Preclinical imaging
View article: Figure S1 from An Oncolytic Poxvirus Encoding <i>hNIS</i>, Shows Antitumor Efficacy and Allows Tumor Imaging in a Liver Cancer Model
Figure S1 from An Oncolytic Poxvirus Encoding <i>hNIS</i>, Shows Antitumor Efficacy and Allows Tumor Imaging in a Liver Cancer Model Open
PET imaging at different time points
View article: MRI as nondestructive 3D imaging method for tumor spheroids
MRI as nondestructive 3D imaging method for tumor spheroids Open
Spheroids, as 3D cell culture models, better replicate human tissue architecture than 2D cultures. However, nondestructive imaging of these spheroids remains challenging, as confocal microscopy cannot sufficiently penetrate uncleared 3D cu…
View article: What are the radiation exposure levels associated with cardiac PET scans compared to other cardiac imaging modalities?
What are the radiation exposure levels associated with cardiac PET scans compared to other cardiac imaging modalities? Open
Cardiac PET imaging generally results in lower or comparable radiation exposure compared to SPECT and is typically lower than CT angiography, while modalities like echocardiography and MRI do not involve ionizing radiation.
View article: High content 3D Imaging by dual-view oblique plane microscopy
High content 3D Imaging by dual-view oblique plane microscopy Open
Oblique plane microscopy (OPM) is a form of light-sheet fluorescence microscopy (LSFM) employing a single microscope objective at the sample for both fluorescence excitation and detection. Dual-view OPM (dOPM) is an optically folded form o…
View article: Multifunctional Nanoplatforms Bridging Diagnostics and Therapeutics in Cancer
Multifunctional Nanoplatforms Bridging Diagnostics and Therapeutics in Cancer Open
Accurate tumor visualization remains a central challenge in oncology, as single-modality imaging often lacks the depth, sensitivity, and specificity needed for precise therapeutic guidance. Nano-theranostic platforms address this by combin…
View article: Customizable FDM-based zebrafish embryo mold for live imaging
Customizable FDM-based zebrafish embryo mold for live imaging Open
Accurate and reproducible orientation of zebrafish embryos is crucial for high-resolution live imaging but remains challenging with standard agarose mounting. Here, we introduce an orientation tool made using fused deposition modeling (FDM…
View article: Hyaluronic Acid-Functionalized Bismuth Sulfide Nanoparticles as Targeted CT Contrast Agents
Hyaluronic Acid-Functionalized Bismuth Sulfide Nanoparticles as Targeted CT Contrast Agents Open
Nanoparticle (NP)-based contrast agents offer a promising alternative to conventional iodinated compounds for computed tomography (CT) imaging. Here, we report hyaluronic acid (HA) –functionalized bismuth sulfide–loaded bovine serum albumi…
View article: What are the radiation exposure levels associated with cardiac PET scans compared to other cardiac imaging modalities?
What are the radiation exposure levels associated with cardiac PET scans compared to other cardiac imaging modalities? Open
Cardiac PET imaging generally results in lower or comparable radiation exposure compared to SPECT and is typically lower than CT angiography, while modalities like echocardiography and MRI do not involve ionizing radiation.
View article: Peptide-Based Probe Targeting Angiotensin Type-1 Receptor Identifies Pancreatic Ductal Adenocarcinoma Using Multispectral Optoacoustic Tomography
Peptide-Based Probe Targeting Angiotensin Type-1 Receptor Identifies Pancreatic Ductal Adenocarcinoma Using Multispectral Optoacoustic Tomography Open
View article: Development of 18F/11C-Labeled Pyrrolo-Pyridine/Pyrimidine LRRK2 Selective PET Radioligands
Development of 18F/11C-Labeled Pyrrolo-Pyridine/Pyrimidine LRRK2 Selective PET Radioligands Open
Background/Objectives: Leucine-rich repeat kinase 2 (LRRK2) is an enzyme implicated in Parkinson’s disease (PD) and a potential therapeutic target. LRRK2 PET radioligands could therefore function as imaging biomarkers for PD and as tools t…
View article: Supplementary Figures S1-S15 from First-in-Human Study of the Radioligand <sup>68</sup>Ga-N188 Targeting Nectin-4 for PET/CT Imaging of Advanced Urothelial Carcinoma
Supplementary Figures S1-S15 from First-in-Human Study of the Radioligand <sup>68</sup>Ga-N188 Targeting Nectin-4 for PET/CT Imaging of Advanced Urothelial Carcinoma Open
Figure S1. Synthesis of N188. Figure S2. Mass spectrometry characterization of N188.Figure S3. SPR characterization of N188.Figure S4. Radio-HPLC characterization of 68Ga-N188.Figure S5. Stability of 68Ga-N188 in serum and normal saline. F…
View article: Reflect: reporting guidelines for preclinical, translational and clinical fluorescence molecular imaging studies
Reflect: reporting guidelines for preclinical, translational and clinical fluorescence molecular imaging studies Open
View article: In vivo volumetric visualization and quantification of cumulus expansion in mice with intravital optical coherence tomography
In vivo volumetric visualization and quantification of cumulus expansion in mice with intravital optical coherence tomography Open
View article: Preoperative risk stratification of colorectal high-grade intraepithelial neoplasia based on endoscopic biopsy: superior performance of 18F-FDG positron emission tomography-computed tomography over contrast-enhanced computed tomography in guiding surgical decision-making
Preoperative risk stratification of colorectal high-grade intraepithelial neoplasia based on endoscopic biopsy: superior performance of 18F-FDG positron emission tomography-computed tomography over contrast-enhanced computed tomography in guiding surgical decision-making Open
View article: Delving into the Inception of BODIPY Dyes: Paradigms of In Vivo Bioimaging, Chemosensing, and Photodynamic/Photothermal Therapy
Delving into the Inception of BODIPY Dyes: Paradigms of In Vivo Bioimaging, Chemosensing, and Photodynamic/Photothermal Therapy Open
Boron-dipyrromethene (BODIPY) dyes belong to a class of organoboron compounds that have become ubiquitous for researchers in areas of fluorescence imaging, photodynamic therapy, and optoelectronics. The intrinsic qualities of BODIPY dyes a…
View article: Neuromelanin-targeted 18F-P3BZA PET/MR imaging of the substantia nigra in rhesus macaques
Neuromelanin-targeted 18F-P3BZA PET/MR imaging of the substantia nigra in rhesus macaques Open
Background Neuromelanin is mostly located in dopaminergic neurons in the substantia nigra (SN) pars compacta, and can be detected by magnetic resonance imaging (MRI). It is a promising imaging-base biomarker for neurological diseases. We p…
View article: qtOCT: quantitative transmission optical coherence tomography
qtOCT: quantitative transmission optical coherence tomography Open
View article: Self-Assembling Amphiphilic Dendrimers (SAADs) for the Detection of CXCR4⁺ Tumors by PET imaging.
Self-Assembling Amphiphilic Dendrimers (SAADs) for the Detection of CXCR4⁺ Tumors by PET imaging. Open
Self-assembling amphiphilic dendrimers (SAADs) were functionalized to develop a novel CXCR4 targeting PET. The amphiphilic dendrimer- NOTA (1, 4, 7-triazacyclononane-1,4,7-triacetic acid) (C18-NOTA) was combined with the CXCR4 antagonist R…
View article: Synthesis and Evaluation of Radiogallium-Labeled Peptide Probes for In Vivo Imaging of Legumain Activity
Synthesis and Evaluation of Radiogallium-Labeled Peptide Probes for In Vivo Imaging of Legumain Activity Open
Legumain (LGMN), a lysosomal cysteine protease, is crucial for tumor progression, invasion, and metastasis, making it a promising target for cancer imaging and therapy. This study developed novel 67Ga-labeled 1,4,7-triazacyclononane-1,4,7-…
View article: Molecular imaging of butyrylcholinesterase associated with amyloid-β plaques distinguishes 5XFAD from wild-type mice
Molecular imaging of butyrylcholinesterase associated with amyloid-β plaques distinguishes 5XFAD from wild-type mice Open
Purpose Diagnosis of Alzheimer’s disease (AD) requires symptoms of dementia and accumulation of amyloid-β (Aβ) and tau in the brain. Molecular imaging of Aβ or tau in AD, though informative, is complicated by the finding that similar chang…
View article: A Novel FAPI-Based Radiopharmaceutical for SPECT Imaging of Fibrotic Interstitial Lung Disease
A Novel FAPI-Based Radiopharmaceutical for SPECT Imaging of Fibrotic Interstitial Lung Disease Open
Objectives: Early and noninvasive detection of fibrotic interstitial lung disease (fILD) is a critical but unmet clinical necessity. This study aimed to evaluate the feasibility of using 99mTc-HYNIC-Glu(PEG4-oncoFAPi)2 (denoted as 99mTc-H-…
View article: Unveiling Primary Bone Tumors of the Spine: A Review of Essential Imaging Clues
Unveiling Primary Bone Tumors of the Spine: A Review of Essential Imaging Clues Open
Primary spinal osseous tumors are relatively rare, comprising ~5–10% of spinal bone neoplasms, whereas metastases account for the vast majority of spinal lesions. Patients commonly present with insidious back pain, sometimes with a focal m…
View article: First-in-Human Biodistribution and Dosimetry of [11C]Trimethoprim
First-in-Human Biodistribution and Dosimetry of [11C]Trimethoprim Open
Trimethoprim (TMP) is a reversible inhibitor of the prokaryotic enzyme dihydrofolate reductase (DHFR) used for the treatment or prophylaxis of bacterial infections. [ 11 C]trimethoprim ([ 11 C]TMP) is a positron emission tomography (PET) i…
View article: Quantitative 3D assessment of muscle dystrophy through X-ray phase-contrast tomography
Quantitative 3D assessment of muscle dystrophy through X-ray phase-contrast tomography Open
Duchenne muscular dystrophy (DMD) is characterized by progressive skeletal muscle degeneration and weakness. DMD is the most common muscular dystrophy; commonly diagnosed in childhood, it has a deadly outcome, typically for respiratory or …
View article: A high-affinity CEA-targeted nanobody for 68Ga PET imaging and 177Lu-based radioisotope therapy: preclinical and first-in-human evaluation
A high-affinity CEA-targeted nanobody for 68Ga PET imaging and 177Lu-based radioisotope therapy: preclinical and first-in-human evaluation Open
Carcinoembryonic antigen (CEA) is a clinically validated biomarker and therapeutic target in colorectal and other epithelial malignancies, yet current antibody-based approaches are hindered by poor pharmacokinetics, limited tumor penetrati…
View article: Stable electron-irradiated [1- <sup>13</sup> C]alanine radicals for metabolic imaging with dynamic nuclear polarization
Stable electron-irradiated [1- <sup>13</sup> C]alanine radicals for metabolic imaging with dynamic nuclear polarization Open
Dissolution dynamic nuclear polarization (dDNP) increases the sensitivity of magnetic resonance experiments by >10 4 -fold, permitting isotopically labeled molecules to be transiently visible in magnetic resonance imaging scans. dDNP mecha…
View article: From Scan to Surgery: Evaluating High-Resolution Computed Tomography (HRCT) and Diffusion-Weighted Magnetic Resonance Imaging (DWI) Accuracy in Detecting Cholesteatoma
From Scan to Surgery: Evaluating High-Resolution Computed Tomography (HRCT) and Diffusion-Weighted Magnetic Resonance Imaging (DWI) Accuracy in Detecting Cholesteatoma Open
View article: Making the Immune Status Visible – Generation and Characterization of Nanobodies Targeting Immune Markers for in vivo Diagnostics
Making the Immune Status Visible – Generation and Characterization of Nanobodies Targeting Immune Markers for in vivo Diagnostics Open
Immunotherapies offer promising treatment options for cancer patients, yet responsiveness is highly dependent on the individual immune status. Thus, profiling of immune activity in the tumor microenvironment (TME) is of increasing importan…
View article: Glutathione-depleting photosensitizers for tumor-specific imaging and pyroptosis-driven photodynamic therapy
Glutathione-depleting photosensitizers for tumor-specific imaging and pyroptosis-driven photodynamic therapy Open
View article: AutoGlom: Software Tool for Segmentation and Analysis of Magnetic Resonance Images of the Kidney
AutoGlom: Software Tool for Segmentation and Analysis of Magnetic Resonance Images of the Kidney Open
Magnetic resonance imaging (MRI) is increasingly important in preclinical and clinical investigations of the kidney. However, there are few user-friendly, flexible, and standardized tools for evaluating MR images for quantitative imaging a…