Systemic scleroderma
View article: PO:33:197 | Systemic sclerosis and endothelial dysfunction: the passive leg movement technique in the assessment of no-mediated vascular impairment
PO:33:197 | Systemic sclerosis and endothelial dysfunction: the passive leg movement technique in the assessment of no-mediated vascular impairment Open
Objectives: To evaluate nitric oxide (NO)-mediated vascular dysfunction in patients with Systemic Sclerosis (SSc) compared to age- and sex-matched healthy controls through passive leg movement (PLM). Materials and Methods: Twenty-one patie…
View article: PO:24:066 | Antibody profile in myositis and early risk of interstitial lung disease: clinical and laboratory correlations in patients with suspected rheumatologic disease
PO:24:066 | Antibody profile in myositis and early risk of interstitial lung disease: clinical and laboratory correlations in patients with suspected rheumatologic disease Open
Background. Interstitial lung disease (ILD) is a frequent comorbidity not only in idiopathic inflammatory myopathies (IIM) but also in other rheumatologic disorders such as Sjögren’s syndrome, systemic sclerosis, and rheumatoid arthritis. …
View article: 305 The Matricellular Protein Mindin Regulates Differential Fibroblast Responses to Manifest Dermal Fibrosis in Scleroderma
305 The Matricellular Protein Mindin Regulates Differential Fibroblast Responses to Manifest Dermal Fibrosis in Scleroderma Open
View article: The clinical case of systemic scleroderma: integration of dermatological, pulmonological and gastroenterological aspects
The clinical case of systemic scleroderma: integration of dermatological, pulmonological and gastroenterological aspects Open
Background. Diffuse cutaneous systemic sclerosis is a multisystem disease of connective tissue characterized by symmetrical thickening of the skin and subcutaneous tissue, combined with fibrous and degenerative changes in the synovial memb…
View article: Immune cells composition in the skin and subcutaneous adipose tissue of patients with systemic sclerosis
Immune cells composition in the skin and subcutaneous adipose tissue of patients with systemic sclerosis Open
Summary Background and objectives Systemic sclerosis (SSc) is a rare, chronic autoimmune disease characterized by fibrosis of the skin and/or internal organs. Emerging evidence suggests that subcutaneous adipose tissue may contribute to sy…
View article: Supplementary Material for “Pruritic papules in systemic sclerosis is associated with scleroderma renal crisis”
Supplementary Material for “Pruritic papules in systemic sclerosis is associated with scleroderma renal crisis” Open
This dataset contains supplementary figures and tables for the accepted manuscript in JAAD, titled “Pruritic papules in systemic sclerosis is associated with scleroderma renal crisis”
View article: Supplementary Material for “Pruritic papules in systemic sclerosis is associated with scleroderma renal crisis”
Supplementary Material for “Pruritic papules in systemic sclerosis is associated with scleroderma renal crisis” Open
This dataset contains supplementary figures and tables for the accepted manuscript in JAAD, titled “Pruritic papules in systemic sclerosis is associated with scleroderma renal crisis”
View article: Mediating role of systemic inflammation in heavy metal-induced metabolic dysfunction-associated steatotic liver disease: Insights from NHANES 2017 to 2020
Mediating role of systemic inflammation in heavy metal-induced metabolic dysfunction-associated steatotic liver disease: Insights from NHANES 2017 to 2020 Open
Introduction: Inflammatory responses play an essential role in metabolic dysfunction-associated steatotic liver disease (MASLD). Objective: This study investigates the mediating role of systemic inflammation in the pathophysiology of heavy…
View article: Sodium thiosulfate for treatment of nephrogenic systemic fibrosis with metastatic pulmonary calcification in a patient undergoing peritoneal dialysis: a case report
Sodium thiosulfate for treatment of nephrogenic systemic fibrosis with metastatic pulmonary calcification in a patient undergoing peritoneal dialysis: a case report Open
Nephrogenic systemic fibrosis (NSF) is a rare systemic disease characterized by widespread, progressive fibrosis of the skin and connective tissue. We report a rare case of NSF and metastatic pulmonary calcification coexisting in a patient…
View article: Table 1_Vimentin immunization induces TH2/TH17 cell activation and autoantibody production in a novel mouse model of bleomycin induced systemic sclerosis.docx
Table 1_Vimentin immunization induces TH2/TH17 cell activation and autoantibody production in a novel mouse model of bleomycin induced systemic sclerosis.docx Open
Introduction Systemic sclerosis (SSc) is an autoimmune disease characterized by progressive fibrosis of the skin and lung tissues. Currently available drugs delay SSc progression but do not reverse the sclerotic lesions or cure the disease…
View article: HEMATOLOGIC MANIFESTATIONS OF PEDIATRIC CONNECTIVE TISSUE DISEASES
HEMATOLOGIC MANIFESTATIONS OF PEDIATRIC CONNECTIVE TISSUE DISEASES Open
The hematopoietic system is frequently affected by autoimmune connective tissue diseases in children, including juvenile systemic lupus erythematosus (JSLE), juvenile dermatomyositis (JDM), juvenile scleroderma (localized and systemic), an…
View article: HEMATOLOGIC MANIFESTATIONS OF PEDIATRIC CONNECTIVE TISSUE DISEASES
HEMATOLOGIC MANIFESTATIONS OF PEDIATRIC CONNECTIVE TISSUE DISEASES Open
The hematopoietic system is frequently affected by autoimmune connective tissue diseases in children, including juvenile systemic lupus erythematosus (JSLE), juvenile dermatomyositis (JDM), juvenile scleroderma (localized and systemic), an…
View article: Scleroderma present with acute gastritis: A rare case report
Scleroderma present with acute gastritis: A rare case report Open
Systemic sclerosis (SSc) is a systemic autoimmune disease in which gastrointestinal manifestations are a frequent complication. In as many as 90% of cases, there is intestinal involvement. The oesophagus and the anorectal tract are the reg…
View article: Scleroderma present with acute gastritis: A rare case report
Scleroderma present with acute gastritis: A rare case report Open
Systemic sclerosis (SSc) is a systemic autoimmune disease in which gastrointestinal manifestations are a frequent complication. In as many as 90% of cases, there is intestinal involvement. The oesophagus and the anorectal tract are the reg…
View article: Novel pleiotropic loci links vascular and immune pathways in systemic sclerosis and primary Raynaud's phenomenon
Novel pleiotropic loci links vascular and immune pathways in systemic sclerosis and primary Raynaud's phenomenon Open
This release contains the summary statistics of the study "Novel pleiotropic loci links vascular and immune pathways in systemic sclerosis and primary Raynaud’s phenomenon", describing the results of the METASOFT meta-analysis. Three summa…
View article: Hypertensive Crisis Unresponsive to Standard Therapy: The Interplay of Pulmonary Hypertension and Scleroderma Renal Crisis in Systemic Sclerosis
Hypertensive Crisis Unresponsive to Standard Therapy: The Interplay of Pulmonary Hypertension and Scleroderma Renal Crisis in Systemic Sclerosis Open
Title Hypertensive Crisis Unresponsive to Standard Therapy: The Interplay of Pulmonary Hypertension and Scleroderma Renal Crisis in Systemic Sclerosis Background Systemic sclerosis (SSc) is a complex autoimmune disease that can affect near…
View article: Data Sheet 1_Severe fatigue is associated with diminished lung function and elevated Galectin-9 levels in early systemic sclerosis.docx
Data Sheet 1_Severe fatigue is associated with diminished lung function and elevated Galectin-9 levels in early systemic sclerosis.docx Open
Introduction Symptoms resembling myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) frequently affect patients with rheumatic diseases, but little is known about their frequency and disease manifestations, particularly in systemic…
View article: Diagnostics, Efficacy, and Safety of Immunomodulatory and Anti-Fibrotic Treatment for Interstitial Lung Disease Associated with Systemic Scleroderma (SSc-ILD)
Diagnostics, Efficacy, and Safety of Immunomodulatory and Anti-Fibrotic Treatment for Interstitial Lung Disease Associated with Systemic Scleroderma (SSc-ILD) Open
Systemic scleroderma (SSc) is an autoimmune disease characterized by excessive collagen production and progressive fibrosis. As the disease advances, vascular injury leads to fibrosis of the skin and internal organs, among which interstiti…
View article: Overlapping Connective Tissue Disease-Polymyositis and Diffuse Systemic Scleroderma: A Case Report
Overlapping Connective Tissue Disease-Polymyositis and Diffuse Systemic Scleroderma: A Case Report Open
Polymyositis with concomitant scleroderma is a rare, progressive condition with profound consequences if not addressed promptly. Severity and symptom presentation varies between patients, and much is unknown about how best to treat overlap…
View article: Raynaud’s Phenomenon, Anticentromere Antibodies and Digital Necrosis (RACAND) Is a Distinct Clinical Syndrome From Systemic Sclerosis: A Case Report and Literature Review
Raynaud’s Phenomenon, Anticentromere Antibodies and Digital Necrosis (RACAND) Is a Distinct Clinical Syndrome From Systemic Sclerosis: A Case Report and Literature Review Open
The occurrence of digital necrosis and Raynaud's phenomenon with anticentromere (ACA) antibodies has been recognized as a rare clinical entity coined RACAND syndrome. Although these features occur in systemic sclerosis (SSc), RACAND syndro…
View article: A Systemic Approach to Systemic Change
A Systemic Approach to Systemic Change Open
A Systemic Approach to Systemic Change
View article: Edentulism and Systemic Disease: A Comprehensive Review of Oral-Systemic Health Interactions
Edentulism and Systemic Disease: A Comprehensive Review of Oral-Systemic Health Interactions Open
Edentulism, or complete tooth loss, is a significant public health problem with consequences that extend far beyond the oral cavity. Functionally, edentulism impairs chewing, speech, and oral proprioception, leading to progressive alveolar…
View article: Redefining Systemic Sclerosis Classification: Anti-Topoisomerase Antibody as a Superior Predictor of Interstitial Lung Disease and Skin Progression Compared to Limited Cutaneous Systemic Sclerosis Subset
Redefining Systemic Sclerosis Classification: Anti-Topoisomerase Antibody as a Superior Predictor of Interstitial Lung Disease and Skin Progression Compared to Limited Cutaneous Systemic Sclerosis Subset Open
Background: Currently, no information exists on the clinical course of anti-topoisomerase I antibody (ATA)-positive limited cutaneous systemic sclerosis (lcSSc). We aimed to evaluate the incidence of and time to the development of intersti…
View article: Pathogenetic features of pulmonary hypertension in systemic sclerosis
Pathogenetic features of pulmonary hypertension in systemic sclerosis Open
Systemic connective tissue diseases may be associated with various forms of pulmonary hypertension (PH). The prevalence of PH varies among different systemic connective tissue diseases, with systemic scleroderma (SSc) having the highest ra…
View article: The Therapeutic Effects of Semaglutide in Congenital Linear Scleroderma.
The Therapeutic Effects of Semaglutide in Congenital Linear Scleroderma. Open
Congenital linear scleroderma (CLS) is a rare connective tissue disorder characterized by unilateral linear induration that can lead to restricted mobility and limb deformities. Various treatments have been proposed, including D-penicillam…
View article: Development of cerebral infarction associated with methotrexate in systemic local scleroderma: a clinical case
Development of cerebral infarction associated with methotrexate in systemic local scleroderma: a clinical case Open
systemic sclerosis is a systemic disease affecting connective tissue and small blood vessels, with an incidence of 7 to 33 cases per 100,000 population in Europe. The drug of choice for the treatment of skin changes (systemic localized scl…
View article: Keratoconus: The Local Manifestation of a Systemic Disease?
Keratoconus: The Local Manifestation of a Systemic Disease? Open
Keratoconus (KC) is the most common ectatic corneal disease. In this review, the systemic aspects of the disease are discussed, including patient age, genetics, systemic inflammatory status and immune system dysregulation, atopy and eye ru…
View article: P096 A study on clinical characteristics and severity of salt-and-pepper pigmentation in systemic sclerosis
P096 A study on clinical characteristics and severity of salt-and-pepper pigmentation in systemic sclerosis Open
Skin manifestation is vital for the diagnosis and subclassification of systemic sclerosis (SSc). Salt-and-pepper pigmentation (SaPP) helps readily identify a case of systemic sclerosis (SSc) but is an overlooked manifestation in terms of p…
View article: Validation of noninvasive screening methods for pulmonary arterial hypertension in patients with systemic sclerosis
Validation of noninvasive screening methods for pulmonary arterial hypertension in patients with systemic sclerosis Open
Pulmonary arterial hypertension (PAH) is a life-threatening condition that leads to early disability and death. As one of the complications of systemic sclerosis (SSc), it is important to develop screening models to improve diagnosis of PA…
View article: Cognitive debriefing of the Scleroderma Health Assessment Questionnaire in diffuse cutaneous systemic sclerosis
Cognitive debriefing of the Scleroderma Health Assessment Questionnaire in diffuse cutaneous systemic sclerosis Open
Background: Systemic sclerosis (scleroderma) is associated with functional disability and poor quality of life. Patient-reported outcome measures provide valuable insights into patients’ experiences, symptoms, and perceptions of their heal…