Tazarotene
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Topical therapies in psoriasis Open
Topical therapy as monotherapy is useful in psoriasis patients with mild disease. Topical agents are also used as adjuvant for moderate-to-severe disease who are being concurrently treated with either ultraviolet light or systemic medicati…
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Skin ageing and topical rejuvenation strategies Open
Skin ageing is a complex process involving the additive effects of skin’s interaction with its external environment, predominantly chronic sun exposure, upon a background of time-dependent intrinsic ageing. Skin health and beauty is consid…
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Topical Tazarotene Gel, 0.1%, as a Novel Treatment Approach for Atrophic Postacne Scars Open
ClinicalTrials.gov identifier: NCT03170596.
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Therapeutic Options for the Treatment of Darier’s Disease: A Comprehensive Review of the Literature Open
Darier’s disease (also known as keratosis follicularis or dyskeratosis follicularis) is an autosomal dominant inherited disorder which manifests as hyperkeratotic greasy papules in the first or second decade of life. Aside from symptom man…
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Pharmacological Agents Used in the Prevention and Treatment of Actinic Keratosis: A Review Open
Actinic keratosis (AK) is among the most commonly diagnosed skin diseases with potentially life-threatening repercussions if left untreated. Usage of pharmacologic agents represents one of many therapeutic strategies that can be used to he…
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Addressing Free Radical Oxidation in Acne Vulgaris. Open
Although the exact pathogenesis of acne vulgaris remains unknown, the presence of excessive reactive oxygen species can be implicated in each of the major abnormalities involved. This presence, along with the positive results of the author…
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Median nail dystrophy involving the thumb nail Open
Median canaliform dystrophy of Heller is a rare entity characterized by a midline or a paramedian ridge or split and canal formation in nail plate of one or both the thumb nails. It is an acquired condition resulting from a temporary defec…
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The multiple uses of azelaic acid in dermatology: mechanism of action, preparations, and potential therapeutic applications Open
Azelaic acid (AZA) is a naturally occurring saturated dicarboxylic acid whose topical application has found multiple uses in dermatology. Its anti-inflammatory, antioxidant and antimicrobial properties against Propionibacterium acne are cu…
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Tazarotene as alternative topical treatment for onychomycosis Open
Our results documented a good clinical outcome using topical tazarotene 0.1% gel in distal and lateral subungual onychomycosis and its fungistatic activity of tazarotene in vitro. The majority of patients appeared cured at a 6-month follow…
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Tretinoin Nanogel 0.025% Versus Conventional Gel 0.025% in Patients with Acne Vulgaris: A Randomized, Active Controlled, Multicentre, Parallel Group, Phase IV Clinical Trial Open
In the treatment of acne vulgaris of the face, tretinoin nanogel formulation appears to be more effective and better tolerated than the conventional gel formulation.
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Management of Darier disease: A review of the literature and update Open
Darier disease (DD) is a rare type of inherited keratinizing disorder with no definitive therapeutic approach. The objective of this study is to provide a detailed literature review of all the available treatment modalities of Darier disea…
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Long-term safety results from a phase 3 open-label study of a fixed combination halobetasol propionate 0.01% and tazarotene 0.045% lotion in moderate-to-severe plaque psoriasis Open
To the Editor: Psoriasis is a chronic immune-mediated disease with a variable natural history marked by remissions and exacerbations that is often refractory to treatment. Topical therapy, first-line for mild disease, is often in combinati…
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Management of Acne Vulgaris With Trifarotene Open
Topical retinoids have an essential role in treatment of acne. Trifarotene, a topical retinoid selective for retinoic acid receptor (RAR) γ, is the most recent retinoid approved for treatment of acne. RAR-γ is the most common isoform of RA…
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Topical Treatments for Kaposi Sarcoma: A Systematic Review Open
Background While treatment options exist for solitary or disseminated Kaposi sarcoma (KS) disease, there are currently no standardized clinical treatment guidelines for cutaneous KS. Objective This systematic review seeks to identify safe …
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Topical retinoids: Novel derivatives, nano lipid‐based carriers, and combinations to improve chemical instability and skin irritation Open
Background Retinoids, defined as synthetic or natural derivatives of vitamin A, have been extensively studied as anti‐aging molecules that are widely applied in cosmetics. However, due to their physicochemical property, retinoids are highl…
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Dupilumab monotherapy suppresses recalcitrant pemphigus vulgaris Open
Pemphigus Vulgaris (PV) is a subgroup of IgG-mediated autoimmune blistering diseases targeting desmosomal adhesion proteins, desmoglein (Dsg) 1 and Dsg 3.1 Systemic corticosteroids are the current first-line treatment. Other treatments aim…
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Efficacy of Topical Treatments for the Management of Symptomatic Oral Lichen Planus: A Systematic Review Open
Oral lichen planus (OLP) is a chronic mucosal inflammatory disease associated with T-cell-mediated immunological dysfunction. Symptomatic OLP is a painful condition, and complete healing is often not achieved. The aim of this systematic re…
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Controlled Release of Tazarotene from Magnetically Responsive Nanofiber Patch: Towards More Efficient Topical Therapy of Psoriasis Open
Electrospun polycaprolactone nanofibers with embedded magnetic nanoparticles were developed for use in the topical delivery of antipsoriatic drugs. To test a hydrophobic drug, a tazarotene has been used, which is an efficient retinoid deri…
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Add‐on effect of PSORI‐CM01 to topical calcipotriol for moderate psoriasis vulgaris: A multi‐center, randomized, double‐blind pilot study Open
Background Mild‐moderate psoriasis vulgaris is a common dermatological autoimmune condition with limited conventional therapeutic options. Safe and effective adjunct therapies to topical non‐steroidal antipsoriatic therapy are needed. The …
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Tazarotene gel with narrow-band UVB phototherapy: a synergistic combination in psoriasis Open
Tazarotene gel significantly enhances the therapeutic efficacy of NB-UVB irradiation with faster clearance and without serious side effects.
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Biomarkers of Tretinoin Precursors and Tretinoin Efficacy in Patients With Moderate to Severe Facial Photodamage Open
ClinicalTrials.gov Identifier: NCT01283464.
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Diclofenac sodium 3% gel for darier's disease treatment Open
We consider topical diclofenac therapy as a useful alternative treatment for DD patients, in which previous therapies have not shown efficacy. We did not observed topical adverse effects, neither systemic absorption symptoms, but werecogni…
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Transcriptomics Analysis Indicates Trifarotene Reverses Acne-Related Gene Expression Changes Open
Background and Objectives: Trifarotene is a topical retinoid selective for retinoic acid receptor gamma that was recently approved for treatment of acne vulgaris. We performed a gene expression analysis to identify the molecular and cellul…
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Upadacitinib for treatment‐resistant Lichen amyloidosis Open
Dear Editor, Lichen amyloidosis (LA) is a skin-limited amyloidosis which occurs following deposition of extracellular heterogenic amyloid proteins in the dermis. Along with macular and nodular amyloidosis, LA belongs to the group of primar…
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Drug screening identifies tazarotene and bexarotene as therapeutic agents in multiple sulfatase deficiency Open
Multiple sulfatase deficiency (MSD, MIM #272200) results from pathogenic variants in the SUMF1 gene that impair proper function of the formylglycine‐generating enzyme (FGE). FGE is essential for the posttranslational activation of cellular…
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Use of Topical Tazarotene for the Treatment of Acne Vulgaris in Pregnancy: A Literature Review. Open
A concern with the increasing use of prescription drugs during pregnancy is teratogenic risk. This risk is undetermined for most drugs approved in the United States (US) from 2000 to 2010. Acne and psoriasis are chronic diseases that typic…
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Tackling acne vulgaris by fabrication of tazarotene-loaded essential oil-based microemulsion: In vitro and in vivo evaluation Open
This study aimed to formulate and optimize an anti-acne drug namely tazarotene (TZR) in essential oil-based microemulsion (ME) using either Jasmine oil (Jas) or Jojoba oil (Joj). TZR-MEs were prepared using two experimental designs (Simple…
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Application of an In Vitro Psoriatic Skin Model to Study Cutaneous Metabolization of Tazarotene Open
Psoriasis is an inflammatory skin disease characterized by the presence of whitish and scaly plaques, which can cover up to 90% of the body surface. These plaques result from the hyperproliferation and abnormal differentiation of keratinoc…
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A Randomized, Double-blind, Placebo-controlled Clinical Trial Evaluating an Oral Anti-aging Skin Care Supplement for Treating Photodamaged Skin. Open
Not applicable. Study precedes FDAAA 801 clinical trial registration and results submission requirements.
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Management of Psoriasis With Topicals: Applying the 2020 AAD-NPF Guidelines of Care to Clinical Practice Open
Topical medications have high utility in the treatment of psoriasis because of their localized effect and ability to be used as both monotherapy and adjunctive therapy. The American Academy of Dermatology (AAD) and the National Psoriasis F…