Detrusor muscle
View article: Heme Modulates Bladder Contractility Through the HO–CO–sGC–cGMP Pathway: Insights into Sickle Cell Disease-Associated Bladder Dysfunction
Heme Modulates Bladder Contractility Through the HO–CO–sGC–cGMP Pathway: Insights into Sickle Cell Disease-Associated Bladder Dysfunction Open
Intravascular hemolysis, a hallmark of sickle cell disease (SCD), leads to elevated plasma heme levels. Although heme is essential for physiological processes, its excess can be deleterious. Heme oxygenase (HO) degrades heme into carbon mo…
View article: Sarcopenia and lower urinary tract diseases: links, mechanisms, and clinical implications
Sarcopenia and lower urinary tract diseases: links, mechanisms, and clinical implications Open
Lower urinary tract diseases (LUTDs), including lower urinary tract symptoms (LUTS), overactive bladder (OAB), urinary incontinence (UI), bladder cancer (BC), prostate cancer (PCa), and benign prostatic hyperplasia (BPH), severely impair t…
View article: Effect of some prostanoid receptor modulators on cholinergic and purinergic pathways in rat model of hemorrhagic cystitis: potential beneficial action of selexipag and alprostadil
Effect of some prostanoid receptor modulators on cholinergic and purinergic pathways in rat model of hemorrhagic cystitis: potential beneficial action of selexipag and alprostadil Open
Acetylcholine (ACh) and adenosine triphosphate (ATP) are the major neurotransmitters in bladder contraction. This study investigates the modulatory role of some prostanoids in cholinergic and purinergic pathways in normal and cystitis. Cys…
View article: Efficacy of Transurethral Resection of the Prostate in Male Patients With Impaired Detrusor Contractile Function and Urinary Retention
Efficacy of Transurethral Resection of the Prostate in Male Patients With Impaired Detrusor Contractile Function and Urinary Retention Open
Objectives Detrusor underactivity (DUA) increasingly affects aging male patients with voiding symptoms, while its management remains challenging, with less favorable surgical outcomes compared to bladder outlet obstruction. Our aim was to …
View article: Immediate evaluation of detrusor muscle status using ex vivo Fluorescence Confocal Microscopy (FCM) at primary Transurethral Resection of Bladder Tumour (TURBT): IB1-LaserCOMPLETE, a prospective, feasibility trial
Immediate evaluation of detrusor muscle status using ex vivo Fluorescence Confocal Microscopy (FCM) at primary Transurethral Resection of Bladder Tumour (TURBT): IB1-LaserCOMPLETE, a prospective, feasibility trial Open
View article: Baclofen-Associated Urinary Retention and Urinary Tract Infections: A Case Report
Baclofen-Associated Urinary Retention and Urinary Tract Infections: A Case Report Open
Introduction: Baclofen is a GABA-B receptor agonist used in the setting of spinal cord injuries to alleviate muscle spasticity by inhibiting excitatory neurotransmission in the spinal cord. Baclofen also possesses the potential to suppress…
View article: Cervical Cancer and Multiple Sclerosis: What is the urodynamic profile? A clinical case study with literature review
Cervical Cancer and Multiple Sclerosis: What is the urodynamic profile? A clinical case study with literature review Open
Introduction: Bladder and sphincter disorders (BSDs) affect nearly 90% of patients with multiple sclerosis (MS) at some point in their disease. Surgeries for pelvic cancers such as radical hysterectomy and radiation therapy for cervical ca…
View article: Cervical Cancer and Multiple Sclerosis: What is the urodynamic profile? A clinical case study with literature review
Cervical Cancer and Multiple Sclerosis: What is the urodynamic profile? A clinical case study with literature review Open
Introduction: Bladder and sphincter disorders (BSDs) affect nearly 90% of patients with multiple sclerosis (MS) at some point in their disease. Surgeries for pelvic cancers such as radical hysterectomy and radiation therapy for cervical ca…
View article: Inhibitory Effects of Ferulic Acid on Acetylcholine- and Platelet-Activating Factor-Induced Contractions in Guinea Pig Urinary Bladder Smooth Muscle
Inhibitory Effects of Ferulic Acid on Acetylcholine- and Platelet-Activating Factor-Induced Contractions in Guinea Pig Urinary Bladder Smooth Muscle Open
Ferulic acid (FA), a hydroxycinnamic acid derivative abundantly present in the cell walls of cereal brans such as rice bran, has recently been suggested to suppress detrusor overactivity when administered orally. However, to the best of ou…
View article: What is the best treatment for high-grade papillary urothelial carcinoma invading the lamina propria with no detrusor muscle involvement?
What is the best treatment for high-grade papillary urothelial carcinoma invading the lamina propria with no detrusor muscle involvement? Open
For high-grade T1 papillary urothelial carcinoma without muscle invasion, initial management typically involves TURBT followed by adjuvant intravesical BCG therapy. Radical cystectomy might be considered for unresponsive or very high-risk …
View article: What is the best treatment for high-grade papillary urothelial carcinoma invading the lamina propria with no detrusor muscle involvement?
What is the best treatment for high-grade papillary urothelial carcinoma invading the lamina propria with no detrusor muscle involvement? Open
For high-grade T1 papillary urothelial carcinoma without muscle invasion, initial management typically involves TURBT followed by adjuvant intravesical BCG therapy. Radical cystectomy might be considered for unresponsive or very high-risk …
View article: En bloc versus conventional resection of primary bladder tumor in terms of presence of detrusor muscle in biopsy specimen: a prospective study
En bloc versus conventional resection of primary bladder tumor in terms of presence of detrusor muscle in biopsy specimen: a prospective study Open
Purpose Transurethral resection of bladder tumor (TURBT) is the crucial and standard approach in the diagnosis and management of urinary bladder cancer. This study compares conventional piecemeal and en bloc resection techniques in terms o…
View article: Additive effects of mirabegron on muscarinic receptor binding and on relaxation of cholinergic detrusor muscle contraction by antimuscarinics
Additive effects of mirabegron on muscarinic receptor binding and on relaxation of cholinergic detrusor muscle contraction by antimuscarinics Open
Mirabegron is the first selective β3-adrenoceptor agonist, to be developed as an alternative to antimuscarinic therapy for patients with overactive bladder (OAB). This agent exerts off-target effects on muscarinic receptors. Its…
View article: Motor Nerve Transfer for Voluntary Physiological Voiding: Scientific Foundations, Historical Review, and Case Report
Motor Nerve Transfer for Voluntary Physiological Voiding: Scientific Foundations, Historical Review, and Case Report Open
BACKGROUND AND OBJECTIVES: We present the surgical transfer of a somatic motor nerve to an autonomic target nerve to recover detrusor activation for functional voiding. The scientific basis of this hybrid nerve transfer, details of the sur…
View article: Detrusor Muscle Thickness and Prostate Volume in the Diagnosis of Bladder Outlet Obstruction
Detrusor Muscle Thickness and Prostate Volume in the Diagnosis of Bladder Outlet Obstruction Open
Introduction: Bladder outlet obstruction (BOO) is a common diagnosis and it is reported to be the most common urological problem of elderly male patients which can lead to detrusor instability in 50% to 70% of men with benign prostatic hyp…
View article: Effect of Oxybutynin on Detrusor Leak Point Pressure in Spinal Cord Injury Patients With Neurogenic Detrusor Overactivity: A Subgroup Analysis
Effect of Oxybutynin on Detrusor Leak Point Pressure in Spinal Cord Injury Patients With Neurogenic Detrusor Overactivity: A Subgroup Analysis Open
Following spinal cord injury, neurogenic detrusor overactivity elevates detrusor leak point pressure, endangering renal function. This research examined oxybutynin's effects on detrusor leak point pressure and urodynamic parameters in 30 i…
View article: The Outcome of Cell Therapy Treating Urinary Incontinence Correlates with Precise Cell Localization in the Sphincter Complex
The Outcome of Cell Therapy Treating Urinary Incontinence Correlates with Precise Cell Localization in the Sphincter Complex Open
Background/Objectives: Urethral sphincter muscle deficiency is the leading cause of stress urinary incontinence. Preclinical and clinical studies suggested that cell therapy may improve the situation. However, the overall efficacy of cell …
View article: Factors predicting presence/absence of Detrusor muscle in TURBT specimen
Factors predicting presence/absence of Detrusor muscle in TURBT specimen Open
View article: β<sub>3</sub>‐Adrenoceptor Agonist Effects on the Urinary Bladder Beyond Detrusor Relaxation
β<sub>3</sub>‐Adrenoceptor Agonist Effects on the Urinary Bladder Beyond Detrusor Relaxation Open
Aims β 3 ‐Adrenoceptor agonists such as mirabegron or vibegron reach pharmacokinetic steady‐state within a few days. However, maximum improvements in symptoms of the overactive bladder syndrome are reached at time points later than 4 weeks…
View article: Transvaginal Electrical Stimulation for Treatment of Overactive Bladder Without Incontinence: A Pilot Cross‐Over Clinical Trial
Transvaginal Electrical Stimulation for Treatment of Overactive Bladder Without Incontinence: A Pilot Cross‐Over Clinical Trial Open
Objectives Few studies look at therapeutic efficacy specifically in the OAB population that lacks urgency incontinence (OAB‐dry). Transvaginal electrical stimulation (TES) improves urgency incontinence in OAB‐wet by targeting the detrusor …
View article: The Role of Morcellation in En Bloc Resection of Large Bladder Tumors
The Role of Morcellation in En Bloc Resection of Large Bladder Tumors Open
Background/Objectives: Conventional transurethral resection of bladder tumor (TURBT) for non-muscle invasive bladder cancer (NMIBC) is usually performed in a piecemeal manner, leading to difficulties in accurate pathological assessment. En…
View article: Enhanced BDNF and ROS in Mucosa of Lower Motor Neuron Lesioned Dog Bladder Following Somatic Motor Nerve Transfer
Enhanced BDNF and ROS in Mucosa of Lower Motor Neuron Lesioned Dog Bladder Following Somatic Motor Nerve Transfer Open
Neurotrophic factors and reactive oxygen species (ROS) modulate neuronal plasticity. In a model of a lower motor neuron lesioned bladder, somatic nerve transfer was used as a reinnervation strategy. Levels of neurotrophins, ROS, and TNF-α …
View article: Contrast‐enhanced ultrasound enables precision diagnosis of preoperative muscle invasion in bladder cancer: a prospective study
Contrast‐enhanced ultrasound enables precision diagnosis of preoperative muscle invasion in bladder cancer: a prospective study Open
Bladder cancer's high mortality underscores the need for precise staging, especially to differentiate between nonmuscle invasive bladder cancer (NMIBC) and muscle invasive bladder cancer (MIBC) types. This prospective study evaluated the e…
View article: Ice water test to predict long-term detrusor activity in persistent neurogenic acontractile detrusor
Ice water test to predict long-term detrusor activity in persistent neurogenic acontractile detrusor Open
View article: Local urothelial cell-driven detrusor contractions
Local urothelial cell-driven detrusor contractions Open
Signaling molecules released from the urothelium by mechanical stretch are known to play a sensory role in bladder contractions via neuronal signaling. It is also theorized that these molecules released from the urothelium could act locall…
View article: VILDAGLIPTIN IMPROVES DETRUSOR CONTRACTILITY IN A MOUSE MODEL OF CYCLOPHOSPHAMIDE-INDUCED OVERACTIVE BLADDER
VILDAGLIPTIN IMPROVES DETRUSOR CONTRACTILITY IN A MOUSE MODEL OF CYCLOPHOSPHAMIDE-INDUCED OVERACTIVE BLADDER Open
Objective: Overactive bladder (OAB) is a common urological disorder associated with detrusor overactivity linked to local tissue inflammation resulting in bladder hypersensitivity. The present study was aimed to investigate the therapeutic…
View article: Cholinergic modulation of contractile responses in caprine urinary bladder smooth muscle: Role of urothelium and atropine sensitivity
Cholinergic modulation of contractile responses in caprine urinary bladder smooth muscle: Role of urothelium and atropine sensitivity Open
View article: Loop Resection or Cold-Cup Biopsy? A Prospective Randomised Study Evaluating the Accuracy of Detrusor Muscle Representation During Transurethral Resection of Bladder Tumours
Loop Resection or Cold-Cup Biopsy? A Prospective Randomised Study Evaluating the Accuracy of Detrusor Muscle Representation During Transurethral Resection of Bladder Tumours Open
View article: Supplementary Figures S1–S2: Sex-specific and urothelium-dependent differences in TRPV4-mediated bladder contractions
Supplementary Figures S1–S2: Sex-specific and urothelium-dependent differences in TRPV4-mediated bladder contractions Open
These supplementary figures illustrate additional findings related to TRPV4-induced bladder contractility in mice. Supplementary Figure S1 shows that TRPV4 activation by GSK1016790A (10 µM) evokes stronger detrusor contractions in male tha…
View article: Supplementary Figures S1–S2: Sex-specific and urothelium-dependent differences in TRPV4-mediated bladder contractions
Supplementary Figures S1–S2: Sex-specific and urothelium-dependent differences in TRPV4-mediated bladder contractions Open
These supplementary figures illustrate additional findings related to TRPV4-induced bladder contractility in mice. Supplementary Figure S1 shows that TRPV4 activation by GSK1016790A (10 µM) evokes stronger detrusor contractions in male tha…