Hyaluronidase
View article: Hyaluronidase for Microstomia in Fibrosing Skin Disease: Systematic Review and Case Series
Hyaluronidase for Microstomia in Fibrosing Skin Disease: Systematic Review and Case Series Open
Supplementary Material of Manuscript: "Hyaluronidase for Microstomia in Fibrosing Skin Disease: Systematic Review and Case Series"
View article: Hyaluronidase for Microstomia in Fibrosing Skin Disease: Systematic Review and Case Series
Hyaluronidase for Microstomia in Fibrosing Skin Disease: Systematic Review and Case Series Open
Supplementary Material of Manuscript: "Hyaluronidase for Microstomia in Fibrosing Skin Disease: Systematic Review and Case Series"
View article: Alteration of Hyaluronic Acid Metabolism in Tumor Microenvironment Can Modulate DNA Repair Gene Expression: Therapeutic Potential for Triple-Negative Breast Cancer
Alteration of Hyaluronic Acid Metabolism in Tumor Microenvironment Can Modulate DNA Repair Gene Expression: Therapeutic Potential for Triple-Negative Breast Cancer Open
Breast and colorectal cancers remain among the leading causes of cancer-related deaths globally, with therapy failure often driven by tumor complexity and interactions with the tumor microenvironment (TME). Hyaluronic acid (HA), a key extr…
View article: Atractylodes Macrocephala Koidz Extracts (AKE) Enhance Skin Barrier Repair via Synergistic Ceramide Upregulation, Hyaluronidase Inhibition, Anti-Inflammatory Action, and Proteins Modulation
Atractylodes Macrocephala Koidz Extracts (AKE) Enhance Skin Barrier Repair via Synergistic Ceramide Upregulation, Hyaluronidase Inhibition, Anti-Inflammatory Action, and Proteins Modulation Open
View article: In Vitro and Ex Vivo Investigations on the Tolerance and Safety of a 3 kDa Sodium Hyaluronate for Topical Application
In Vitro and Ex Vivo Investigations on the Tolerance and Safety of a 3 kDa Sodium Hyaluronate for Topical Application Open
(1) Background: Low-molecular-weight hyaluronic acid displays moisturizing and anti-aging properties and reduces UV-induced inflammation when applied topically. A 3 kDa sodium hyaluronate oligosaccharide (Extra-Low HA) was designed, and st…
View article: Bioactivity profiling of spider venoms reveals predominant hyaluronidase activities
Bioactivity profiling of spider venoms reveals predominant hyaluronidase activities Open
Spider venoms are primarily composed of small neurotoxic peptides. However, recent studies suggested a hitherto overlooked diversity of spider venom enzymes, although their functional space still remains largely unexplored. We tested 10 sp…
View article: Bioinspired honeycomb-mimetic adaptive hyaluronic acid hydrogel composite scaffold: intelligent prevention and treatment of infection of bone implants and promotion of bone repair
Bioinspired honeycomb-mimetic adaptive hyaluronic acid hydrogel composite scaffold: intelligent prevention and treatment of infection of bone implants and promotion of bone repair Open
Addressing two major challenges in the field of bone implants: bacterial infection and delayed bone fusion, this study draws inspiration from the beehive structure to develop an adaptive enzyme-responsive hydrogel composite scaffold. The s…
View article: Biochemical and physiological characterization of Sp-H, a hyaluronidase isolated from the venom of the scorpionfish Scorpaena plumieri
Biochemical and physiological characterization of Sp-H, a hyaluronidase isolated from the venom of the scorpionfish Scorpaena plumieri Open
Hyaluronidases are ubiquitous enzymes in animal venoms, where they act as auxiliary toxins that facilitate the diffusion of other components by hydrolyzing hyaluronic acid (HA) in the extracellular matrix. In this study, we purified and bi…
View article: A PROBABLE CASE OF HYALURONIC ACID INJECTION-INDUCED MAST CELL ACTIVATION SYNDROME WITH REFRACTORY VASOPLEGIA: A RARE COMPLICATION REVERSED WITH HYALURONIDASE
A PROBABLE CASE OF HYALURONIC ACID INJECTION-INDUCED MAST CELL ACTIVATION SYNDROME WITH REFRACTORY VASOPLEGIA: A RARE COMPLICATION REVERSED WITH HYALURONIDASE Open
View article: Hyalase in Dermatology: Applications Beyond Filler Management
Hyalase in Dermatology: Applications Beyond Filler Management Open
Background Hyaluronic acid (HA) is a key extracellular matrix component in the skin. Hyaluronidase is an enzyme that breaks down HA into monosaccharides. The FDA has approved this enzyme for hypodermoclysis, drug absorption enhancement, an…
View article: Characterization of a Hyaluronidase from Paenibacillus residui BSSK58 and Evaluation of Its Industrial Applicability
Characterization of a Hyaluronidase from Paenibacillus residui BSSK58 and Evaluation of Its Industrial Applicability Open
Hyaluronidase is a hydrolytic enzyme that cleaves β-1,4-glycosidic linkages in high-molecular-weight hyaluronic acid, generating low-molecular-weight oligosaccharides with enhanced biological functions. These products exhibit immunomodulat…
View article: The Safety, Tolerability, and Pharmacokinetics of ALT-BB4 (A Novel Recombinant Hyaluronidase): A Randomized, Double-Blinded, Placebo-Controlled, Phase 1 Study in Healthy Volunteers
The Safety, Tolerability, and Pharmacokinetics of ALT-BB4 (A Novel Recombinant Hyaluronidase): A Randomized, Double-Blinded, Placebo-Controlled, Phase 1 Study in Healthy Volunteers Open
View article: Salmonella typhimurium co-expressing cytolysin A and hyaluronidase suppresses tumor growth and metastasis
Salmonella typhimurium co-expressing cytolysin A and hyaluronidase suppresses tumor growth and metastasis Open
Recently, various attenuated bacteria have been studied as cancer therapies due to their unique characteristics, which include tumor-targeting bioactivity and immunogenicity. Previously, we reported a Salmonella typhimurium strain, CNC018,…
View article: Intelligent hyaluronidase-responsive supramolecular nanoassemblies for programmable dual-drug delivery and NIR-II photothermal therapy of atherosclerosis
Intelligent hyaluronidase-responsive supramolecular nanoassemblies for programmable dual-drug delivery and NIR-II photothermal therapy of atherosclerosis Open
The development of controllable nanoplatforms with disease-specific responsiveness and programmable therapeutic functions is vital for treating complex cardiovascular diseases such as atherosclerosis. Herein, we present an intelligent, nex…
View article: Comparative Evaluation of Sodium Bicarbonate and Hyaluronidase as Adjuncts to Lignocaine in Peribulbar Block During Cataract Surgery
Comparative Evaluation of Sodium Bicarbonate and Hyaluronidase as Adjuncts to Lignocaine in Peribulbar Block During Cataract Surgery Open
View article: A Bioactive Emulgel Formulation of Equisetum telmateia Ehrh. Methanol Extract: Integrating Antioxidant Activity, Skin Enzyme Inhibition, and Permeation Kinetics
A Bioactive Emulgel Formulation of Equisetum telmateia Ehrh. Methanol Extract: Integrating Antioxidant Activity, Skin Enzyme Inhibition, and Permeation Kinetics Open
Equisetum telmateia Ehrh. (great horsetail) belongs to the Equisetaceae family and its aerial parts have been traditionally used for skin conditions and to achieve healthy and resilient skin, nails, and hair. This study aimed to evaluate t…
View article: Time course and contributors to greater glycocalyx thickness and integrity following Western diet consumption
Time course and contributors to greater glycocalyx thickness and integrity following Western diet consumption Open
We observed greater glycocalyx thickness and integrity starting as early as 1 wk after mice began a Western diet. Greater glycocalyx thickness was dependent on the hyaluronan content in the glycocalyx. Differences in glycocalyx integrity b…
View article: Optimization of Culture Conditions for Human Ovarian Stem Cells Using Gelatin-Coated Surfaces
Optimization of Culture Conditions for Human Ovarian Stem Cells Using Gelatin-Coated Surfaces Open
The addition of gelatin to the culture dishes seems to be beneficial in the culture of stem cells isolated from the human ovarian tissue and their further expansion.
View article: Enhanced Doxorubicin Cytotoxicity on Breast Cancer Spheroids by Aptamer Targeted Co‐Delivery with Hyaluronidase
Enhanced Doxorubicin Cytotoxicity on Breast Cancer Spheroids by Aptamer Targeted Co‐Delivery with Hyaluronidase Open
Breast cancer is one of the most prevalent solid tumors in women and can be classified into subtypes based on molecular characteristics, such as hormone receptor status and HER2 expression. Aptamers, highly specific affinity molecules, are…
View article: Enzymatic Management of Facial Overfilled Syndrome: A Case Series and Narrative Review
Enzymatic Management of Facial Overfilled Syndrome: A Case Series and Narrative Review Open
Background Facial overfilled syndrome (FOS) is an increasingly recognized complication of injectable aesthetic procedures, characterized by undesirable facial volume and contour irregularities. While hyaluronidase is well‐established for m…
View article: Preliminary Analysis of Bilberry NaDES Extracts as Versatile Active Ingredients of Natural Dermocosmetic Products: In Vitro Evaluation of Anti-Tyrosinase, Anti-Hyaluronidase, Anti-Collagenase, and UV Protective Properties
Preliminary Analysis of Bilberry NaDES Extracts as Versatile Active Ingredients of Natural Dermocosmetic Products: In Vitro Evaluation of Anti-Tyrosinase, Anti-Hyaluronidase, Anti-Collagenase, and UV Protective Properties Open
Bilberry (Vaccinium myrtillus L.) fruits represent the recognized wellspring of bioactive compounds with various documented bioactivities. Although bilberry leaves are often treated as industrial by-products, they also represent a valuable…
View article: Anatomical Guideline for Retrobulbar Hyaluronidase Injection
Anatomical Guideline for Retrobulbar Hyaluronidase Injection Open
Background Vision loss following cosmetic filler injections is a rare but devastating complication resulting from inadvertent intravascular embolization, most often affecting the ophthalmic artery. Retrobulbar hyaluronidase injection has b…
View article: Comparison of Soda Bicarbonate and Hyaluronidase as an Adjuvant to Bupivacaine in Supraclavicular Brachial Plexus Block: A Double Blinded Randomised Clinical Study
Comparison of Soda Bicarbonate and Hyaluronidase as an Adjuvant to Bupivacaine in Supraclavicular Brachial Plexus Block: A Double Blinded Randomised Clinical Study Open
Introduction: For upper limb surgeries, brachial plexus nerve blocks with additives offer efficient analgesia and prolonged regional block. Hyaluronidase is an enzyme, which catalyses the hyaluronan and lowers its viscosity, improving tiss…
View article: A new protocol (THIS and FAT) for the treatment of filler-induced vascular occlusion: a case series
A new protocol (THIS and FAT) for the treatment of filler-induced vascular occlusion: a case series Open
Introduction Hyaluronic acid (HA) fillers are generally safe; however, the most significant complication is vascular occlusion. Several therapeutic protocols have been proposed for managing ischemia. De Lorenzi introduced the HDPH protocol…
View article: Preliminary isolation and screening of halophilic archaea with potential to produce cellulase, chitinase, xylanase, and hyaluronidase enzymes
Preliminary isolation and screening of halophilic archaea with potential to produce cellulase, chitinase, xylanase, and hyaluronidase enzymes Open
View article: Road-Roller Technique Using Hyaluronidase-Enhanced Local Anaesthesia for Split-Thickness Skin Grafts
Road-Roller Technique Using Hyaluronidase-Enhanced Local Anaesthesia for Split-Thickness Skin Grafts Open
Large split-thickness skin grafts (SSGs) can often be harvested under local anaesthesia, but traditional infiltration requires numerous needle passes across the donor area, which can cause significant discomfort and incomplete anaesthesia,…
View article: Hyaluronidase: structure, mechanism of action, diseases and therapeutic targets
Hyaluronidase: structure, mechanism of action, diseases and therapeutic targets Open
Hyaluronidase (HAase), a family of enzymes critical for regulating physiological and pathological states, catalyzes the degradation of hyaluronic acid (HA), a key component of the extracellular matrix (ECM). By modulating ECM composition a…
View article: A COMPARATIVE EFFICACY OF STEROID PLUS BUPIVACAINE, 5% DEXTROSE AND HYALURONIDASE FOR MEDIAN NERVE BLOCK IN CARPAL TUNNEL SYNDROME: A RANDOMIZED CONTROL TRAIL
A COMPARATIVE EFFICACY OF STEROID PLUS BUPIVACAINE, 5% DEXTROSE AND HYALURONIDASE FOR MEDIAN NERVE BLOCK IN CARPAL TUNNEL SYNDROME: A RANDOMIZED CONTROL TRAIL Open
Background: Carpal Tunnel Syndrome (CTS) produces three main events including pain and numbness together with functional disability. Multiple physicians have studied individual treatment methods including steroid mixed with bupivacaine and…
View article: Use of Pre and Post Comparison of Intra-lesional Infiltration of Dexamethasone Plus Hyaluronidase in Management of Patients with OSMF
Use of Pre and Post Comparison of Intra-lesional Infiltration of Dexamethasone Plus Hyaluronidase in Management of Patients with OSMF Open
Background: Oral Submucous Fibrosis (OSMF) is a potentially malignant condition of the oral mucosa, characterized by fibrosis and epithelial atrophy. Treatment options have varied, with intra-lesional steroid injections being commonly used…
View article: Prospective Anti-Aging Benefits of Mackerel Scad Collagen Peptides Through Anti-Hyaluronidase Activity
Prospective Anti-Aging Benefits of Mackerel Scad Collagen Peptides Through Anti-Hyaluronidase Activity Open