Bone marrow aspirate
View article: Bone marrow aspirate Cit-H3 was identified as a novel biomarker of minimal residual disease in neuroblastoma
Bone marrow aspirate Cit-H3 was identified as a novel biomarker of minimal residual disease in neuroblastoma Open
Background Neuroblastoma (NB) is the most prevalent extracranial solid tumor in children. Neutrophils release neutrophil extracellular traps (NETs) following intense or prolonged activation. Neutrophil elastase (ELA2) and citrullinated his…
View article: Out of Sight, Should not be out of mind: A perplexing case of Malaria
Out of Sight, Should not be out of mind: A perplexing case of Malaria Open
Malaria diagnosis is often difficult in cases with low parasitaemia and atypical presentations. We report a 30-year-old male with high-grade fever, chills, and vomiting. At admission, he was afebrile, pale, and had progressive splenomegaly…
View article: Piperacillin-tazobactam-induced hemophagocytic lymphohistiocytosis in a patient with community-acquired pneumonia: A case report and literature review on diagnostic challenges of elevated procalcitonin
Piperacillin-tazobactam-induced hemophagocytic lymphohistiocytosis in a patient with community-acquired pneumonia: A case report and literature review on diagnostic challenges of elevated procalcitonin Open
Rationale: piperacillin-tazobactam, a widely used broad-spectrum antibiotic, carries a risk of severe adverse reactions, including rare but life-threatening hemophagocytic lymphohistiocytosis (HLH). Elevated procalcitonin (PCT), typically …
View article: Lymphoma-Associated Bone Marrow Hemophagocytosis (LA-BMHPC): A Retrospective, Single-Center Study of 67 Patients
Lymphoma-Associated Bone Marrow Hemophagocytosis (LA-BMHPC): A Retrospective, Single-Center Study of 67 Patients Open
View article: Moderate‐Severe Thrombocytopenia Portends Poor Outcomes in Multiple Myeloma
Moderate‐Severe Thrombocytopenia Portends Poor Outcomes in Multiple Myeloma Open
Background Malignant plasma cells in multiple myeloma (MM) reprogram the bone marrow microenvironment to support tumor expansion. This myeloma cell–hematopoietic stem cell interaction leads to fewer hematopoietic stem cells in the bone mar…
View article: Case Report: Pitfalls in bone marrow evaluation: importance of adequate bone marrow sampling
Case Report: Pitfalls in bone marrow evaluation: importance of adequate bone marrow sampling Open
Bone marrow evaluation is a powerful diagnostic tool, but it comes with several potential pitfalls. These include issues related to sampling errors, technical challenges during processing, and misinterpretation of the findings due to simil…
View article: A large dataset of bone marrow cells in myelodysplastic syndrome for classification systems
A large dataset of bone marrow cells in myelodysplastic syndrome for classification systems Open
Bone marrow smear cytomorphology serves as the cornerstone for diagnosing hematological malignancies. It is particularly complex in myelodysplastic syndrome (MDS), which brings challenges to automated image analysis approaches. This datase…
View article: Dual-Action Regenerative Therapies: Regeneration and Antimicrobial Effects of Platelet- and Marrow-Derived Biologics
Dual-Action Regenerative Therapies: Regeneration and Antimicrobial Effects of Platelet- and Marrow-Derived Biologics Open
This review explores the dual regenerative and antimicrobial properties of platelet- and marrow-derived biologics, including platelet-rich plasma (PRP), bone marrow aspirate concentrate (BMAC), autologous protein solutions, and plasma frac…
View article: Diagnosis and Management of Visceral Leishmaniasis in Children: A French Retrospective Study
Diagnosis and Management of Visceral Leishmaniasis in Children: A French Retrospective Study Open
Introduction Few studies have investigated the diagnosis and management of pediatric visceral leishmaniasis (VL) in high-income countries. Methods All children hospitalized for VL in university hospitals across mainland France between Janu…
View article: Evaluation of Clonality in Patients with B-cell Lymphoid Malignancies by Immunohistochemistry Panel and Flow Cytometry Analysis
Evaluation of Clonality in Patients with B-cell Lymphoid Malignancies by Immunohistochemistry Panel and Flow Cytometry Analysis Open
Objective: To assess various methods for clonality detection in patients with B-cell lymphoblastic leukemia. Study Design: Descriptive diagnostic studyPlace and Duration of Study: This study was conducted at the Department of Pathology and…
View article: Effectiveness of percutaneous autologous bone marrow injection in delayed and non-union of long bones after definitive fixation
Effectiveness of percutaneous autologous bone marrow injection in delayed and non-union of long bones after definitive fixation Open
Background: Delayed and non-union of long bones remain challenging complications despite stable fixation. Percutaneous autologous bone marrow injection (PABMI) provides osteogenic stimulation without the morbidity of open grafting. Methods…
View article: Long-term follow-up of patients with large segmental bone defects treated with 3D-printed polycaprolactone/tricalcium phosphate scaffolds
Long-term follow-up of patients with large segmental bone defects treated with 3D-printed polycaprolactone/tricalcium phosphate scaffolds Open
Introduction The Induced Membrane Technique (IMT) combined with autologous bone grafting has proven effective in achieving union in many cases of non-healing bone defects. However, this treatment strategy remainschallenging in very large d…
View article: A rare disease: primary bone lymphoma case report
A rare disease: primary bone lymphoma case report Open
Primary bone lymphoma (PBL) is a rare subtype of non-Hodgkin lymphoma, comprising a small proportion of primary bone malignancies and extranodal lymphomas. It typically presents with nonspecific symptoms such as localized bone pain, leadin…
View article: A case report: pediatric rhabdomyosarcoma presenting with bone marrow metastasis
A case report: pediatric rhabdomyosarcoma presenting with bone marrow metastasis Open
This case highlights that RMS can initially present with bone marrow metastasis, mimicking hematologic malignancies. When primitive immature cells are observed in bone marrow aspirates, RMS should be considered in the differential diagnosi…
View article: Dynamic monitoring of circulating plasma cells in multiple myeloma: A Prospective multicenter study in China
Dynamic monitoring of circulating plasma cells in multiple myeloma: A Prospective multicenter study in China Open
Background The minimally invasive nature of circulating plasma cells (CPCs) measurement provides a valuable alternative for real-time tumor monitoring. A growing body of Western evidence has revealed the prognostic significance of CPCs in …
View article: Predicting genetic alterations in Acute Myeloid Leukemia through AI-based analysis of bone marrow morphology
Predicting genetic alterations in Acute Myeloid Leukemia through AI-based analysis of bone marrow morphology Open
Acute myeloid leukemia (AML) is characterized by significant genetic heterogeneity, with diverse cytogenetic and molecular alterations that profoundly influence prognosis and therapeutic decisions. Rapid and precise identification of key a…
View article: An Arthroscopic Technique for Addressing Cartilage Defects in the Glenoid Using Bone Marrow Aspiration Concentrate After Failed Bankart Repair
An Arthroscopic Technique for Addressing Cartilage Defects in the Glenoid Using Bone Marrow Aspiration Concentrate After Failed Bankart Repair Open
View article: 138 Pathologic Hallmarks of VEXAS Syndrome: Insights from a Seven-Case Series
138 Pathologic Hallmarks of VEXAS Syndrome: Insights from a Seven-Case Series Open
Introduction/Objective VEXAS syndrome is an autoinflammatory disorder caused by somatic UBA1 mutations, with characteristic bone marrow findings. Methods/Case Report We retrospectively reviewed cases diagnosed with VEXAS syndrome between 2…
View article: Diagnostic Challenges in Visceral Leishmaniasis in a 17‐Month‐Old Female: A Case Report
Diagnostic Challenges in Visceral Leishmaniasis in a 17‐Month‐Old Female: A Case Report Open
Visceral leishmaniasis is an uncommon infectious disease. In this report, we present a case of VL in a 17‐month‐old child who presented with a fever and splenomegaly. After the patient failed to respond to several courses of antibiotics, a…
View article: 23 Exploring the Validation of Bone Marrow Biopsies using a Digital Pathology System Approved for FFPE Cut Sections
23 Exploring the Validation of Bone Marrow Biopsies using a Digital Pathology System Approved for FFPE Cut Sections Open
Introduction Digital pathology (DP) with whole slide imaging (WSI) is a rapidly advancing field with great potential in applications such as telepathology and artificial intelligence (AI). Our laboratory uses a modern and popular high-thro…
View article: 257 Pediatric Chronic Myeloid Leukemia Incidentally Diagnosed in a Trauma Patient: A Rare Presentation
257 Pediatric Chronic Myeloid Leukemia Incidentally Diagnosed in a Trauma Patient: A Rare Presentation Open
Introduction/Objective Chronic Myeloid Leukemia (CML) is a myeloproliferative neoplasm characterized by the presence of the BCR-ABL1 fusion gene resulting from the t(9;22)(q34;q11) translocation, commonly known as the Philadelphia chromoso…
View article: Caprine Bone-Derived Biomaterials for Guided Bone Regeneration: A Comprehensive Review of Macroscopic and Histological Findings
Caprine Bone-Derived Biomaterials for Guided Bone Regeneration: A Comprehensive Review of Macroscopic and Histological Findings Open
Guided bone regeneration (GBR) is a key approach in oral and orthopedic reconstruction, relying on barrier membranes and graft materials to direct bone formation. While bovine and porcine xenografts dominate clinical use, caprine bone-deri…
View article: Atypical morphological appearance of acute lymphoblastic leukemia confirmed by immunophenotyping
Atypical morphological appearance of acute lymphoblastic leukemia confirmed by immunophenotyping Open
Despite significant advances in diagnostic techniques for acute leukemia, namely immunophenotyping and molecular biology, morphology remains the first essential examination for detecting leukemia and determining whether it is myeloblastic …
View article: Caprine Bone-Derived Biomaterials for Guided Bone Regeneration: A Comprehensive Review of Macroscopic and Histological Findings
Caprine Bone-Derived Biomaterials for Guided Bone Regeneration: A Comprehensive Review of Macroscopic and Histological Findings Open
Guided bone regeneration (GBR) is a key approach in oral and orthopedic reconstruction, relying on barrier membranes and graft materials to direct bone formation. While bovine and porcine xenografts dominate clinical use, caprine bone-deri…
View article: Atypical morphological appearance of acute lymphoblastic leukemia confirmed by immunophenotyping
Atypical morphological appearance of acute lymphoblastic leukemia confirmed by immunophenotyping Open
Despite significant advances in diagnostic techniques for acute leukemia, namely immunophenotyping and molecular biology, morphology remains the first essential examination for detecting leukemia and determining whether it is myeloblastic …
View article: Cell-derived extracellular matrix scaffolds augmented with bone marrow aspirate concentrate promote cartilage regeneration
Cell-derived extracellular matrix scaffolds augmented with bone marrow aspirate concentrate promote cartilage regeneration Open
This study aimed to evaluate the effects of cell-derived (BMSCs and chondrocytes) extracellular matrix (ECM) scaffolds incorporating bone marrow aspirate concentrate (BMAC) on cartilage regeneration, and to determine whether BMAC-loaded BM…
View article: Circular RNA GCLC promotes osteogenic differentiation of bone marrow mesenchymal stem cells via modulating miR-516b-5p/GNAS axis
Circular RNA GCLC promotes osteogenic differentiation of bone marrow mesenchymal stem cells via modulating miR-516b-5p/GNAS axis Open
Objective Osteoporosis (OP) is a systemic bone disease without effective treatment at present. The aim of this study is to explore the role of the circular RNA GCLC (circGCLC) in the osteogenic differentiation of bone marrow mesenchymal st…
View article: Calcified Cartilage Zone Debridement With Hyaluronic Acid–Based Scaffold and Bone Marrow Aspirate Concentrate
Calcified Cartilage Zone Debridement With Hyaluronic Acid–Based Scaffold and Bone Marrow Aspirate Concentrate Open
View article: Arthroscopic-Assisted Management of Subchondral Bone Marrow Lesions of the Knee
Arthroscopic-Assisted Management of Subchondral Bone Marrow Lesions of the Knee Open
View article: Comparative Performance of Calcium Phosphate Grafts and Iliac Crest Autograft in Posterolateral Spinal Fusion in Rabbits
Comparative Performance of Calcium Phosphate Grafts and Iliac Crest Autograft in Posterolateral Spinal Fusion in Rabbits Open
Background Calcium phosphate (CaP) biomaterials are widely used in surgical applications such as spinal fusion to substitute for or extend autogenous bone graft. Preclinical testing in standardized animal models is useful for evaluating th…