Tableting
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The synthesis of active pharmaceutical ingredients (APIs) using continuous flow chemistry Open
The implementation of continuous flow processing as a key enabling technology has transformed the way we conduct chemistry and has expanded our synthetic capabilities. As a result many new preparative routes have been designed towards comm…
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Applications of machine vision in pharmaceutical technology: A review Open
The goal of this paper is to give an introduction to analysis of images acquired by a digital camera with visible illumination and to review its applications as a Process Analytical Technology (PAT) which has great potential in pharmaceuti…
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Effect of particle size distribution on flowability of granulated lactose Open
The flowability of powders used in tableting significantly affects tablet weight and content uniformity of active pharmaceutical ingredients. Use of granulated materials instead of powdered materials can improve flowability. In this study,…
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Control of Pharmaceutical Cocrystal Polymorphism on Various Scales by Mechanochemistry: Transfer from the Laboratory Batch to the Large-Scale Extrusion Processing Open
We\ndemonstrate a controllable mechanochemical synthesis of cocrystal\npolymorphs of ascorbic acid (vitamin C) and nicotinamide (vitamin\nB3) on different scales and without using bulk solvents. Next to the\npreviously described polymorph …
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Design and pharmaceutical applications of porous particles Open
Porous particles have been developed as a novel carrier to improve drug delivery, dissolution, tableting, and so on, which can be prepared by many methods.
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End-to-end continuous manufacturing of conventional compressed tablets: From flow synthesis to tableting through integrated crystallization and filtration Open
An end-to-end continuous pharmaceutical manufacturing process was developed for the production of conventional direct compressed tablets on a proof-of-concept level for the first time. The output reaction mixture of the flow synthesis of a…
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Microcrystalline Cellulose: The Inexhaustible Treasure for Pharmaceutical Industry Open
Microcrystalline cellulose (MCC) is pure partially depolymerized cellulose synthesized from α-cellulose precursor. The MCC can be synthesized by different processes such as reactive extrusion, enzyme mediated, steam explosion and acid hydr…
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Microencapsulation of Salmonella-Specific Bacteriophage Felix O1 Using Spray-Drying in a pH-Responsive Formulation and Direct Compression Tableting of Powders into a Solid Oral Dosage Form Open
The treatment of enteric bacterial infections using oral bacteriophage therapy can be challenging since the harsh acidic stomach environment renders phages inactive during transit through the gastrointestinal tract. Solid oral dosage forms…
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Spray Drying for Direct Compression of Pharmaceuticals Open
Tableting by direct compression (DC) is one of the simplest and most cost-effective drug manufacturing approaches. However, most active pharmaceutical ingredients (APIs) and excipients lack the compression and flow properties required to m…
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Polymorphism of chlorpropamide on liquid-assisted mechanical treatment: choice of liquid and type of mechanical treatment matter Open
Different types of mechanical treatment (tableting, grinding, milling,etc.) are important technological operations in the pharmaceutical industry.
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Assessment and prediction of tablet properties using transmission and backscattering Raman spectroscopy and transmission NIR spectroscopy Open
This study investigated whether Raman and Near Infrared (NIR) spectroscopy could predict tablet properties. Granules were produced on a continuous line by varying granulation parameters. Tableting process parameters were adjusted to obtain…
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Preparation of Microcrystalline Cellulose from Cotton and its Evaluation as Direct Compressible Excipient in the Formulation of Naproxen Tablets Open
Microcrystalline cellulose (MCC) was prepared by acid hydrolysis from the cellulose purified from the cotton. Chemical assay, determination of degree of polymerization (DP) and FT-IR confirm the identification of prepared microcrystalline …
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Scaled-Up Production and Tableting of Grindable Electrospun Fibers Containing a Protein-Type Drug Open
The aims of this work were to develop a processable, electrospun formulation of a model biopharmaceutical drug, β-galactosidase, and to demonstrate that higher production rates of biopharmaceutical-containing fibers can be achieved by usin…
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Monitoring the concentration of flowing pharmaceutical powders in a tableting feed frame Open
The use of process analytical technology (PAT) tools is increasing steadily in the pharmaceutical industry. Such tools are now located throughout the process. When producing tablets, the tableting step itself may be the ideal moment to ass…
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Scaling Tableting Processes from Compaction Simulator to Rotary Presses—Mind the Sub-Processes Open
Compaction simulators are frequently used in the formulation and process development of tablets, bringing about the advantages of flexibility, low material consumption, and high instrumentation to generate the most possible process underst…
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Formulation design of granules prepared by wet granulation method using a multi-functional single-punch tablet press to avoid tableting failures Open
We previously determined "Tableting properties" by using a multi-functional single-punch tablet press (GTP-1). We plotted "Compactability" on the x-axis against "Manufacturability" on the y-axis to allow visual evaluation of "Tableting pro…
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Along the Process Chain to Probiotic Tablets: Evaluation of Mechanical Impacts on Microbial Viability Open
Today, probiotics are predominantly used in liquid or semi-solid functionalized foods, showing a rapid loss of cell viability. Due to the increasing spread of antibiotic resistance, probiotics are promising in pharmaceutical development be…
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Liquisolid tablets for dissolution enhancement of a hypolipidemic drug Open
This investigation was aimed to improve the dissolution rate of the poorly soluble drug lovastatin, by formulating it as a liquisolid compact. Different liquisolid compacts were prepared using mathematical formulae to calculate the require…
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Development of paracetamol-caffeine co-crystals to improve compressional, formulation and <i>in vivo</i> performance Open
Paracetamol, a frequently used antipyretic and analgesic drug, has poor compression moldability owing to its low plasticity. In this study, new co-crystals of paracetamol (PCM) with caffeine (as a co-former) were prepared and delineated. C…
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Understanding solid-state processing of pharmaceutical cocrystals via milling: Role of tablet excipients Open
Discovery of novel cocrystal systems and improvement of their physicochemical properties dominates the current literature on cocrystals yet the required end-product formulation is rarely addressed. Drug product manufacturing includes compl…
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Lubricant sensitivity in function of paddle movement in the forced feeder of a high-speed tablet press Open
The results elucidated that during manufacturing of tablets using MgSt-containing blends care should not only be taken during the blending step prior to tableting, but also during the tableting process itself, as paddle speed can affect ta…
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Impact of Powder Properties on the Rheological Behavior of Excipients Open
With the emergence of quality by design in the pharmaceutical industry, it becomes imperative to gain a deeper mechanistic understanding of factors impacting the flow of a formulation into tableting dies. Many flow characterization techniq…
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Process Modification of Pharmaceutical Tablet Manufacturing Operations: An Eco-Efficiency Approach Open
A process improvement in a tablet manufacturing process within a pharmaceutical industry was carried out based on an eco-efficiency approach. As it is one of the most energy consuming processes in the production line, the tablet manufactur…
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SIMULTANEOUS COCRYSTALLIZATION AND MICRONIZATION OF PARACETAMOL-DIPICOLINIC ACID COCRYSTAL BY SUPERCRITICAL ANTISOLVENT (SAS) Open
Objective: This present study aims to produce cocrystal of paracetamol (PCA)-dipicolinic acid (DPA) using supercritical antisolvent (SAS) cocrystallization process in order to improve tabletability profile of PCA. Methods: The PCA-DPA …
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Influence of High, Disperse API Load on Properties along the Fused-Layer Modeling Process Chain of Solid Dosage Forms Open
In order to cope with the increasing number of multimorbid patients due to demographic changes, individualized polypill solutions must be developed. One promising tool is fused layer modeling (FLM) of dosage forms with patient-specific dos…
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The Challenge of Die Filling in Rotary Presses—A Systematic Study of Material Properties and Process Parameters Open
For the efficient and safe production of pharmaceutical tablets, a deep process understanding is of high importance. An essential process step during tableting is the die filling, as it is responsible for a consistent tablet weight and dru…
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Flow and Tableting Behaviors of Some Egyptian Kaolin Powders as Potential Pharmaceutical Excipients Open
The present work aimed at assessing the pharmaceutical tableting properties of some Egyptian kaolin samples belong to the Abu Zenima kaolin deposits (estimated at 120 million tons). Four representative samples were selected based on kaolin…
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Tableting properties of microcrystalline cellulose obtained from wheat straw measured with a single punch bench top tablet press Open
The objective of this work was to study the relation between the manufacturing conditions of microcrystalline cellulose (MCC), its physicochemical properties and its tableting behavior. Two different preparation procedures were used to pro…
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Modulation of the powder properties of lamotrigine by crystal forms Open
The mechanical properties of powders determine the ease of manufacture and ultimately the quality of the oral solid dosage forms. Although poor mechanical properties of an active pharmaceutical ingredient (API) can be mitigated by using su…
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Interpretable artificial neural networks for retrospective QbD of pharmaceutical tablet manufacturing based on a pilot-scale developmental dataset Open
As the pharmaceutical industry increasingly adopts the Pharma 4.0. concept, there is a growing need to effectively predict the product quality based on manufacturing or in-process data. Although artificial neural networks (ANNs) have emerg…