Bronchiectasis
View article: A Glycan-Based Ligand Panel for Phenotypic Profiling and Selective Immunomodulation of Alveolar Macrophage
A Glycan-Based Ligand Panel for Phenotypic Profiling and Selective Immunomodulation of Alveolar Macrophage Open
The balance of alveolar macrophage (AM) polarization is severely disrupted in chronic in-flammatory diseases like bronchiectasis, where a persistent pro-inflammatory (M1) phe-notype perpetuates inflammation. To address this, we developed a…
View article: TAP-I Deficiency Presenting With Chronic Granulomatous Rubella Virus-Driven Cutaneous Ulceration: A Case Report and Scoping Literature Review
TAP-I Deficiency Presenting With Chronic Granulomatous Rubella Virus-Driven Cutaneous Ulceration: A Case Report and Scoping Literature Review Open
Autosomal recessive mutations in TAP1, TAP2, TAPBP, or B2M , are associated with major histocompatibility complex (MHC) class I deficiency. Individuals may present with granulomatous skin ulceration, but the underlying antigenic triggers r…
View article: A Case of Combined Immunodeficiency Due to ARPC1b Deficiency (Actin-Related Protein 2/3 Complex Subunit 1B)
A Case of Combined Immunodeficiency Due to ARPC1b Deficiency (Actin-Related Protein 2/3 Complex Subunit 1B) Open
Introduction Actin-related protein 2/3 complex subunit 1B (ARPC1b) is an important molecule for cytoskeletal dynamics. Loss-of-function mutations in the ARPC1b gene have been shown to disrupt protein structure, causing an autosomal recessi…
View article: Changing the Underlying Causes of Recurrent Pneumonia In Children: A Systematic Review
Changing the Underlying Causes of Recurrent Pneumonia In Children: A Systematic Review Open
Background Recurrent pneumonia (RP) is a common diagnosis in children, leading to increased morbidity rates, frequent hospitalizations, and longer treatments. Asthma has traditionally been the most common underlying cause. However, recentl…
View article: Clinical and prognostic characteristics of stable bronchiectasis in adults with pseudomonas aeruginosa colonization: a prospective cohort study
Clinical and prognostic characteristics of stable bronchiectasis in adults with pseudomonas aeruginosa colonization: a prospective cohort study Open
Background: Bacterial infection and colonization are gradually associated with disease severity and prognosis in bronchiectasis. The impact of Pseudomonas aeruginosa (PA) colonization on the clinical features and disease progression in sta…
View article: Is the combination of Myelodysplastic syndromes and pulmonary fibrosis accidental or inevitable?
Is the combination of Myelodysplastic syndromes and pulmonary fibrosis accidental or inevitable? Open
Introduction: We diagnosed and managed a patient with pulmonary fibrosis combined with myelodysplastic syndrome (MDS). This paper aims to investigate, through analysis of our clinical case, a review of the existing literature, and relevant…
View article: The first reported case of <i>Mycobacterium shinjukuense</i> pulmonary disease from China
The first reported case of <i>Mycobacterium shinjukuense</i> pulmonary disease from China Open
Background This report describes the first clinical case of Mycobacterium shinjukuense pulmonary disease (PD) originating in China, thereby extending the known geographic distribution of this nontuberculous mycobacterial (NTM) species beyo…
View article: Prevalence and Nationality Distribution of Known and Novel Genetic Variants in Children With Primary Ciliary Dyskinesia in the State of Qatar
Prevalence and Nationality Distribution of Known and Novel Genetic Variants in Children With Primary Ciliary Dyskinesia in the State of Qatar Open
Primary ciliary dyskinesia (PCD) is a genetic disease caused by variants affecting more than 50 cilia genes. We report the prevalence and distribution of all known and novel variants in children with PCD in Qatar. The cohort included 28 ch…
View article: Clinical, Radiological and Microbiological Profile of Bronchiectasis in Adults in a Tertiary Care Hospital: A Cross Sectional Study
Clinical, Radiological and Microbiological Profile of Bronchiectasis in Adults in a Tertiary Care Hospital: A Cross Sectional Study Open
Background Bronchiectasis is a chronic respiratory disorder characterized by irreversible bronchial dilatation, recurrent infections, and progressive lung damage. Varying etiological factors and clinical presentations geographically, neces…
View article: Bronchiectasis Treatment Goals, Unmet Needs, and Emerging Therapies: A Podcast
Bronchiectasis Treatment Goals, Unmet Needs, and Emerging Therapies: A Podcast Open
Bronchiectasis is a chronic and progressive inflammatory lung disease characterized by dilated airways, impaired mucociliary clearance, recurrent infections, and inflammation. In this podcast, we discuss the heterogeneous causes and comple…
View article: Modulator Therapy: Rates and Stages of Respiratory Microbiome Restoration in Cystic Fibrosis Patients Chronically Infected with <em>Pseudomonadota</em>
Modulator Therapy: Rates and Stages of Respiratory Microbiome Restoration in Cystic Fibrosis Patients Chronically Infected with <em>Pseudomonadota</em> Open
Chronic lung infection with Pseudomonadota (PCH) in patients with cystic fibrosis (pwCF) is difficult to eradicate. CFTR modulators have a potential role in the prevention of airway infections, but their ability to eradicate chronic infect…
View article: Kartagener syndrome rarely revealed by chronic diarrhea in an adult: A case report
Kartagener syndrome rarely revealed by chronic diarrhea in an adult: A case report Open
Kartagener syndrome, a subset of primary ciliary dyskinesia, is characterized by the clinical triad of chronic sinusitis, cylindric bronchiectasis, and situs inversus totalis. Gastrointestinal manifestations are rarely described. We report…
View article: Basic and Descriptive Spectrum of Tuberculosis in a Large Cohort of Hospitalized Patients.
Basic and Descriptive Spectrum of Tuberculosis in a Large Cohort of Hospitalized Patients. Open
After 143 years from the discovery of Koch bacillus, the natural history of tuberculosis (TB) is characterized by heterogeneity and gaps of staging defining. The aim of the study consists in assessing the prevalence and characteristics of …
View article: Spectrum of Post Tuberculosis Chronic Lung Disease in Patients with Previous Bacteriologically Confirmed Pulmonary Tuberculosis.
Spectrum of Post Tuberculosis Chronic Lung Disease in Patients with Previous Bacteriologically Confirmed Pulmonary Tuberculosis. Open
The discovery of anti- tuberculosis (TB) drugs, in the middle of last century, did not resolve the goal of a better healing, and the most important cause is represented by delayed diagnosis of TB disease. We conducted a single-center case …
View article: Impact of Systemic Inflammation on Ocular Surface Disease in Patients with Cystic Fibrosis and Non-Cystic Fibrosis Bronchiectasis
Impact of Systemic Inflammation on Ocular Surface Disease in Patients with Cystic Fibrosis and Non-Cystic Fibrosis Bronchiectasis Open
Objective: To characterize the findings on the ocular surface of patients with cystic fibrosis (CF) and non-cystic fibrosis bronchiectasis (NCFB) and to correlate them with the degree of inflammation and systemic severity. Methods: This wo…
View article: Reply to ‘Comment on “High Airway‐to‐Vessel Volume Ratio and Visual Bronchiectasis Are Associated With Exacerbations in <scp>COPD</scp> ”’
Reply to ‘Comment on “High Airway‐to‐Vessel Volume Ratio and Visual Bronchiectasis Are Associated With Exacerbations in <span>COPD</span> ”’ Open
View article: Bronchiectasis, Low IgG Levels and Lack of Vaccination are Risk Factors for Covid-19 Hospitalization in X-linked Agammaglobulinemia – A Retrospective Multicenter Study
Bronchiectasis, Low IgG Levels and Lack of Vaccination are Risk Factors for Covid-19 Hospitalization in X-linked Agammaglobulinemia – A Retrospective Multicenter Study Open
X-linked agammaglobulinemia (XLA) is caused by loss-of-function variants in Bruton’s tyrosine kinase, leading to absence of circulating B lymphocytes and inability to produce antibodies. Despite the fear that patients with XLA would be at …
View article: Allergic Bronchopulmonary Aspergillosis Presenting with Pulmonary Solid Lesions and Elevated Serum Carcinoembryonic Antigen Mimicking Lung Cancer
Allergic Bronchopulmonary Aspergillosis Presenting with Pulmonary Solid Lesions and Elevated Serum Carcinoembryonic Antigen Mimicking Lung Cancer Open
View article: Anaesthetic Considerations for a Patient with Kartagener’s Syndrome Undergoing Emergency Surgery: A Case Report
Anaesthetic Considerations for a Patient with Kartagener’s Syndrome Undergoing Emergency Surgery: A Case Report Open
Kartagener Syndrome (KS) is a rare genetic disorder resulting from autosomal recessive inheritance and is characterised by ciliary dyskinesia. It typically presents with the distinctive triad of chronic sinusitis, situs inversus, and bronc…
View article: Immunology and Biologics in the Treatment of Allergic Bronchopulmonary Aspergillosis in Cystic Fibrosis
Immunology and Biologics in the Treatment of Allergic Bronchopulmonary Aspergillosis in Cystic Fibrosis Open
Allergic bronchopulmonary aspergillosis (ABPA) is mediated by hypersensitivity reactions to Aspergillus fumigatus, which is ubiquitous in the environment. People with Cystic Fibrosis (PwCF) are at an increased risk for developing ABPA, whi…
View article: Proposed treatment algorithms for dogs with chronic bronchitis associated with irreversible airway changes: bronchiectasis and/or bronchomalacia
Proposed treatment algorithms for dogs with chronic bronchitis associated with irreversible airway changes: bronchiectasis and/or bronchomalacia Open
Chronic bronchitis (CB) in dogs involves persistent inflammation of the bronchial walls and excessive mucus production within the airways, with or without bronchial infection, and may lead to degenerative airway changes such as bronchiecta…
View article: Pulmonary tuberculosis versus Mycoplasma pneumoniae pneumonia in children: A retrospective analysis of clinical and imaging characteristics
Pulmonary tuberculosis versus Mycoplasma pneumoniae pneumonia in children: A retrospective analysis of clinical and imaging characteristics Open
This study aims to examine the differences in clinical and imaging characteristics between pulmonary tuberculosis and Mycoplasma pneumoniae pneumonia in pediatric patients. A retrospective analysis was conducted on the clinical data of 37 …
View article: Post-flexible Bronchoscopy Escherichia coli Empyema: A Rare Complication or an Inflammatory Bacterial Translocation?
Post-flexible Bronchoscopy Escherichia coli Empyema: A Rare Complication or an Inflammatory Bacterial Translocation? Open
Empyema is an unusual complication of diagnostic bronchoscopy. We report a case of a male patient in his late 70s with bronchiectasis who developed a right lower lobe empyema 10 days after undergoing flexible bronchoscopy for incidentally …
View article: Validation of bronchial airway gene expression associated with bronchiectasis in nasal epithelium
Validation of bronchial airway gene expression associated with bronchiectasis in nasal epithelium Open
Objectives Examine bronchial epithelium-derived gene expression signature of bronchiectasis (BE) in nasal epithelium. Methods We studied 220 participants from the Detection of Early Lung Cancer Among Military Personnel study with bulk RNA-…
View article: Case Report: Fatal massive hemoptysis secondary to pulmonary actinomycosis: a diagnostic and therapeutic challenge in a multidisciplinary approach
Case Report: Fatal massive hemoptysis secondary to pulmonary actinomycosis: a diagnostic and therapeutic challenge in a multidisciplinary approach Open
Background Actinomyces infections tend to involve the head and neck, while lung infections are relatively rare, and fatal hemoptysis due to pulmonary actinomycosis is even rarer. Case presentation A 74-year-old male patient who presented w…
View article: Coverage of Pneumococcal Vaccination in Patients with Respiratory Diseases in the Chelyabinsk Region
Coverage of Pneumococcal Vaccination in Patients with Respiratory Diseases in the Chelyabinsk Region Open
Relevance. Streptococcus pneumoniae (pneumococcus) is one of the main causes of life-threatening infections, which leads to significant morbidity and mortality worldwide. Vaccination provides not only effective protection against pneumococ…
View article: Challenges in Advanced Lung Disease: Perspectives on Alpha 1 Antitrypsin Deficiency and Bronchiectasis
Challenges in Advanced Lung Disease: Perspectives on Alpha 1 Antitrypsin Deficiency and Bronchiectasis Open
Taking place during the 2025 European Respiratory Society (ERS) International Congress held in Amsterdam, the Netherlands, this symposium presented up-to-date expert perspectives on the challenges of advanced lung disease, focusing on alph…
View article: The Burden of Exacerbations in Non-cystic Fibrosis Bronchiectasis: Real-World Evidence from the UK, France, and Japan
The Burden of Exacerbations in Non-cystic Fibrosis Bronchiectasis: Real-World Evidence from the UK, France, and Japan Open
Bronchiectasis is a progressive respiratory condition that contributes to significant morbidity, reduced quality of life, and increased healthcare utilisation. At the European Respiratory Society (ERS) Congress held in Amsterdam, the Nethe…
View article: Tuberculosis sequelae
Tuberculosis sequelae Open
A 59-year-old male, a farmer, a chronic alcoholic, presented to the emergency department with complaints of breathing difficulty, cough with expectoration, and fever for the past 3 days. The patient gives a history of tubercular pleural ef…
View article: Evaluation of the Use of Molecular Sequencing Methods to Investigate the Lung Microbiome in Bronchiectasis
Evaluation of the Use of Molecular Sequencing Methods to Investigate the Lung Microbiome in Bronchiectasis Open