Fosfomycin
View article: Detection of aac3IIc, aac(6)Ib and armA gene encoding aminoglycoside resistance in Klebsiella pneumoniae in Burkina Faso.
Detection of aac3IIc, aac(6)Ib and armA gene encoding aminoglycoside resistance in Klebsiella pneumoniae in Burkina Faso. Open
Background: Klebsiella pneumoniae is the second most frequently isolated bacterium in medical bacteriology laboratory after Escherichia coli. It can be responsible for many infections including urinary tract infections and pneumonia. The t…
View article: Cranberry and Other Non-Antibiotic Approaches for the Prevention of Recurrent Urinary Tract Infections
Cranberry and Other Non-Antibiotic Approaches for the Prevention of Recurrent Urinary Tract Infections Open
Urinary tract infection (UTI) is one of the most common bacterial infections worldwide, especially among women. It is defined by the presence of clinical signs and symptoms involving the genitourinary tract, together with a significant bac…
View article: Intravenous Fosfomycin for Gram-Negative and Gram-Positive Bacterial Infections: A Systematic Review of the Clinical Evidence
Intravenous Fosfomycin for Gram-Negative and Gram-Positive Bacterial Infections: A Systematic Review of the Clinical Evidence Open
Background: The increasing worldwide problem of bacterial infections caused by multidrug-resistant Gram-negative and Gram-positive pathogens has led to consideration of intravenous fosfomycin, especially in combination antimicrobial regime…
View article: Isolation and characterization of Salmonella enterica serovars from poultry in Egypt: a comprehensive genetic analysis of ESBLs, MCR, integron and other resistance genes
Isolation and characterization of Salmonella enterica serovars from poultry in Egypt: a comprehensive genetic analysis of ESBLs, MCR, integron and other resistance genes Open
Objectives Salmonella enterica is a major foodborne pathogen increasingly associated with antimicrobial resistance, particularly in poultry production. The present study aimed to investigate the prevalence and serotypes of Salmonella isola…
View article: Molecular characterisation of fosfomycin resistant Enterococci faecalis isolated from a tertiary care medical hospital in northern India
Molecular characterisation of fosfomycin resistant Enterococci faecalis isolated from a tertiary care medical hospital in northern India Open
To our knowledge this study is the first to explore FOS resistance in E. faecalis isolates from this part of the country. Increased resistance to FOS as compared to what has been reported previously calls for strict implementation of infec…
View article: Dual chitosan hydrogel and polylactic acid microparticle delivery system reduces Staphylococcal osteomyelitis and soft tissue infection
Dual chitosan hydrogel and polylactic acid microparticle delivery system reduces Staphylococcal osteomyelitis and soft tissue infection Open
Osteomyelitis, an infection of bone, is traditionally treated with long-term, systemic, high-dose antibiotics, which can lead to kidney and liver damage and accelerate the development of antibiotic resistance. Localized delivery may mitiga…
View article: Novel lytic phages improve the antibiofilm activity of dalbavancin, daptomycin, and fosfomycin against vancomycin-resistant enterococci
Novel lytic phages improve the antibiofilm activity of dalbavancin, daptomycin, and fosfomycin against vancomycin-resistant enterococci Open
Periprosthetic joint infections (PJI) caused by Enterococcus spp., especially vancomycin-resistant strains (VRE), are challenging to treat due to biofilm tolerance and limited antibiotic options. Bacteriophages offer a promising adjunct th…
View article: The Effect of Cranberry (Vaccinium macrocarpon) Fruit Extract on VEGF Levels in Wistar Rats (Rattus norvegicus) with Cystitis Model
The Effect of Cranberry (Vaccinium macrocarpon) Fruit Extract on VEGF Levels in Wistar Rats (Rattus norvegicus) with Cystitis Model Open
Cystitis, often caused by Escherichia coli, triggers inflammation and tissue damage in the bladder. While the anti-adhesion properties of cranberry (Vaccinium macrocarpon) against uropathogenic bacteria are well known, its role in the subs…
View article: Healthcare-associated infections in a resource-limited setting: Microbial contamination and antimicrobial resistance in a Cameroonian referral hospital
Healthcare-associated infections in a resource-limited setting: Microbial contamination and antimicrobial resistance in a Cameroonian referral hospital Open
Antimicrobial resistance is a silent pandemic threatening the lives of millions on the African continent. This exploratory study investigates microbial contamination of surfaces and medical devices, evaluates antibiotic resistance profiles…
View article: Overcoming the drug resistance barrier: progress in fosfomycin combination therapy against multidrug-resistant pathogens
Overcoming the drug resistance barrier: progress in fosfomycin combination therapy against multidrug-resistant pathogens Open
In the intensifying global crisis of antimicrobial resistance (AMR), the “old” antibiotic fosfomycin has regained prominence because of its unique mechanism of action and potent activity against numerous multidrug-resistant (MDR) pathogens…
View article: A double-blind, randomized, placebo-controlled, multicenter trial to evaluate the efficacy and safety of systemic enzyme therapy as part of comprehensive treatment in patients with exacerbation of chronic recurrent cystitis. Preliminary results
A double-blind, randomized, placebo-controlled, multicenter trial to evaluate the efficacy and safety of systemic enzyme therapy as part of comprehensive treatment in patients with exacerbation of chronic recurrent cystitis. Preliminary results Open
BACKGROUND: According to the current classification of urinary tract infections, recurrent chronic cystitis may be categorized as either uncomplicated or complicated lower urinary tract infection and is characterized by at least two exacer…
View article: Antimicrobial Resistance Patterns of Escherichia coli Isolates from Female Urinary Tract Infection Patients in Lebanon: An Age-Specific Analysis
Antimicrobial Resistance Patterns of Escherichia coli Isolates from Female Urinary Tract Infection Patients in Lebanon: An Age-Specific Analysis Open
Urinary tract infections (UTIs) are a global health concern, with over 150 million cases annually, primarily caused by Escherichia coli. Due to anatomical differences, females, especially children and postmenopausal women, are four times m…
View article: Assessing the Genomic Landscape of <i>Salmonella enterica</i> Isolated From Cattle Faeces on a Nigerian Farm
Assessing the Genomic Landscape of <i>Salmonella enterica</i> Isolated From Cattle Faeces on a Nigerian Farm Open
Antibiotic resistance is a global menace, particularly in low‐ and middle‐income countries where antimicrobial resistance (AMR) in zoonotic pathogens like Salmonella is on the rise. This study investigates the phenotypic and genotypic AMR …
View article: Hidden risks of first-line regimen switching in antiretroviral therapy-treated patients
Hidden risks of first-line regimen switching in antiretroviral therapy-treated patients Open
Background: Dolutegravir (DTG) became central to South Africa’s (SA’s) first-line human immunodeficiency virus (HIV) regimen since 2019, offering improved tolerability, fewer drug–drug interactions, and a higher resistance barrier compared…
View article: In Vitro Activity of Nitroxoline (5‐Nitro‐8‐Hydroxyquinoline) Against <i>Aspergillus</i> Species
In Vitro Activity of Nitroxoline (5‐Nitro‐8‐Hydroxyquinoline) Against <i>Aspergillus</i> Species Open
Background Nitroxoline is an old antibiotic currently approved for the treatment of uncomplicated urinary tract infections. Its mode of action is based on the chelation of bivalent cations, such as zinc. Objectives As zinc plays a central …
View article: 134 Antimicrobial Resistance Patterns of Clinical Isolates in Dhaka, Bangladesh: A Retrospective Study
134 Antimicrobial Resistance Patterns of Clinical Isolates in Dhaka, Bangladesh: A Retrospective Study Open
Introduction/Objective Antimicrobial resistance (AMR) has emerged as a critical global health challenge, particularly in developing nations like Bangladesh where irrational antibiotic use is prevalent. This study evaluated resistance patte…
View article: Phenotypic and Molecular Analysis of Fosfomycin Resistance Among P. aeruginosa Isolates from Cystic Fibrosis Patients
Phenotypic and Molecular Analysis of Fosfomycin Resistance Among P. aeruginosa Isolates from Cystic Fibrosis Patients Open
View article: Antimicrobial resistance in clinical wound infections: A study on Escherichia coli and Pseudomonas aeruginosa isolates from patients in Imo state, Nigeria
Antimicrobial resistance in clinical wound infections: A study on Escherichia coli and Pseudomonas aeruginosa isolates from patients in Imo state, Nigeria Open
Background: The growing resistance of Escherichia coli and Pseudomonas aeruginosa to antimicrobial treatments poses a major public health concern, particularly in the treatment of hospital-acquired wound infections.Aim: This study investig…
View article: Antimicrobial resistance in clinical wound infections: A study on Escherichia coli and Pseudomonas aeruginosa isolates from patients in Imo state, Nigeria
Antimicrobial resistance in clinical wound infections: A study on Escherichia coli and Pseudomonas aeruginosa isolates from patients in Imo state, Nigeria Open
Background: The growing resistance of Escherichia coli and Pseudomonas aeruginosa to antimicrobial treatments poses a major public health concern, particularly in the treatment of hospital-acquired wound infections.Aim: This study investig…
View article: Co-resistance between oral antibiotics for pyelonephritis and those for cystitis—applying an escalation antibiogram model to local community data
Co-resistance between oral antibiotics for pyelonephritis and those for cystitis—applying an escalation antibiogram model to local community data Open
Objectives We applied an escalation antibiogram to community urine data to assess how presumptive resistance to first-line antibiotics for cystitis affects resistance to antibiotics used to treat pyelonephritis. Methods We extracted suscep…
View article: Role Of Efflux Pump Genes In Antibiotic Resistance of Klebsiella pneumoniae Bacteria Isolated From Clinical Causes: A Narrative Review
Role Of Efflux Pump Genes In Antibiotic Resistance of Klebsiella pneumoniae Bacteria Isolated From Clinical Causes: A Narrative Review Open
Klebsiella pneumoniae is an opportunistic pathogen, mostly affecting those with weakened immune systems and immune-compromised and cause nosocomial infections. Which are commonly acquired in hospitals Pathogens causing acute respiratory in…
View article: Development and in Vitro Evaluation of Hydrophilic and Hydrophobic Polymer-Based Sustained Release Matrix Tablets of Fosfomycin for the Prolonged Management of Recurrent Urinary Tract Infections
Development and in Vitro Evaluation of Hydrophilic and Hydrophobic Polymer-Based Sustained Release Matrix Tablets of Fosfomycin for the Prolonged Management of Recurrent Urinary Tract Infections Open
The present study aimed to develop and evaluate sustained release matrix tablets of Fosfomycin to improve therapeutic efficacy and patient compliance in the management of recurrent urinary tract infections (UTIs). Formulations (MTF1–MTF5) …
View article: Antimicrobial resistance patterns of Escherichia coli and Klebsiella pneumoniae isolated from patients with urinary tract infections: a prospective study from a tertiary care hospital in Hyderabad
Antimicrobial resistance patterns of Escherichia coli and Klebsiella pneumoniae isolated from patients with urinary tract infections: a prospective study from a tertiary care hospital in Hyderabad Open
Background: Urinary tract infections (UTI) are among the most prevalent healthcare-associated infections (HAI), with E. coli and K. pneumoniae being the leading etiological agents. The increasing trend of antimicrobial resistance among the…
View article: CO27 | <i>Pseudomonas aeruginosa</i> MDR strain bacteraemia successfully treated with piperacillin/tazobactam: when beta-lactam continuous infusion, therapeutic drug monitoring and fosfomycin combination make everything easier
CO27 | <i>Pseudomonas aeruginosa</i> MDR strain bacteraemia successfully treated with piperacillin/tazobactam: when beta-lactam continuous infusion, therapeutic drug monitoring and fosfomycin combination make everything easier Open
Premises: Pseudomonas aeruginosa is a common cause of healthcare-associated infections. In case of sepsis, beta-lactam antibiotics continuous infusion (CI) and therapeutic drug monitoring (TDM) guided therapy, allow to reach a higher rate …
View article: GNB Uropathogens and their Antibiotic Resistance Trends: A Report in Eastern India
GNB Uropathogens and their Antibiotic Resistance Trends: A Report in Eastern India Open
Background: Urinary tract infections are one of the commonest infections in India and worldwide leading toincreased mortality and morbidity. Prevalence of bacterial agents causing UTI and it’s antibiogram varies in dif-ferent geographical …
View article: Sensitivitas Fosfomycin pada ISK Akibat Infeksi Enterobacteriaceae Penghasil ESBL pada Pasien di RS X Tahun 2023
Sensitivitas Fosfomycin pada ISK Akibat Infeksi Enterobacteriaceae Penghasil ESBL pada Pasien di RS X Tahun 2023 Open
Infeksi saluran kemih (ISK) merupakan salah satu infeksi yang paling umum terjadi pada manusia. Namun, penggunaan dan penyalahgunaan antibiotik yang intensif dan ekstensif selama 50 tahun terakhir seperti dalam penggunaan karbapenem, resis…
View article: What is the treatment for a urinary tract infection (UTI)?
What is the treatment for a urinary tract infection (UTI)? Open
The treatment of UTIs commonly involves antibiotics tailored to the infection's type and severity, with nitrofurantoin and fosfomycin being common choices for uncomplicated cases. More complex cases may require stronger antibiotics tailore…
View article: What is the treatment for a urinary tract infection (UTI)?
What is the treatment for a urinary tract infection (UTI)? Open
The treatment of UTIs commonly involves antibiotics tailored to the infection's type and severity, with nitrofurantoin and fosfomycin being common choices for uncomplicated cases. More complex cases may require stronger antibiotics tailore…
View article: Susceptibility of multidrug-resistant Escherichia coli and Klebsiella pneumoniae to oral antibiotics in Australia
Susceptibility of multidrug-resistant Escherichia coli and Klebsiella pneumoniae to oral antibiotics in Australia Open
The favourable results support the use of mecillinam, tebipenem, sulopenem, faropenem, fosfomycin, and omadacycline against multidrug-resistant E. coli. Mecillinam, sulopenem, and fosfomycin may be useful for multidrug-resistant K. pneumon…
View article: Impact of ceftazidime avibactam on colonization by carbapenem resistant Enterobacterales during treatment of related infections
Impact of ceftazidime avibactam on colonization by carbapenem resistant Enterobacterales during treatment of related infections Open