Amiloride
View article: A REVIEW ARTICLE ON ANALYTICAL METHOD DEVELOPMENT AND VALIDATION OF LOSARTAN AND HYDROCHLOROTHIAZIDE IN COMBINED TABLET FORMULATIONS BY UV METHOD
A REVIEW ARTICLE ON ANALYTICAL METHOD DEVELOPMENT AND VALIDATION OF LOSARTAN AND HYDROCHLOROTHIAZIDE IN COMBINED TABLET FORMULATIONS BY UV METHOD Open
Hydrochlorothiazide is a diuretic drug prescribed for managing high blood pressure and oedema caused by fluid retention. Hydrochlorothiazide is a thiazide drug that blocks the reabsorption of sodium and chloride ions from the distal convol…
View article: A REVIEW ARTICLE ON ANALYTICAL METHOD DEVELOPMENT AND VALIDATION OF LOSARTAN AND HYDROCHLOROTHIAZIDE IN COMBINED TABLET FORMULATIONS BY UV METHOD
A REVIEW ARTICLE ON ANALYTICAL METHOD DEVELOPMENT AND VALIDATION OF LOSARTAN AND HYDROCHLOROTHIAZIDE IN COMBINED TABLET FORMULATIONS BY UV METHOD Open
Hydrochlorothiazide is a diuretic drug prescribed for managing high blood pressure and oedema caused by fluid retention. Hydrochlorothiazide is a thiazide drug that blocks the reabsorption of sodium and chloride ions from the distal …
View article: Diuretics — A Review of the Current Knowledge
Diuretics — A Review of the Current Knowledge Open
Diuretics are medicines that make the body pass more urine and salt. They work by blocking sodium (salt) reabsorption in different parts of the kidney: • Proximal tubule – SGLT2 inhibitors, carbonic anhydrase inhibitors. • Loop of Henle – …
View article: Diuretics — A Review of the Current Knowledge
Diuretics — A Review of the Current Knowledge Open
Diuretics are medicines that make the body pass more urine and salt. They work by blocking sodium (salt) reabsorption in different parts of the kidney: • Proximal tubule – SGLT2 inhibitors, carbonic anhydrase inhibitors. • Loop of He…
View article: Determinants of diuresis/natriuresis following ambulatory intravenous loop diuretics for worsening heart failure
Determinants of diuresis/natriuresis following ambulatory intravenous loop diuretics for worsening heart failure Open
Background The use of intravenous (IV) diuretics in an outpatient setting may represent an alternative to conventional hospitalization. Our objective was to identify factors associated with diuretic response during ambulatory IV diuretic s…
View article: Lithium Induced Nephrogenic Diabetes Insipidus in a Bipolar Disorder Patient
Lithium Induced Nephrogenic Diabetes Insipidus in a Bipolar Disorder Patient Open
Nephrogenic diabetes insipidus (NDI) is an uncommon but serious side effect of long-term lithium treatment, which is frequently used to treat bipolar disorder. Lithium disrupts the expression of aquaporin-2 in the collecting ducts, w…
View article: Lithium Induced Nephrogenic Diabetes Insipidus in a Bipolar Disorder Patient
Lithium Induced Nephrogenic Diabetes Insipidus in a Bipolar Disorder Patient Open
Nephrogenic diabetes insipidus (NDI) is an uncommon but serious side effect of long-term lithium treatment, which is frequently used to treat bipolar disorder. Lithium disrupts the expression of aquaporin-2 in the collecting ducts, which i…
View article: Extracellular serine proteases activate amiloride-insensitive ENaC channels and decrease migration and invasion ability of human leukemia cell lines
Extracellular serine proteases activate amiloride-insensitive ENaC channels and decrease migration and invasion ability of human leukemia cell lines Open
In clinical practice, leukemia cells can exhibit drug resistance to standard treatments; therefore, identification of new therapeutic strategies is needed to prevent leukemia relapse. Here, it was shown for the first time that serine prote…
View article: Ifosfamide-Induced Partial Arginine Vasopressin Resistance Responsive to Vasopressin/Desmopressin and Amiloride
Ifosfamide-Induced Partial Arginine Vasopressin Resistance Responsive to Vasopressin/Desmopressin and Amiloride Open
View article: Automated patch-clamp recordings for detecting activators and inhibitors of the epithelial sodium channel (ENaC)
Automated patch-clamp recordings for detecting activators and inhibitors of the epithelial sodium channel (ENaC) Open
The epithelial sodium channel (ENaC) is crucial for sodium absorption in several epithelial tissues including lung and kidney. Its involvement in various renal and pulmonary disorders makes ENaC a potential drug target. High-throughput scr…
View article: Transgenically expressed human delta epithelial sodium channel facilitated fluid absorption in mouse fetal lung explants
Transgenically expressed human delta epithelial sodium channel facilitated fluid absorption in mouse fetal lung explants Open
The findings of our study highlight the significance of δ-ENaC in lung fluid regulation. Transgenic expression of human δ-ENaC contributes to fluid absorption increase, supporting its potential as a pathway for alveolar fluid clearance in …
View article: Ecofriendly Stability Indicating RP-UHPLC Method for Simultaneous Estimation of Amiloride and Hydrochlorothiazide in Bulk and pharmaceutical dosage form using AGREE and GAPI Tools
Ecofriendly Stability Indicating RP-UHPLC Method for Simultaneous Estimation of Amiloride and Hydrochlorothiazide in Bulk and pharmaceutical dosage form using AGREE and GAPI Tools Open
An easy, quick and reliable RP-UHPLC technique for the quantification of Amiloride (AML) and Hydrochlorothiazide (HCTZ) is established as well as validated in the present article using the green analytical chemistry (GAC) tools. The mobile…
View article: Small Extracellular Vesicles with a High Sphingomyelin Content Isolated from Hypertensive Diabetic db/db Mice Inhibits Calcium Mobilization and Augments Amiloride-Sensitive Epithelial Sodium Channel Activity
Small Extracellular Vesicles with a High Sphingomyelin Content Isolated from Hypertensive Diabetic db/db Mice Inhibits Calcium Mobilization and Augments Amiloride-Sensitive Epithelial Sodium Channel Activity Open
Extracellular vesicles (EVs) contain bioactive lipids that play a key role in pathophysiology. We hypothesized that EVs released from salt-loaded hypertensive diabetic db/db mice have increased bioactive lipid content that inhibits intrace…
View article: Modeling ocular surface ion and water transport by generation of lipid- and mucin-producing human meibomian gland and conjunctival epithelial cells
Modeling ocular surface ion and water transport by generation of lipid- and mucin-producing human meibomian gland and conjunctival epithelial cells Open
We generated human meibomian gland and conjunctival epithelial cells producing lipids and mucins. We identified ion channels including ENaC, CFTR, TMEM16a, and KCNQ1, as well as NKCC. We found that electrolyte and water flux are regulated …
View article: Low pH induces amiloride-sensitive expression of leukemia inhibitory factor in endometrial cells
Low pH induces amiloride-sensitive expression of leukemia inhibitory factor in endometrial cells Open
An association has been reported between a lower pH in the uterus and an increased rate of implantation. How low pH regulates endometrial function is unclear. This study investigated the effect of low pH on the expression of leukemia inhib…
View article: Amiloride sensitizes prostate cancer cells to the reversible tyrosine kinase inhibitor lapatinib by modulating Erbb3 subcellular localization
Amiloride sensitizes prostate cancer cells to the reversible tyrosine kinase inhibitor lapatinib by modulating Erbb3 subcellular localization Open
Neoadjuvant therapy (NAT) has been studied in clinically localized prostate cancer (PCa) to improve the outcomes from radical prostatectomy (RP) by ‘debulking’ of high-risk PCa; however, using androgen deprivation therapy (ADT) at this poi…
View article: Hexamethylene amiloride induces lysosome-mediated cell death in multiple myeloma through transcription factor E3
Hexamethylene amiloride induces lysosome-mediated cell death in multiple myeloma through transcription factor E3 Open
Multiple myeloma (MM) is the second common hematological malignancy characterized by the abnormal proliferation of plasma cells. Although advances in the past decades have led to improved outcomes and longer survival, MM remains largely in…
View article: Formulation and Evaluation of Gastroretentive Floating Microspheres of Amiloride Hydrochloride
Formulation and Evaluation of Gastroretentive Floating Microspheres of Amiloride Hydrochloride Open
Background: Amiloride, a potassium-sparing diuretic, is widely prescribed for the management of hypertension, congestive heart failure, and various renal disorders. However, its low oral bioavailability due to extensive first-pass metaboli…
View article: Differential Effect of TRPV1 Modulators on Neural and Behavioral Responses to Taste Stimuli
Differential Effect of TRPV1 Modulators on Neural and Behavioral Responses to Taste Stimuli Open
In our diet, we ingest a variety of compounds that are TRPV1 modulators. It is important to understand if these compounds alter neural and behavioral responses to taste stimuli representing all taste qualities. Here, we will summarize the …
View article: Gitelman syndrome patient managed with amiloride during pregnancy and lactation
Gitelman syndrome patient managed with amiloride during pregnancy and lactation Open
Gitelman Syndrome (GS) is a rare autosomal-recessive tubular disorder characterized by hypokalemia, hypomagnesemia, metabolic alkalosis, hyperreninemic hyperaldosteronism, and normotension. Management of GS during pregnancy is particularly…
View article: 5/6 Nephrectomy impairs acute kaliuretic responses and predisposes to postprandial hyperkalemia
5/6 Nephrectomy impairs acute kaliuretic responses and predisposes to postprandial hyperkalemia Open
Rats who underwent 5/6 nephrectomy demonstrate a reduced ability to excrete an acute K + load with the development of postprandial hyperkalemia. 5/6 Nephrectomy attenuates K + -induced natriuresis and impairs ENaC regulation despite intact…
View article: A novel lipophilic amiloride derivative efficiently kills chemoresistant breast cancer cells
A novel lipophilic amiloride derivative efficiently kills chemoresistant breast cancer cells Open
Derivatives of the potassium-sparing diuretic amiloride are preferentially cytotoxic toward tumor cells relative to normal cells, and have the capacity to target tumor cell populations resistant to currently employed therapeutic agents. Ho…
View article: Amiloride Sensitizes Prostate Cancer Cells to the Reversible Tyrosine Kinase Inhibitor Lapatinib by Modulating ERBB3 Subcellular Localization
Amiloride Sensitizes Prostate Cancer Cells to the Reversible Tyrosine Kinase Inhibitor Lapatinib by Modulating ERBB3 Subcellular Localization Open
Neoadjuvant therapy (NAT) has been studied in clinically localized prostate cancer (PCa) to improve the outcomes from radical prostatectomy (RP) by ‘debulking’ of high-risk PCa; however, using androgen deprivation at this point risks castr…
View article: The Use of Amiloride and Sodium-Glucose Cotransporter 2 Inhibitors in Cisplatin-Induced Hypomagnesemia: A Case Report and Review of the Literature
The Use of Amiloride and Sodium-Glucose Cotransporter 2 Inhibitors in Cisplatin-Induced Hypomagnesemia: A Case Report and Review of the Literature Open
Cisplatin, a chemotherapy agent widely used since its FDA approval in 1978 for testicular cancer, is associated with nephrotoxicity and hypomagnesemia. Magnesium supplementation is not only a treatment for hypomagnesemia but also a well-es…
View article: Amiloride versus furosemide for the treatment of edema in patients with nephrotic syndrome: A pilot study (<scp>AMILOR</scp>)
Amiloride versus furosemide for the treatment of edema in patients with nephrotic syndrome: A pilot study (<span>AMILOR</span>) Open
Aim In rodent models of nephrotic syndrome (NS), edema formation was prevented by blockade of the epithelial sodium channel ENaC with amiloride. However, apart from case reports, there is no evidence favoring ENaC blockade in patients with…
View article: Amiloride reduces fructosamine-3-kinase expression to restore sunitinib sensitivity in renal cell carcinoma
Amiloride reduces fructosamine-3-kinase expression to restore sunitinib sensitivity in renal cell carcinoma Open
View article: Low exposition to lithium prevents nephrogenic diabetes insipidus but not microcystic dilations of the collecting ducts in long‐term rat model
Low exposition to lithium prevents nephrogenic diabetes insipidus but not microcystic dilations of the collecting ducts in long‐term rat model Open
Lithium induces nephrogenic diabetes insipidus (NDI) and microcystic chronic kidney disease (CKD). As previous clinical studies suggest that NDI is dose‐dependent and CKD is time‐dependent, we investigated the effect of low exposition to l…
View article: Effects of furosemide, acetazolamide and amiloride on renal cortical and medullary tissue oxygenation in non‐anaesthetised healthy sheep
Effects of furosemide, acetazolamide and amiloride on renal cortical and medullary tissue oxygenation in non‐anaesthetised healthy sheep Open
It has been proposed that diuretics can improve renal tissue oxygenation through inhibition of tubular sodium reabsorption and reduced metabolic demand. However, the impact of clinically used diuretic drugs on the renal cortical and medull…
View article: Amiloride vs. furosemide for the treatment of edema in human nephrotic syndrome: a pilot study (AMILOR)
Amiloride vs. furosemide for the treatment of edema in human nephrotic syndrome: a pilot study (AMILOR) Open
In rodent models of nephrotic syndrome (NS), edema formation was prevented by blockade of the epithelial sodium channel ENaC with amiloride. The monocentric randomized controlled AMILOR study investigated the antiedematous effect of amilor…
View article: 4-(Azolyl)-Benzamidines as a Novel Chemotype for ASIC1a Inhibitors
4-(Azolyl)-Benzamidines as a Novel Chemotype for ASIC1a Inhibitors Open
Acid-sensing ion channels (ASICs) play a key role in the perception and response to extracellular acidification changes. These proton-gated cation channels are critical for neuronal functions, like learning and memory, fear, mechanosensati…