Mycoplasma genitalium
View article: Optimizing Nucleic Acid Extraction from Extended Bovine Semen for Endemic and High-Consequence Pathogens
Optimizing Nucleic Acid Extraction from Extended Bovine Semen for Endemic and High-Consequence Pathogens Open
Accurate pathogen detection in bovine semen is crucial for animal health surveillance and international trade. Semen presents unique challenges due to the presence of PCR inhibitors from seminal plasma and extender components, reducing nuc…
View article: The role of P30 adhesin detected by ultrasensitive ELISA in the clinical diagnosis and management of Mycoplasma pneumoniae
The role of P30 adhesin detected by ultrasensitive ELISA in the clinical diagnosis and management of Mycoplasma pneumoniae Open
P30 is a reliable biomarker for the rapid diagnosis of MP, with superior accuracy to serology and practical advantages over PCR in clinical settings. While its predictive value for macrolide resistance is modest, integration with other bio…
View article: Клинический случай неуспеха терапии персистирующей микоплазменной инфекции, обусловленной Mycoplasma genitalium, с выявленной лекарственной устойчивостью к макролидам и фторхинолонам
Клинический случай неуспеха терапии персистирующей микоплазменной инфекции, обусловленной Mycoplasma genitalium, с выявленной лекарственной устойчивостью к макролидам и фторхинолонам Open
Mycoplasma genitalium является патогеном, принадлежащим к группе возбудителей инфекций, передаваемых половым путем. Клиническая картина микоплазменной инфекции не имеет специфических симптомов и сопровождается такими заболеваниями, как уре…
View article: Prevalence of Chlamydia trachomatis, Ureaplasma spp., Mycoplasma hominis and Mycoplasma genitalium in patients with sterile pyuria
Prevalence of Chlamydia trachomatis, Ureaplasma spp., Mycoplasma hominis and Mycoplasma genitalium in patients with sterile pyuria Open
View article: Evaluation of Mycoplasma genitalium positivity and co-infection with Chlamydia trachomatis and/or Neisseria gonorrhoeae at various care sites across the United States
Evaluation of Mycoplasma genitalium positivity and co-infection with Chlamydia trachomatis and/or Neisseria gonorrhoeae at various care sites across the United States Open
MG positivity was high and MG co-infection with CT was common. These findings improve understanding of MG prevalence and may help inform the targeting of MG screening to specific patient populations. Co-infection data support using multipl…
View article: Development and clinical evaluation of a novel SHERLOCK test for <i>Mycoplasma genitalium</i>
Development and clinical evaluation of a novel SHERLOCK test for <i>Mycoplasma genitalium</i> Open
Mycoplasma genitalium (MG) is a sexually transmitted pathogen associated with urethritis. Nucleic acid amplification tests are the gold standard for its diagnosis but often require specialized equipment, which limits their use in point-of-…
View article: Generating Whole Bacterial Genomes from Clinical Samples using a Target Enrichment Workflow
Generating Whole Bacterial Genomes from Clinical Samples using a Target Enrichment Workflow Open
Obtaining complete genomes of bacterial sexually transmitted infections (STIs) directly from clinical samples is challenging due to the presence of human DNA, microbiota, and very low bacterial pathogen loads. Culture is often not an optio…
View article: Analysis of <i>Neisseria gonorrhoeae</i> and <i>Mycoplasma genitalium</i> from nucleic acid amplification test specimens, Nunavut region of Inuit Nunangat, Canada, 2020–2023
Analysis of <i>Neisseria gonorrhoeae</i> and <i>Mycoplasma genitalium</i> from nucleic acid amplification test specimens, Nunavut region of Inuit Nunangat, Canada, 2020–2023 Open
This study analyzed Neisseria gonorrhoeae (GC) and Mycoplasma genitalium (Mgen) from remnant nucleic acid amplification test (NAAT) specimens in Nunavut, Canada (2020–2023) to assess strain distribution, antimicrobial resistance (AMR), and…
View article: Symptomatic Mycoplasma genitalium infections in men who have sex with men and trans women: Should we skip macrolides?
Symptomatic Mycoplasma genitalium infections in men who have sex with men and trans women: Should we skip macrolides? Open
View article: The Quantitative Detection of Urogenital Mycoplasmas in Men with Urolithiasis
The Quantitative Detection of Urogenital Mycoplasmas in Men with Urolithiasis Open
Urease-positive urogenital mycoplasmas are considered to be responsible for the formation of urinary stones. They are usually a part of the normal flora in the human urogenital tract, causing asymptomatic infections. However, many symptoma…
View article: What is the treatment for urethritis caused by Ureaplasma urealyticum in men?
What is the treatment for urethritis caused by Ureaplasma urealyticum in men? Open
The literature suggests using doxycycline as a primary treatment for urethritis caused by *Ureaplasma urealyticum*, with alternatives like azithromycin and moxifloxacin available if necessary.
View article: What is the treatment for urethritis caused by Ureaplasma urealyticum in men?
What is the treatment for urethritis caused by Ureaplasma urealyticum in men? Open
The literature suggests using doxycycline as a primary treatment for urethritis caused by *Ureaplasma urealyticum*, with alternatives like azithromycin and moxifloxacin available if necessary.
View article: Clinical evaluation of two commercial PCR kits for the detection of nonviral sexually transmitted infections
Clinical evaluation of two commercial PCR kits for the detection of nonviral sexually transmitted infections Open
Introduction. Sexually transmitted infections (STIs) are a worldwide health issue with a high number of asymptomatic cases and the possibility of multiple infections. Gap statement. New multiplex real-time PCR kits targeting pathogens invo…
View article: Factors that contribute to the success of primary isolation of Mycoplasma genitalium from clinical samples
Factors that contribute to the success of primary isolation of Mycoplasma genitalium from clinical samples Open
Introduction. Mycoplasma genitalium , a small and slow-growing bacterium, has gained notoriety due to rapidly increasing rates of antibiotic resistance. Gap Statement. M. genitalium is difficult to culture, limiting efforts to understand i…
View article: Piercing Through: Lefamulin Treatment of an Antibiotic-Resistant Mycoplasma Genitalium Urethritis
Piercing Through: Lefamulin Treatment of an Antibiotic-Resistant Mycoplasma Genitalium Urethritis Open
Multidrug-resistant (MDR) Mycoplasma genitalium (M. genitalium) presents a significant risk of treatment failure in many sexually transmitted infections (STIs) and can result in persistent and recurrent urethritis or cervicitis. This case …
View article: Chronic sexually acquired reactive arthritis, associated with extragenital Mycoplasma genitalium infection in an MSM – a case report
Chronic sexually acquired reactive arthritis, associated with extragenital Mycoplasma genitalium infection in an MSM – a case report Open
Reactive arthritis is included in the spectrum of seronegative spondyloarthritides, occurring secondary to triggers of genitourinary and gastrointestinal tract infections. We describe a case of sexually acquired reactive arthritis in an MS…
View article: Disrupted Vaginal Microbiota and Increased HPV Infection Risk Among Non-Vaccinated Women: Findings from a Prospective Cohort Study in Kazakhstan
Disrupted Vaginal Microbiota and Increased HPV Infection Risk Among Non-Vaccinated Women: Findings from a Prospective Cohort Study in Kazakhstan Open
Introduction: Vaginal microbiota has emerged as an important factor influencing human papillomavirus (HPV) persistence and host immunity. While HPV infection is often transient, persistent infections with high-risk HPV genotypes significan…
View article: High frequency of sexually transmitted infections in patients with precancerous cervical lesions in Brazil
High frequency of sexually transmitted infections in patients with precancerous cervical lesions in Brazil Open
Introduction Cervical cancer is strongly associated with persistent human papillomavirus (HPV) infection, the most common sexually transmitted infection (STI) worldwide. While most infections are cleared naturally, co-infections with non-H…
View article: Microbiota of Cervical Canal in Nine Patients Diagnosed with Ectopic Pregnancy: Case Series
Microbiota of Cervical Canal in Nine Patients Diagnosed with Ectopic Pregnancy: Case Series Open
Dysbiosis, or an altered microbiota composition, has been implicated in chronic endometrial inflammation and recurrent implantation failure. Despite growing research on the relationship between the genital microbiome and reproductive healt…
View article: Features of the use of the antibacterial drug josamycin in gynecological practice
Features of the use of the antibacterial drug josamycin in gynecological practice Open
Background. Currently, urogenital chlamydia occupies the first place in terms of prevalence among all bacterial sexually transmitted diseases. Along with chlamydia, other intracellular pathogens, mycoplasmas and ureaplasmas, are attracting…
View article: A novel azithromycin resistance mutation in <i>Mycoplasma genitalium</i> induced <i>in vitro</i>
A novel azithromycin resistance mutation in <i>Mycoplasma genitalium</i> induced <i>in vitro</i> Open
Background Mycoplasma genitalium is a sexually transmitted bacterium of increasing concern due to issues around antimicrobial resistance. Resistance is typically mediated by SNPs; however, the difficulty of isolation and culture of M. geni…
View article: Mycoplasma Genitalium: An Under-Diagnosed Sexually Transmitted Infection
Mycoplasma Genitalium: An Under-Diagnosed Sexually Transmitted Infection Open
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View article: Efficacy and tolerability of the combination of minocycline and metronidazole for macrolide-resistant <i>Mycoplasma genitalium</i>
Efficacy and tolerability of the combination of minocycline and metronidazole for macrolide-resistant <i>Mycoplasma genitalium</i> Open
Background and objectives Curing Mycoplasma genitalium is challenging in the context of rising antimicrobial resistance and limited therapeutic options. There is an urgent need for globally relevant and effective treatment options using re…
View article: Automated <i>Mycoplasma genitalium</i> molecular macrolide resistance detection and nucleic acid target semi-quantitation: patient demographic considerations
Automated <i>Mycoplasma genitalium</i> molecular macrolide resistance detection and nucleic acid target semi-quantitation: patient demographic considerations Open
Recent work has optimized parameters of a real-time reverse transcriptase PCR-based laboratory-developed test on the Panther Fusion system which detects Mycoplasma genitalium-specific macrolide resistance-associated mutations LDT (MRM-LDT)…
View article: Mycoplasma genitalium Infections and Associated Antimicrobial Resistance in Canada, 1980–2023
Mycoplasma genitalium Infections and Associated Antimicrobial Resistance in Canada, 1980–2023 Open
Background: We aimed to describe trends in M. genitalium prevalence and associated resistance in Canada between 1980 and 2022. Methods: Ecological study and a scoping review. We collected publicly available data published by the government…
View article: Maternal–fetal transfer and longitudinal trends of antibodies to <i>Chlamydia trachomatis</i> and <i>Mycoplasma genitalium</i> in early childhood
Maternal–fetal transfer and longitudinal trends of antibodies to <i>Chlamydia trachomatis</i> and <i>Mycoplasma genitalium</i> in early childhood Open
Introduction Sexually transmitted infections caused by Chlamydia trachomatis and Mycoplasma genitalium can have significant implications during early childhood. This study aimed to assess maternal antibodies to C. trachomatis and M. genita…
View article: Infektionen mit den humanpathogenen Mykoplasmenspezies M. genitalium und M. pneumoniae
Infektionen mit den humanpathogenen Mykoplasmenspezies M. genitalium und M. pneumoniae Open
View article: Prevalence and epidemiology of Mycoplasma genitalium and the absence of macrolide resistance in M. genitalium among pregnant women attending antenatal care in Zambia
Prevalence and epidemiology of Mycoplasma genitalium and the absence of macrolide resistance in M. genitalium among pregnant women attending antenatal care in Zambia Open
Introduction Mycoplasma genitalium (MG) is a sexually transmitted bacterium of public health importance, associated with genitourinary disorders, and adverse reproductive and perinatal outcomes. Global data on MG prevalence and antimicrobi…
View article: A genome-wide investigation of Mycoplasma hominis genes associated with gynecological infections or infertility
A genome-wide investigation of Mycoplasma hominis genes associated with gynecological infections or infertility Open
Background and aim Mycoplasma hominis is a human pathogenic bacterium that causes a wide range of genital infections and reproductive issues. Previously, based on an extended multilocus sequence typing scheme, we provided evidence for the …
View article: Mycoplasma genitalium molecular typing in men with non-gonococcal urethritis discriminates between phylogenetic clusters based on sexual preference and antibiotic resistance
Mycoplasma genitalium molecular typing in men with non-gonococcal urethritis discriminates between phylogenetic clusters based on sexual preference and antibiotic resistance Open
Introduction. Mycoplasma genitalium is a sexually transmitted bacterium associated with non-gonococcal urethritis (NGU) in men. The rising macrolide and fluoroquinolone resistance in M. genitalium has become a public health concern, requir…