Brown adipose tissue
View article: Effect of habitual cold exposure on brown adipose tissue activity in Arctic adults: a systematic review.
Effect of habitual cold exposure on brown adipose tissue activity in Arctic adults: a systematic review. Open
Brown adipose tissue (BAT) is crucial for non-shivering thermogenesis, a key adaptation for humans in Arctic environments. The discovery of BAT presence in human adults has ignited curiosity due to its potential role in combating obesity, …
View article: Sub-chronic exposure to crude acetylene results in the development of deleterious cardio metabolic changes in Sprague Dawley rats
Sub-chronic exposure to crude acetylene results in the development of deleterious cardio metabolic changes in Sprague Dawley rats Open
Objective Calcium carbide-derived acetylene is widely used as an artificial fruit ripening agent despite its potential health risks. This study aimed to investigate the effects of sub-chronic exposure to crude acetylene on cardiometabolic …
View article: <b>Adipose TGR5 deletion promotes hepatic steatosis through decreasing adiponectin secretion in mice</b>
<b>Adipose TGR5 deletion promotes hepatic steatosis through decreasing adiponectin secretion in mice</b> Open
Metabolic dysfunction–associated steatotic liver disease (MASLD) has emerged as a global epidemic, yet its underlying molecular mechanisms remain elusive, and therapeutic options are limited. The interorgan communication between liver and …
View article: Adipose TGR5 Deletion Promotes Hepatic Steatosis Through Decreasing Adiponectin Secretion in Mice
Adipose TGR5 Deletion Promotes Hepatic Steatosis Through Decreasing Adiponectin Secretion in Mice Open
Metabolic dysfunction–associated steatotic liver disease (MASLD) has emerged as a global epidemic, yet its underlying molecular mechanisms remain elusive, and therapeutic options are limited. The interorgan communication between liver and …
View article: <b>Adipose TGR5 deletion promotes hepatic steatosis through decreasing adiponectin secretion in mice</b>
<b>Adipose TGR5 deletion promotes hepatic steatosis through decreasing adiponectin secretion in mice</b> Open
Metabolic dysfunction–associated steatotic liver disease (MASLD) has emerged as a global epidemic, yet its underlying molecular mechanisms remain elusive, and therapeutic options are limited. The interorgan communication between liver and …
View article: Thiamine transporter 2 and Janus kinase 2 inhibitor, fedratinib suppresses thermogenic activation of human neck area-derived adipocytes
Thiamine transporter 2 and Janus kinase 2 inhibitor, fedratinib suppresses thermogenic activation of human neck area-derived adipocytes Open
Introduction: Brown adipocytes consume higher amounts of metabolic substrates and regulators including thiamine during adrenergic stimulation supporting heat generation. Our previous findings showed that fedratinib, a potent inhibitor of t…
View article: Isomeranzin activates Gnas-AMPK signaling to drive white adipose browning and curb obesity in mice
Isomeranzin activates Gnas-AMPK signaling to drive white adipose browning and curb obesity in mice Open
Obesity is a major global health challenge, and promoting the browning of white adipose tissue (WAT) represents a promising therapeutic strategy. However, pharmacological approaches to induce adipose thermogenesis remain limited. Through a…
View article: Melinjo-derived Gnetin C restores metabolic balance via dual adipose and hepatic effects in high-fat diet mice
Melinjo-derived Gnetin C restores metabolic balance via dual adipose and hepatic effects in high-fat diet mice Open
Multi-organ regulation underlies metabolic health, especially in the context of adipose-liver dysfunction during obesity. Previous findings identified Melinjo seed extract (MSE) as a promising modulator of metabolic disorders, although its…
View article: The role of immune responses and microbiota in adipose tissue homeostasis
The role of immune responses and microbiota in adipose tissue homeostasis Open
White and brown adipose tissue form a metabolic organ that plays a crucial role in regulating body energy homeostasis. Adipose tissue is richly vascularized and innervated to respond to a variety of environmental signals. Adipose tissue al…
View article: Herbal Combination of <i>Angelica gigas</i> , <i>Zingiber officinale</i> , and <i>Aconitum carmichaeli</i> Alleviates High Fat Diet‐Induced Non‐Alcoholic Fatty Liver Disease in Mice Through <scp>NRF2</scp> ‐Mediated Regulation of Adipogenesis and Non‐Shivering Thermogenesis
Herbal Combination of <i>Angelica gigas</i> , <i>Zingiber officinale</i> , and <i>Aconitum carmichaeli</i> Alleviates High Fat Diet‐Induced Non‐Alcoholic Fatty Liver Disease in Mice Through <span>NRF2</span> ‐Mediated Regulation of Adipogenesis and Non‐Shivering Thermogenesis Open
Obesity is a complex metabolic disorder characterized by excessive fat accumulation and is closely associated with non‐alcoholic fatty liver disease (NAFLD), a condition that increases the risk of metabolic complications such as insulin re…
View article: A metabolic comparison of <scp>GIPR</scp> agonism versus <scp>GIPR</scp> antagonism in male mice
A metabolic comparison of <span>GIPR</span> agonism versus <span>GIPR</span> antagonism in male mice Open
Aims Targeting the glucose dependent insulinotropic polypeptide receptor ( GIPR ) is of growing interest for treating type 2 diabetes and obesity, though the optimal approach remains unclear. Both GIPR agonism and antagonism, respectively,…
View article: Neuroplastin-55 is a receptor of Manf and protects against diet-induced obesity by promoting adipose browning
Neuroplastin-55 is a receptor of Manf and protects against diet-induced obesity by promoting adipose browning Open
The browning of white adipose tissue (WAT) enhances thermogenesis and holds great potential in obesity treatment. Membrane receptors have been proven as essential factors during WAT browning. In this study, we found that transmembrane rece…
View article: KBN2202 Suppresses Adipose Tissue Expansion in a High-Fat Diet-Induced Obesity Mouse Model
KBN2202 Suppresses Adipose Tissue Expansion in a High-Fat Diet-Induced Obesity Mouse Model Open
Obesity treatments increasingly target multiple pathways beyond appetite suppression. We evaluated KBN2202, a salicylate-derived small molecule, in a high-fat diet (60% kcal) mouse model using female and male C57BL/6J mice treated for 8 we…
View article: Gabpα‐Pparγ Complex Determines Glycolytic Capacity and Lactic Acid Homeostasis in Brown Fat
Gabpα‐Pparγ Complex Determines Glycolytic Capacity and Lactic Acid Homeostasis in Brown Fat Open
Glycolysis in brown adipose tissue (BAT) plays a critical role in fueling thermogenesis. However, the transcriptional control of glycolysis in brown fat remains poorly understood. Here, GA binding protein alpha chain (Gabpα) is identified …
View article: Targeting Adipose Tissue Function Protects Against Heart Failure with Preserved Ejection Fraction
Targeting Adipose Tissue Function Protects Against Heart Failure with Preserved Ejection Fraction Open
This study seeks to develop a better understanding of how the targeting of adipose tissue (AT) can mediate outcomes in cardiac function. Obesity is highly prevalent among individuals with heart failure with preserved ejection fraction (HFp…
View article: Maternal gestational diabetes mellitus modulates adipose tissue remodeling and CTRP6 expression in a depot- and sex-specific manner in mouse offspring
Maternal gestational diabetes mellitus modulates adipose tissue remodeling and CTRP6 expression in a depot- and sex-specific manner in mouse offspring Open
Objective This study aimed to explore how maternal gestational diabetes mellitus (GDM) affects adipose tissue remodeling and the expression of C1q/TNF-related protein 6 (CTRP6) in offspring, with a focus on sex- and depot-specific differen…
View article: Anti-Obesity Effects of Carnosine Supplementation and Exercise in Mice Fed a High-Fat Diet with Concomitant UCP1 Expression in White Adipocytes
Anti-Obesity Effects of Carnosine Supplementation and Exercise in Mice Fed a High-Fat Diet with Concomitant UCP1 Expression in White Adipocytes Open
Obesity and obesity-related diseases represent increasingly serious global health challenges, and effective preventive strategies are urgently needed. This study investigated the anti-obesity effects of carnosine and anserine, representati…
View article: Interesterified Palm Oil Consumption Drives Brown Adipose Tissue Whitening and Functional Impairment in High-Fat Diet Mice
Interesterified Palm Oil Consumption Drives Brown Adipose Tissue Whitening and Functional Impairment in High-Fat Diet Mice Open
This study investigates how the consumption of interesterified palm oil (IPO) affects the metabolic and morphological features of brown adipose tissue (BAT) in C57BL/6 mice fed a high-fat diet (HFD). Mice were divided into four groups: con…
View article: Data from: Sex-specific thermoregulatory effects of estrogen signaling in Reprimo lineage cells
Data from: Sex-specific thermoregulatory effects of estrogen signaling in Reprimo lineage cells Open
Estrogens have considerable impact on energy homeostasis and metabolic health. In mice, signaling through estrogen receptor alpha (ERα) alters energy intake and expenditure, effects that may be mediated by specific regions or cellular sub-…
View article: Editorial: Dietary influences on white and brown adipose tissue: mechanisms and health implications
Editorial: Dietary influences on white and brown adipose tissue: mechanisms and health implications Open
View article: Data from: Sex-specific thermoregulatory effects of estrogen signaling in Reprimo lineage cells
Data from: Sex-specific thermoregulatory effects of estrogen signaling in Reprimo lineage cells Open
Estrogens have considerable impact on energy homeostasis and metabolic health. In mice, signaling through estrogen receptor alpha (ERα) alters energy intake and expenditure, effects that may be mediated by specific regions or cellular sub-…
View article: Purinergic adipocyte-macrophage crosstalk promotes degeneration of thermogenic brown adipose tissue
Purinergic adipocyte-macrophage crosstalk promotes degeneration of thermogenic brown adipose tissue Open
Loss of brown adipose tissue (BAT) activity observed during ageing, obesity and living at thermoneutrality is associated with lipid accumulation, fibrosis and tissue inflammation in BAT. The mechanisms that promote this degenerative proces…
View article: Mitochondrial Respiratory Supercomplex Assembly Factor <scp>COX7RP</scp> Contributes to Lifespan Extension in Mice
Mitochondrial Respiratory Supercomplex Assembly Factor <span>COX7RP</span> Contributes to Lifespan Extension in Mice Open
COX7RP is a critical factor that assembles mitochondrial respiratory chain complexes into supercomplexes, which is considered to modulate energy production efficiency. Whether COX7RP contributes to metabolic homeostasis and lifespan remain…
View article: 11-Oxygenated Androgens Inhibit Brown Adipose Tissue Differentiation
11-Oxygenated Androgens Inhibit Brown Adipose Tissue Differentiation Open
Introduction Women with polycystic ovary syndrome (PCOS) and PCOS animal models have diminished brown adipose tissue (BAT) activity, potentially contributing to metabolic dysfunction. Besides classical androgens, adrenal 11-oxygenated andr…
View article: Dietary Lard at 25% Fat Energy Level Enhances Adipose Tissue Browning and Gut Microbiota Remodeling in Mice Relative to Soybean Oil
Dietary Lard at 25% Fat Energy Level Enhances Adipose Tissue Browning and Gut Microbiota Remodeling in Mice Relative to Soybean Oil Open
To examine the disparities in adipose tissue browning between diets rich in lard and soybean oil under low and recommended caloric intake conditions. In this study, sixty 8‐week‐old male C57BL/6J mice were randomly divided into four groups…
View article: Assessing the interaction of the UCP system and fatty acids on epicardial adipose tissue mitochondrial respiration
Assessing the interaction of the UCP system and fatty acids on epicardial adipose tissue mitochondrial respiration Open
Background Epicardial adipose tissue (EAT) exhibits brown‐like features, including the expression of uncoupling protein 1 (UCP1). EAT interacts dynamically with cardiac cells to modulate local cardiac tissue physiology and metabolic functi…
View article: Brown Adipose Tissue and Metabolic Markers Differ Between Greenlanders and Danes With Cold Activation
Brown Adipose Tissue and Metabolic Markers Differ Between Greenlanders and Danes With Cold Activation Open
Context Brown adipose tissue (BAT) is a thermogenic tissue that converts energy into heat in response to cold exposure, and is therefore a promising target for improving cardiometabolic health. Habitually cold-exposed Arctic people represe…
View article: Grape Seed Flavanols Restore Peripheral Clock of White Adipose Tissue in Obese Rats Under Circadian Alterations
Grape Seed Flavanols Restore Peripheral Clock of White Adipose Tissue in Obese Rats Under Circadian Alterations Open
Background: White adipose tissue (WAT) exhibits diurnal oscillations regulated by clock genes, which autonomously control its functionality. These rhythms are modulated by the central clock and external factors, such as light exposure and …
View article: Adipo-epithelial transdifferentiation: old data and new perspectives
Adipo-epithelial transdifferentiation: old data and new perspectives Open
White and brown adipose tissues are organized to form a true organ. White store energy that is provided to the organism in the intervals between meals and brown burns lipids to produce heat. When the cold exposure is chronic, white convert…
View article: Effect of Acute Cold Exposure on Differential Expression of Tissue D-I and D-II Iodothyroinine Deiodinase [T4-5’-Deiodinase] Activity in Congenic Lean and Obese LA/Ntul//-cp Rats: Iodothyroinine Deiodinase Activity in Obese Rats
Effect of Acute Cold Exposure on Differential Expression of Tissue D-I and D-II Iodothyroinine Deiodinase [T4-5’-Deiodinase] Activity in Congenic Lean and Obese LA/Ntul//-cp Rats: Iodothyroinine Deiodinase Activity in Obese Rats Open
Thyroid hormones are known to play a critical role in metabolic adaptation to chronic changes in diet and environment. The prohormone tetraiodothyronine (T4) is converted to the active form, triiodothyronine (T3) in peripheral tissues via …