Bradykinin
View article: Development of Norrin-Based Protein Therapeutic for Activation of Norrin-Wnt Signaling in Human Retinal Endothelial Cells
Development of Norrin-Based Protein Therapeutic for Activation of Norrin-Wnt Signaling in Human Retinal Endothelial Cells Open
Norrin–Wnt signaling is essential for retinal vascular development and generation of the inner blood retinal barrier. Norrin itself is a potential therapeutic for retinal vascular repair. We explored the feasibility of producing a recombin…
View article: Abdominal Pain Attacks and Angioedema in a Patient With a Homozygous MEFV Mutation: Concurrent FXII Hereditary Angioedema
Abdominal Pain Attacks and Angioedema in a Patient With a Homozygous MEFV Mutation: Concurrent FXII Hereditary Angioedema Open
View article: Editorial: Bradykinin and histamine mediated angioedema
Editorial: Bradykinin and histamine mediated angioedema Open
View article: THE PLASMA KININS (BRADYKININ)-AN IMPORTANT CARDIOPROTECTIVE PEPTIDE WITH THERAPEUTIC POTENTIAL IN CARDIOVASCULAR DISEASES
THE PLASMA KININS (BRADYKININ)-AN IMPORTANT CARDIOPROTECTIVE PEPTIDE WITH THERAPEUTIC POTENTIAL IN CARDIOVASCULAR DISEASES Open
View article: THE PLASMA KININS (BRADYKININ)-AN IMPORTANT CARDIOPROTECTIVE PEPTIDE WITH THERAPEUTIC POTENTIAL IN CARDIOVASCULAR DISEASES
THE PLASMA KININS (BRADYKININ)-AN IMPORTANT CARDIOPROTECTIVE PEPTIDE WITH THERAPEUTIC POTENTIAL IN CARDIOVASCULAR DISEASES Open
View article: LEKTI-Grafted Sunflower Trypsin Inhibitor: A Potential Therapeutic for Skin Diseases
LEKTI-Grafted Sunflower Trypsin Inhibitor: A Potential Therapeutic for Skin Diseases Open
Kallikrein 5 (KLK5) is a serine protease expressed in the outer skin layers, where it regulates the barrier function by cleaving desmosomal proteins. Elevated KLK5 causes excessive proteolysis, leading to corneocyte overdesquamation and ba…
View article: Association between Toll-like receptor 9 signaling defect and developing post-infectious irritable bowel syndrome
Association between Toll-like receptor 9 signaling defect and developing post-infectious irritable bowel syndrome Open
Introduction Post-infectious irritable bowel syndrome (PI-IBS) is a functional gastrointestinal disorder that develops after intestinal infection. A follow-up study after a waterborne outbreak of gastroenteritis indicated involvement of sp…
View article: Abstract 095: Silent Catalyst‐ Insular Stroke Unveils Orolingual Angioedema After Tenecteplase‐ A Case Beyond ACE Inhibitors
Abstract 095: Silent Catalyst‐ Insular Stroke Unveils Orolingual Angioedema After Tenecteplase‐ A Case Beyond ACE Inhibitors Open
Background Orolingual angioedema is a rare, potentially life‑threatening complication of thrombolysis in acute ischemic stroke, with reported incidence ranging from 0.9‐5.1% for rtPA agents including Tenecteplase. Previously recognized ris…
View article: Real-World Outcomes of Adding long-acting beta agonist to inhaled corticosteroids in Preschool-Aged Children with uncontrolled Severe Asthma
Real-World Outcomes of Adding long-acting beta agonist to inhaled corticosteroids in Preschool-Aged Children with uncontrolled Severe Asthma Open
View article: Status quo and future developments in the diagnosis and treatment of hereditary angioedema
Status quo and future developments in the diagnosis and treatment of hereditary angioedema Open
Summary Hereditary angioedema (HAE) is a rare hereditary disease characterized by edema, which can be life‐threatening in case of swelling in the larynx. The most common form of HAE is caused by a mutation of the SERPING1 gene and is chara…
View article: A Novel Class of Complement 3a Receptor Agonists and Antagonists Derived from the TLQP-21 Peptide
A Novel Class of Complement 3a Receptor Agonists and Antagonists Derived from the TLQP-21 Peptide Open
The complement 3a receptor (C3aR) is a G-protein-coupled receptor (GPCR) involved in inflammatory, metabolic, and neurological diseases. Two endogenous ligands (C3a and TLQP-21) and small molecules (SB290157 and JR14a) differentially signa…
View article: The Biological Variation in Serum ACE and CPN/CPB2 Activity in Healthy Individuals as Measured by the Degradation of Dabsylated Bradykinin—Reference Data and the Importance of Pre-Analytical Standardization
The Biological Variation in Serum ACE and CPN/CPB2 Activity in Healthy Individuals as Measured by the Degradation of Dabsylated Bradykinin—Reference Data and the Importance of Pre-Analytical Standardization Open
Background: Bradykinin (BK) is an inflammatory mediator. The degradation of labeled synthetic BK in biofluids can be used to report on the activity of angiotensin-converting enzyme (ACE) and basic carboxypeptidases N and CBP2, for which th…
View article: Icatibant Acts as a Balanced Ligand of MRGPRX2 in Human Skin Mast Cells
Icatibant Acts as a Balanced Ligand of MRGPRX2 in Human Skin Mast Cells Open
MRGPRX2 (Mas-related G protein-coupled receptor member X2) is implicated in mast cell (MC)-driven disorders due to its ability to bind diverse ligands, which may be G-protein-biased or balanced, with the latter activating both G-proteins a…
View article: SERS- and SEIRA-Based Characterization and Sensing of Highly Selective Bradykinin B2 Receptor Antagonists
SERS- and SEIRA-Based Characterization and Sensing of Highly Selective Bradykinin B2 Receptor Antagonists Open
One of the major challenges in diagnosing various diseases, including neurological and neurodegenerative disorders, as well as carcinogenesis, is detecting unlabeled neurotransmitters. Surface-enhanced Raman spectroscopy (SERS) and surface…
View article: Peptide-grafted nanogels for sustained endothelin and bradykinin blockade in osteoarthritis
Peptide-grafted nanogels for sustained endothelin and bradykinin blockade in osteoarthritis Open
Osteoarthritis (OA) is a widespread cause of physical disability and chronic pain, yet it lacks a pharmacological cure due to the difficulty of delivering drugs to avascular cartilage. We recently developed peptide-grafted nanogels for int…
View article: Targeting Kinin B1R Attenuates Hypertension Through AT1R-Dependent Mechanisms
Targeting Kinin B1R Attenuates Hypertension Through AT1R-Dependent Mechanisms Open
BACKGROUND: Neurogenic hypertension is chronically high blood pressure that is initiated and maintained through excessive sympathetic nervous system activity and has been associated with increased B1R (kinin B1 receptor) activation. We pre…
View article: Bradykinin-Mediated Angioedema Induced by Drugs
Bradykinin-Mediated Angioedema Induced by Drugs Open
Angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin II receptor blockers (ARBs) are among the most widespread drugs for the prevention of cardiovascular mortality and morbidity. Nevertheless, they are known to cause bradykinin…
View article: Assessment of the myocardial effects of Bradykinin inhibitors by cardiac magnetic resonance (CMR) in discharged COVID-19 patients
Assessment of the myocardial effects of Bradykinin inhibitors by cardiac magnetic resonance (CMR) in discharged COVID-19 patients Open
View article: Bradykinin Receptors in Metabolic Disorders: A Comprehensive Review
Bradykinin Receptors in Metabolic Disorders: A Comprehensive Review Open
The kallikrein–kinin system and its B1 and B2 receptors are key regulators in metabolic disorders such as obesity, diabetes, and insulin resistance. Obesity, a chronic and multifactorial condition often associated with comorbidities like t…
View article: İlkokul 4. Sınıf Öğrencilerinin Akademik Azimleri İle Öz Düzenleme Becerileri Arasındaki İlişkinin İncelenmesi
İlkokul 4. Sınıf Öğrencilerinin Akademik Azimleri İle Öz Düzenleme Becerileri Arasındaki İlişkinin İncelenmesi Open
Akademik azim öğrencilerin hedeflerine ulaşmasında etkisi oldukça ön planda olan bir etmen olarak karşımıza çıkmaktadır. Akademik konularda azimli olan bireylerin kendilerine en uygun öğrenme stratejilerini belirleyebilen; yani öz düzenlem…
View article: Bromelain enhances nitric oxide bioavailability: Bradykinin’s link to TRPV1/Ca2+ /AMPK/autophagy signaling
Bromelain enhances nitric oxide bioavailability: Bradykinin’s link to TRPV1/Ca2+ /AMPK/autophagy signaling Open
Bromelain, a protease enzyme extracted from the pineapple stem, is suggested to protect against atherosclerosis, non-alcohol fatty liver diseases, and coagulation dysfunction. However, the mechanism underlying the vascular protection of br…
View article: Impact of bradykinin type 2 receptor overexpression on cardiovascular function in mice
Impact of bradykinin type 2 receptor overexpression on cardiovascular function in mice Open
Bradykinin is an endogenous peptide playing an important role in regulation of vascular function and permeability, but cardiovascular effects of endogenous bradykinin remain incompletely understood. We studied whether genetically engineere…
View article: Crucian Carp-Derived ACE-Inhibitory Peptides with In Vivo Antihypertensive Activity: Insights into Bioactivity, Mechanism, and Safety
Crucian Carp-Derived ACE-Inhibitory Peptides with In Vivo Antihypertensive Activity: Insights into Bioactivity, Mechanism, and Safety Open
This study explores the identification, characterization, and biological evaluation of angiotensin I-converting enzyme (ACE)-inhibitory peptides derived from enzymatic hydrolysates of crucian carp swim bladders. Following sequential purifi…
View article: Kırâat İlminde “Râ” Harfinin Telaffuz Keyfiyeti Etrafında Ezrak Tarîkinin Terkîkâtı
Kırâat İlminde “Râ” Harfinin Telaffuz Keyfiyeti Etrafında Ezrak Tarîkinin Terkîkâtı Open
Kur’ân-ı Kerîm’in doğru telaffuzunu esas alan kırâat ilmi, zaman içinde daha sistematik bir yapı kazanmış ve bu disiplin zengin bir külliyat oluşturmuştur. Literatürde, kırâat ihtilaflarının bulunduğu yerlerde bir usûl takip edilerek okunm…
View article: Üniversite Kız Ögrencilerinin Premenstrual Semptomlarla Basa Çıkma Düzeyleri ve Yasam Kalitesi Arasındaki Iliskinin Incelemesi
Üniversite Kız Ögrencilerinin Premenstrual Semptomlarla Basa Çıkma Düzeyleri ve Yasam Kalitesi Arasındaki Iliskinin Incelemesi Open
Amaç: Bu tanımlayıcı çalışmada, üniversite kız öğrencilerinde premenstrual semptomlarla (PMS) başa çıkma düzeyleri ve yaşam kalitesi arasındaki ilişkinin incelenmesi amaçlanmıştır. Örneklem ve Yöntem: Çalışmaya 287 kız öğrenci dahil edilmi…
View article: Acute effect of statins on vascular reactivity in maternal and placental arteries from pregnancies complicated by preeclampsia
Acute effect of statins on vascular reactivity in maternal and placental arteries from pregnancies complicated by preeclampsia Open
Introduction This study aimed to investigate the acute effects of statins on maternal and fetoplacental vascular reactivity in vessels from pregnancies affected by pre-eclampsia (PE), a leading cause of maternal and fetal morbidity and mor…
View article: İklim Değişikliği Farkındalığı ve İklim Değişikliği Anksiyetesi Arasındaki İlişkinin Belirlenmesi
İklim Değişikliği Farkındalığı ve İklim Değişikliği Anksiyetesi Arasındaki İlişkinin Belirlenmesi Open
Bu çalışma, lise öğrencilerinin iklim değişikliği farkındalık düzeyleri ile iklim değişikliği anksiyete durumları arasındaki ilişkiyi ve her iki duruma ayrı ayrı etki edebilecek değişkenleri belirlemeyi amaçlamaktadır. Çalışmanın verileri,…
View article: Evaluation of the effect of an extract of <i>Sphingomonas xenophaga</i> present in a Thermal Spring Water in the management of sensitive skin associated with cutaneous vascular disorder
Evaluation of the effect of an extract of <i>Sphingomonas xenophaga</i> present in a Thermal Spring Water in the management of sensitive skin associated with cutaneous vascular disorder Open
Objective La Roche Posay Thermal Spring Water (LRP TSW), which contains specific minerals and possesses a unique microbial composition, has proven anti‐oxidant, anti‐inflammatory, pre‐ and post‐biotic properties and an ability to improve s…
View article: A family case of hereditary angioedema type II
A family case of hereditary angioedema type II Open
Hereditary angioedema (NAO) is a rare, potentially life-threatening genetically determined disease that belongs to primary immunodeficiency without infectious manifestations. The main manifestations of NAO are localized, acute, transient, …
View article: Strophanthus sarmentosus Extracts and the Strophanthus Cardenolide Ouabain Inhibit Snake Venom Proteases from Echis ocellatus
Strophanthus sarmentosus Extracts and the Strophanthus Cardenolide Ouabain Inhibit Snake Venom Proteases from Echis ocellatus Open
Strophanthus sarmentosus is recognised for various ethnomedicinal applications, including treatment after snakebites. However, only limited scientific evidence exists on its antivenomous capabilities. This study investigates the efficacy o…