Coats' disease
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Coats disease: An overview of classification, management and outcomes Open
Coats disease is an idiopathic retinal vascular disorder with retinal telangiectasia with intraretinal and/or subretinal exudation without appreciable retinal or vitreal traction. The condition is sporadic with no associated systemic abnor…
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The Diabetic Retinopathy Clinical Research Network (DRCR.net) and Its Contributions to the Treatment of Diabetic Retinopathy Open
Over the past two decades, the Diabetic Retinopathy Clinical Research Network (now known as the DRCR Retina Network) has contributed to multiple and substantial advances in the clinical care of diabetic eye disease. Network studies helped …
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Laryngotracheal Microbiota in Adult Laryngotracheal Stenosis Open
The laryngotracheal region resides at the intersection between the heavily studied nasal cavity and lungs; however, examination of the microbiome in chronic inflammatory conditions of the subglottis and trachea remains scarce. To date, stu…
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A review of diabetic retinopathy: Datasets, approaches, evaluation metrics and future trends Open
Diabetic Retinopathy (DR) is the condition caused due to uncontrolled diabetes that can lead to vision impairment. It greatly affects the retinal blood vessels and diminishes the fundus light-sensitive inner coating. Early diagnosis and re…
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Imaging in Retinopathy of Prematurity Open
Retinopathy of prematurity (ROP) is a leading cause of preventable childhood blindness worldwide. Barriers to ROP screening and difficulties with subsequent evaluation and management include poor access to care, lack of physicians trained …
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Coats′ disease of adult-onset in 48 eyes Open
Adult-onset Coats' disease has less extensive involvement, more benign natural course, and a more favorable treatment outcome as against the childhood-onset disease. The bilateral presentation emphasizes the need for regular follow-up to d…
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MR Imaging Features to Differentiate Retinoblastoma from Coats’ Disease and Persistent Fetal Vasculature Open
Retinoblastoma mimickers, or pseudoretinoblastoma, are conditions that show similarities with the pediatric cancer retinoblastoma. However, false-positive retinoblastoma diagnosis can cause mistreatment, while false-negative diagnosis can …
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Von Hippel-Lindau Disease and the Eye Open
Retinal hemangioblastoma (also referred to as retinal capillary hemangioma) is a benign lesion originating from the endothelial and glial components of the neurosensory retina and optic nerve head. Historically known as a manifestation of …
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Comparison of Optical Coherence Tomography With Fundus Photographs, Fluorescein Angiography, and Histopathologic Analysis in Assessing Coats Disease Open
Optical coherence tomography may show the transient and permanent effects of Coats disease on the retina. These results suggest that exudates and fluid in the macular subretinal space appear later in the disease and may result in fibrosis …
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Successful use of intravitreal ranibizumab injection and combined treatment in the management of Coats' disease Open
Purpose To observe the efficacy of intravitreal ranibizumab ( IVR ) combined with another ablative therapy, such as laser photocoagulation, for Coats' disease. Methods Patients younger than 16 years of age who were diagnosed with Coats' di…
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Asymmetric diabetic retinopathy Open
Increasing prevalence of diabetes mellitus warrants recognition of factors related to asymmetric diabetic retinopathy (DR). This thematic synthesis based on an iterative literature review conducted in Medline and Google Scholar pertaining …
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Treatment of stage 3 Coats’ disease by endolaser photocoagulation via a two-port pars plana nonvitrectomy approach Open
Endolaser photocoagulation by a two-port pars plana nonvitrectomy approach is an effective treatment for advanced Coats' disease with serous retinal detachment. The long-term safety of the approach needs further investigation.
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Etiologies and clinical characteristics of young patients with angle-closure glaucoma: a 15-year single-center retrospective study Open
Purpose To investigate the etiologies and the clinical characteristics of angle-closure glaucoma (ACG) patients younger than 40 years old in Chinese. Methods Inpatients with diagnosis of ACG and diagnosed age younger than or equal to 40 ye…
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Differences in aqueous concentrations of cytokines in paediatric and adult patients with Coats' disease Open
Purpose To investigate the differential aqueous concentrations of vascular endothelia growth factor ( VEGF ) and inflammatory cytokines in paediatric and adult patients with Coats' disease. Methods A total of 20 eyes of 20 patients with Co…
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Vogt-Koyanagi-Harada Disease and Birdshot Retinochoroidopathy, Similarities and Differences: A Glimpse into the Clinicopathology of Stromal Choroiditis, a Perspective and a Review Open
The purpose of this work was to give a comprehensive and updated review on two primary stromal choroiditis entities, Vogt-Koyanagi-Harada disease (VKH) and birdshot retinochoroiditis (BRC). Their appraisal has become much more precise than…
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Lesions simulating retinoblastoma at a tertiary care center Open
The rate of misdiagnosis upon referral to our center was close to 40%. The most common pseudo-retinoblastomas entities include Coats' disease, PHPV and FEVR. An accurate diagnosis is essential for management of pseudo-retinoblastoma cases.
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The future application of artificial intelligence and telemedicine in the retina: A perspective Open
The development of artificial intelligence (AI) and deep learning provided precise image recognition and classification in the medical field. Ophthalmology is an exceptional department to translate AI applications since noninvasive imaging…
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Retinal detachments in the pediatric population Open
In this review, we present a concise summary of the more commonly seen types of retinal detachments (RDs) that one can encounter in pediatric patients. A spectrum of diseases from rhegmatogenous RD in Stickler syndrome, Marfan syndrome, an…
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Accuracy and Reliability of Eye-Based vs Quadrant-Based Diagnosis of Plus Disease in Retinopathy of Prematurity Open
Graders had lower reliability and accuracy using quadrant-based diagnosis combining grades of individual quadrants than with eye-based diagnosis, suggesting that eye-based diagnosis has advantages over quadrant-based diagnosis. This has im…
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Fluorescein Angiographic Abnormalities in the Contralateral Eye with Normal Fundus in Children with Unilateral Coats' Disease Open
Coats' disease may more often be a bilateral disease with asymmetry than previously thought. Patients with Coats' disease should undergo careful examination of the fellow eye with FA in order to detect and treat vascular abnormalities that…
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Moyamoya Disease Associated With Morning Glory Disc Anomaly and Other Ophthalmic Findings: A Mini-Review Open
Moyamoya disease (MMD) is a chronic cerebrovascular disease that frequently results in intracranial ischemia or hemorrhage. Its concurrence with varying ophthalmic findings is relatively rare yet may lead to irreversible blindness. We perf…
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Longitudinal Examination of Fellow-Eye Vascular Anomalies in Coats' Disease With Widefield Fluorescein Angiography: A Multicenter Study Open
BACKGROUND AND OBJECTIVE: Retinovascular anomalies in the fellow eyes of patients with Coats' disease have been described, but the clinical significance is unknown, as well as whether these lesions progress over time. PATIENTS AND METHODS:…
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Clinical spectrum, genetic associations and management outcomes of Coats-like exudative retinal vasculopathy in autosomal recessive retinitis pigmentosa Open
Background: Coats-like retinal vasculopathy in retinitis pigmentosa (RP) is rare. This study describes its clinical spectrum, management outcomes and genetic associations in patients with autosomal recessive RP (arRP). Materials and method…
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iTRAQ-Based Proteomics Investigation of Aqueous Humor from Patients with Coats' Disease Open
The 46 Coats' disease-specific proteins may provide additional insights into the mechanism of Coats' disease and represent potential biomarkers for identifying individuals with Coats' disease.
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Ultra‐wide field imaging in the diagnosis and management of adult‐onset Coats’ disease Open
Ultra-wide field imaging provides information that can help in the diagnosis and management of adult-onset Coat's disease. This may lead to better visual outcomes in Coats' disease.
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Digital innovations for retinal care in diabetic retinopathy Open
Aim The purpose of this review is to examine the applications of novel digital technology domains for the screening and management of patients with diabetic retinopathy (DR). Methods A PubMed engine search was performed, using the terms “T…
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Coats’ disease: characteristics, management, outcome, and scleral external drainage with anterior chamber maintainer for stage 3b disease Open
To report on the characteristics and outcome of management of Coats’ disease, and to describe a novel surgical technique for management of stage 3B with total retinal detachment (RD) by scleral external drainage with anterior chamber (AC-m…
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Incontinentia pigmenti‐associated ocular anomalies of paediatric incontinentia pigmenti patients in China Open
Purpose To characterize ocular manifestations in a cohort of paediatric patients with incontinentia pigmenti ( IP ) and to define the guidelines for grading of IP ‐associated retinopathy ( IPR ). Methods This retrospective review was perfo…
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Risk of tractional retinal detachment following intravitreal bevacizumab along with subretinal fluid drainage and cryotherapy for stage 3B Coats′ disease Open
Simultaneous injection of bevacizumab along with subretinal drainage and cryotherapy for advanced Coats' disease could not avoid TRD.
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Treatment of Coats’ disease: an analysis of pooled results Open
Vitreoretinal fibrosis and TRD increase after treatment in Coats' disease. The combination of anti-VEGF agents and cryotherapy may lead to higher risk for TRD. Presence of pre-treatment fibrosis is the highest risk factor for post-treatmen…