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Formation of Chromosomal Domains by Loop Extrusion Open
Topologically associating domains (TADs) are fundamental structural and functional building blocks of human interphase chromosomes, yet the mechanisms of TAD formation remain unclear. Here, we propose that loop extrusion underlies TAD form…
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Printability and Shape Fidelity of Bioinks in 3D Bioprinting Open
Three-dimensional bioprinting uses additive manufacturing techniques for the automated fabrication of hierarchically organized living constructs. The building blocks are often hydrogel-based bioinks, which need to be printed into structure…
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Proposal to assess printability of bioinks for extrusion-based bioprinting and evaluation of rheological properties governing bioprintability Open
The development and formulation of printable inks for extrusion-based 3D bioprinting has been a major challenge in the field of biofabrication. Inks, often polymer solutions with the addition of crosslinking to form hydrogels, must not onl…
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Structural built-up of cement-based materials used for 3D-printing extrusion techniques Open
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Real-time imaging of DNA loop extrusion by condensin Open
Live imaging of DNA loop extrusion To spatially organize chromosomes, ring-shaped protein complexes including condensin and cohesin have been hypothesized to extrude DNA loops. Condensin has been shown to exhibit a DNA-translocating motor …
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Microfluidic Bioprinting of Heterogeneous 3D Tissue Constructs Using Low‐Viscosity Bioink Open
A novel bioink and a dispensing technique for 3D tissue-engineering applications are presented. The technique incorporates a coaxial extrusion needle using a low-viscosity cell-laden bioink to produce highly defined 3D biostructures. The e…
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Human cohesin compacts DNA by loop extrusion Open
Cohesin extrudes DNA loops DNA is folded into loops in eukaryotic cells by a process that depends on a ring-shaped adenosine triphosphatase complex called cohesin. Davidson et al. and Kim et al. now show that in the presence of the NIPBLMA…
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Chromatin organization by an interplay of loop extrusion and compartmental segregation Open
Significance Human DNA is 2 m long and is folded into a 10-μm-sized cellular nucleus. Experiments have revealed two major features of genome organization: Segregation of alternating active and inactive regions into compartments, and format…
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Additive Manufacturing of Metallic and Ceramic Components by the Material Extrusion of Highly-Filled Polymers: A Review and Future Perspectives Open
Additive manufacturing (AM) is the fabrication of real three-dimensional objects from metals, ceramics, or plastics by adding material, usually as layers. There are several variants of AM; among them material extrusion (ME) is one of the m…
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FDM 3D Printing of Polymers Containing Natural Fillers: A Review of their Mechanical Properties Open
As biodegradable thermoplastics are more and more penetrating the market of filaments for fused deposition modeling (FDM) 3D printing, fillers in the form of natural fibers are convenient: They have the clear advantage of reducing cost, ye…
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Microparticles, Microspheres, and Microcapsules for Advanced Drug Delivery Open
Microparticles, microspheres, and microcapsules are widely used constituents of multiparticulate drug delivery systems, offering both therapeutic and technological advantages. Microparticles are generally in the 1–1000 µm size range, serve…
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Additive Manufacturing Technologies Used for Processing Polymers: Current Status and Potential Application in Prosthetic Dentistry Open
There are 7 categories of additive manufacturing (AM) technologies, and a wide variety of materials can be used to build a CAD 3D object. The present article reviews the main AM processes for polymers for dental applications: stereolithogr…
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Extrusion-based additive manufacturing with cement-based materials – Production steps, processes, and their underlying physics: A review Open
This article offers a comprehensive overview of the underlying physics relevant to an understanding of materials processing during the various production steps in extrusion-based 3D concrete printing (3DCP). Understanding the physics gover…
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Starch-based biodegradable materials: Challenges and opportunities Open
This paper reviews the recent development of starch-based materials, including both fundamental and application researches. In order to overcome the weakness of pure starch-based materials, such as lower mechanical properties found in natu…
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Extrusion Bioprinting of Shear‐Thinning Gelatin Methacryloyl Bioinks Open
Bioprinting is an emerging technique for the fabrication of 3D cell‐laden constructs. However, the progress for generating a 3D complex physiological microenvironment has been hampered by a lack of advanced cell‐responsive bioinks that ena…
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Nanomaterials by severe plastic deformation: review of historical developments and recent advances Open
Severe plastic deformation (SPD) is effective in producing bulk ultrafine-grained and nanostructured materials with large densities of lattice defects. This field, also known as NanoSPD, experienced a significant progress within the past t…
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Experimental Optimization of Fused Deposition Modelling Processing Parameters: A Design-for-Manufacturing Approach Open
The Additive Manufacturing (AM) technology initially was developed as a rapid prototyping tool for visualization and validation of designs. The recent development of AM technologies, such as Fused Deposition Modelling (FDM), is driving it …
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Additive Manufacturing Processes in Medical Applications Open
Additive manufacturing (AM, 3D printing) is used in many fields and different industries. In the medical and dental field, every patient is unique and, therefore, AM has significant potential in personalized and customized solutions. This …
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Recent Advances in Extrusion‐Based 3D Printing for Biomedical Applications Open
Additive manufacturing, or 3D printing, has become significantly more commonplace in tissue engineering over the past decade, as a variety of new printing materials have been developed. In extrusion‐based printing, materials are used for a…
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Synthesis by extrusion: continuous, large-scale preparation of MOFs using little or no solvent Open
Continuous flow mechanochemical and melt-phase synthesis at kg h−1 rates from solid reagents and either no solvent, or only minimal solvent, is reported.
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3D Printing PDMS Elastomer in a Hydrophilic Support Bath via Freeform Reversible Embedding Open
Polydimethylsiloxane (PDMS) elastomer is used in a wide range of biomaterial applications including microfluidics, cell culture substrates, flexible electronics, and medical devices. However, it has proved challenging to 3D print PDMS in c…
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3D Printing of Transparent and Conductive Heterogeneous Hydrogel–Elastomer Systems Open
A hydrogel-dielectric-elastomer system, polyacrylamide and poly(dimethylsiloxane) (PDMS), is adapted for extrusion printing for integrated device fabrication. A lithium-chloride-containing hydrogel printing ink is developed and printed ont…
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Rapid Continuous Multimaterial Extrusion Bioprinting Open
The development of a multimaterial extrusion bioprinting platform is reported. This platform is capable of depositing multiple coded bioinks in a continuous manner with fast and smooth switching among different reservoirs for rapid fabrica…
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A flexible-dose dispenser for immediate and extended release 3D printed tablets Open
The advances in personalised medicine increased the demand for a fast, accurate and reliable production method of tablets that can be digitally controlled by healthcare staff. A flexible dose tablet system is presented in this study that p…
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Process–Structure–Properties in Polymer Additive Manufacturing via Material Extrusion: A Review Open
This article provides a database of the mechanical properties of additively manufactured polymeric materials fabricated using material extrusion (e.g., fused filament fabrication (FFF)). Mechanical properties available in the literatures a…
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Three-dimensional bioprinting of complex cell laden alginate hydrogel structures Open
Different bioprinting techniques have been used to produce cell-laden alginate hydrogel structures, however these approaches have been limited to 2D or simple three-dimension (3D) structures. In this study, a new extrusion based bioprintin…
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Extrusion-Based 3D Printing Applications of PLA Composites: A Review Open
Polylactic acid (PLA) is the most widely used raw material in extrusion-based three-dimensional (3D) printing (fused deposition modeling, FDM approach) in many areas since it is biodegradable and environmentally friendly, however its utili…
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Effects of porosity on the mechanical properties of additively manufactured components: a critical review Open
In the present review, the effect of porosity on the mechanical properties of the fabricated parts, which are additively manufactured by powder bed fusion and filament extrusion-based technologies, are discussed in detail. Usually, additiv…
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Extrusion 3D Printing of Polymeric Materials with Advanced Properties Open
3D printing is a rapidly growing technology that has an enormous potential to impact a wide range of industries such as engineering, art, education, medicine, and aerospace. The flexibility in design provided by this technique offers many …
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Rheological characterisation of ceramic inks for 3D direct ink writing: A review Open
3D printing is a competitive manufacturing technology, which has opened up new possibilities for the fabrication of complex ceramic structures and customised parts. Extrusion-based technologies, also known as direct ink writing (DIW) or ro…