Rapid eye movement sleep ≈ Rapid eye movement sleep
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The nasal and gut microbiome in Parkinson's disease and idiopathic rapid eye movement sleep behavior disorder Open
Background Increasing evidence connects the gut microbiota and the onset and/or phenotype of Parkinson's disease (PD). Differences in the abundances of specific bacterial taxa have been reported in PD patients. It is, however, unknown whet…
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An electrophysiological marker of arousal level in humans Open
Deep non-rapid eye movement sleep (NREM) and general anesthesia with propofol are prominent states of reduced arousal linked to the occurrence of synchronized oscillations in the electroencephalogram (EEG). Although rapid eye movement (REM…
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Evolution of prodromal Parkinson’s disease and dementia with Lewy bodies: a prospective study Open
Parkinson’s disease has a long prodromal stage with various subclinical motor and non-motor manifestations; however, their evolution in the years before Parkinson’s disease is diagnosed is unclear. We traced the evolution of early motor an…
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Risk factors for neurodegeneration in idiopathic rapid eye movement sleep behavior disorder: A multicenter study Open
Objective To assess whether risk factors for Parkinson disease and dementia with Lewy bodies increase rate of defined neurodegenerative disease in idiopathic rapid eye movement (REM) sleep behavior disorder (RBD). Methods Twelve centers ad…
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Brain neural patterns and the memory function of sleep Open
Sleep is crucial for healthy cognition, including memory. The two main phases of sleep, REM (rapid eye movement) and non-REM sleep, are associated with characteristic electrophysiological patterns that are recorded using surface and intrac…
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Prevalence and determinants of rapid eye movement sleep behavior disorder in the general population Open
In our middle-to-older age population-based sample, the prevalence of RBD was 1.06%, with no difference between men and women. RBD was associated with antidepressant and antipsychotic use and with minor differences in sleep structure.
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Disruption of hierarchical predictive coding during sleep Open
Significance Sleeping disrupts the conscious awareness of external sounds. We investigated the stage of processing at which this disruption occurs. In the awake brain, when a regular sequence of sounds is presented, a hierarchy of brain ar…
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The Clinical Phenotype of Idiopathic Rapid Eye Movement Sleep Behavior Disorder at Presentation: A Study in 203 Consecutive Patients Open
A commentary on this article appears in this issue on page 7.
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The coeruleus/subcoeruleus complex in idiopathic rapid eye movement sleep behaviour disorder Open
Idiopathic rapid eye movement sleep behaviour disorder is characterized by nocturnal violence, increased muscle tone during rapid eye movement sleep and the lack of any other neurological disease. However, idiopathic rapid eye movement sle…
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A Motor Theory of Sleep-Wake Control: Arousal-Action Circuit Open
Wakefulness, rapid eye movement (REM) sleep, and non–rapid eye movement (NREM) sleep are characterized by distinct electroencephalogram (EEG), electromyogram (EMG), and autonomic profiles. The circuit mechanism coordinating these changes d…
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The microstructure of REM sleep: Why phasic and tonic? Open
Rapid eye movement (REM) sleep is a peculiar neural state that occupies 20-25% of nighttime sleep in healthy human adults and seems to play critical roles in a variety of functions spanning from basic physiological mechanisms to complex co…
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Many Faces of Parkinson’s Disease: Non-Motor Symptoms of Parkinson’s Disease Open
Parkinson's disease (PD) is a multi-systemic disorder that is characterized by a combination of motor and non-motor symptoms (NMS). The dopaminergic neurodegeneration of PD is involved in the genesis of NMS, but other conditions and side e…
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Alpha-synuclein seeds in olfactory mucosa of patients with isolated REM sleep behaviour disorder Open
Isolated REM sleep behaviour disorder (RBD) is an early-stage α-synucleinopathy in most, if not all, affected subjects. Detection of pathological α-synuclein in peripheral tissues of patients with isolated RBD may identify those progressin…
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REM Sleep Behavior Disorder and Cognitive Impairment in Parkinson’s Disease Open
RBD in PD is associated with a more impaired cognitive profile and higher MCI diagnosis frequency, suggesting more severe and widespread neurodegeneration. This patient subgroup and their caregivers should receive targeted medical attentio…
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Prodromal Parkinsonism and Neurodegenerative Risk Stratification in REM Sleep Behavior Disorder Open
RBD are impaired across a range of clinical measures consistent with prodromal PD and suggestive of a more severe nonmotor subtype. Clinical risk stratification has the potential to select higher risk patients for neuroprotective intervent…
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Rapid eye movement sleep promotes cortical plasticity in the developing brain Open
Rapid eye movement sleep plays a critical role in shaping developing circuits in the cerebral cortex.
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Regional Delta Waves In Human Rapid Eye Movement Sleep Open
Although the EEG slow wave of sleep is typically considered to be a hallmark of nonrapid eye movement (NREM) sleep, recent work in mice has shown that slow waves can also occur in REM sleep. Here, we investigated the presence and cortical …
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REM Sleep at its Core – Circuits, Neurotransmitters, and Pathophysiology Open
Rapid eye movement (REM) sleep is generated and maintained by the interaction of a variety of neurotransmitter systems in the brainstem, forebrain, and hypothalamus. Within these circuits lies a core region that is active during REM sleep,…
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The Neurobiological Mechanisms and Treatments of REM Sleep Disturbances in Depression Open
Most depressed patients suffer from sleep abnormalities, which are one of the critical symptoms of depression. They are robust risk factors for the initiation and development of depression. Studies about sleep electroencephalograms have sh…
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Cerebrospinal fluid, plasma, and saliva in the BioFIND study: Relationships among biomarkers and Parkinson's disease Features Open
Objective: Examine relationships among neurodegenerative biomarkers and PD motor and nonmotor symptoms. Background: CSF alpha‐synuclein is decreased in PD versus healthy controls, but whether plasma and saliva alpha‐synuclein differentiate…
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Dreaming in NREM Sleep: A High-Density EEG Study of Slow Waves and Spindles Open
Dreaming can occur in both rapid eye movement (REM) and non-REM (NREM) sleep. We recently showed that in both REM and NREM sleep, dreaming is associated with local decreases in slow wave activity (SWA) in posterior brain regions. To expand…
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Enteric nervous system α-synuclein immunoreactivity in idiopathic REM sleep behavior disorder Open
The present findings of pSyn immunostaining of colonic biopsies in a substantial proportion of iRBD participants raise the possibility that this tissue marker may be a suitable candidate to study further as a prodromal PD marker in at-risk…
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Video-polysomnography procedures for diagnosis of rapid eye movement sleep behavior disorder (RBD) and the identification of its prodromal stages: guidelines from the International RBD Study Group Open
Video-polysomnography (v-PSG) is essential for diagnosing rapid eye movement (REM) sleep behavior disorder (RBD). Although there are current American Academy of Sleep Medicine standards to diagnose RBD, several aspects need to be addressed…
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GBA mutations are associated with Rapid Eye Movement Sleep Behavior Disorder Open
Rapid eye movement sleep behavior disorder and GBA mutations are both associated with Parkinson's disease. The GBA gene was sequenced in idiopathic rapid eye movement sleep behavior disorder patients ( n = 265), and compared to controls ( …
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Sleep Disturbance as Potential Risk and Progression Factor for Parkinson’s Disease Open
Sleep disturbances are common and a major source of disability in Parkinson’s disease (PD). Primary and secondary insomnia, rapid eye movement sleep behavior disorder (RDB), central sleep apnea, restless legs, and nocturnal akinesia are co…
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Basal ganglia dysfunction in idiopathic REM sleep behaviour disorder parallels that in early Parkinson’s disease Open
SEE POSTUMA DOI101093/AWW131 FOR A SCIENTIFIC COMMENTARY ON THIS ARTICLE: Resting state functional magnetic resonance imaging dysfunction within the basal ganglia network is a feature of early Parkinson's disease and may be a diagnostic bi…
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Short-Chain Fatty Acid-Producing Gut Microbiota Is Decreased in Parkinson’s Disease but Not in Rapid-Eye-Movement Sleep Behavior Disorder Open
Twenty studies on gut microbiota in PD have been reported, whereas only one study has been reported on iRBD from Germany. iRBD has the highest likelihood ratio to develop PD. Our meta-analysis of iRBD in Japan and Germany revealed increase…
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Melatonin for Rapid Eye Movement Sleep Behavior Disorder in Parkinson's disease: A Randomised Controlled Trial Open
Background Melatonin may reduce REM‐sleep behavior disorder (RBD) symptoms in Parkinson's disease (PD), though robust clinical trials are lacking. Objective To assess the efficacy of prolonged‐release (PR) melatonin for RBD in PD. Methods …
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Speech Biomarkers in Rapid Eye Movement Sleep Behavior Disorder and Parkinson Disease Open
Objective This multilanguage study used simple speech recording and high‐end pattern analysis to provide sensitive and reliable noninvasive biomarkers of prodromal versus manifest α‐synucleinopathy in patients with idiopathic rapid eye mov…
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EEG desynchronization during phasic REM sleep suppresses interictal epileptic activity in humans Open
Summary Objective Rapid eye movement ( REM ) sleep has a suppressing effect on epileptic activity. This effect might be directly related to neuronal desynchronization mediated by cholinergic neurotransmission. We investigated whether inter…