana Bayes, Fahmida B. Kakan, Rezina Parveen, Mohammad S. Ahtesam , et al. · 2025

Background: Helicobacter pylori is a Gram-negative bacterium that ranks among the most prevalent chronic infections around the globe. It's closely associated with conditions like gastritis, peptic ulcers, gastric cancer, and mucosa-assiste…

Gastric Cancer after Helicobacter pylori Eradication: Characteristics, Diagnosis, and Management Open

Seokho Myeong, Ilsoo Kim, Donghoon Kang, Yu Kyung Cho, Jae Myung Park · 2025

Background Helicobacter pylori (H. pylori) eradication is one of the most well-established strategies for the prevention of gastric cancer and is recommended in several countries, particularly in high-risk countries. However, gastric cance…

Weifuchun alleviates MNNG-induced chronic atrophic gastritis by improving the gastric and intestinal microbiota homeostasis Open

Yingying Chen, Ping Feng, Xiaoqin Lou, Hai-ying Wang, Yanlan Hong , et al. · 2025

Purpose Chronic atrophic gastritis (CAG) is a prevalent condition that can undergo precancerous lesions of gastric cancer (PLGC) and thus progression to gastric cancer. Weifuchun (WFC), a traditional Chinese herbal compound, is employed in…

Beyond H. pylori: Streptococcal Co-Infections and Their Hidden Impact on Gastric Lesions in Vietnam Open

Nghiem Xuan Hoan, Dao Phuong Giang, Nguyen, Minh Trang, Nguyen Thi Loan, Le Huu Song , et al. · 2025

Background/Objectives: Helicobacter pylori (H. pylori) is a well-established pathogen associated with chronic gastritis and gastric malignancies. Recent studies suggest that members of the Streptococcus anginosus group (SAG), particularly …

Epithelial cell-derived exosomes carry NamiRNA-143-5p and promote ASPN expression in fibroblasts to drive Helicobacter pylori infected gastritis progression Open

Zheng Zhang, Shuyue Yang, Mengran Zhao, Wenjing Sun, Rui Xu , et al. · 2025

In Helicobacter pylori (H. pylori) associated gastritis, fibroblasts are recruited to inflammatory sites and secrete multiple pro-inflammatory cytokines, but the underlying mechanism remains unclear. Here, immunohistochemical staining reve…

Inhibition of microRNA-155 regulates gastric mucosal barrier repair and inflammation by targeting SOCS1 for the treatment of acute gastritis Open

Lei Luo, Kai Zhang, Siyu Mu, Shuangyong Liu, † Wen-Jing Xiao , et al. · 2025

Acute gastritis is a common gastrointestinal disorder characterized by rapid onset of mucosal injury and infiltration of inflammatory cells, often induced by chemical irritants such as ethanol. Although inflammation is essential for mucosa…

Gastric organoids: A promising model for studying “inflammation-cancer” transition in atrophic gastritis Open

Chang Liu, Chen-Heng Wu, Yue-Bo Jia, Jun-Xin Qiu, Xin-Yuan Li , et al. · 2025

Current experimental models struggle to simulate the complex process of the transformation from atrophic gastritis to gastric cancer, while gastric organoid technology, especially region-specific modeling, provides a more precise in vitro …

STUDY OF THE FUNCTIONAL STATE OF THE GASTRIC MUCOSA IN PATIENTS WITH CHRONIC IRON DEFICIENCY ANEMIA Open

Sultonova Hilola Zohidjon qizi · 2025

Chronic iron deficiency anemia (IDA) is commonly associated with structural and functional changes of the gastric mucosa, including reduced acidity, mucosal atrophy, and Helicobacter pylori infection. In this study, 48 IDA patients were ex…

Expression and analysis of NLRP6 in chronic gastritis in children Open

Siyu Gu, Dalei Li, Jun Sun, Jiangyan Liu, Kangwei Mao · 2025

STUDY OF THE FUNCTIONAL STATE OF THE GASTRIC MUCOSA IN PATIENTS WITH CHRONIC IRON DEFICIENCY ANEMIA Open

Sultonova Hilola Zohidjon qizi · 2025

Chronic iron deficiency anemia (IDA) is commonly associated with structural and functional changes of the gastric mucosa, including reduced acidity, mucosal atrophy, and Helicobacter pylori infection. In this study, 48 IDA patients were ex…

Helicobacter pylori gastritis: epidemiological and diagnostic aspects at the Niamey General Referral Hospital Open

Department of Basic and Mixed Sciences, Faculty of Health Sciences, Abdou Moumouni University of Niamey, AB Abani Bako, Laboratory of Anatomical and Cytological Pathology of the Niamey General Referral Hospital, HZ El-Hadji Lamine, Visceral Surgery Department of the Niamey General Referral Hospital , et al. · 2025

Introduction : Helicobacter pylori (H. pylori ) infection is the most widespread disease in the world according to the WHO. The aim of our study was to contribute to the study of the diagnostic aspects of chronic gastritis induced by H. py…

Emphysematous Gastritis Secondary to Embolic Infarction: A Case Report Open

Yat Cheung Chung, Niyaz Naqash · 2025

Molecular Biomarkers in Peptic Ulcer Disease: Bridging Pathophysiology and Personalized Management Open

Nishant Gite*, Maaz Aquil, Girish Gore, Parth Khandelwal, Amol Jadhav, Patel Huzaifa · 2025

Molecular Biomarkers in Peptic Ulcer Disease: Bridging Pathophysiology and Personalized Management. Peptic Ulcer Disease (PUD) presents a persistent global healthcare burden, marked by an epidemiological shift toward increasing Nonsteroida…

Molecular Biomarkers in Peptic Ulcer Disease: Bridging Pathophysiology and Personalized Management Open

Nishant Gite*, Maaz Aquil, Girish Gore, Parth Khandelwal, Amol Jadhav, Patel Huzaifa · 2025

Molecular Biomarkers in Peptic Ulcer Disease: Bridging Pathophysiology and Personalized Management. Peptic Ulcer Disease (PUD) presents a persistent global healthcare burden, marked by an epidemiological shift toward increasing Nonsteroida…

Microbial oncogenesis within the gastric niche: how the gastric microbiota influences H. pylori-induced disease progression Open

MaKayla S. Lowe, Richard M. Peek · 2025

Chronic pathogens incur a significant public health burden, contributing to the development of 1 in 5 cancer cases worldwide. Helicobacter pylori , a Gram-negative bacterium that colonizes the gastric mucosa, is the strongest known risk fa…

A look into atrophic gastritis: A narrative review Open

Chieh Chen, Da-Ming Liao, Chieh Chen · 2025

Atrophic gastritis represents a prevalent chronic condition affecting the digestive system. It is characterized by the progressive atrophy of the stomach’s glandular and parietal cells, which are subsequently replaced by connective tissue,…

Serum tRF-18-HR05X6D2 may serve as a promising potential diagnostic biomarker for gastric cancer Open

Li Xian, Weiwei Zhang, Yalan Chen, Nan Huang, Xinyuan Jia , et al. · 2025

Gastric cancer (GC) presents with insidious early symptoms that lack distinctiveness. Coupled with insufficient screening awareness and limited diagnostic methods, these symptoms are difficult to distinguish from manifestations of benign c…

Helicobacter pylori cagA, vacA and babA2 genotypes and gastroduodenal diseases: a cross-sectional study from the Mekong Delta of Vietnam Open

Thi Hong Nhung Thai, Thai Hoa Nguyen, Thi Mai Ngan Nguyen, Thi Minh Thi Ha · 2025

Introduction. The cagA and vacA genes encode the CagA and VacA proteins, which are the two main toxins of Helicobacter pylori . Regardless of whether the illness is benign or malignant, the majority of Asian H. pylori strains are cagA ( + …

Autoimmune Metaplastic Atrophic Gastritis Reporting: Are Pathologists and Endoscopists on the Same Page? Open

Nicole Vienneau, Hwajeong Lee, Xulang Zhang, Eun-Dong Park, Madeline Cleary , et al. · 2025

Background/Objectives: Autoimmune metaplastic atrophic gastritis (AMAG) is a chronic, autoimmune-mediated condition associated with increased risk of malignancy and nutritional deficiencies, yet diagnostic and follow-up processes remain in…

Dual-Algorithm Integration Framework Reveals Qing-Wei-Zhi-Tong’s Dual Mechanisms in Chronic Gastritis Open

Zhijie Shu, Ying Huang, Yujie Xi, Bo Zhang, Rui Cai , et al. · 2025

Background: Chronic gastritis (CG) involves gastric mucosal imbalance, with H. pylori (>90% cases), acid-pepsin imbalance, and bile reflux as druggable mechanisms. FDA-approved drugs show limited efficacy against antibiotic-resistant strai…

Agave Fructans as a Carbon Source to Develop a Postbiotic-Based Strategy for the Prophylaxis and Treatment of Helicobacter pylori Infection Open

Enrique A. Sanhueza-Carrera, Natalia C. Hernández-Delgado, Carolina Romo-González, César Castro-De la Mora, Claudia Mendoza-Camacho , et al. · 2025

Helicobacter pylori is a Gram-negative bacterium that inhabits the gastric mucosa and infects over 50% of the global population, predominantly in developing countries. The organism causes chronic gastritis and is associated with gastric ca…

A Re-evaluation of the Association Between Helicobacter pylori Infection and Pediatric Recurrent Abdominal Pain: A Systematic Review of Organic Versus Functional Etiologies Open

Rizqi Primasane Hariyani, Jauhari Tri Wasisto, Trini Handayani, Rizqi Primasane Hariyani, Jauhari Tri Wasisto , et al. · 2025

Introduction: The association between Helicobacter pylori infection and Recurrent Abdominal Pain (RAP) in children is a subject of long-standing, significant controversy. While numerous studies in hospital-based settings report a significa…

Clinical and etiological aspects of chronic gastritis, associated with duodenogastral reflux Open

L.A Fomina, Ivanov Nn · 2025

The purpose of the study is to find out the effect of duodenogastral reflux (DGR) on the clinical manifestations of chronic erosive gastritis (HAG), the prevalence of Helicobacter infection among patients with the HAG and DGR association a…