Cathepsin B
View article: Structural and Proteomic Analysis of the Mouse Cathepsin B-DARPin 4m3 Complex Reveals Species-Specific Binding Determinants
Structural and Proteomic Analysis of the Mouse Cathepsin B-DARPin 4m3 Complex Reveals Species-Specific Binding Determinants Open
Cathepsin B (CatB) is a lysosomal cysteine protease that plays a major role in various pathologies and is therefore considered a valuable therapeutic target. To address species-specific inhibitor challenges, we characterized the selective …
View article: Data Sheet 1_CU Cilia – an application for image analysis by machine learning – reveals significance of cysteine cathepsin K activity for primary cilia of human thyroid epithelial cells.pdf
Data Sheet 1_CU Cilia – an application for image analysis by machine learning – reveals significance of cysteine cathepsin K activity for primary cilia of human thyroid epithelial cells.pdf Open
Introduction Cysteine cathepsins K and L are crucial for proper thyroid function in mice. Inhibition of cysteine peptidases in rodent thyroid epithelial cells in vitro results in loss of primary cilia, highlighting the significance of prot…
View article: Lysosomal acidity and cathepsin L activate eosinophils via ARG1-mediated arginine metabolism in allergic airway inflammation
Lysosomal acidity and cathepsin L activate eosinophils via ARG1-mediated arginine metabolism in allergic airway inflammation Open
Eosinophils are the predominant immune cells implicated in the pathogenesis of asthma, highlighting the need for strategies to mitigate their effects. While previous studies have implicated the importance of lysosomes in eosinophil functio…
View article: Cathepsin B hyperactivation facilitates exosome release of CVB3 particles and exacerbation of acute pancreatitis by impairing lysosomal integrity and acidification
Cathepsin B hyperactivation facilitates exosome release of CVB3 particles and exacerbation of acute pancreatitis by impairing lysosomal integrity and acidification Open
Lysosomal cathepsin B (CTSB) exhibits diverse roles in physiological and pathological processes. Upregulation and trypsinogen-activating function of CTSB have been reported in experimental secretagogue-elicited AP. Whether CTSB regulates t…
View article: Cathepsin S contributes to influenza-induced lung injury by driving inflammation, promoting apoptosis, and disrupting epithelial barrier integrity
Cathepsin S contributes to influenza-induced lung injury by driving inflammation, promoting apoptosis, and disrupting epithelial barrier integrity Open
Influenza virus infection causes significant morbidity and mortality worldwide, with severe cases often driven by excessive host inflammatory responses and disruption of epithelial barrier function. Here, we identified cathepsin S (CTSS), …
View article: Image 6_Unraveling the gut microbiota–SCFAs–cathepsin C pathway in preeclampsia: a novel therapeutic target.tif
Image 6_Unraveling the gut microbiota–SCFAs–cathepsin C pathway in preeclampsia: a novel therapeutic target.tif Open
Introduction Preeclampsia (PE) is a severe obstetric syndrome linked to impaired maternal-fetal immune tolerance, placental insufficiency, and systemic inflammatory activation. Emerging studies suggest that gut microbiota and its metabolit…
View article: Image 1_Unraveling the gut microbiota–SCFAs–cathepsin C pathway in preeclampsia: a novel therapeutic target.tif
Image 1_Unraveling the gut microbiota–SCFAs–cathepsin C pathway in preeclampsia: a novel therapeutic target.tif Open
Introduction Preeclampsia (PE) is a severe obstetric syndrome linked to impaired maternal-fetal immune tolerance, placental insufficiency, and systemic inflammatory activation. Emerging studies suggest that gut microbiota and its metabolit…
View article: Image 2_Unraveling the gut microbiota–SCFAs–cathepsin C pathway in preeclampsia: a novel therapeutic target.tif
Image 2_Unraveling the gut microbiota–SCFAs–cathepsin C pathway in preeclampsia: a novel therapeutic target.tif Open
Introduction Preeclampsia (PE) is a severe obstetric syndrome linked to impaired maternal-fetal immune tolerance, placental insufficiency, and systemic inflammatory activation. Emerging studies suggest that gut microbiota and its metabolit…
View article: Image 8_Unraveling the gut microbiota–SCFAs–cathepsin C pathway in preeclampsia: a novel therapeutic target.jpeg
Image 8_Unraveling the gut microbiota–SCFAs–cathepsin C pathway in preeclampsia: a novel therapeutic target.jpeg Open
Introduction Preeclampsia (PE) is a severe obstetric syndrome linked to impaired maternal-fetal immune tolerance, placental insufficiency, and systemic inflammatory activation. Emerging studies suggest that gut microbiota and its metabolit…
View article: Unraveling the gut microbiota–SCFAs–cathepsin C pathway in preeclampsia: a novel therapeutic target
Unraveling the gut microbiota–SCFAs–cathepsin C pathway in preeclampsia: a novel therapeutic target Open
Introduction Preeclampsia (PE) is a severe obstetric syndrome linked to impaired maternal-fetal immune tolerance, placental insufficiency, and systemic inflammatory activation. Emerging studies suggest that gut microbiota and its metabolit…
View article: Image 7_Unraveling the gut microbiota–SCFAs–cathepsin C pathway in preeclampsia: a novel therapeutic target.tif
Image 7_Unraveling the gut microbiota–SCFAs–cathepsin C pathway in preeclampsia: a novel therapeutic target.tif Open
Introduction Preeclampsia (PE) is a severe obstetric syndrome linked to impaired maternal-fetal immune tolerance, placental insufficiency, and systemic inflammatory activation. Emerging studies suggest that gut microbiota and its metabolit…
View article: Image 5_Unraveling the gut microbiota–SCFAs–cathepsin C pathway in preeclampsia: a novel therapeutic target.tif
Image 5_Unraveling the gut microbiota–SCFAs–cathepsin C pathway in preeclampsia: a novel therapeutic target.tif Open
Introduction Preeclampsia (PE) is a severe obstetric syndrome linked to impaired maternal-fetal immune tolerance, placental insufficiency, and systemic inflammatory activation. Emerging studies suggest that gut microbiota and its metabolit…
View article: Table 1_Unraveling the gut microbiota–SCFAs–cathepsin C pathway in preeclampsia: a novel therapeutic target.docx
Table 1_Unraveling the gut microbiota–SCFAs–cathepsin C pathway in preeclampsia: a novel therapeutic target.docx Open
Introduction Preeclampsia (PE) is a severe obstetric syndrome linked to impaired maternal-fetal immune tolerance, placental insufficiency, and systemic inflammatory activation. Emerging studies suggest that gut microbiota and its metabolit…
View article: Image 3_Unraveling the gut microbiota–SCFAs–cathepsin C pathway in preeclampsia: a novel therapeutic target.tif
Image 3_Unraveling the gut microbiota–SCFAs–cathepsin C pathway in preeclampsia: a novel therapeutic target.tif Open
Introduction Preeclampsia (PE) is a severe obstetric syndrome linked to impaired maternal-fetal immune tolerance, placental insufficiency, and systemic inflammatory activation. Emerging studies suggest that gut microbiota and its metabolit…
View article: Image 4_Unraveling the gut microbiota–SCFAs–cathepsin C pathway in preeclampsia: a novel therapeutic target.tif
Image 4_Unraveling the gut microbiota–SCFAs–cathepsin C pathway in preeclampsia: a novel therapeutic target.tif Open
Introduction Preeclampsia (PE) is a severe obstetric syndrome linked to impaired maternal-fetal immune tolerance, placental insufficiency, and systemic inflammatory activation. Emerging studies suggest that gut microbiota and its metabolit…
View article: <scp>CD8</scp> <sup>+</sup> T Cells Negatively Modulate Ischemia‐Induced Angiogenesis in Mice
<span>CD8</span> <sup>+</sup> T Cells Negatively Modulate Ischemia‐Induced Angiogenesis in Mice Open
Angiogenesis‐related therapeutic approaches to peripheral arterial disease (PAD) deserve attention. CD8 + T cells play important roles in human pathobiology, and we investigated the involvement of cytotoxic CD8 + T cells in angiogenesis in…
View article: S100 Calcium-Binding Protein P and Cathepsin E as Key Mediators in Pancreatic Cancer Tumorigenesis
S100 Calcium-Binding Protein P and Cathepsin E as Key Mediators in Pancreatic Cancer Tumorigenesis Open
Background/Objectives: Pancreatic cancer (PC) remains one of the deadliest malignancies, with challenges that hinder early detection and few actionable molecular targets. In this study, we aimed to identify biomarkers predictive of PC to s…
View article: An immunometabolic prodrug strategy overcomes DHODH inhibitor resistance in refractory melanoma
An immunometabolic prodrug strategy overcomes DHODH inhibitor resistance in refractory melanoma Open
View article: Evaluation of the pharmacological cathepsin S inhibitor LY3000328 on autoimmune diabetes in mice
Evaluation of the pharmacological cathepsin S inhibitor LY3000328 on autoimmune diabetes in mice Open
There is an emerging role for the lysosomal protease cathepsin S (CTSS) in the pathogenesis of type 1 diabetes (T1D). This is supported by key findings, including that circulating levels of CTSS are increased in individuals with T1D, and t…
View article: A Cathepsin D aspartyl proteinase is the initiator of the haemoglobin digestion cascade in the poultry red mite, Dermanyssus gallinae
A Cathepsin D aspartyl proteinase is the initiator of the haemoglobin digestion cascade in the poultry red mite, Dermanyssus gallinae Open
Background The poultry red mite, Dermanyssus gallinae , is a haematophagous ectoparasite causing significant economic losses in the commercial egg laying sector. Blood meal digestion by D. gallinae is required for nutrient acquisition, wit…
View article: Altered Transcriptome Signature in Primary Human Myotubes Exposed to Inclusion Body Myositis Serum: A Pilot Case Comparison of Anti-cN1A Positive and Negative Sera
Altered Transcriptome Signature in Primary Human Myotubes Exposed to Inclusion Body Myositis Serum: A Pilot Case Comparison of Anti-cN1A Positive and Negative Sera Open
Inclusion body myositis (IBM) is a late-onset, treatment-resistant inflammatory myopathy. Approximately half of IBM patients develop autoantibodies against cytosolic 5′-nucleotidase 1A (cN1A), but their role in disease pathogenesis remains…
View article: Peptide-based targeted covalent inhibitors of cysteine proteases
Peptide-based targeted covalent inhibitors of cysteine proteases Open
Targeted covalent inhibitors (TCIs) can modulate dysregulated enzymes by covalently engaging with nucleophilic residues in active sites. Cysteine cathepsins, implicated in diseases such as cancer, osteoporosis, and viral infections, are pr…
View article: Dataset for "Targeted, receptor-mediated delivery of a masked ᴅ-amino acid cell penetrating peptide for cell-specific phototoxicity"
Dataset for "Targeted, receptor-mediated delivery of a masked ᴅ-amino acid cell penetrating peptide for cell-specific phototoxicity" Open
Photodynamic therapy is an innovative treatment option for cancer, but current approaches are limited by poor tumor selectivity and low uptake. Here, we introduce a novel concept for a targeted phototoxic peptide, in which a lysosomally ac…
View article: Cathepsin B causes trogocytosis-mediated CAR T cell dysfunction 2477
Cathepsin B causes trogocytosis-mediated CAR T cell dysfunction 2477 Open
Description Chimeric antigen receptor (CAR) T cell therapy has shown remarkable efficacy in cancer treatment. Still, most patients receiving CAR T cells relapse within 5 years of treatment. CAR-mediated trogocytosis (CMT) is a potential tu…
View article: Single-Cell Transcriptomics and Super-Resolution Confocal Imaging Reveal Differential Regulation and Subcellular Localization of Cathepsin L in Response to IFN-a in Primary CD14 Monocytes 9097
Single-Cell Transcriptomics and Super-Resolution Confocal Imaging Reveal Differential Regulation and Subcellular Localization of Cathepsin L in Response to IFN-a in Primary CD14 Monocytes 9097 Open
Description Interferons (IFNs) are essential for orchestrating immune responses, influencing autoimmune disorders, malignancies, and immune defense. Despite their importance to the immune response, a comprehensive single-cell transcriptomi…
View article: TMIC-49. Cathepsin B as a potential mediator of senescence-driven BTIC malignancy near the lateral ventricles
TMIC-49. Cathepsin B as a potential mediator of senescence-driven BTIC malignancy near the lateral ventricles Open
Glioblastoma (GBM), the most common malignant primary brain tumor in adults, has a median survival of 15 months and 5-year survival rate of only 6.9%. Standard of care, including radiation and chemotherapy, can induce cellular senescence i…
View article: Table 1_Targeting cystatin F activation enhances NK cell cytotoxicity in glioblastoma models.docx
Table 1_Targeting cystatin F activation enhances NK cell cytotoxicity in glioblastoma models.docx Open
Introduction Glioblastoma (GBM) is a highly invasive brain tumor with limited treatment options and poor prognosis. Natural killer (NK) cells are key effectors of antitumor immunity, capable of eliminating cancer stem-like cells. However, …
View article: TFEB DysfunctionMediates Lysosomal Membrane Permeabilization-InducedPyroptosis in Deoxynivalenol-Exposed Intestinal Epithelium
TFEB DysfunctionMediates Lysosomal Membrane Permeabilization-InducedPyroptosis in Deoxynivalenol-Exposed Intestinal Epithelium Open
Deoxynivalenol (DON), a prevalent mycotoxin in cereals, triggers lysosomal membrane permeabilization (LMP) in intestinal epithelial cells, resulting in Transcription Factor EB (TFEB) dysfunction and subsequent pyroptosis. Both in vivo porc…
View article: Design and Evaluationof Dual-Targeted RadionuclideTherapeutics for NTS1 with Improved Tumor Retention through EndolysosomalTrapping
Design and Evaluationof Dual-Targeted RadionuclideTherapeutics for NTS1 with Improved Tumor Retention through EndolysosomalTrapping Open
This study investigates the development of neurotensin receptor subtype 1-(NTS1-) targeted constructs incorporated with an irreversible cysteine protease inhibitor (i.e., cysteine protease trapping agent (CPTA)) to improve tumor retention …
View article: IGF2 BP2 knockdown-mediated suppression effects of TC cell migration, invasion, and EMT are partially reversed by CTSH overexpression.
IGF2 BP2 knockdown-mediated suppression effects of TC cell migration, invasion, and EMT are partially reversed by CTSH overexpression. Open
(A-E) TPC-1 and BCPAP cells were divided into three groups: si-NC + pcDNA, si-IGF2 BP2#2 + pcDNA, and si-IGF2 BP2#2 + pcDNA-CTSH. (A and B) Cell migration and invasion abilities were assessed by transwell assays. Scale bars: …