Glucuronide
View article: Alterations in Trace Element and Metabolite Profiles by Graphene Nanosheets and Multi‐Walled Carbon Nanotubes as Soil Contaminants in Foot Tissues of the Chinese White Jade Snails ( <scp> <i>Achatina fulica</i> </scp> )
Alterations in Trace Element and Metabolite Profiles by Graphene Nanosheets and Multi‐Walled Carbon Nanotubes as Soil Contaminants in Foot Tissues of the Chinese White Jade Snails ( <span> <i>Achatina fulica</i> </span> ) Open
The increasing applications of carbon nanomaterials (NMs) raise concerns about their potential as soil contaminants, yet predictive models for NM‐related soil contamination risks remain scarce. This study established the Chinese white jade…
View article: Electrochemical Simulation of 25B-NBOMe Phase I Metabolism and Metabolite Profiling by HPLC-QTOF-MS
Electrochemical Simulation of 25B-NBOMe Phase I Metabolism and Metabolite Profiling by HPLC-QTOF-MS Open
This is the first report on the electrochemical simulation of phase I metabolism of 2-(4-bromo-2,5-dimethoxyphenyl)-N-[(2-methoxyphenyl)methyl]ethanamine (25B-NBOMe), a relatively new psychoactive substance available on the illicit drug ma…
View article: Volumetric Absorptive Microsampling of Saliva for Pharmacokinetic Evaluation of Mycophenolic Acid and Its Glucuronide Metabolite in Pediatric Renal Transplant Recipients: Bioanalytical Method Validation and Clinical Feasibility Evaluation
Volumetric Absorptive Microsampling of Saliva for Pharmacokinetic Evaluation of Mycophenolic Acid and Its Glucuronide Metabolite in Pediatric Renal Transplant Recipients: Bioanalytical Method Validation and Clinical Feasibility Evaluation Open
Background: Mycophenolic acid (MPA) is frequently used in pediatric renal transplantation as part of immunosuppressive therapy, yet therapeutic drug monitoring (TDM) remains challenging. Accurate monitoring is essential due to MPA’s narrow…
View article: Plasmid-transformed Bifidobacterium longum 105A secreting β-glucuronidase for prodrug conversion of SN-38 glucuronide
Plasmid-transformed Bifidobacterium longum 105A secreting β-glucuronidase for prodrug conversion of SN-38 glucuronide Open
The development of tumor-selective prodrug activation strategies remains a major challenge in cancer pharmacotherapy. In this study, we focused on SN-38 glucuronide (SN-38G), a highly hydrophilic prodrug with low membrane permeability that…
View article: Supplementary Data from Anti-HER2, High-DAR Antibody Fragment–Drug Conjugates with a Glucuronide-Based MMAE Linker–Payload Demonstrate Superior Efficacy over IgG-Based ADCs
Supplementary Data from Anti-HER2, High-DAR Antibody Fragment–Drug Conjugates with a Glucuronide-Based MMAE Linker–Payload Demonstrate Superior Efficacy over IgG-Based ADCs Open
Supplementary data describing expanded methods and experimental details
View article: Supplementary Figure 9 from Anti-HER2, High-DAR Antibody Fragment–Drug Conjugates with a Glucuronide-Based MMAE Linker–Payload Demonstrate Superior Efficacy over IgG-Based ADCs
Supplementary Figure 9 from Anti-HER2, High-DAR Antibody Fragment–Drug Conjugates with a Glucuronide-Based MMAE Linker–Payload Demonstrate Superior Efficacy over IgG-Based ADCs Open
Supplementary Figure 9 showing FDC DAR stability in human, rat and mouse serum over 24h
View article: Supplementary Figure 4 from Anti-HER2, High-DAR Antibody Fragment–Drug Conjugates with a Glucuronide-Based MMAE Linker–Payload Demonstrate Superior Efficacy over IgG-Based ADCs
Supplementary Figure 4 from Anti-HER2, High-DAR Antibody Fragment–Drug Conjugates with a Glucuronide-Based MMAE Linker–Payload Demonstrate Superior Efficacy over IgG-Based ADCs Open
Supplementary Figure 4 showing biophysical data for the conjugation of a dummy payload to the TCT(H) scFv
View article: Supplementary Table 5 from Anti-HER2, High-DAR Antibody Fragment–Drug Conjugates with a Glucuronide-Based MMAE Linker–Payload Demonstrate Superior Efficacy over IgG-Based ADCs
Supplementary Table 5 from Anti-HER2, High-DAR Antibody Fragment–Drug Conjugates with a Glucuronide-Based MMAE Linker–Payload Demonstrate Superior Efficacy over IgG-Based ADCs Open
Supplementary Table 5 showing the ADC and FDC molar conjugate and payload concentrations at various doses
View article: Supplementary Figure 10 from Anti-HER2, High-DAR Antibody Fragment–Drug Conjugates with a Glucuronide-Based MMAE Linker–Payload Demonstrate Superior Efficacy over IgG-Based ADCs
Supplementary Figure 10 from Anti-HER2, High-DAR Antibody Fragment–Drug Conjugates with a Glucuronide-Based MMAE Linker–Payload Demonstrate Superior Efficacy over IgG-Based ADCs Open
Supplementary Figure showing the relationship between FDC DAR and binding kinetics (on and off rates)
View article: Supplementary Table 3 from Anti-HER2, High-DAR Antibody Fragment–Drug Conjugates with a Glucuronide-Based MMAE Linker–Payload Demonstrate Superior Efficacy over IgG-Based ADCs
Supplementary Table 3 from Anti-HER2, High-DAR Antibody Fragment–Drug Conjugates with a Glucuronide-Based MMAE Linker–Payload Demonstrate Superior Efficacy over IgG-Based ADCs Open
Supplementary Table 3 showing the pharmacokinetic parameters derived from the plots in Figure 2b
View article: Supplementary Table 2 from Anti-HER2, High-DAR Antibody Fragment–Drug Conjugates with a Glucuronide-Based MMAE Linker–Payload Demonstrate Superior Efficacy over IgG-Based ADCs
Supplementary Table 2 from Anti-HER2, High-DAR Antibody Fragment–Drug Conjugates with a Glucuronide-Based MMAE Linker–Payload Demonstrate Superior Efficacy over IgG-Based ADCs Open
Supplementary Table 2 showing the half lives determined from the plots in Supplementary Figure 5
View article: Supplementary Figure 3 from Anti-HER2, High-DAR Antibody Fragment–Drug Conjugates with a Glucuronide-Based MMAE Linker–Payload Demonstrate Superior Efficacy over IgG-Based ADCs
Supplementary Figure 3 from Anti-HER2, High-DAR Antibody Fragment–Drug Conjugates with a Glucuronide-Based MMAE Linker–Payload Demonstrate Superior Efficacy over IgG-Based ADCs Open
Supplementary Figure 3 showing the 3D structural model of the TCT(H) scFv highlighting lysine arrangement and full amino acid sequence
View article: Supplementary Figure 1 from Anti-HER2, High-DAR Antibody Fragment–Drug Conjugates with a Glucuronide-Based MMAE Linker–Payload Demonstrate Superior Efficacy over IgG-Based ADCs
Supplementary Figure 1 from Anti-HER2, High-DAR Antibody Fragment–Drug Conjugates with a Glucuronide-Based MMAE Linker–Payload Demonstrate Superior Efficacy over IgG-Based ADCs Open
Supplementary Figure 1 showing TCT(H) scFv purification
View article: Supplementary Figure 8 from Anti-HER2, High-DAR Antibody Fragment–Drug Conjugates with a Glucuronide-Based MMAE Linker–Payload Demonstrate Superior Efficacy over IgG-Based ADCs
Supplementary Figure 8 from Anti-HER2, High-DAR Antibody Fragment–Drug Conjugates with a Glucuronide-Based MMAE Linker–Payload Demonstrate Superior Efficacy over IgG-Based ADCs Open
Supplementary Figure 8 showing liver toxicity markers (AST and ALT) for TCT(H) scFv, FDC, trastuzumab IgG and ADC and corresponding liver and kidney histology showing insignificant tissue damage
View article: Supplementary Table 4 from Anti-HER2, High-DAR Antibody Fragment–Drug Conjugates with a Glucuronide-Based MMAE Linker–Payload Demonstrate Superior Efficacy over IgG-Based ADCs
Supplementary Table 4 from Anti-HER2, High-DAR Antibody Fragment–Drug Conjugates with a Glucuronide-Based MMAE Linker–Payload Demonstrate Superior Efficacy over IgG-Based ADCs Open
Supplementary Table 4 showing the uptake data from Figure 3a
View article: Supplementary Figure 7 from Anti-HER2, High-DAR Antibody Fragment–Drug Conjugates with a Glucuronide-Based MMAE Linker–Payload Demonstrate Superior Efficacy over IgG-Based ADCs
Supplementary Figure 7 from Anti-HER2, High-DAR Antibody Fragment–Drug Conjugates with a Glucuronide-Based MMAE Linker–Payload Demonstrate Superior Efficacy over IgG-Based ADCs Open
Supplementary Figure 7 showing evidence of immunogenic cell death (ICD) for FDCs compared to ADCs and control molecules
View article: Supplementary Figure 6 from Anti-HER2, High-DAR Antibody Fragment–Drug Conjugates with a Glucuronide-Based MMAE Linker–Payload Demonstrate Superior Efficacy over IgG-Based ADCs
Supplementary Figure 6 from Anti-HER2, High-DAR Antibody Fragment–Drug Conjugates with a Glucuronide-Based MMAE Linker–Payload Demonstrate Superior Efficacy over IgG-Based ADCs Open
Supplementary Figure 6 showing (a to c) binding of the scFv, FDC, IgG and ADC to CD64, CD32 and CD16 Fc-Gamma Receptors by SPR and (d) binding of the same test molecules to human monocytes extracted from PBMCs
View article: <i>In Vitro</i> Evaluation of the Potential Interactions of Zearalenone-14-sulfate and Zearalenone-14-glucuronide with Human Cytochrome P450 Enzymes, Organic Anion Transporting Polypeptides, and ATP-Binding Cassette Multidrug Transporters
<i>In Vitro</i> Evaluation of the Potential Interactions of Zearalenone-14-sulfate and Zearalenone-14-glucuronide with Human Cytochrome P450 Enzymes, Organic Anion Transporting Polypeptides, and ATP-Binding Cassette Multidrug Transporters Open
Zearalenone (ZEN) is a mycotoxin that is typically produced by Fusarium strains. ZEN and its derivatives are common food contaminants and known xenoestrogens. Previous studies demonstrated the interactions of ZEN and zearalenols wit…
View article: A Parent–Metabolite Middle-Out PBPK Model for Genistein and Its Glucuronide Metabolite in Rats: Integrating Liver and Enteric Metabolism with Hepatobiliary and Enteroluminal Transport to Assess Glucuronide Recycling
A Parent–Metabolite Middle-Out PBPK Model for Genistein and Its Glucuronide Metabolite in Rats: Integrating Liver and Enteric Metabolism with Hepatobiliary and Enteroluminal Transport to Assess Glucuronide Recycling Open
Background: Glucuronide recycling in the gut and liver profoundly affects the systemic and/or local exposure of drugs and their glucuronide metabolites, impacting both clinical efficacy and toxicity. This recycling also alters drug exposur…
View article: Development of LC-MS/MS and GC-MS/MS Methods for the Detection of Ethyl Glucuronide (EtG) and Ethyl Palmitate (EtPa) in Hair
Development of LC-MS/MS and GC-MS/MS Methods for the Detection of Ethyl Glucuronide (EtG) and Ethyl Palmitate (EtPa) in Hair Open
Alcohol abuse is a widespread addiction globally, leading to long-term health issues and social consequences. Ethyl glucuronide (EtG) and ethyl palmitate (EtPa) are frequently requested by local authorities, solicitors, or private individu…
View article: Targeting INF2 with DiosMetin 7-O-β-D-Glucuronide: a new stratagem for colorectal cancer therapy
Targeting INF2 with DiosMetin 7-O-β-D-Glucuronide: a new stratagem for colorectal cancer therapy Open
INF2 is a CRC-specific biomarker associated with poor prognosis. DiosMetin 7-O-β-D-Glucuronide, as an INF2 inhibitor, shows promise as a targeted therapeutic agent for CRC treatment.
View article: Pharmacokinetics of Chloramphenicol and Chloramphenicol Glucuronide in Horses Following Administration Per Rectum or via Nasogastric Intubation
Pharmacokinetics of Chloramphenicol and Chloramphenicol Glucuronide in Horses Following Administration Per Rectum or via Nasogastric Intubation Open
Chloramphenicol is a broad‐spectrum antibiotic used in equine practice. It is known to produce adverse effects of hyporexia/anorexia after oral administration. Administration per rectum (PR) could mitigate the appetite suppression seen wit…
View article: Simultaneous one-pot multienzymatic synthesis and purification of Uridine-5′-Diphosphate-α-D-glucuronide and Uridine-5′-Diphosphate-α-d-xylose
Simultaneous one-pot multienzymatic synthesis and purification of Uridine-5′-Diphosphate-α-D-glucuronide and Uridine-5′-Diphosphate-α-d-xylose Open
View article: Research on the application of the HPLC/PDA method to enhance the quality standards of Folium nelumbinis based on the bioactive nuciferine and quercetin 3-O-glucuronide
Research on the application of the HPLC/PDA method to enhance the quality standards of Folium nelumbinis based on the bioactive nuciferine and quercetin 3-O-glucuronide Open
View article: Identification of Mitapivat's In Vivo Metabolites in the Rat Model by Quadrupole‐Time‐of‐Flight (Q‐TOF) Mass Spectrometry
Identification of Mitapivat's In Vivo Metabolites in the Rat Model by Quadrupole‐Time‐of‐Flight (Q‐TOF) Mass Spectrometry Open
Mitapivat is a novel, first‐in‐class, allosteric activator of pyruvate kinase enzyme. It has been approved by the US FDA in February 2022 for disease modifying treatment of haemolytic anaemia in adults. In the current study, the in vivo me…
View article: Curcumin Is Primarily Distributed in Lung, Spleen and Liver, Metabolized to Glucuronide and Sulfate, and Excreted through Bile and Urine by Using an Amorphous Curcumin Formulation with High Absorbability
Curcumin Is Primarily Distributed in Lung, Spleen and Liver, Metabolized to Glucuronide and Sulfate, and Excreted through Bile and Urine by Using an Amorphous Curcumin Formulation with High Absorbability Open
Curcumin (CUR), a polyphenol, is a promising compound for use in functional foods owing to various biological properties. However, the kinetics of CUR remains unclear because CUR has extremely low water solubility and absorbability. Here, …
View article: Pharmacokinetics of single-dose oral acetaminophen with and without concurrent administration of silymarin or N-acetylcysteine in orange-winged Amazon parrots (Amazona amazonica)
Pharmacokinetics of single-dose oral acetaminophen with and without concurrent administration of silymarin or N-acetylcysteine in orange-winged Amazon parrots (Amazona amazonica) Open
Objective To determine the pharmacokinetics of acetaminophen ( N -acetyl-para-aminophenol [APAP]) and its metabolites after oral administration of a single dose of APAP, with or without silymarin or N -acetylcysteine (NAC), to orange-winge…
View article: The acyl glucuronide of 2-(4-diethylamino-2-hydroxybenzoyl)benzoic acid: Synthesis, structural assignment, occurrence as a human phase II metabolite of Uvinul® A Plus and acute aquatic toxicity
The acyl glucuronide of 2-(4-diethylamino-2-hydroxybenzoyl)benzoic acid: Synthesis, structural assignment, occurrence as a human phase II metabolite of Uvinul® A Plus and acute aquatic toxicity Open
This work was undertaken to address the potential environmental impact of the UVA filter Uvinul® A Plus (DHHB) upon its biotransformation in humans. For this purpose, the putative human metabolite 3 was prepared by a three-step synthetic s…
View article: In Vivo Metabolic Studies of 2‐Hydroxyethyl Salicylate in Horses
In Vivo Metabolic Studies of 2‐Hydroxyethyl Salicylate in Horses Open
2‐Hydroxyethyl salicylate (2HES), a nonsteroidal anti‐inflammatory drug (NSAID), is a medication to treat musculoskeletal injuries and inflammation swelling of humans and horses. Its misuse could affect the performance of horses and mask i…
View article: Neuroprotection by resveratrol-glucuronide and quercetin-glucuronide via binding to polyphenol- and glycosaminoglycan-binding sites in the laminin receptor.
Neuroprotection by resveratrol-glucuronide and quercetin-glucuronide via binding to polyphenol- and glycosaminoglycan-binding sites in the laminin receptor. Open