Corneal ulceration
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Neurotrophic keratitis: current challenges and future prospects Open
Neurotrophic keratitis (NK) is a degenerative corneal disease caused by damage of trigeminal corneal innervation, which leads to spontaneous epithelial breakdown and corneal ulceration. The impairment of corneal sensory innervation causes …
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Use of Topical Insulin to Treat Refractory Neurotrophic Corneal Ulcers Open
Purpose: To report the clinical course of 6 patients with refractory neurotrophic corneal ulcers that were treated with topical insulin drops. Methods: Retrospective chart review of patients who had neurotrophic corneal ulcers or epithelia…
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Corneal Fibroblasts as Sentinel Cells and Local Immune Modulators in Infectious Keratitis Open
The cornea serves as a barrier to protect the eye against external insults including microbial pathogens and antigens. Bacterial infection of the cornea often results in corneal melting and scarring that can lead to severe visual impairmen…
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Involvement of NADPH oxidases in alkali burn-induced corneal injury Open
Chemical burns are a major cause of corneal injury. Oxidative stress, inflammatory responses and neovascularization after the chemical burn aggravate corneal damage, and lead to loss of vision. Although NADPH oxidases (Noxs) play a crucial…
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Corneal Ulcer in Dogs and Cats: Novel Clinical Application of Regenerative Therapy Using Subconjunctival Injection of Autologous Platelet-Rich Plasma Open
Background: Corneal ulcer could be a major source of distress in small animals, with many contributing agents. In recent years, few studies evaluated the efficacy of platelet-rich plasma (PRP) in healing corneal ulcers. Aim: This study aim…
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Update on surgical management of corneal ulceration and perforation Open
Corneal ulcerations are a medical emergency, and in recalcitrant cases, leading to perforation, a surgical ophthalmological emergency. The urgency of the treatment is dictated by the necessity of preventing complications that can lead to s…
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Corneal toxicity induced by vesicating agents and effective treatment options Open
The vesicating agents sulfur mustard (SM) and lewisite (LEW) are potent chemical warfare agents that primarily cause damage to the ocular, skin, and respiratory systems. However, ocular tissue is the most sensitive organ, and vesicant expo…
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Tissue Adhesives for the Management of Corneal Perforations and Challenging Corneal Conditions Open
Corneal perforations are ophthalmological emergencies which can have serious and detrimental consequences, if not managed timely and appropriately. These are a significant cause of ocular morbidity and can result in decreased vision, blind…
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Topical Cross-Linked HA-Based Hydrogel Accelerates Closure of Corneal Epithelial Defects and Repair of Stromal Ulceration in Companion Animals Open
PURPOSE: The purpose of this study was to determine the safety of topical ocular administration of a cross-linked, modified hyaluronic acid (xCMHA-S) hydrogel, and its effectiveness in accelerating repair and closure of acute and nonhealin…
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DNase I improves corneal epithelial and nerve regeneration in diabetic mice Open
DNase I has been reported to improve diabetic wound healing through the clearance of neutrophils extracellular traps (NETs) caused by neutrophil aggregation. However, the function of DNase I on diabetic corneal wound healing remains unclea…
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Role of steroids in the treatment of bacterial keratitis Open
Bacterial keratitis can lead to severe visual impairment from corneal ulceration, subsequent scarring, and possible perforation. The mainstay of treatment is topical antibiotics, whereas the use of adjunctive topical corticosteroid drops r…
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Corneal collagen cross-linking for bacterial infectious keratitis Open
The current evidence on the effectiveness of PACK-CXL for bacterial keratitis is of low certainty and clinically heterogenous in regard to outcomes. There are five ongoing RCTs enrolling 1136 participants that may provide better answers in…
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Clinical efficacy of conjunctival flap surgery in the treatment of refractory fungal keratitis Open
The aim of the present study was to investigate the use and effectiveness of a selective, partial, pedunculated (tongue-shaped) conjunctival flap (CF) for the treatment of refractory fungal keratitis (FK) with or without perforation. A tot…
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Human cornea-derived extracellular matrix hydrogel for prevention of post-traumatic corneal scarring: A translational approach Open
Corneal scarring and opacification are a significant cause of blindness affecting millions worldwide. The current standard of care for corneal blindness is corneal transplantation, which suffers from several drawbacks. One alternative appr…
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Conjunctival flap surgery in the management of ocular surface disease (Review) Open
Literature regarding conjunctival flap surgery was reviewed to describe and discuss the rationale for this type of procedure. The conjunctival flap is an acknowledged surgery for the treatment of various corneal diseases with a chronically…
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Pivotal Role of Corneal Fibroblasts in Progression to Corneal Ulcer in Bacterial Keratitis Open
The shape and transparency of the cornea are essential for clear vision. However, its location at the ocular surface renders the cornea vulnerable to pathogenic microorganisms in the external environment. Pseudomonas aeruginosa and Staphyl…
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Cisd2 plays an essential role in corneal epithelial regeneration Open
This study was supported by the Ministry of Science and Technology (MOST) and Chang Gung Medical Research Foundation, Taiwan.
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Eyelid Molluscum Contagiosum Lesions in Two Patients with Unilateral Chronic Conjunctivitis Open
Molluscum contagiosum (MC) is a viral infection of the skin and mucosal tissues characterized by skin-colored or transparent round nodules with a dimple or pit in the center. The infection is caused by a DNA poxvirus called the MC virus. A…
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Clinical Characteristics and Risk Factors of Recurrent Mooren’s Ulcer Open
Purpose. To investigate the clinical characteristics of Mooren’s ulcer in East China and to identify the potential risk factors that affect the recurrence of Mooren’s ulcer. Methods. We reviewed the medical records of 95 patients (100 eyes…
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Dextran Sulfate Polymer Wafer Promotes Corneal Wound Healing Open
Eye injuries due to corneal abrasions, chemical spills, penetrating wounds, and microbial infections cause corneal scarring and opacification that result in impaired vision or blindness. However, presently available eye drop formulations o…
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Plasminogen-Dependent Collagenolytic Properties of<i>Staphylococcus aureus</i>in Collagen Gel Cultures of Human Corneal Fibroblasts Open
Our results suggest that S. aureus may promote collagen degradation both by upregulating pro-MMP1 expression in corneal fibroblasts, with pro-MMP-1 then being converted to active MMP-1 by plasmin, and by directing plasmin activity toward c…
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Corneal Collagen Cross-linking for Treatment of Bacterial and Herpetic Keratitis Open
Although, CXL seems promising in the treatment of patients with refractory bacterial keratitis, but in some cases, it is ineffective. CXL may be an alternative treatment for refractory cases of HSV keratitis but recurrence is possible.
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The Therapeutic Effects and Possible Mechanism of Pranoprofen in Mouse Model of Corneal Alkali Burns Open
Objective . To investigate therapeutic effects and possible mechanism of pranoprofen in a mouse model of corneal alkali burns and provide new evidence for the clinical treatment of corneal alkali burns. Methods . A unilateral alkali burn w…
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Topical Pirfenidone-Loaded Liposomes Ophthalmic Formulation Reduces Haze Development after Corneal Alkali Burn in Mice Open
Corneal chemical burns (CCBs) frequently result in corneal fibrosis or haze, an opacity of the cornea that obstructs vision and induces corneal blindness. Diverse strategies have been employed to prevent or reduce CCB-related corneal haze.…
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Inhibition by Epigallocatechin Gallate of IL-1–Induced Urokinase-Type Plasminogen Activator Expression and Collagen Degradation by Corneal Fibroblasts Open
EGCG inhibits IL-1β-induced collagen degradation by corneal fibroblasts, with this effect likely being mediated by suppression of the upregulation of uPA, the uPA-mediated conversion of plasminogen to plasmin, and the plasmin-mediated acti…
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Recurrent corneal melting in the paraneoplastic pemphigus associated with Castleman’s disease Open
Corneal ulceration and melting, in addition to conjunctivitis, as a complication of CD-associated PNP, can be successfully managed with systemic and local immunosuppressants.
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Microbial keratitis: A five years retrospective clinical study in tertiary eye hospital of eastern region of Nepal Open
Background: Corneal ulcer is a sight threatening disease of significant public health concern. Early diagnosis with microbiological identification of the causative organism and institution of the proper medical therapy are important for su…
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Pseudomonas aeruginosa-Derived Extracellular Vesicles Modulate Corneal Inflammation: Role in Microbial Keratitis? Open
Pseudomonas aeruginosa keratitis occurs following trauma, in immunocompromised patients, and in otherwise healthy contact lens wearers. Characterized by a light-blocking infiltrate, P. aeruginosa keratitis is the most serious complication …
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Neurotrophic keratopathy Open
Neurotrophic keratopathy is a clinical entity which involves all degrees of degenerative corneal and conjunctival changes secondary to loss of sensory function in the nasociliary branch of the trigeminal nerve with or without decreased tea…
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Amniotic membrane transplantation for infectious corneal ulcer treatment: a cohort retrospective study Open
BACKGROUND Corneal ulcer is one of the most common causes of corneal blindness. This study aimed to describe the outcomes of amniotic membrane transplantation (AMT) in patients with infectious corneal ulcer. METHODS A retrospective cohort …