Reversing ≈ Reversing
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Arctic browning: extreme events and trends reversing arctic greening Open
NOAA's recent assessment of Arctic greenness has reported a remarkable finding: the Arctic is browning (Epstein et al., 2015). Whilst a clear greening trend has been apparent for most of the satellite record's 33 year history (indicating a…
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Reversing Years for Global Food Security: A Review of the Food Security Situation in Sub-Saharan Africa (SSA) Open
All around the world, inequalities persist in the complex web of social, economic, and ecological factors that mediate food security outcomes at different human and institutional scales. There have been rapid and continuous improvements in…
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Fiber networks amplify active stress Open
Significance Living organisms generate forces to move, change shape, and maintain their internal functions. These forces are typically produced by molecular motors embedded in networks of fibers. Although these motors are traditionally reg…
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Current Status of Latency Reversing Agents Facing the Heterogeneity of HIV-1 Cellular and Tissue Reservoirs Open
One of the most explored therapeutic approaches aimed at eradicating HIV-1 reservoirs is the "shock and kill" strategy which is based on HIV-1 reactivation in latently-infected cells ("shock" phase) while maintaining antiretroviral therapy…
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A Subset of Latency-Reversing Agents Expose HIV-Infected Resting CD4+ T-Cells to Recognition by Cytotoxic T-Lymphocytes Open
Resting CD4+ T-cells harboring inducible HIV proviruses are a critical reservoir in antiretroviral therapy (ART)-treated subjects. These cells express little to no viral protein, and thus neither die by viral cytopathic effects, nor are ef…
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Can we undo our first impressions? The role of reinterpretation in reversing implicit evaluations. Open
Little work has examined whether implicit evaluations can be effectively "undone" after learning new revelations. Across 7 experiments, participants fully reversed their implicit evaluation of a novel target person after reinterpreting ear…
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Electroreductive Olefin–Ketone Coupling Open
A user-friendly approach is presented to sidestep the venerable Grignard addition to unactivated ketones to access tertiary alcohols by reversing the polarity of the disconnection. In this work a ketone instead acts as a nucleophile when a…
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The effectiveness of net negative carbon dioxide emissions in reversing anthropogenic climate change Open
Artificial removal of CO _2 from the atmosphere (also referred to as negative emissions) has been proposed as a means to restore the climate system to a desirable state, should the impacts of climate change become ‘dangerous’. Here we expl…
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The Current Status of Latency Reversing Agents for HIV-1 Remission Open
Combinatory antiretroviral therapy (cART) reduces human immunodeficiency virus type 1 (HIV-1) replication but is not curative because cART interruption almost invariably leads to a rapid rebound of viremia due to the persistence of stable …
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A Macromolecule Reversing Antibiotic Resistance Phenotype and Repurposing Drugs as Potent Antibiotics Open
In order to mitigate antibiotic resistance, a new strategy to increase antibiotic potency and reverse drug resistance is needed. Herein, the translocation mechanism of an antimicrobial guanidinium‐functionalized polycarbonate is leveraged …
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Strategizing and the Initiation of Interorganizational Collaboration through Prospective Resourcing Open
In this paper, we explain how managers establish resource complementarity during their strategizing efforts for interorganizational collaboration. Based on a longitudinal field study at an automotive company, we show that resource compleme…
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Sign-Reversing Orbital Polarization in the Nematic Phase of FeSe due to theSymmetry Breaking in the Self-Energy Open
To understand the nematicity in Fe-based superconductors, nontrivial k dependence of the orbital polarization [ΔE_{xz}(k), ΔE_{yz}(k)] in the nematic phase, such as the sign reversal of the orbital splitting between Γ and X, Y points in Fe…
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Reversing the surface charge of MSC‐derived small extracellular vesicles by εPL‐PEG‐DSPE for enhanced osteoarthritis treatment Open
Mesenchymal stem cell‐derived small extracellular vesicles (MSC‐sEVs) possess a great therapeutical potential for osteoarthritis (OA) treatment. However, the steric and electrostatic hindrance of cartilage matrix leads to very limited dist…
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<i>meta</i> C–H Arylation of Electron-Rich Arenes: Reversing the Conventional Site Selectivity Open
Controlling site selectivity of C-H activation without using a directing group remains a significant challenge. While Pd(II) catalysts modulated by a mutually repulsive pyridine-type ligand have been shown to favor the relatively electron-…
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Academic careers and the COVID-19 pandemic: Reversing the tide Open
The pandemic has affected research operations and disproportionately affected underrepresented minority researchers, requiring concrete strategies to reverse these losses.
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Earth’s magnetic field is probably not reversing Open
Significance Earth’s magnetic field is generated in Earth’s convecting liquid iron outer core and protects Earth’s surface from harmful solar radiation. The field has varied on different timescales throughout geological history, and these …
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Reversing resistance to counter antimicrobial resistance in the World Health Organisation’s critical priority of most dangerous pathogens Open
The speed at which bacteria develop antimicrobial resistance far outpace drug discovery and development efforts resulting in untreatable infections. The World Health Organisation recently released a list of pathogens in urgent need for the…
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Ongoing Clinical Trials of Human Immunodeficiency Virus Latency-Reversing and Immunomodulatory Agents Open
In chronic human immunodeficiency virus (HIV)-1 infection, long-lived latently infected cells are the major barrier to virus eradication and functional cure. Several therapeutic strategies to perturb, eliminate, and/or control this reservo…
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Innate Immune Activity Correlates with CD4 T Cell-Associated HIV-1 DNA Decline during Latency-Reversing Treatment with Panobinostat Open
The pharmaceutical reactivation of dormant HIV-1 proviruses by histone deacetylase inhibitors (HDACi) represents a possible strategy to reduce the reservoir of HIV-1-infected cells in individuals treated with suppressive combination antire…
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Rational Design of Antibiotic Treatment Plans: A Treatment Strategy for Managing Evolution and Reversing Resistance Open
The development of reliable methods for restoring susceptibility after antibiotic resistance arises has proven elusive. A greater understanding of the relationship between antibiotic administration and the evolution of resistance is key to…
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The Beneficial Effects of Cardiac Rehabilitation Open
Cardiac rehabilitation (CR) is a combined range of measures aimed at providing patients with cardiovascular disease with the optimum psychological and physical conditions so that they themselves can prevent their disease from progressing o…
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IRE1α Disruption in Triple-Negative Breast Cancer Cooperates with Antiangiogenic Therapy by Reversing ER Stress Adaptation and Remodeling the Tumor Microenvironment Open
Cancer cells exploit the unfolded protein response (UPR) to mitigate endoplasmic reticulum (ER) stress caused by cellular oncogene activation and a hostile tumor microenvironment (TME). The key UPR sensor IRE1α resides in the ER and deploy…
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Reversing extinction trends: new uses of (old) herbarium specimens to accelerate conservation action on threatened species Open
Summary Although often not collected specifically for the purposes of conservation, herbarium specimens offer sufficient information to reconstruct parameters that are needed to designate a species as ‘at‐risk’ of extinction. While such de…
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Female genital schistosomiasis and HIV/AIDS: Reversing the neglect of girls and women Open
Since the 2000s, we have known that female genital schistosomiasis (FGS) is likely the most neglected gynecologic condition and HIV/AIDS cofactor across sub-Saharan Africa.To date, the global health and HIV/AIDS communities have not used t…
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Reversing membrane wetting in membrane distillation: comparing dryout to backwashing with pressurized air Open
Wetting of saline water through membrane distillation pores can be reversed with either drying out the membrane, or more effectively, by backwashing with pressurized air to force out wetting feed water.
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SS‐31 Provides Neuroprotection by Reversing Mitochondrial Dysfunction after Traumatic Brain Injury Open
SS‐31, a novel mitochondria‐targeted peptide, has been proven to provide neuroprotection in a variety of neurological diseases. Its role as a mitochondrial reactive oxygen species (ROS) scavenger and the underlying pathophysiological mecha…
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Gadofullerene inhibits the degradation of apolipoprotein B100 and boosts triglyceride transport for reversing hepatic steatosis Open
Fullerene nanomaterials protect the liver from lipid accumulation by promoting the transport of lipids out of liver.
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De-Escalation by Reversing the Escalation with a Stronger Synergistic Package of Contact Tracing, Quarantine, Isolation and Personal Protection: Feasibility of Preventing a COVID-19 Rebound in Ontario, Canada, as a Case Study Open
Since the beginning of the COVID-19 pandemic, most Canadian provinces have gone through four distinct phases of social distancing and enhanced testing. A transmission dynamics model fitted to the cumulative case time series data permits us…
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Mechanism for Collective Cell Alignment in Myxococcus xanthus Bacteria Open
Myxococcus xanthus cells self-organize into aligned groups, clusters, at various stages of their lifecycle. Formation of these clusters is crucial for the complex dynamic multi-cellular behavior of these bacteria. However, the mechanism un…
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Trehalose limits opportunistic mycobacterial survival during HIV co-infection by reversing HIV-mediated autophagy block Open
Opportunistic bacterial infections amongst HIV–infected individuals contribute significantly to HIV-associated mortality. The role of HIV-mediated modulation of innate mechanisms like autophagy in promoting opportunistic infections, howeve…