Dihydroxyacetone
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Computational protein design enables a novel one-carbon assimilation pathway Open
Significance This paper describes the development of a computationally designed enzyme that is the cornerstone of a novel metabolic pathway. This enzyme, formolase, performs a carboligation reaction, directly fixing one-carbon units into t…
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Strong Impact of Platinum Surface Structure on Primary and Secondary Alcohol Oxidation during Electro-Oxidation of Glycerol Open
Herein we describe a combined experimental and computational study of electrochemical glycerol oxidation in acidic media on Pt(111) and Pt(100) electrodes. Our results show that glycerol oxidation is a very structure-sensitive reaction in …
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Glycerol electro-oxidation on bismuth-modified platinum single crystals Open
Herein we describe the role of Bi adatom irreversibly adsorbed on platinum single-crystal electrodes toward the oxidation of glycerol. Our results show that the presence of bismuth on the Pt(1 1 1) electrode improves the activity of the re…
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Production of 4-Hydroxybenzoic Acid by an Aerobic Growth-Arrested Bioprocess Using Metabolically Engineered Corynebacterium glutamicum Open
Corynebacterium glutamicum was metabolically engineered to produce 4-hydroxybenzoic acid (4-HBA), a valuable aromatic compound used as a raw material for the production of liquid crystal polymers and paraben. C. glutamicum was found to hav…
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Employing bacterial microcompartment technology to engineer a shell-free enzyme-aggregate for enhanced 1,2-propanediol production in Escherichia coli Open
Bacterial microcompartments (BMCs) enhance the breakdown of metabolites such as 1,2-propanediol (1,2-PD) to propionic acid. The encapsulation of proteins within the BMC is mediated by the presence of targeting sequences. In an attempt to r…
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Gas-Phase Oxidation of Glycerol to Dihydroxyacetone over Tailored Iron Zeolites Open
ISSN:2155-5435
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Selective Electro-Oxidation of Glycerol to Dihydroxyacetone by PtAg Skeletons Open
Developing high-performance electrocatalysts for the selective conversion of glycerol into value-added chemicals is of great significance. Herein, three-dimensional nanoporous PtAg skeletons were studied as catalysts for the electro-oxidat…
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An experimental and theoretical study of glycerol oxidation to 1,3‐dihydroxyacetone over bimetallic Pt‐Bi catalysts Open
It is important to utilize glycerol, the main by‐product of biodiesel, to manufacture value‐added chemicals such as 1,3‐dihydroxyacetone (DHA). In the present work, the performance of five different catalysts (Pt‐Bi/AC, Pt‐Bi/ZSM‐5, Pt/MCM…
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Mechanistic Origins of the pH Dependency in Au-Catalyzed Glycerol Electro-oxidation: Insight from First-Principles Calculations Open
Electrocatalytic oxidation of glycerol (EOG) is an attractive approach to convert surplus glycerol to value-added products. Experiments have shown that EOG activity and selectivity depend not only on the electrocatalyst but also on the ele…
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Dihydroxyacetone: An Updated Insight into an Important Bioproduct Open
Currently obtained from glycerol through microbial fermentation, the demand of 1,3‐dihydroxyacetone (DHA) has significantly grown during the course of the last decade, driven by the consumer passion for a tan and increasing awareness of UV…
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Mechanistic Analysis of an Engineered Enzyme that Catalyzes the Formose Reaction Open
An enzyme that catalyzes the formose reaction, termed “formolase”, was recently engineered through a combination of computational protein design and directed evolution. We have investigated the kinetic role of the computationally designed …
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Oxidative Fermentation of Acetic Acid Bacteria and Its Products Open
Acetic acid bacteria (AAB) are a group of Gram-negative, strictly aerobic bacteria, including 19 reported genera until 2021, which are widely found on the surface of flowers and fruits, or in traditionally fermented products. Many AAB stra…
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Evidence for tunneling in base-catalyzed isomerization of glyceraldehyde to dihydroxyacetone by hydride shift under formose conditions Open
Significance This paper describes experimental and computational evidence that the hydride shift that converts glyceraldehyde to dihydroxyacetone at basic pH with Ca 2+ catalysis proceeds primarily by quantum tunneling. This answers the la…
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Promoting Role of Bismuth on Hydrotalcite-Supported Platinum Catalysts in Aqueous Phase Oxidation of Glycerol to Dihydroxyacetone Open
Bismuth plays important roles in promoting the oxidation of alcohols towards high-value-added chemicals over a noble metal loading catalyst. Herein, Mg–Al hydrotalcite-supported platinum–bismuth nanoparticles (Pt–Bi/HT) were prepared by th…
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Glycerol to Glyceraldehyde Oxidation Reaction Over Pt-Based Catalysts Under Base-Free Conditions Open
Glycerol valorization through partial oxidation is a good way of obtaining many different molecules with high added value such as glyceric acid, tartronic acid, dihydroxyacetone, etc. Among the potential products, glyceraldehyde is an inte…
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Converting Glycerol into Valuable Trioses by Cu<sup>δ+</sup>‐Single‐Atom‐Decorated WO<sub>3</sub> under Visible Light Open
Photocatalytic selective oxidation under visible light presents a promising approach for the sustainable transformation of biomass‐derived wastes. However, achieving both high conversion and excellent selectivity poses a significant challe…
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Amorphous antimony oxide as reaction pathway modulator toward electrocatalytic glycerol oxidation for selective dihydroxyacetone production Open
Achievement of an efficient and stable electrocatalytic glycerol oxidation reaction (EGOR) is limited by a lack of strategies for designing advanced electrocatalysts that satisfy the desired product selectivity, high electrocatalytic activ…
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Chemical and Metabolic Controls on Dihydroxyacetone Metabolism Lead to Suboptimal Growth of Escherichia coli Open
DHA is an attractive triose molecule with a wide range of applications, notably in cosmetics and the food and pharmaceutical industries. DHA is found in many species, from microorganisms to humans, and can be used by Escherichia coli as a …
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Newly discovered roles of triosephosphate isomerase including functions within the nucleus Open
Triosephosphate isomerase (TPI) is best known as a glycolytic enzyme that interconverts the 3-carbon sugars dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (G3P). TPI is an essential enzyme that is required for the catabol…
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Dihydroxyacetone conversion into lactic acid in an aqueous medium in the presence of metal salts: influence of the ionic thermodynamic equilibrium on the reaction performance Open
Different Lewis acid aluminium complexes catalyse the successive reactions to convert dihydroxyacetone into lactic acid in an aqueous medium.
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Enantioselective Reductive Oligomerization of Carbon Dioxide into <span>l</span>-Erythrulose via a Chemoenzymatic Catalysis Open
A cell-free enantioselective transformation of the carbon atom of CO2 has never been reported. In the urgent context of transforming CO2 into products of high value, the enantiocontrolled synthesis of chiral compounds from CO2 would be hig…
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Enzyme Architecture: Optimization of Transition State Stabilization from a Cation–Phosphodianion Pair Open
The side chain cation of R269 lies at the surface of l-glycerol 3-phosphate dehydrogenase (GPDH) and forms an ion pair to the phosphodianion of substrate dihydroxyacetone phosphate (DHAP), which is buried at the nonpolar protein interior. …
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Engineering Saccharomyces cerevisiae for Succinic Acid Production From Glycerol and Carbon Dioxide Open
Previously, our lab replaced the endogenous FAD-dependent pathway for glycerol catabolism in S. cerevisiae by the synthetic NAD-dependent dihydroxyacetone (DHA) pathway. The respective modifications allow the full exploitation of glycerol'…
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Degradable high <i>T</i><sub>g</sub> sugar-derived polycarbonates from isosorbide and dihydroxyacetone Open
Step-growth polymerization and degradation behavior of fully sugar-derived high Tg alternating and random polycarbonates from isosorbide and dihydroxyacetone.
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Continuous Liquid-Phase Upgrading of Dihydroxyacetone to Lactic Acid over Metal Phosphate Catalysts Open
The performance of Brønsted- and Lewis-acidic La, Nb, and Zr phosphates (LaPO, NbPO, and ZrPO) during the aqueous phase conversion of dihydroxyacetone (DHA) to lactic acid (LA) is investigated using a fixed-bed reactor. Mass-transfer pheno…
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Monitoring acute metabolic changes in the liver and kidneys induced by fructose and glucose using hyperpolarized [2‐<sup>13</sup>C]dihydroxyacetone Open
Purpose To investigate acute changes in glucose metabolism in liver and kidneys in vivo after a bolus injection of either fructose or glucose, using hyperpolarized [2‐ 13 C]dihydroxyacetone. Methods Spatially registered, dynamic, multislic…
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Glycerol electro-oxidation to dihydroxyacetone on phosphorous-doped Pd/CNT nanoparticles in alkaline medium Open
In this communication report, a comparative study between P-doped Pd/CNT and bare Pd/CNT catalyst was carried out to decouple the effects of phosphorous-doping on electro-oxidation of glycerol. The initial characterization results suggeste…
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Molecular Basis of Sulfosugar Selectivity in Sulfoglycolysis Open
The sulfosugar sulfoquinovose (SQ) is produced by essentially all photosynthetic organisms on Earth and is metabolized by bacteria through the process of sulfoglycolysis. The sulfoglycolytic Embden-Meyerhof-Parnas pathway metabolizes SQ to…
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Dihydroxyacetone levels in electronic cigarettes: Wick temperature and toxin formation Open
Recently, we reported the presence of dihydroxyacetone (DHA), the active ingredient in sunless tanners, in the aerosol of an electronic cigarette. DHA has been shown to react with DNA in vitro. The FDA restricts the use of DHA to external …
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Cinnamaldehyde Enhances Antimelanoma Activity through Covalently Binding ENO1 and Exhibits a Promoting Effect with Dacarbazine Open
At present, melanoma is a common malignant tumor with the highest mortality rate of all types of skin cancer. Although the first option for treating melanoma is with chemicals, the effects are unsatisfactory and include poor medication res…