Chlamydiae
View article: Insights into chlamydial infection at the sub-cellular level using label-free Raman spectroscopy in comparison to electron microscopy
Insights into chlamydial infection at the sub-cellular level using label-free Raman spectroscopy in comparison to electron microscopy Open
Intracellular infections are difficult to study as the host cell protects the pathogen from direct observation from the outside. Transmission electron microscopy (TEM) is the most commonly used method for subcellular analysis. However, sam…
View article: A review of zoonotic chlamydiae species in Africa: assessing their burden and potential impact through One Health perspective
A review of zoonotic chlamydiae species in Africa: assessing their burden and potential impact through One Health perspective Open
View article: Development of shuttle vector-based transformation systems for veterinary and zoonotic chlamydiae
Development of shuttle vector-based transformation systems for veterinary and zoonotic chlamydiae Open
In veterinary medicine, the obligate intracellular bacteria Chlamydia ( C. ) abortus , Chlamydia caviae , and Chlamydia pecorum are known to cause ovine enzootic abortion, conjunctivitis in guinea pigs, and ocular/urogenital disease in koa…
View article: Statistical analysis supports the size control mechanism of Chlamydia development
Statistical analysis supports the size control mechanism of Chlamydia development Open
Chlamydia is an intracellular bacterium that reproduces via an unusual developmental cycle that only occurs within a eukaryotic host cell. A replicating form of the bacterium (RB) repeatedly divides to produce about a thousand progeny, whi…
View article: The adaptation of chlamydiae to facultative host multicellularity
The adaptation of chlamydiae to facultative host multicellularity Open
The phylum Chlamydiota consists of obligate intracellular bacteria comprising the human pathogen Chlamydia trachomatis and a large variety of species infecting animals and protists. Despite their diversity, a feature shared by all known ch…
View article: Recruitment of the cellular lipid transport protein CERT to C. psittaci inclusions regulates the timing of bacterial egress
Recruitment of the cellular lipid transport protein CERT to C. psittaci inclusions regulates the timing of bacterial egress Open
Egress of intracellular pathogens is highly regulated and carefully timed. For the zoonotic bacterium C. psittaci , the predominant egress pathway is Chlamydia -containing sphere (CCS) formation, a calcium-dependent sequential mechanism in…
View article: <i>Chlamydia trachomatis</i> exploits sphingolipid metabolic pathways during infection of phagocytes
<i>Chlamydia trachomatis</i> exploits sphingolipid metabolic pathways during infection of phagocytes Open
Chlamydiae are obligate intracellular pathogens that utilize host cell metabolites for catabolic and anabolic processes. The bacteria replicate in epithelial cells from which they take up sphingolipids (SL) and incorporate them into the ch…
View article: Pangenomics reveals alternative environmental lifestyles among chlamydiae
Pangenomics reveals alternative environmental lifestyles among chlamydiae Open
Chlamydiae are highly successful strictly intracellular bacteria associated with diverse eukaryotic hosts. Here we analysed metagenome-assembled genomes of the “Genomes from Earth’s Microbiomes” initiative from diverse environmental sample…
View article: Pangenomics reveals alternative environmental lifestyles among chlamydiae
Pangenomics reveals alternative environmental lifestyles among chlamydiae Open
Chlamydiae are highly successful strictly intracellular bacteria associated with diverse eukaryotic hosts. Here we analysed metagenome-assembled genomes of the “Genomes from Earth’s Microbiomes” initiative from diverse environmental sample…
View article: The secreted host-cell protein clusterin interacts with PmpD and promotes Chlamydia trachomatis infection
The secreted host-cell protein clusterin interacts with PmpD and promotes Chlamydia trachomatis infection Open
Attachment and uptake into host cells are pivotal steps in the life cycle of the Chlamydiaceae , a family of obligate intracellular pathogens. Chlamydia trachomatis (Ctr) possesses a family of nine polymorphic membrane proteins (Pmps), whi…
View article: Dectin-1 stimulating <i>β</i>-glucans inhibit <i>Chlamydia</i> infections both <i>in vitro</i> and <i>in vivo</i>
Dectin-1 stimulating <i>β</i>-glucans inhibit <i>Chlamydia</i> infections both <i>in vitro</i> and <i>in vivo</i> Open
Chlamydia trachomatis and Candida albicans are common inhabitants of the female genital tract. Candida albicans can impact the viability and pathogenesis of some bacteria. Previously, we investigated physical interactions between Ch. trach…
View article: Prevalence of chlamydiae in dairy cattle herds and factors contributing to the spread of infections
Prevalence of chlamydiae in dairy cattle herds and factors contributing to the spread of infections Open
Introduction Different Chlamydia species affect cattle and contribute to economic losses. One of them, C. pecorum , is a globally endemic livestock pathogen. Despite its endemicity, prevalence data from Poland have so far been limited. The…
View article: The emerging role of <i>Fusobacteria</i> in carcinogenesis
The emerging role of <i>Fusobacteria</i> in carcinogenesis Open
The Fusobacterium genus comprises Gram‐negative, obligate anaerobic bacteria that typically reside in the periodontium of the oral cavity, gastrointestinal tract, and female genital tract. The association of Fusobacterial spp. with colorec…
View article: The adaptation of chlamydiae to facultative host multicellularity
The adaptation of chlamydiae to facultative host multicellularity Open
Summary The phylum Chlamydiota consists of obligate intracellular bacteria comprising the human pathogen Chlamydia trachomatis and a large variety of species infecting animals and protists. Despite their enormous diversity, a feature share…
View article: Overexpressing the ClpC AAA+ unfoldase accelerates developmental cycle progression in <i>Chlamydia trachomatis</i>
Overexpressing the ClpC AAA+ unfoldase accelerates developmental cycle progression in <i>Chlamydia trachomatis</i> Open
Chlamydia is an obligate intracellular bacterium that undergoes a complex biphasic developmental cycle, alternating between the smaller, infectious, non-dividing elementary body (EB) and the larger, non-infectious but dividing reticulate b…
View article: Novel symbionts reveal amoebae as significant hosts for environmental chlamydiae
Novel symbionts reveal amoebae as significant hosts for environmental chlamydiae Open
Chlamydiae represent a diverse group of obligate intracellular bacteria with elusive hosts in environmental settings. This study used one of the largest collections of wild amoebae (Dictyostelium discoideum and D. giganteum, 106 clones) co…
View article: <i>Chlamydia trachomatis</i> Inc Ct226 is vital for FLI1 and LRRF1 recruitment to the chlamydial inclusion
<i>Chlamydia trachomatis</i> Inc Ct226 is vital for FLI1 and LRRF1 recruitment to the chlamydial inclusion Open
The obligate intracellular pathogen, Chlamydia trachomatis , establishes an intracellular niche within a host membrane-derived vacuole called the chlamydial inclusion. From within this inclusion, C. trachomatis orchestrates numerous host-p…
View article: <i>Chlamydia</i> -containing spheres are a novel and predominant form of egress by the pathogen <i>Chlamydia psittaci</i>
<i>Chlamydia</i> -containing spheres are a novel and predominant form of egress by the pathogen <i>Chlamydia psittaci</i> Open
The egress of intracellular bacteria from host cells and cellular tissues is a critical process during the infection cycle. This process is essential for bacteria to spread inside the host and can influence the outcome of an infection. For…
View article: Identification of homologs of the Chlamydia trachomatis effector CteG reveals a family of Chlamydiaceae type III secreted proteins that can be delivered into host cells
Identification of homologs of the Chlamydia trachomatis effector CteG reveals a family of Chlamydiaceae type III secreted proteins that can be delivered into host cells Open
Chlamydiae are a large group of obligate endosymbionts of eukaryotes that includes the Chlamydiaceae family, comprising several animal pathogens. Among Chlamydiaceae, Chlamydia trachomatis causes widespread ocular and urogenital infections…
View article: Insights into Chlamydia Development and Host Cells Response
Insights into Chlamydia Development and Host Cells Response Open
Chlamydia infections commonly afflict both humans and animals, resulting in significant morbidity and imposing a substantial socioeconomic burden worldwide. As an obligate intracellular pathogen, Chlamydia interacts with other cell organel…
View article: The MraY Inhibitor Muraymycin D2 and Its Derivatives Induce Enlarged Cells in Obligate Intracellular Chlamydia and Wolbachia and Break the Persistence Phenotype in Chlamydia
The MraY Inhibitor Muraymycin D2 and Its Derivatives Induce Enlarged Cells in Obligate Intracellular Chlamydia and Wolbachia and Break the Persistence Phenotype in Chlamydia Open
Chlamydial infections and diseases caused by filarial nematodes are global health concerns. However, treatment presents challenges due to treatment failures potentially caused by persisting Chlamydia and long regimens against filarial infe…
View article: Spectroscopic Measurements of Light Emissions from High Current Arcs
Spectroscopic Measurements of Light Emissions from High Current Arcs Open
Due to the destructive impact of lightning, and the risk of increasing strikes attributed to climate change on the natural and built environment, work has been carried out to study the temperature and light emitted by laboratory generated …
View article: HtrA, fatty acids, and membrane protein interplay in <i>Chlamydia trachomatis</i> to impact stress response and trigger early cellular exit
HtrA, fatty acids, and membrane protein interplay in <i>Chlamydia trachomatis</i> to impact stress response and trigger early cellular exit Open
Chlamydia trachomatis is an intracellular bacterial pathogen that undergoes a biphasic developmental cycle, consisting of intracellular reticulate bodies and extracellular infectious elementary bodies. A conserved bacterial protease, HtrA,…
View article: Aberrant Bodies: An Alternative Metabolic Homeostasis Allowing Survivability?
Aberrant Bodies: An Alternative Metabolic Homeostasis Allowing Survivability? Open
The Chlamydiae phylum is comprised of obligate intracellular bacteria including human pathogens such as Chlamydia trachomatis and lesser-known Chlamydia-related bacteria like Waddlia chondrophila or Simkania negevensis. Despite broad diffe…
View article: Oral bacteriophages: metagenomic clues to interpret microbiomes
Oral bacteriophages: metagenomic clues to interpret microbiomes Open
Bacteriophages are bacterial viruses that are distributed throughout the environment. Lytic phages and prophages in saliva, oral mucosa, and dental plaque interact with the oral microbiota and can change biofilm formation. The interactions…
View article: Metabolic dormancy in <i>Chlamydia trachomatis</i> treated with different antibiotics
Metabolic dormancy in <i>Chlamydia trachomatis</i> treated with different antibiotics Open
Diseases caused by Chlamydia spp. are often associated with persistent infections. Chlamydial persistence is commonly associated with a unique non-infectious intracellular developmental form, termed an aberrant form. Although infectious ch…
View article: Chlamydiae in corals: shared functional potential despite broad taxonomic diversity
Chlamydiae in corals: shared functional potential despite broad taxonomic diversity Open
Cnidarians, such as corals and sea anemones, associate with a wide range of bacteria that have essential functions, including nutrient cycling and the production of antimicrobial compounds. Within cnidarians, bacteria can colonize all micr…
View article: Zoonotic and other veterinary chlamydiae – an update, the role of the plasmid and plasmid-mediated transformation
Zoonotic and other veterinary chlamydiae – an update, the role of the plasmid and plasmid-mediated transformation Open
The obligate intracellular bacterial genus Chlamydia harbours species with zoonotic potential, particularly C. psittaci, causative agent of psittacosis, and C. abortus, which may lead to miscarriage in pregnant women. The impact of other b…
View article: Branching model with state dependent offspring distribution for <i>Chlamydia</i> spread
Branching model with state dependent offspring distribution for <i>Chlamydia</i> spread Open
Chlamydiae are bacteria with an interesting unusual developmental cycle. Initially, a single bacterium in its infectious form (elementary body, EB) enters the host cell, where it converts into its dividing form (reticulate body, RB), and d…
View article: Chlamydiae as symbionts of photosynthetic dinoflagellates
Chlamydiae as symbionts of photosynthetic dinoflagellates Open
Chlamydiae are ubiquitous intracellular bacteria and infect a wide diversity of eukaryotes, including mammals. However, chlamydiae have never been reported to infect photosynthetic organisms. Here, we describe a novel chlamydial genus and …