Urinalysis
View article: Treatment of Urinary Tract Infection in Pregnancy Caused by Enterococcus faecalis: An Alternative Management
Treatment of Urinary Tract Infection in Pregnancy Caused by Enterococcus faecalis: An Alternative Management Open
Background: Urinary tract infections (UTIs) during pregnancy are a significant public health concern due to their potential risk to maternal and child health. Among other prevalent organisms, Enterococcus faecalis has emerged as a key path…
View article: Artificial intelligence–based diagnosis of diabetic kidney disease using urinary VOC biosensor data
Artificial intelligence–based diagnosis of diabetic kidney disease using urinary VOC biosensor data Open
Background Diabetic kidney disease (DKD) remains a leading cause of chronic kidney disease worldwide. However, current diagnostic methods rely on indirect biomarkers or invasive renal biopsy. This study aimed to evaluate the feasibility of…
View article: First in, but Not Best Dressed
First in, but Not Best Dressed Open
A 59-year-old gentleman presented with maculopapular exanthem, acute kidney injury, and eosinophilia post use of amoxicillin. He was diagnosed with drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome. His RegiSCAR score …
View article: The Unlikely Duo: Gross Hematuria and Clubbing Revealing Hidden Malignancy
The Unlikely Duo: Gross Hematuria and Clubbing Revealing Hidden Malignancy Open
A previously healthy 47-year-old Saudi male presented with a two-month history of painless gross hematuria and notable digital clubbing. The hematuria was intermittent, dark red, and unassociated with dysuria, flank pain, or systemic sympt…
View article: Drug Use After Emergency Department‐Initiated Injectable Buprenorphine: A Secondary Analysis of the <scp>ED</scp> ‐ <scp>INNOVATION</scp> Ancillary Safety and Feasibility Trial
Drug Use After Emergency Department‐Initiated Injectable Buprenorphine: A Secondary Analysis of the <span>ED</span> ‐ <span>INNOVATION</span> Ancillary Safety and Feasibility Trial Open
Study Objective To characterize opioid and nonopioid drug use in the week following emergency department (ED)‐initiated extended‐release buprenorphine (XR‐BUP) treatment using both self‐reported data and urine drug screens (UDS). Methods T…
View article: Diagnosis and Therapeutic Management of Canine Babesiosis Infection in Nagaland, India- A Case Report
Diagnosis and Therapeutic Management of Canine Babesiosis Infection in Nagaland, India- A Case Report Open
Background: A 4-month-old, non-descriptive male dog was presented to the Veterinary Clinical Complex, College of Veterinary Science and Animal Husbandry, Jalukie, Nagaland, with progressive weight loss, reduced appetite, lethargy and emaci…
View article: Biomarkers of Drug‐Induced Kidney Injury: Use in Clinical Trials and Recent Examples of Impact on Drug Development
Biomarkers of Drug‐Induced Kidney Injury: Use in Clinical Trials and Recent Examples of Impact on Drug Development Open
This manuscript describes the scope of implementation and impact of a regulatory agency‐qualified panel of six urine biomarkers on drug development, the process for which was conducted and funded by the Critical Path Institute, the Foundat…
View article: Clinical Implications of Vasoactive Intestinal Peptide and 5-Hydroxytryptamine in Diabetic Neurogenic Bladder and Their Relationship with Post-Void Residual Urine Volume
Clinical Implications of Vasoactive Intestinal Peptide and 5-Hydroxytryptamine in Diabetic Neurogenic Bladder and Their Relationship with Post-Void Residual Urine Volume Open
Objective: To elucidate the clinical significance of vasoactive intestinal peptide (VIP) and 5-hydroxytryptamine (5-HT) in diabetic neurogenic bladder (DNB). A key objective is to determine the diagnostic, stratifying, and prognostic value…
View article: Diagnostic test accuracy of dipstick urinalysis in clean catch urine for urinary tract infection in febrile infants presenting to emergency departments: a post-hoc analysis of the FIDO study
Diagnostic test accuracy of dipstick urinalysis in clean catch urine for urinary tract infection in febrile infants presenting to emergency departments: a post-hoc analysis of the FIDO study Open
Summary: Background: Studies where urine is typically obtained via invasive methods, show dipstick urinalysis can accurately screen for urinary tract infection (UTI) in febrile infants under 90 days old. However, evidence is limited in set…
View article: Sepsis secondary to cystitis in a guinea pig ( <i>Cavia porcellus</i> )
Sepsis secondary to cystitis in a guinea pig ( <i>Cavia porcellus</i> ) Open
Cystitis is a frequent, often chronic and recurrent disease in guinea pigs ( Cavia porcellus ). This report describes a case of a 2‐year‐old, entire, female Abyssinian guinea pig with fatal cystitis. The animal was presented with progressi…
View article: Clinical trial on the pharmacokinetics, pharmacodynamics and safety of tolvaptan in healthy Chinese males: an open-label, single and multiple dosage, parallel group study
Clinical trial on the pharmacokinetics, pharmacodynamics and safety of tolvaptan in healthy Chinese males: an open-label, single and multiple dosage, parallel group study Open
Background To determine the pharmacokinetics (PK), pharmacodynamics (PD) and safety of tolvaptan in healthy Chinese males. Methods Three separate clinical trials were carried out on healthy Chinese males aged 18–45 years. Fifty received a …
View article: Tubulointerstitial nephritis uveitis syndrome with Fanconi syndrome: Two case reports and literature review
Tubulointerstitial nephritis uveitis syndrome with Fanconi syndrome: Two case reports and literature review Open
Rationale: Tubulointerstitial nephritis uveitis syndrome (TINU) is a rare form of acute interstitial nephritis accompanied by uveitis. However, few cases of TINU associated with Fanconi syndrome (FS) have been reported, and the clinical ch…
View article: Prevention of urinary tract infections after gynecological and oncogynecological surgeries
Prevention of urinary tract infections after gynecological and oncogynecological surgeries Open
Aim. To evaluate the efficacy of the dietary supplement NefroBest-N® for the prevention of urinary tract infections and inflammation after gynecological and oncogynecological surgeries. Materials and methods. The observational study includ…
View article: Determining the feasibility of randomising infants, children and young people to invasive and non-invasive urine sampling techniques (FROG): Protocol for a multicentre randomised controlled feasibility trial and mixed methods perspectives’ study of RCT feasibility.
Determining the feasibility of randomising infants, children and young people to invasive and non-invasive urine sampling techniques (FROG): Protocol for a multicentre randomised controlled feasibility trial and mixed methods perspectives’ study of RCT feasibility. Open
Background Urinary tract infections (UTI) are the second most common serious bacterial infection in children. When healthcare practitioners are unsure if an infant, child, or young person has a UTI they perform a urine test. A midstream s…
View article: Association of urine cytology and cystoscopy findings with histologic diagnosis of urinary bladder lesions
Association of urine cytology and cystoscopy findings with histologic diagnosis of urinary bladder lesions Open
Objectives: Neoplastic urinary bladder lesions are responsible for significant morbidity and mortality throughout the world. The diagnostic armentarium used by the urologists for urinary bladder lesions includes urinary cytology, cystoscop…
View article: Urinary lipid metabolites and progression of kidney disease in individuals with type 2 diabetes
Urinary lipid metabolites and progression of kidney disease in individuals with type 2 diabetes Open
Objective A substantial proportion of individuals with type 2 diabetes (T2D) experience a fast decline (FD) in kidney function, a high-risk phenotype not reliably identified by current clinical markers. This study aimed to evaluate the pot…
View article: Case Report: Severe kidney involvement in a case of very early onset inflammatory bowel disease
Case Report: Severe kidney involvement in a case of very early onset inflammatory bowel disease Open
Background Patients affected by very early onset inflammatory bowel disease (VEO-IBD) are frequently refractory to standard treatments. Despite the lack of randomized clinical trials, vedolizumab emerged as an effective and safe alternativ…
View article: Comparative Diagnostic Performance of Urinary Neutrophil Gelatinase-Associated Lipocalin and Renal Resistive Index in Patients of Decompensated Cirrhosis with Acute Kidney Injury.
Comparative Diagnostic Performance of Urinary Neutrophil Gelatinase-Associated Lipocalin and Renal Resistive Index in Patients of Decompensated Cirrhosis with Acute Kidney Injury. Open
Background: Acute kidney injury (AKI) in decompensated cirrhosis carries high mortality, with prognosisvarying by etiology. Accurate differentiation between acute tubular necrosis (ATN) and other AKI causesremains challenging using convent…
View article: LC-MS/MS Detection of Tryptophan, Kynurenine, Kynurenic Acid, and Quinolinic Acid in Urine Samples from Drug-Positive and Illicit Drug-Negative Patients with a Known History of Substance Use Disorder
LC-MS/MS Detection of Tryptophan, Kynurenine, Kynurenic Acid, and Quinolinic Acid in Urine Samples from Drug-Positive and Illicit Drug-Negative Patients with a Known History of Substance Use Disorder Open
Introduction: Currently, there are few tools for monitoring recovery in substance use disorder. As substance use has increased in prevalence, tools for measuring recovery are needed to improve therapeutic outcomes. Measuring the kynurenine…
View article: Effects of concentrated urine on complications and plasma creatinine: a prospective study in elective non-cardiac surgery patients
Effects of concentrated urine on complications and plasma creatinine: a prospective study in elective non-cardiac surgery patients Open
Objectives The urine concentration of metabolic end products increases in response to low habitual water intake or acute dehydration. We examined the impact of concentrated urine on surgical outcomes with special attention given to plasma …
View article: Cytokeratin 18 and soluble cluster of differentiation-36: markers for nephropathy in patients with metabolic dysfunction-associated fatty liver disease
Cytokeratin 18 and soluble cluster of differentiation-36: markers for nephropathy in patients with metabolic dysfunction-associated fatty liver disease Open
Background Metabolic Dysfunction-Associated Fatty Liver Disease (MAFLD) is considered the hepatic aspect of metabolic disorders and is associated with an increased risk of chronic kidney disease (CKD). Aim This study aimed to assess the po…
View article: The Renal Activity Index for Lupus: Validation for Prediction of Kidney Inflammation in Adult Patients with Lupus Nephritis
The Renal Activity Index for Lupus: Validation for Prediction of Kidney Inflammation in Adult Patients with Lupus Nephritis Open
Objective To evaluate the ability of the Renal Activity Index for Lupus (RAIL) score, a urine biomarker-derived score, to capture and predict the course of active LN in adult patients. Methods Available serial urine samples collected up to…
View article: Predictive value of dipstick urinalysis in children aged 0-12 months for acute pyelonephritis
Predictive value of dipstick urinalysis in children aged 0-12 months for acute pyelonephritis Open
View article: Preclinical Evaluation of Tribulus terrestris, Hibiscus sabdariffa and Boerhaavia diffusa for Anti-urolithiatic Activity Using COM Crystal Aggregation Assay
Preclinical Evaluation of Tribulus terrestris, Hibiscus sabdariffa and Boerhaavia diffusa for Anti-urolithiatic Activity Using COM Crystal Aggregation Assay Open
Objective: The current study was undertaken for “Preclinical Evaluation of Tribulus terrestris, Hibiscus sabdariffa, and Boerhaavia diffusa for Anti-urolithiatic Activity Using COM Crystal Aggregation Assay”. Background: The third most pre…
View article: Myocardial injury complicating diabetic ketoacidosis in type 1 diabetes mellitus with concurrent thyroid storm: Case report and literature review
Myocardial injury complicating diabetic ketoacidosis in type 1 diabetes mellitus with concurrent thyroid storm: Case report and literature review Open
Rationale: Diabetic ketoacidosis (DKA) and thyrotoxic storm are life-threatening endocrine emergencies that sometimes occur together, but myocardial injury in this setting is rare. This case is unique in showing myocardial injury during si…
View article: Imaging and clinical features of an adult dog with nephrotic syndrome diagnosed with concurrent gastro‐oesophageal and jejuno‐jejunal intussusceptions
Imaging and clinical features of an adult dog with nephrotic syndrome diagnosed with concurrent gastro‐oesophageal and jejuno‐jejunal intussusceptions Open
A 2‐year‐old, female, spayed Australian Kelpie presented for acute retching and excessive swallowing with a recent history of progressive abdominal distension and swelling in all four limbs. Bloodwork and urinalysis were consistent with ne…
View article: The impact of urine pH on lithogenic risk profile in children with urolithiasis
The impact of urine pH on lithogenic risk profile in children with urolithiasis Open
Background Urinary pH is known to influence the solubility and excretion of lithogenic substances, yet its relationship with other metabolic parameters in pediatric stone formers remains underexplored. This study investigated the associati…
View article: Acute Oral Toxicity Study of Exapar Premix in Wistar Rats: A Polyherbal Formulation for Uterine Cleansing and Restoration in Veterinary Practice
Acute Oral Toxicity Study of Exapar Premix in Wistar Rats: A Polyherbal Formulation for Uterine Cleansing and Restoration in Veterinary Practice Open
Aims: The present study evaluated the acute oral toxicity potential of Exapar Premix in Wistar rats following the OECD-423 and 425 guidelines. Study Design: Acute oral toxicity study based on a single-dose administration protocol. Place an…
View article: Medical and social profile of patients with hypertensive (hypertension) disease with predominant renal involvement according to the dataset data
Medical and social profile of patients with hypertensive (hypertension) disease with predominant renal involvement according to the dataset data Open
Objective. To present, on the basis of the dataset, the medical and social profile of patients with hypertensive disease (hypertension) with predominant renal involvement and to consider the diagnostic significance of some biomarkers of th…
View article: Predictive value of dipstick urinalysis in children aged 0-12 months for acute pyelonephritis
Predictive value of dipstick urinalysis in children aged 0-12 months for acute pyelonephritis Open