Generation R
View article: Child Developmental Patterns by Age 4 Years Across Subtypes of Hypertensive Disorders of Pregnancy
Child Developmental Patterns by Age 4 Years Across Subtypes of Hypertensive Disorders of Pregnancy Open
Importance Exposure to hypertensive disorders of pregnancy (HDP) during the fetal stage has been linked to developmental delays in children. However, the associations between HDP subtypes and longitudinal patterns in child development rema…
View article: Preliminary Evidence Linking Maternal Sleep-Disordered Breathing During Pregnancy to Early Childhood Development: A 3-Year Pilot Cohort Study in Japan
Preliminary Evidence Linking Maternal Sleep-Disordered Breathing During Pregnancy to Early Childhood Development: A 3-Year Pilot Cohort Study in Japan Open
Background/Objectives: Obstructive sleep apnea (OSA) during pregnancy may reduce maternal oxygenation, cause sleep fragmentation, and influence offspring development. This pilot study explored potential associations between OSA during preg…
View article: Maternal adverse childhood experiences and perinatal outcomes: A retrospective inceptive cohort study
Maternal adverse childhood experiences and perinatal outcomes: A retrospective inceptive cohort study Open
Introduction Adverse childhood experiences (ACEs) are associated with poor health and social outcomes in adulthood. However, research on the relationship between ACEs and perinatal outcomes remains limited, and the effect of cumulative ACE…
View article: Early Childhood Caries and Its Associated Factors Among 5-Year-Old Children in Shenzhen City, China: A Cross-Sectional Study
Early Childhood Caries and Its Associated Factors Among 5-Year-Old Children in Shenzhen City, China: A Cross-Sectional Study Open
Background: Early childhood caries (ECC) remains a critical public health challenge, yet recent prevalence data and risk factors are scarce in rapidly urbanizing regions like Shenzhen City, China. Objectives: This study aimed to assess ECC…
View article: Developmental Language Disorder and Offending: A Prospective Longitudinal Cohort Study with Linked Education and Crime Data
Developmental Language Disorder and Offending: A Prospective Longitudinal Cohort Study with Linked Education and Crime Data Open
Background. Individuals with Developmental Language Disorder (DLD) are disproportionally represented in the criminal justice system. The prospective associations between DLD and offending, and the educational and criminal justice pathways …
View article: Association between early childhood caries and anthropometric growth and nutritional status in preschool children: a cross-sectional study
Association between early childhood caries and anthropometric growth and nutritional status in preschool children: a cross-sectional study Open
Objective To estimate the prevalence and dmft burden of early childhood caries (ECC) among preschool children and to examine associations between ECC and anthropometric growth indicators (HAZ, WAZ, WHZ) as well as behavioral and parental f…
View article: Socioeconomic and maternal mental health factors associated with the parenting and development of children in an early childhood promotion program: analysis via structural equation modeling
Socioeconomic and maternal mental health factors associated with the parenting and development of children in an early childhood promotion program: analysis via structural equation modeling Open
Socioeconomic disparities and the presence of maternal anxiety were associated with unresponsive parenting and with the risk of developmental delay among children participating in the PCF in the Federal District.
View article: Health and socioeconomic characteristics underlying educational attainment of children born preterm in England: a population cohort study using linked data
Health and socioeconomic characteristics underlying educational attainment of children born preterm in England: a population cohort study using linked data Open
Background Preterm birth (PTB) is a leading cause of atypical brain development and cognitive impairment, however, there are sparse data on its impact on statutory educational assessments. We aimed to describe school readiness at 5 years a…
View article: Early-Life Genetic Determinants of Height and their Time-Dependent Links to Type 2 Diabetes
Early-Life Genetic Determinants of Height and their Time-Dependent Links to Type 2 Diabetes Open
Stature in infancy and childhood is a fundamental indicator of pediatric health, yet its genetic determinants are incompletely understood. We performed genome-wide association studies of childhood length/height across 12 time points from b…
View article: Trajectories of child emotional and behavioural difficulties before and during the COVID‐19 pandemic in a longitudinal UK cohort
Trajectories of child emotional and behavioural difficulties before and during the COVID‐19 pandemic in a longitudinal UK cohort Open
Background There are substantial age‐related changes in emotional and behavioural problems over childhood. In order to establish the impact of the Covid‐19 pandemic on child emotional and behavioural problems, longitudinal designs which ta…
View article: Prenatal phthalate mixture exposure increases early childhood internalising problems via maternal oxidative stress
Prenatal phthalate mixture exposure increases early childhood internalising problems via maternal oxidative stress Open
Prenatal phthalate exposure has been linked to internalising problems in children. Maternal oxidative stress is a plausible biological mechanism underlying this association as it is induced by phthalates and is associated with early intern…
View article: Fat-free mass is associated with neurodevelopment outcomes in extremely preterm infants up to 3 years of age
Fat-free mass is associated with neurodevelopment outcomes in extremely preterm infants up to 3 years of age Open
Background Extremely preterm infants represent a highly vulnerable population, facing a high risk of growth faltering and adverse neurodevelopment. Despite advances in neonatal care, nutritional strategies to support adequate growth, which…
View article: Early socioeconomic conditions to children’s trait resilience: longitudinal mediation effects of mothers’ and fathers’ parenting
Early socioeconomic conditions to children’s trait resilience: longitudinal mediation effects of mothers’ and fathers’ parenting Open
View article: Associations between genetic predisposition to mental health problems and academic achievement: a developmental perspective using two population‐based cohorts
Associations between genetic predisposition to mental health problems and academic achievement: a developmental perspective using two population‐based cohorts Open
Background Children's cognitive abilities play an important role throughout their academic career, but recent studies highlight the negative impacts of aggression, inattention, and impulsivity on academic success. These behaviors and trait…
View article: Association Between Parental Social Position and Childhood Overweight: Mediation by Lifestyle and <scp>BMI</scp> Patterns During Pregnancy
Association Between Parental Social Position and Childhood Overweight: Mediation by Lifestyle and <span>BMI</span> Patterns During Pregnancy Open
In high‐income countries, children born to parents with low socio‐economic position (SEP) or with non‐Western ethnicity are disproportionally affected by obesity as early as preschool age. We assessed how much of these associations were me…
View article: Reducing social disparities in child emotional and behavioral problems by hypothetical physical activity and screen time interventions
Reducing social disparities in child emotional and behavioral problems by hypothetical physical activity and screen time interventions Open
Purpose To estimate how social disparities in child psychiatric symptoms might change following hypothetical interventions targeting sports, outdoor play, and screen time at age 10. Methods We used data from 9,778 children of the Generatio…
View article: Particulate matter exposure during pregnancy and birth outcomes: exposure windows of susceptibility and socioeconomic inequalities
Particulate matter exposure during pregnancy and birth outcomes: exposure windows of susceptibility and socioeconomic inequalities Open
View article: Heterogeneity in the association between a dietary pattern high in fat, sugar, and sodium and adverse pregnancy outcomes by maternal characteristics: a United States pregnancy cohort study
Heterogeneity in the association between a dietary pattern high in fat, sugar, and sodium and adverse pregnancy outcomes by maternal characteristics: a United States pregnancy cohort study Open
This work may provide clues that contribute to a deeper understanding of the heterogeneity in dietary responses in pregnancy.
View article: Prevalence of Pincer Morphology in Early Adolescents From the General Population: A Population‐Based Study
Prevalence of Pincer Morphology in Early Adolescents From the General Population: A Population‐Based Study Open
Objective Pincer morphology can lead to femoroacetabular impingement syndrome (FAIS) and may be a modifiable risk factor for hip osteoarthritis (OA). Currently, no studies investigate the prevalence of pincer morphology in early adolescenc…
View article: Copy number variants and their implications for developmental and behavioural problems in cleft lip and/or palate
Copy number variants and their implications for developmental and behavioural problems in cleft lip and/or palate Open
Cleft lip and/or palate (CL/P) is the most common craniofacial congenital anomaly and has been associated with higher risk of neurodevelopmental and behavioural problems indicating potential shared genetic factors between CL/P and neurodev…
View article: Associations of dietary patterns and obesity development in school‐aged children: results from the <scp>CHILD</scp> Cohort Study
Associations of dietary patterns and obesity development in school‐aged children: results from the <span>CHILD</span> Cohort Study Open
Objective We aimed to understand data‐driven dietary patterns in Canadian preschoolers and their impact on obesity development among male and female individuals. Methods In the prospective, population‐based Canadian pregnancy cohort, the C…
View article: Developmental trajectories of internalizing problems among individuals born very preterm/very low birthweight: early risk and resilience factors
Developmental trajectories of internalizing problems among individuals born very preterm/very low birthweight: early risk and resilience factors Open
View article: Neurodevelopmental challenges at age four following fetal exposure to maternal opioid maintenance treatment
Neurodevelopmental challenges at age four following fetal exposure to maternal opioid maintenance treatment Open
Background The impact of intrauterine exposure to maternal opioid use disorder (OUD) and opioid maintenance treatment (OMT) on child development is not fully understood. This population-based cohort study investigated the neurodevelopmenta…
View article: Association of maternal dietary patterns in early pregnancy with gestational weight gain: Yazd Birth Cohort
Association of maternal dietary patterns in early pregnancy with gestational weight gain: Yazd Birth Cohort Open
Background: Abnormal gestational weight gain (GWG) can carry risks for both the mother and the baby. Diet imbalances are the determining factor in the weight gain of pregnant women. Objective: This study aimed to assess the relationship be…
View article: Maternal Urinary Fluoride Levels of a Large Pregnancy Cohort in the United States: Findings from the ADORE Study
Maternal Urinary Fluoride Levels of a Large Pregnancy Cohort in the United States: Findings from the ADORE Study Open
MUFsg in this population of midwestern US women exceeds the safety benchmark for pregnancy. While we cannot account for all sources of fluoride, MUFsg was correlated to PWS fluoridation. Because so many exceeded the safety benchmark for MU…
View article: Optic disc parameters and associations with early life exposures in over 3000 12-year-old children: findings from the ALSPAC cohort
Optic disc parameters and associations with early life exposures in over 3000 12-year-old children: findings from the ALSPAC cohort Open
Objectives We aimed to investigate the distribution of small optic discs and large cup-to-disc ratio in children and to examine associations with maternal and environmental factors. Methods Retinal photographs were graded from over 3000 12…
View article: Healthy Lifestyle in the First 1000 Days and Overweight and Obesity Throughout Childhood
Healthy Lifestyle in the First 1000 Days and Overweight and Obesity Throughout Childhood Open
OBJECTIVES Investigate associations of different family healthy lifestyle scores (HLS) during the first 1000 days with childhood overweight and obesity (OWOB). METHODS Cohort-specific analyses were conducted on participants (n = 25 006) fr…
View article: Maternal Fasting Plasma Glucose Level in Early Gestation and Developmental Delay in 2-year-old Children
Maternal Fasting Plasma Glucose Level in Early Gestation and Developmental Delay in 2-year-old Children Open
Background The association of maternal hyperglycemia with childhood developmental delay has been examined; however, only 2 studies used maternal blood glucose level as a continuous variable as an exposure. A present study aimed to investig…
View article: Associations between maternal fish intake and polyunsaturated fatty acid status with childhood asthma in a high fish‐eating population
Associations between maternal fish intake and polyunsaturated fatty acid status with childhood asthma in a high fish‐eating population Open
Background Studies investigating associations between prenatal polyunsaturated fatty acid status (PUFAs), in particular the anti‐inflammatory n‐3 PUFAs, and the development of childhood asthma have yielded conflicting results. Objective To…
View article: Additional file 1 of The effects of familial factors on the early childhood caries of preschool children: a cross-sectional study
Additional file 1 of The effects of familial factors on the early childhood caries of preschool children: a cross-sectional study Open
Supplementary Material 1