Neuroeffector
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High-resolution structure-function mapping of intact hearts reveals altered sympathetic control of infarct border zones Open
Remodeling of injured sympathetic nerves on the heart after myocardial infarction (MI) contributes to adverse outcomes such as sudden arrhythmic death, yet the underlying structural mechanisms are poorly understood. We sought to examine mi…
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Heterogeneous cardiac sympathetic innervation gradients promote arrhythmogenesis in murine dilated cardiomyopathy Open
Ventricular arrhythmias (VAs) in heart failure are enhanced by sympathoexcitation. However, radiotracer studies of catecholamine uptake in failing human hearts demonstrate a proclivity for VAs in patients with reduced cardiac sympathetic i…
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Activation of Norepinephrine Neurons in the NTS (A2 population) is Sufficient to Suppress Pulsatile LH Secretion in Female Mice Open
The overarching goal of this work is to identify neural pathways underlying inhibition of pulsatile luteinizing hormone (LH) secretion during stress. Stress-induced suppression of LH secretion is mediated, at least in part, by suppression …
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Predictors of positive treatment response to PTNS in women with overactive bladder Open
Percutaneous tibial nerve stimulation (PTNS) is a non-invasive treatment for overactive bladder (OAB). PTNS involves peripheral neuromodulation that uses electrical stimulation to target the spinal cord roots, mainly S3, which controls bla…
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The role of Ano1 in mediating cholinergic neurotransmission in the murine gastric fundus Open
Gastrointestinal (GI) motility relies on coordinated enteric motor neurotransmission. Excitatory and inhibitory enteric neurons innervate the cells of the SIP syncytium, an electrical syncytium comprising smooth muscle cells (SMCs), inters…
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Vascular Sympathetic Neurotransmission and Endothelial Dysfunction Open
Endothelium is an important regulator of vascular tone via release of various endothelium-derived substances. Several studies have reported that endothelium may decrease the release of noradrenaline from vascular postganglionic sympathetic…
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Aberrant reflex mechanisms contributing to reno‐vascular hypertension: a pain in the neck? Open
Reno-vascular hypertension has been studied extensively over the course of the last 80 years using the Goldblatt two kidney one clip (2K1C) model. Ample evidence indicates that activation of the renin angiotensin aldosterone system (RAAS) …
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Neuroeffector coupling in the heart: determinants of function and survival of cardiac sympathetic neurons Open
Rationale: The sympathetic branch of the autonomic nervous system (ANS) operates continuous control on the function and structure of cardiac cells (Bers et al., 2009). In basal conditions, neuronal input to sino-atrial node (SAN) cardiomyo…
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The Impact of <i>PLCG2*M28L</i> and Diet on Neuro‐metabolic and Vascular Dysfunction in Novel Mouse Models of Late‐Onset Alzheimer's Disease Open
Background MODEL‐AD has developed and characterized novel mouse models that aim to better phenocopy human LOAD for preclinical testing. More than 40 different models carrying combinations of LOAD risk factors have been created and assessed…