Chronic Migraine
View article: Patients with migraine have decreased serum zinc levels dataset
Patients with migraine have decreased serum zinc levels dataset Open
View article: Greater occipital nerve block for the treatment of migraine: An umbrella review, systematic review, and meta-analysis
Greater occipital nerve block for the treatment of migraine: An umbrella review, systematic review, and meta-analysis Open
Background Greater occipital nerve block (GONB) has become an established treatment for migraine. Though numerous systematic reviews and randomised control trials (RCTs) are cited as supporting evidence, the quality and consistency of this…
View article: Patients with migraine have decreased serum zinc levels dataset
Patients with migraine have decreased serum zinc levels dataset Open
View article: Associations between good days per month and migraine-related disease impact in the real-world: a post hoc analysis from the REVIEW study of eptinezumab in chronic migraine
Associations between good days per month and migraine-related disease impact in the real-world: a post hoc analysis from the REVIEW study of eptinezumab in chronic migraine Open
View article: Exposure–Response Modeling of Monthly Migraine Days for Efficacy of Atogepant in Patients With Episodic or Chronic Migraine
Exposure–Response Modeling of Monthly Migraine Days for Efficacy of Atogepant in Patients With Episodic or Chronic Migraine Open
This work aimed to develop an appropriate model to evaluate the exposure–response relationship (ERR) for monthly migraine days (MMD) in atogepant's key migraine prevention clinical trials to support dose selection. The ERR between atogepan…
View article: Selective vulnerability of GABAergic neurons in chronic migraine
Selective vulnerability of GABAergic neurons in chronic migraine Open
Background Migraine is the second leading cause of neurological disability and has a strong genetic component. Previous linkage studies have identified a candidate migraine susceptibility locus on chromosome Xq24-28, which harbors several …
View article: Exploratory Pain Profiling With Quantitative Sensory Testing ( <scp>QST</scp> ) in Episodic and Chronic Migraine
Exploratory Pain Profiling With Quantitative Sensory Testing ( <span>QST</span> ) in Episodic and Chronic Migraine Open
Background Migraine pain profiling studies vary by sensory modalities, methods, anatomical sites and characteristics. This exploratory study aimed to identify pain profiling parameters using quantitative sensory testing (QST) for episodic …
View article: Transcranial Direct Current Stimulation (tDCS) for chronic migraine: a randomized clinical trial with 20 patients (pylot study)
Transcranial Direct Current Stimulation (tDCS) for chronic migraine: a randomized clinical trial with 20 patients (pylot study) Open
Chronic migraine is a disabling and often treatment-resistant neurological disorder. Transcranial direct current stimulation (tDCS) is a non-invasive neuromodulation technique with emerging evidence for pain management. To assess the effic…
View article: Clinic and Genetic Factors Associated with Non Response to Erenumab
Clinic and Genetic Factors Associated with Non Response to Erenumab Open
Background: Monoclonal antibodies targeting the calcitonin gene-related peptide (CGRP) pathway, such as erenumab (ERE) are effective migraine preventive therapies for many patients. Identifying clinic and genetic factors associated with tr…
View article: Real‐world effectiveness and safety of galcanezumab for the treatment of migraine: A systematic review and meta‐analysis
Real‐world effectiveness and safety of galcanezumab for the treatment of migraine: A systematic review and meta‐analysis Open
Objective This study aimed to summarize and pool real‐world evidence on the clinical effectiveness and safety of galcanezumab. Background Migraine is a disabling primary headache disorder. Several drugs that target calcitonin gene‐related …
View article: Vitamin D Deficiency and Supplementation in Migraine: A Scoping Review of Clinical Efficacy, Evidence Gaps, and Research Priorities
Vitamin D Deficiency and Supplementation in Migraine: A Scoping Review of Clinical Efficacy, Evidence Gaps, and Research Priorities Open
Background and Objectives: Migraine is a debilitating neurological disorder affecting 10%–20% of the global population, with significant socioeconomic burdens. Vitamin D deficiency, prevalent in over 1 billion individuals, has been propose…
View article: What is the most effective treatment for chronic migraine?
What is the most effective treatment for chronic migraine? Open
Multiple pharmacological treatments, including topiramate, propranolol, amitriptyline, and CGRP monoclonal antibodies, are effective for chronic migraine prevention, offering options based on patient-specific responses and tolerability.
View article: What is the most effective treatment for chronic migraine?
What is the most effective treatment for chronic migraine? Open
Multiple pharmacological treatments, including topiramate, propranolol, amitriptyline, and CGRP monoclonal antibodies, are effective for chronic migraine prevention, offering options based on patient-specific responses and tolerability.
View article: Magnesium supplementation for migraine prophylaxis
Magnesium supplementation for migraine prophylaxis Open
This is a protocol for a Cochrane Review (intervention). The objectives are as follows: To evaluate the benefits and harms of magnesium supplementation for preventing episodic or chronic migraine in children and adults compared to usual ph…
View article: What are the most effective treatments for migraine headaches?
What are the most effective treatments for migraine headaches? Open
Effective migraine management involves combining pharmacological treatments like triptans for acute episodes and preventive agents such as beta-blockers and CGRP inhibitors, with behavioral therapy showing potential merits.
View article: Therapeutic observation of transcutaneous auricular vagus nerve stimulation for chronic migraine in pediatric patients: a case report
Therapeutic observation of transcutaneous auricular vagus nerve stimulation for chronic migraine in pediatric patients: a case report Open
Background Although interest in migraine has increased in recent years, important gaps remain in understanding and optimizing its management. These gaps are particularly pronounced in pediatric migraine, which continues to be understudied.…
View article: What are the most effective treatments for migraine headaches?
What are the most effective treatments for migraine headaches? Open
Effective migraine management involves combining pharmacological treatments like triptans for acute episodes and preventive agents such as beta-blockers and CGRP inhibitors, with behavioral therapy showing potential merits.
View article: Beyond Stroke—Investigating Heart-Brain Connections in Migraine and Pain: A Mini Review
Beyond Stroke—Investigating Heart-Brain Connections in Migraine and Pain: A Mini Review Open
The patent foramen ovale (PFO), a congenital interatrial communication caused by incomplete septal closure, has long been recognised as a factor contributing to cryptogenic stroke, especially among younger adults. However, recent evidence …
View article: CD200/CD200R1 alleviates central sensitization in a chronic migraine model by promoting STAT6 phosphorylation and modulating microglial M2 polarization
CD200/CD200R1 alleviates central sensitization in a chronic migraine model by promoting STAT6 phosphorylation and modulating microglial M2 polarization Open
View article: ODTs (Orally Disintegrating Tablets): An Improved Rapid Treatment to Migraine
ODTs (Orally Disintegrating Tablets): An Improved Rapid Treatment to Migraine Open
Migraine is a neurological disorder which mainly affects the neurons in the brain from degranulation of peptides which further leads to release of certain histaminic hormones that causes severe pain and chronic headache along this, t…
View article: ODTs (Orally Disintegrating Tablets): An Improved Rapid Treatment to Migraine
ODTs (Orally Disintegrating Tablets): An Improved Rapid Treatment to Migraine Open
Migraine is a neurological disorder which mainly affects the neurons in the brain from degranulation of peptides which further leads to release of certain histaminic hormones that causes severe pain and chronic headache along this, the pat…
View article: CD200/CD200R1 alleviates central sensitization in a chronic migraine model by promoting STAT6 phosphorylation and modulating microglial M2 polarization
CD200/CD200R1 alleviates central sensitization in a chronic migraine model by promoting STAT6 phosphorylation and modulating microglial M2 polarization Open
View article: ANALGESIC PHARMACOTHERAPY IN DYSMENORRHEA AND THE RISK OF DEVELOPING CHRONIC MIGRAINE
ANALGESIC PHARMACOTHERAPY IN DYSMENORRHEA AND THE RISK OF DEVELOPING CHRONIC MIGRAINE Open
Introduction and Purpose: Dysmenorrhea, particularly primary dysmenorrhea, is a common gynecological condition characterized by cyclical and often severe pain, typically managed with analgesics such as NSAIDs, acetaminophen, and opioids. H…
View article: Calcitonin Gene-related Peptide (CGRP) Inhibitors in Episodic and Chronic Migraines: A Multiple Treatment Comparison (MTC) Meta-Analysis
Calcitonin Gene-related Peptide (CGRP) Inhibitors in Episodic and Chronic Migraines: A Multiple Treatment Comparison (MTC) Meta-Analysis Open
Migraine is a common neurological disorder affecting approximately 15% of adults worldwide, characterized by recurrent pulsating headaches. Conventional treatments often provide insufficient relief and may cause medication-overuse headache…
View article: Development of Patient-Friendly Oral Thin Film of Flunarizine for Migraine Management
Development of Patient-Friendly Oral Thin Film of Flunarizine for Migraine Management Open
The development of patient-friendly dosage forms, such as oral thin films (OTFs), represents a viable alternative to improving drug compliance and delivering quick therapeutic benefits (1,3). Flunarizine, a calcium chan…
View article: Development of Patient-Friendly Oral Thin Film of Flunarizine for Migraine Management
Development of Patient-Friendly Oral Thin Film of Flunarizine for Migraine Management Open
The development of patient-friendly dosage forms, such as oral thin films (OTFs), represents a viable alternative to improving drug compliance and delivering quick therapeutic benefits (1,3). Flunarizine, a calcium channel blocker used in …
View article: Delivering headache care to underserved populations: Results of a neurology clinic embedded in primary care
Delivering headache care to underserved populations: Results of a neurology clinic embedded in primary care Open
Background/Objective Underserved populations have worse access to neurologic care and higher risk for worse headache disease burden. We embedded a neurology clinic offering headache services within a primary care clinic treating an underse…
View article: Lasmiditan as a potential targeted therapy for vestibular migraine? A case study
Lasmiditan as a potential targeted therapy for vestibular migraine? A case study Open
Background Vestibular migraine (VM) is a common migraine subtype. Treatment options in the acute stage are limited. Case Here, we present the case of a 53-year-old woman experiencing frequent episodes of sensory aura, as well as vertigo an…
View article: Abnormal neurovascular coupling in the precuneus associated with migraine chronification: A multimodal magnetic resonance imaging study
Abnormal neurovascular coupling in the precuneus associated with migraine chronification: A multimodal magnetic resonance imaging study Open
Background Neurovascular coupling (NVC) reflects the interaction between cerebral blood flow (CBF) and functional activity. However, the relationship between NVC and migraine chronification remains unclear. This study investigated the stat…
View article: Exploring Contraindicated Medications and Corresponding Targeted Genes for Migraine Through Integrated Genetic Approaches
Exploring Contraindicated Medications and Corresponding Targeted Genes for Migraine Through Integrated Genetic Approaches Open
Objective To identify contraindicated medications and corresponding target genes for migraine and its subtypes. Method Utilizing the Genome‐Wide Association Studies (GWAS) for 14 medication‐use categories from UK Biobank and GWAS for migra…