Flavivirus
View article: The Nipah Virus: A Review of Epidemiology, Pathophysiology, and Management
The Nipah Virus: A Review of Epidemiology, Pathophysiology, and Management Open
The zoonotic pathogen Nipah virus (NiV) has emerged as a significant global health threat, provoking outbreaks characterised by high mortality and substantial transmission potential. First identified in 1998–1999 in Malaysia and Singapore …
View article: The Nipah Virus: A Review of Epidemiology, Pathophysiology, and Management
The Nipah Virus: A Review of Epidemiology, Pathophysiology, and Management Open
The zoonotic pathogen Nipah virus (NiV) has emerged as a significant global health threat, provoking outbreaks characterised by high mortality and substantial transmission potential. First identified in 1998–1999 in Malaysia and Singapore …
View article: Neural and endothelial cell-derived extracellular vesicles mediate Zika virus genome dissemination and productive infection in vivo
Neural and endothelial cell-derived extracellular vesicles mediate Zika virus genome dissemination and productive infection in vivo Open
Zika virus (ZIKV) is a neurotropic flavivirus linked to severe neurodevelopmental defects following prenatal exposure. While the mechanisms by which ZIKV spreads within the central nervous system remain incompletely understood, extracellul…
View article: Potential vectors associated to Oropouche virus transmission in Cuba, 2024
Potential vectors associated to Oropouche virus transmission in Cuba, 2024 Open
From May to October 2024, Cuba experienced an outbreak of Oropouche virus (OROV), an Orthobunyavirus previously restricted to the Amazon region. As no Orthobunyavirus circulation had been previously reported in Cuba, the local vector invol…
View article: Genotype-Resolved NS5 Stability Predicts Japanese Encephalitis Virus Fitness
Genotype-Resolved NS5 Stability Predicts Japanese Encephalitis Virus Fitness Open
Japanese encephalitis virus (JEV) remains a major health threat across Asia, yet the contribution of genotype-specific variation in the multifunctional NS5 protein to viral fitness is not fully resolved. This study evaluated how sequence d…
View article: Evidence of much wider distribution of the potential West Nile virus vector, Culex modestus, in the UK
Evidence of much wider distribution of the potential West Nile virus vector, Culex modestus, in the UK Open
Culex modestus is a primary vector of West Nile virus (WNV) in Europe, feeding on both avian and mammalian hosts. Since its rediscovery in the UK in Kent in 2010, its range has been reported throughout the coastal parts of the Thames Estua…
View article: Tetravalent microprojection-based dengue chimeric virus vaccine raises potent neutralising antibodies in mice
Tetravalent microprojection-based dengue chimeric virus vaccine raises potent neutralising antibodies in mice Open
Dengue virus (DENV) is endemic throughout the tropical regions of the world. Due to the risk posed to the population living in dengue-endemic areas, the development of a dengue vaccine has been considered a high priority by the WHO for the…
View article: Usutu virus (USUV) forward primer complementing the Jost et al. primer set
Usutu virus (USUV) forward primer complementing the Jost et al. primer set Open
We designed an additional forward primer, USUV_MM_for, to detect Usutu virus (USUV) in diagnostic samples that is compatible with the reverse primer as well as the probe of the primer pair published by Jöst et al. (2011). The combined prim…
View article: Adenoviral Vectors Expressing Optimized preM/E Genes of WNV Deliver Long-Term Protection Against Lethal West Nile Virus Challenge
Adenoviral Vectors Expressing Optimized preM/E Genes of WNV Deliver Long-Term Protection Against Lethal West Nile Virus Challenge Open
Background/Objectives: Flaviviruses, including West Nile virus (WNV), pose global health challenges due to their worldwide distribution, pathogenicity, and lack of effective treatments or vaccines. Today, WNV is considered the most importa…
View article: Optimizing Humoral Immunity for Durable and Broad Protection in Flavivirus Vaccines
Optimizing Humoral Immunity for Durable and Broad Protection in Flavivirus Vaccines Open
Flavivirus infections, including dengue, Zika, West Nile, and Japanese encephalitis, remain a major global health concern. Although several vaccines are licensed, the durability and qualitative features of vaccine-induced antibodies differ…
View article: Usutu virus (USUV) forward primer complementing the Jost et al. primer set
Usutu virus (USUV) forward primer complementing the Jost et al. primer set Open
We designed an additional forward primer, USUV_MM_for, to detect Usutu virus (USUV) in diagnostic samples that is compatible with the reverse primer as well as the probe of the primer pair published by Jöst et al. (2011). The combined prim…
View article: Diagnostic capabilities for detecting West Nile fever
Diagnostic capabilities for detecting West Nile fever Open
Background. West Nile fever is a viral disease transmitted to humans through the bites of infected mosquitoes. This virus belongs to the flavivirus family and is widespread in warm climates. West Nile fever may be asymptomatic, but some pa…
View article: Potential vectors associated to Oropouche virus transmission in Cuba, 2024
Potential vectors associated to Oropouche virus transmission in Cuba, 2024 Open
From May to October 2024, Cuba experienced an outbreak of Oropouche virus (OROV), an Orthobunyavirus previously restricted to the Amazon region. As no Orthobunyavirus circulation had been previously reported in Cuba, the local vector invol…
View article: Pathogenesis and seroprevalence of dengue virus in HIV-endemic regions: A global perspective
Pathogenesis and seroprevalence of dengue virus in HIV-endemic regions: A global perspective Open
View article: ZIKV infection causes placental inflammation through activating PANoptosis
ZIKV infection causes placental inflammation through activating PANoptosis Open
Infection by the Zika virus (ZIKV) during pregnancy can cause congenital Zika syndrome (CZS) or other central nervous system conditions in infants, underscoring the importance of understanding the role of ZIKV-induced placental damage in t…
View article: Potential vectors associated to Oropouche virus transmission in Cuba, 2024
Potential vectors associated to Oropouche virus transmission in Cuba, 2024 Open
From May to October 2024, Cuba experienced an outbreak of Oropouche virus (OROV), an Orthobunyavirus previously restricted to the Amazon region. As no Orthobunyavirus circulation had been previously reported in Cuba, the local vector invol…
View article: Therapeutic Antibodies for Mosquito‐Borne Orthoflavivirus Infections: Discovery, Engineering Approaches, and Advances in mRNA‐Based Delivery Systems
Therapeutic Antibodies for Mosquito‐Borne Orthoflavivirus Infections: Discovery, Engineering Approaches, and Advances in mRNA‐Based Delivery Systems Open
Mosquito‐borne orthoflaviviruses such as Zika virus (ZIKV), dengue (DENV), yellow fever (YFV), West Nile (WNV), and Japanese encephalitis virus (JEV) are major public health concerns worldwide due to their epidemic potential, immune evasio…
View article: Editorial: Innovative vaccine strategies for enhanced flavivirus immunization
Editorial: Innovative vaccine strategies for enhanced flavivirus immunization Open
View article: Dissecting antibody-dependent enhancement modulation by Fc-modified cross-neutralizing human monoclonal antibody
Dissecting antibody-dependent enhancement modulation by Fc-modified cross-neutralizing human monoclonal antibody Open
Background Dengue is a mosquito-borne disease caused by four dengue virus serotypes (DENV1 to DENV4). Secondary infections can generate flavivirus cross-reactive antibodies at sub-neutralizing levels. This phenomenon can significantly incr…
View article: Comparing human pediatric immune responses to primary infection with dengue, chikungunya and Zika viruses
Comparing human pediatric immune responses to primary infection with dengue, chikungunya and Zika viruses Open
Background The four dengue virus serotypes (DENV1-4), Zika virus (ZIKV) and chikungunya virus (CHIKV) have similar epidemiology and transmission cycles and are the most prevalent arthropod-borne viruses in humans, with half the world’s pop…
View article: West Nile Virus Pilot Screening in Field-Collected Aedes japonicus (Theobald, 1901): An Update of Species Distribution in Poland, 2025
West Nile Virus Pilot Screening in Field-Collected Aedes japonicus (Theobald, 1901): An Update of Species Distribution in Poland, 2025 Open
(1) Background: The Asian bush mosquito Aedes japonicus is an invasive species in Europe, including Poland. Given its laboratory-confirmed competence for West Nile virus (WNV) transmission and its detection as a WNV vector in field-collect…
View article: Serological cross-reactivity and identification of an acute Seoul orthohantavirus case in a dengue outbreak from Vietnam
Serological cross-reactivity and identification of an acute Seoul orthohantavirus case in a dengue outbreak from Vietnam Open
Background In dengue-endemic regions like Vietnam, viral haemorrhagic fevers (VHFs) with overlapping clinical presentations often lead to misdiagnoses. This study investigated alternative VHF pathogens in patients clinically suspected of d…
View article: Determinant host differences in ZIKV sfRNA accumulation
Determinant host differences in ZIKV sfRNA accumulation Open
Zika virus ( Orthoflavivirus zikaese) is part of the Orthoflavivirus genus that contains several viral species posing major and expanding burdens to public health worldwide. Upon infection, orthoflaviviruses produce viral RNA fragments nam…
View article: Flavivirus Attenuation via Targeting the Specific Disulfide Bond of NS1 Protein to Promote Its Degradation
Flavivirus Attenuation via Targeting the Specific Disulfide Bond of NS1 Protein to Promote Its Degradation Open
Flaviviruses are an important group of human pathogens that have caused extensive outbreaks worldwide during the last decades. Although live-attenuated vaccines (LAVs) that induce strong and long-lasting cellular and humoral responses repr…
View article: Seroprevalence of Arboviruses and Genetic Characterization of Orbiviruses in Sloths from Western Panama
Seroprevalence of Arboviruses and Genetic Characterization of Orbiviruses in Sloths from Western Panama Open
Arthropod-borne viruses (arboviruses) are an increasingly significant threat to public health in tropical regions. In this study, we investigated the seroprevalence of various arboviruses in two species of sloth (Choloepus hoffmanni and Br…
View article: Wild Mammals as Sentinels for West Nile Virus Circulation: Evidence from Serbia
Wild Mammals as Sentinels for West Nile Virus Circulation: Evidence from Serbia Open
West Nile fever is a mosquito-borne zoonotic disease caused by West Nile virus (WNV), maintained in an enzootic cycle between avian hosts and Culex mosquitoes. While birds are the principal reservoirs, WNV also infects a wide range of mamm…
View article: Flavivirus Nonstructural Protein 1-Driven Coagulation via Tissue Factor-Bearing Microvesicles: A Pilot Study
Flavivirus Nonstructural Protein 1-Driven Coagulation via Tissue Factor-Bearing Microvesicles: A Pilot Study Open
View article: Antiviral Compounds from Natural Sources Against Human Arboviruses: An Updated Review Including Illustrative In Silico Analysis
Antiviral Compounds from Natural Sources Against Human Arboviruses: An Updated Review Including Illustrative In Silico Analysis Open
Arboviruses such as dengue (DENV), Zika (ZIKV), and chikungunya (CHIKV) remain major global health threats, especially in tropical regions, with no effective antiviral treatments available. Recent research highlights progress in identifyin…
View article: New insight into the epidemiological trends of respiratory syncytial virus infection and the underlying anti-respiratory syncytial virus mechanisms of andrographolide: integrating Global Burden of Disease database, network pharmacological analysis, and <i>in vitro</i> experiments
New insight into the epidemiological trends of respiratory syncytial virus infection and the underlying anti-respiratory syncytial virus mechanisms of andrographolide: integrating Global Burden of Disease database, network pharmacological analysis, and <i>in vitro</i> experiments Open
Respiratory syncytial virus (RSV) infection causes severe burdens and harms worldwide every year, lacking specific therapeutic drugs. Andrographolide is a marketed agent, whose antiviral mechanisms between RSV and the host remain unknown. …
View article: Yellow Fever: New Insights on an Old Disease
Yellow Fever: New Insights on an Old Disease Open
Yellow fever (YF) is an acute arboviral hemorrhagic disease caused by the yellow fever virus (YFV), species Orthoflavivirus flavi, of the Flaviviridae family. YF remains a significant public health threat in endemic regions of Africa and S…