Leukopenia
View article: The Value of <i>Camellia sinensis</i> in the Management of Toxicity Induced by Cancer Treatments
The Value of <i>Camellia sinensis</i> in the Management of Toxicity Induced by Cancer Treatments Open
While radiotherapy is one of the main treatments for head and neck cancer, adverse effects limit its effectiveness and affect patients' quality of life. Although various radioprotective substances have been proposed, comprehensive strategi…
View article: Role of Inflammatory Markers in the Diagnosis of Sepsis in Neonates and Infants Under 3 Months of Age: A Single-Center Study
Role of Inflammatory Markers in the Diagnosis of Sepsis in Neonates and Infants Under 3 Months of Age: A Single-Center Study Open
Background Sepsis is a life-threatening condition characterized by organ failure resulting from an abnormal immune response to an infection. Diagnostic biomarkers are crucial tools for determining the presence or absence of disease and for…
View article: Kaposi sarcoma in an immunocompromised adolescent: A case report from Libreville University Hospital (Gabon)
Kaposi sarcoma in an immunocompromised adolescent: A case report from Libreville University Hospital (Gabon) Open
Introduction: Kaposi sarcoma (KS) is a multifocal vascular tumor driven by human herpesvirus-8 (HHV-8). It is a major opportunistic malignancy in the HIV era in sub-Saharan Africa. In children and adolescents, KS is uncommon but often pres…
View article: Kaposi sarcoma in an immunocompromised adolescent: A case report from Libreville University Hospital (Gabon)
Kaposi sarcoma in an immunocompromised adolescent: A case report from Libreville University Hospital (Gabon) Open
Introduction: Kaposi sarcoma (KS) is a multifocal vascular tumor driven by human herpesvirus-8 (HHV-8). It is a major opportunistic malignancy in the HIV era in sub-Saharan Africa. In children and adolescents, KS is uncommon but often pres…
View article: Real-world efficacy and toxicity of ipilimumab and nivolumab as a first-line treatment for advanced renal cell carcinoma according to IMDC risk criteria-A multi-center retrospective analysis on behalf of the GUARDIANS group.
Real-world efficacy and toxicity of ipilimumab and nivolumab as a first-line treatment for advanced renal cell carcinoma according to IMDC risk criteria-A multi-center retrospective analysis on behalf of the GUARDIANS group. Open
Ipilimumab and nivolumab are recommended as first-line therapy for patients with metastatic or advanced renal cell carcinoma (aRCC) and International Metastatic RCC Database Consortium (IMDC) intermediate or poor risk. We retrospectively e…
View article: Kaposi sarcoma in an immunocompromised adolescent: A case report from Libreville University Hospital (Gabon)
Kaposi sarcoma in an immunocompromised adolescent: A case report from Libreville University Hospital (Gabon) Open
Introduction: Kaposi sarcoma (KS) is a multifocal vascular tumor driven by human herpesvirus-8 (HHV-8). It is a major opportunistic malignancy in the HIV era in sub-Saharan Africa. In children and adolescents, KS is uncommon but often pres…
View article: PO:14:195 | Real-world effectiveness of anifrolumab in achieving treatment targets and reducing systemic lupus erythematosus disease burden: 6-month interim analysis of the REVEAL study
PO:14:195 | Real-world effectiveness of anifrolumab in achieving treatment targets and reducing systemic lupus erythematosus disease burden: 6-month interim analysis of the REVEAL study Open
Background. Following the recent approval of anifrolumab (ANI) for the treatment of moderate-to-severe Systemic Lupus Erythematosus (SLE), real-world data remain limited beyond those from clinical trials. Real-world eVidencE of Anifrolumab…
View article: Association Between Cytomegalovirus Viremia Clearance and Post-Solid Organ Transplant Mortality in Patients With Refractory Cytomegalovirus Infection: SOLSTICE Post Hoc Analysis
Association Between Cytomegalovirus Viremia Clearance and Post-Solid Organ Transplant Mortality in Patients With Refractory Cytomegalovirus Infection: SOLSTICE Post Hoc Analysis Open
Cytomegalovirus (CMV) infection following solid organ transplant (SOT) is associated with increased mortality risk. In the phase 3 SOLSTICE study (NCT02931539), more transplant recipients achieved CMV clearance after 8 weeks with maribavir…
View article: EVALUATING FACTORS ASSOCIATED WITH LYMPHOPENIA IN LUNG CANCER PATIENTS TREATED WITH PROTON THERAPY
EVALUATING FACTORS ASSOCIATED WITH LYMPHOPENIA IN LUNG CANCER PATIENTS TREATED WITH PROTON THERAPY Open
View article: Population pharmacokinetics and optimized dosing of piperacillin-tazobactam in hematological patients with febrile neutropenia
Population pharmacokinetics and optimized dosing of piperacillin-tazobactam in hematological patients with febrile neutropenia Open
Hematological patients with febrile neutropenia receiving piperacillin-tazobactam may experience pharmacokinetic alterations that compromise drug exposure. We aimed to characterize the population pharmacokinetics of piperacillin in plasma …
View article: Tuberculosis-triggered cytokine storm with hemophagocytic lymphohistiocytosis and tuberculous spondylitis in an apparently immunocompetent host: a case report and literature review
Tuberculosis-triggered cytokine storm with hemophagocytic lymphohistiocytosis and tuberculous spondylitis in an apparently immunocompetent host: a case report and literature review Open
Hemophagocytic lymphohistiocytosis (HLH) secondary to disseminated tuberculosis (TB) is a rare, life-threatening hyperinflammatory syndrome. We present a 60-year-old man with recurrent fever and syncope. Workup revealed cytopenias, hyperfe…
View article: Piperacillin-tazobactam-induced hemophagocytic lymphohistiocytosis in a patient with community-acquired pneumonia: A case report and literature review on diagnostic challenges of elevated procalcitonin
Piperacillin-tazobactam-induced hemophagocytic lymphohistiocytosis in a patient with community-acquired pneumonia: A case report and literature review on diagnostic challenges of elevated procalcitonin Open
Rationale: piperacillin-tazobactam, a widely used broad-spectrum antibiotic, carries a risk of severe adverse reactions, including rare but life-threatening hemophagocytic lymphohistiocytosis (HLH). Elevated procalcitonin (PCT), typically …
View article: Artificial Neural Network as a Tool to Predict Severe Toxicity of Anticancer Drug Therapy in Patients with Gastric Cancer: A Retrospective Study
Artificial Neural Network as a Tool to Predict Severe Toxicity of Anticancer Drug Therapy in Patients with Gastric Cancer: A Retrospective Study Open
Background. The aim of the study was to develop a predictive model of anticancer drug therapy toxicity in patients with gastric cancer. Methods. The retrospective study included 100 patients with stage II-IV gastric cancer who underwent 4 …
View article: Late-onset severe neutropenia in patients with relapsing remitting multiple sclerosis treated with ocrelizumab: case report and literature review
Late-onset severe neutropenia in patients with relapsing remitting multiple sclerosis treated with ocrelizumab: case report and literature review Open
Objective To describe two cases of recurrent, delayed-onset severe neutropenia several months following ocrelizumab therapy in patients with relapsing–remitting multiple sclerosis (RRMS). Background A rare adverse effect of ocrelizumab is …
View article: A multi-omics approach exploring the gut-liver axis following combined radiation exposure and burn injury in a Sinclair minipig model
A multi-omics approach exploring the gut-liver axis following combined radiation exposure and burn injury in a Sinclair minipig model Open
While radiation and burn injury have distinct local and systemic effects, they both negatively impact intestinal permeability/function. In a nuclear attack, combined thermal burns and radiation exposure (e.g., combined injury (CI)) would b…
View article: Prognosis and Prevalence of Hyperchloremia in Dogs and Cats
Prognosis and Prevalence of Hyperchloremia in Dogs and Cats Open
Objective To determine the prevalence, case‐fatality rate, and primary disease processes associated with high corrected chloride concentration (hyper[Cl − ]) in dogs and cats. Design Single‐center retrospective study. Setting Electrical me…
View article: Decitabine plus all-<i>trans</i> retinoic acid versus decitabine monotherapy for myelodysplastic syndromes with excess blasts: a multicenter, randomized controlled trial
Decitabine plus all-<i>trans</i> retinoic acid versus decitabine monotherapy for myelodysplastic syndromes with excess blasts: a multicenter, randomized controlled trial Open
Despite standard treatment with hypomethylating agents, the prognosis of patients with higher-risk myelodysplastic syndrome (MDS) remains poor. All-trans retinoic acid (ATRA) has demonstrated promising efficacy in unfit patients with acute…
View article: Polygenic Variation Underlying Neutrophil Counts Modifies the Penetrance of Duffy‐Null Neutropenia
Polygenic Variation Underlying Neutrophil Counts Modifies the Penetrance of Duffy‐Null Neutropenia Open
View article: Obinutuzumab in systemic lupus erythematosus: a real-world experience
Obinutuzumab in systemic lupus erythematosus: a real-world experience Open
Objectives To describe the real-world efficacy and safety of obinutuzumab in a heterogeneous systemic lupus erythematosus (SLE) population, including severe or refractory manifestations. Methods We retrospectively analyzed 56 SLE patients …
View article: Pegylated granulocyte colony-stimulating factor primary prophylaxis versus no prophylaxis in patients with unresectable pancreatic cancer treated with modified-FOLFIRINOX: a randomized, open-label, multicenter, phase 2 trial
Pegylated granulocyte colony-stimulating factor primary prophylaxis versus no prophylaxis in patients with unresectable pancreatic cancer treated with modified-FOLFIRINOX: a randomized, open-label, multicenter, phase 2 trial Open
Summary: Background: FOLFIRINOX treatment for pancreatic cancer often causes severe neutropenia, leading to dose reductions and potentially fatal outcomes. Despite this, high-level evidence supporting pegylated granulocyte colony-stimulati…
View article: Efficacy and Safety of Mecapegfilgrastim for Prophylaxis of Neutropenia During Chemotherapy for Malignant Tumors: A Single-Center, Retrospective Cohort Study
Efficacy and Safety of Mecapegfilgrastim for Prophylaxis of Neutropenia During Chemotherapy for Malignant Tumors: A Single-Center, Retrospective Cohort Study Open
Objective The objective of this study was to investigate the effectiveness and safety of prophylactic thiopefilgrastim for the clinical treatment of chemotherapy-induced neutropenia in cancer patients. Methods A retrospective analysis was …
View article: Real-World Outcomes of Subcutaneous PHESGO® in HER2-Positive Breast Cancer: Pathological Response, Se-Quencing, and Safety
Real-World Outcomes of Subcutaneous PHESGO® in HER2-Positive Breast Cancer: Pathological Response, Se-Quencing, and Safety Open
Background: Subcutaneous pertuzumab and trastuzumab with hyaluronidase (PHESGO®) shortens chair time versus intravenous dual HER2 blockade, but Asian real-world data are scarce. Methods: We retrospectively reviewed 47 Asian patients with H…
View article: The real-world clinical effectiveness of durvalumab in advanced biliary tract cancer: a mimic comparative analysis through survival data reconstruction
The real-world clinical effectiveness of durvalumab in advanced biliary tract cancer: a mimic comparative analysis through survival data reconstruction Open
Background The TOPAZ-1 study results represented significant advancement in the treatment of advanced biliary tract cancer (BTC) by combining durvalumab with gemcitabine–cisplatin (DGC). However, the highly selected patient population may …
View article: Viral Coinfections Potentially Associated with Feline Chronic Gingivostomatitis in Cats with Feline Infectious Peritonitis
Viral Coinfections Potentially Associated with Feline Chronic Gingivostomatitis in Cats with Feline Infectious Peritonitis Open
Feline infectious peritonitis (FIP) is a fatal but now treatable disease in cats caused by feline coronavirus (FCoV). This study prospectively investigated viral coinfections in 100 cats diagnosed with FIP and subsequently treated with ora…
View article: Clinical signs, clinical pathology and outcomes in horses infected naturally with equine encephalosis virus
Clinical signs, clinical pathology and outcomes in horses infected naturally with equine encephalosis virus Open
Background Equine encephalosis (EE) is caused by an Orbivirus from the family Sedoreoviridae and is thus similar to African horse sickness (AHS) and Bluetongue viruses (BTV). These viruses are transmitted by Culicoides midges. Equine encep…
View article: Inflammatory markers predict bloodstream infections risk in hematological malignancy patients with chemotherapy induced neutropenia
Inflammatory markers predict bloodstream infections risk in hematological malignancy patients with chemotherapy induced neutropenia Open
Chemotherapy-induced neutropenia (CIN) and febrile neutropenia (FN) significantly increase the risk of invasive infections, which can progress to septic shock or sepsis and may ultimately result in death. our purpose of this study is to co…
View article: Diagnostic Utility of Monocyte Distribution Width for Early Sepsis Detection in Cancer-Enriched Emergency Cohort
Diagnostic Utility of Monocyte Distribution Width for Early Sepsis Detection in Cancer-Enriched Emergency Cohort Open
Background: Timely recognition of sepsis remains a critical clinical challenge, particularly in cancer patients, who are at higher risk due to immunosuppression. Monocyte distribution width (MDW) has emerged as a biomarker with potential u…
View article: Allopurinol Add‐on 6‐Mercaptopurine Strategy Improves Efficacy and Reduces Toxicity in Pediatric Patients With Acute Lymphoblastic Leukemia
Allopurinol Add‐on 6‐Mercaptopurine Strategy Improves Efficacy and Reduces Toxicity in Pediatric Patients With Acute Lymphoblastic Leukemia Open
The short‐term efficacy of allopurinol add‐on thiopurine therapy has been well documented; however, the long‐term effects and dose recommendations are poorly detailed. This study aimed to elucidate the long‐term implications of this combin…
View article: Clinical and diagnostic characteristics of dengue inchildren during the 2023–2024 outbreak in BuenosAires, Argentina
Clinical and diagnostic characteristics of dengue inchildren during the 2023–2024 outbreak in BuenosAires, Argentina Open
Introduction. Dengue fever presents a broad clinical spectrum in pediatrics, and there is limited information on its course in children. During 2023-2024, Argentina experienced its largest dengue epidemic. Objective. To describe the clinic…
View article: Lipegfilgrastim for primary prophylaxis of febrile neutropenia in patients treated for advanced-stage classical Hodgkin lymphoma: successful outcomes from a multicenter cohort study
Lipegfilgrastim for primary prophylaxis of febrile neutropenia in patients treated for advanced-stage classical Hodgkin lymphoma: successful outcomes from a multicenter cohort study Open
In patients with classical Hodgkin lymphoma (c-HL) undergoing ABVD chemotherapy for advanced disease, the optimal strategy to prevent febrile neutropenia (FN)—defined as fever ≥38 °C with absolute neutrophil count (ANC) <1000/mm³—remains d…