Platelet aggregation inhibitor
View article: Administration of eptifibatide as rescue therapy during mechanical thrombectomy in acute ischemic stroke
Administration of eptifibatide as rescue therapy during mechanical thrombectomy in acute ischemic stroke Open
Background The success of the technical implementation of mechanical thrombectomy (MT) depends on many factors. Considering the experience of the interventional radiologist and the anatomical vascular differences of individual patients, it…
View article: In maintenance antiplatelet therapy for stroke sequelae, is aspirin or clopidogrel better?
In maintenance antiplatelet therapy for stroke sequelae, is aspirin or clopidogrel better? Open
Both aspirin and clopidogrel are effective for secondary prevention of recurrent strokes, with clopidogrel showing a potentially better profile in reducing broader cardiovascular events. Patient-specific factors and genetic considerations …
View article: The efficacy and safety of prasugrel in acute coronary syndrome: a propensity-matched Korean cohort study focused on age and weight of patients
The efficacy and safety of prasugrel in acute coronary syndrome: a propensity-matched Korean cohort study focused on age and weight of patients Open
Background The clinical benefits of prasugrel compared to clopidogrel in acute coronary syndrome (ACS) patients undergoing percutaneous coronary intervention (PCI) are well established. However, significant safety concerns persist, particu…
View article: Circulating MRP8/14 drives faster platelet COX-1 recovery via MRP4 impairing the duration of aspirin response
Circulating MRP8/14 drives faster platelet COX-1 recovery via MRP4 impairing the duration of aspirin response Open
Low-dose aspirin is a cornerstone of cardiovascular prevention in high-risk patients, inhibiting platelet cyclooxygenase (COX-1) and reducing thromboxane (TX) A2 production for 24 hours. However, the duration of this effect varies among in…
View article: In maintenance antiplatelet therapy for stroke sequelae, is aspirin or clopidogrel better?
In maintenance antiplatelet therapy for stroke sequelae, is aspirin or clopidogrel better? Open
Both aspirin and clopidogrel are effective for secondary prevention of recurrent strokes, with clopidogrel showing a potentially better profile in reducing broader cardiovascular events. Patient-specific factors and genetic considerations …
View article: Impact of an Anticoagulation Management Service-led Intervention on Rates of Antiplatelet and Gastric Bleeding Prophylaxis Use in Ambulatory Care Patients on Background Direct Oral Anticoagulants
Impact of an Anticoagulation Management Service-led Intervention on Rates of Antiplatelet and Gastric Bleeding Prophylaxis Use in Ambulatory Care Patients on Background Direct Oral Anticoagulants Open
Background: Patients on long-term anticoagulation face increased bleeding risk when antiplatelets are co-prescribed, especially upper gastrointestinal (GI) bleeding. Guidelines recommend limiting antiplatelet use to highly select patients …
View article: Editorial: New concepts in revascularization strategies and antithrombotic therapies in patients with non-ST elevated acute coronary syndromes
Editorial: New concepts in revascularization strategies and antithrombotic therapies in patients with non-ST elevated acute coronary syndromes Open
View article: Management of antithrombotic therapy in gonioscopy-assisted transluminal trabeculotomy
Management of antithrombotic therapy in gonioscopy-assisted transluminal trabeculotomy Open
View article: Study protocol for low-dose evaluation of aspirin in patients with ST-elevation myocardial infarction undergoing percutaneous coronary intervention (LEAST): a multicenter, double-blind, randomized controlled clinical trial
Study protocol for low-dose evaluation of aspirin in patients with ST-elevation myocardial infarction undergoing percutaneous coronary intervention (LEAST): a multicenter, double-blind, randomized controlled clinical trial Open
ClinicalTrials.gov (NCT06756945).
View article: Dual-action salivary peptide drives black fly feeding efficiency
Dual-action salivary peptide drives black fly feeding efficiency Open
Black flies (Simulidae) employ salivary peptides to optimize blood-feeding efficiency through anticoagulation and analgesia, yet the molecular mechanisms underlying their analgesic effects remain unclear. Here, we identified a novel Kunitz…
View article: Comparative Efficacy and Safety of De-escalation, Abbreviation, and Standard Potent P2Y <sub>12</sub> Inhibitor–Based Dual Antiplatelet Therapy Strategies After Acute Coronary Syndrome: A Network Meta-Analysis
Comparative Efficacy and Safety of De-escalation, Abbreviation, and Standard Potent P2Y <sub>12</sub> Inhibitor–Based Dual Antiplatelet Therapy Strategies After Acute Coronary Syndrome: A Network Meta-Analysis Open
Background The efficacy and safety of de-escalation from potent P2Y 12 inhibitor-based dual antiplatelet therapy (DAPT) to clopidogrel-based DAPT, or abbreviation to potent P2Y 12 inhibitor monotherapy, compared with standard 12-month DAPT…
View article: Antithrombotic strategies and DOAC dosing following left atrial appendage occlusion: a network meta-analysis
Antithrombotic strategies and DOAC dosing following left atrial appendage occlusion: a network meta-analysis Open
Aims The optimal short-term antithrombotic strategy following left atrial appendage occlusion (LAAO) remains uncertain, with the need to balance thromboembolic prevention and bleeding risk presenting a critical challenge. Recent evidence s…
View article: A Cross-Sectional Study to Assess Prescription Pattern and Evaluate Monitoring Parameters of Anticoagulant and Antiplatelet Agents at Tertiary Care Hospital in Dakshina Kannada
A Cross-Sectional Study to Assess Prescription Pattern and Evaluate Monitoring Parameters of Anticoagulant and Antiplatelet Agents at Tertiary Care Hospital in Dakshina Kannada Open
Antiplatelet drugs prevent arterial thrombosis by inhibiting thromboxane formation, while anticoagulants target clotting factors to address venous thrombosis. Optimizing treatment and balancing bleeding risks are crucial, requiring monitor…
View article: A Cross-Sectional Study to Assess Prescription Pattern and Evaluate Monitoring Parameters of Anticoagulant and Antiplatelet Agents at Tertiary Care Hospital in Dakshina Kannada
A Cross-Sectional Study to Assess Prescription Pattern and Evaluate Monitoring Parameters of Anticoagulant and Antiplatelet Agents at Tertiary Care Hospital in Dakshina Kannada Open
Antiplatelet drugs prevent arterial thrombosis by inhibiting thromboxane formation, while anticoagulants target clotting factors to address venous thrombosis. Optimizing treatment and balancing bleeding risks are crucial, requiring m…
View article: The Role of Antiplatelet Agents in Clinical Practice: Mechanism of Action, Indications, Limitations, And Future Directions - A Comprehensive Review
The Role of Antiplatelet Agents in Clinical Practice: Mechanism of Action, Indications, Limitations, And Future Directions - A Comprehensive Review Open
Antiplatelet agents have revolutionized the management of thrombotic disorders. They target important pathways in platelet activation and aggregation. Their ability to prevent arterial thrombosis makes them essential in treating cardiovasc…
View article: Impact of CYP2C19 point-of-care testing on the clinical outcome in patients receiving personalized clopidogrel therapy: systemic review and meta-analysis
Impact of CYP2C19 point-of-care testing on the clinical outcome in patients receiving personalized clopidogrel therapy: systemic review and meta-analysis Open
Objective Evidence on the utility of CYP2C19 point-of-care (POC) testing to guide antiplatelet therapy selection in patients with acute coronary syndrome (ACS) or stable coronary artery disease (CAD) undergoing percutaneous coronary interv…
View article: The Role of Antiplatelet Agents in Clinical Practice: Mechanism of Action, Indications, Limitations, And Future Directions - A Comprehensive Review
The Role of Antiplatelet Agents in Clinical Practice: Mechanism of Action, Indications, Limitations, And Future Directions - A Comprehensive Review Open
Antiplatelet agents have revolutionized the management of thrombotic disorders. They target important pathways in platelet activation and aggregation. Their ability to prevent arterial thrombosis makes them essential in treating card…
View article: Hemocompatibility Outcomes After Aspirin Withdrawal in Long‐Term <scp>HeartMate</scp> 3 Left Ventricular Assist Device Patients on Vitamin K Antagonists
Hemocompatibility Outcomes After Aspirin Withdrawal in Long‐Term <span>HeartMate</span> 3 Left Ventricular Assist Device Patients on Vitamin K Antagonists Open
Background Left Ventricular Assist Devices, particularly Heart Mate 3 (HM3), have improved outcomes for advanced heart failure patients. Despite advancements, hemocompatibility‐related adverse events (HRAEs) continue to pose significant ch…
View article: Multifaceted Effects of Thymoquinone on Platelet Calcium Homeostasis
Multifaceted Effects of Thymoquinone on Platelet Calcium Homeostasis Open
Thymoquinone (TQ), the main bioactive ingredient of Nigella sativa, exhibits numerous pharmacological activities and is used for the prevention of many diseases including hypertension and cancer. However, information concerning the effects…
View article: Laboratory Resistance to Antiplatelet Therapy as Part of Secondary Prevention After Atherothrombotic Stroke in the Early Recovery Period (On the Example of Clinical Cases)
Laboratory Resistance to Antiplatelet Therapy as Part of Secondary Prevention After Atherothrombotic Stroke in the Early Recovery Period (On the Example of Clinical Cases) Open
Introduction. Atherosclerosis of a major cerebral artery is the main cause of atherothrombotic ischemic stroke. Platelets are actively involved in the pathogenesis of the formation and progression of an atherosclerotic plaque. Acetylsalicy…
View article: Safety and efficacy of short-term tirofiban combined with dual antiplatelet therapy after flow diverter placement for intracranial aneurysms: a multicenter retrospective study and nomogram for thromboembolic event prediction
Safety and efficacy of short-term tirofiban combined with dual antiplatelet therapy after flow diverter placement for intracranial aneurysms: a multicenter retrospective study and nomogram for thromboembolic event prediction Open
Background Flow diverters (FDs) are increasingly applied for intracranial aneurysms, but their high metal coverage raises thromboembolic risk. Dual antiplatelet therapy (DAPT) with aspirin and clopidogrel is standard, yet clopidogrel resis…
View article: Can ticagrelor be used as monotherapy for secondary prevention of acute coronary syndrome (ACS)?
Can ticagrelor be used as monotherapy for secondary prevention of acute coronary syndrome (ACS)? Open
Ticagrelor monotherapy following short-term DAPT seems effective in reducing bleeding risk without increasing ischemic events in ACS patients post-PCI, but further research is necessary to fully validate its use outside of controlled trial…
View article: Comparison between single and dual antiplatelet therapy in patients on oral anticoagulants undergoing coil embolization for unruptured intracranial aneurysms: a retrospective multicenter cohort study
Comparison between single and dual antiplatelet therapy in patients on oral anticoagulants undergoing coil embolization for unruptured intracranial aneurysms: a retrospective multicenter cohort study Open
Purpose The optimal antiplatelet therapy for patients on continuous oral anticoagulants (OACs) who are undergoing coil embolization for unruptured intracranial aneurysms (UIAs) is remains unknown. This study evaluated the efficacy and safe…
View article: What are the benefits and risks of dual antiplatelet therapy with clopidogrel and aspirin compared to single antiplatelet therapy for secondary stroke prevention?
What are the benefits and risks of dual antiplatelet therapy with clopidogrel and aspirin compared to single antiplatelet therapy for secondary stroke prevention? Open
DAPT with clopidogrel and aspirin may reduce recurrent stroke risk compared to aspirin alone but increases bleeding risks, particularly beyond 21 days. Individual assessment is essential.
View article: Can ticagrelor be used as monotherapy for secondary prevention of acute coronary syndrome (ACS)?
Can ticagrelor be used as monotherapy for secondary prevention of acute coronary syndrome (ACS)? Open
Ticagrelor monotherapy following short-term DAPT seems effective in reducing bleeding risk without increasing ischemic events in ACS patients post-PCI, but further research is necessary to fully validate its use outside of controlled trial…
View article: What are the benefits and risks of dual antiplatelet therapy with clopidogrel and aspirin compared to single antiplatelet therapy for secondary stroke prevention?
What are the benefits and risks of dual antiplatelet therapy with clopidogrel and aspirin compared to single antiplatelet therapy for secondary stroke prevention? Open
DAPT with clopidogrel and aspirin may reduce recurrent stroke risk compared to aspirin alone but increases bleeding risks, particularly beyond 21 days. Individual assessment is essential.
View article: Can ticagrelor be used as monotherapy for secondary prevention of acute coronary syndrome (ACS)?
Can ticagrelor be used as monotherapy for secondary prevention of acute coronary syndrome (ACS)? Open
Ticagrelor monotherapy following short-term DAPT seems effective in reducing bleeding risk without increasing ischemic events in ACS patients post-PCI, but further research is necessary to fully validate its use outside of controlled trial…
View article: Case Report: Severe thrombocytopenia in the context of concomitant tirofiban and ibuprofen use: does ibuprofen matter?
Case Report: Severe thrombocytopenia in the context of concomitant tirofiban and ibuprofen use: does ibuprofen matter? Open
Tirofiban is a glycoprotein (GP) IIb/IIIa receptor antagonist that inhibits platelet-to-platelet interactions and thrombosis by preventing fibrinogen from binding to platelets. While it has the potential to cause thrombocytopenia and bleed…
View article: Can ticagrelor be used as monotherapy for secondary prevention of acute coronary syndrome (ACS)?
Can ticagrelor be used as monotherapy for secondary prevention of acute coronary syndrome (ACS)? Open
Ticagrelor monotherapy following short-term DAPT seems effective in reducing bleeding risk without increasing ischemic events in ACS patients post-PCI, but further research is necessary to fully validate its use outside of controlled trial…
View article: P2Y12 Inhibitor or Aspirin Following Dual Antiplatelet Therapy After Percutaneous Coronary Intervention: A Systematic Review and Meta-Analysis
P2Y12 Inhibitor or Aspirin Following Dual Antiplatelet Therapy After Percutaneous Coronary Intervention: A Systematic Review and Meta-Analysis Open
Purpose Current guidelines recommend aspirin monotherapy for secondary prevention following dual antiplatelet therapy (DAPT) completion after percutaneous coronary intervention (PCI). However, recent evidence suggests P2Y12 inhibitor monot…