Genetic model
View article: Accelerating Genetic Gains in Cowpea through Rapid-Cycle Genomic Selection for Nutrient-Use Efficiency
Accelerating Genetic Gains in Cowpea through Rapid-Cycle Genomic Selection for Nutrient-Use Efficiency Open
Cowpea (Vigna unguiculata L. Walp.) serves as a critical protein source and soil fertility enhancer in sub-Saharan African smallholder systems, yet poor nutrient-use efficiency (NUE) under low-input conditions constrains productivity. Gene…
View article: A Unified Stochastic Model for Modern Human Dispersal and Admixture
A Unified Stochastic Model for Modern Human Dispersal and Admixture Open
Archaeological and genetic evidence provide rich, albeit often fragmented, insights into modern human origins and diversification. However, a comprehensive theoretical framework capable of integrating the stochastic nature of these process…
View article: Supplementary Table S4 from Genetic Susceptibility to Nonalcoholic Fatty Liver Disease and Risk for Pancreatic Cancer: Mendelian Randomization
Supplementary Table S4 from Genetic Susceptibility to Nonalcoholic Fatty Liver Disease and Risk for Pancreatic Cancer: Mendelian Randomization Open
Supplementary Table S4 shows results of univariate analysis for 17 imaging and biopsy validated SNPs in the PanScan sample
View article: Supplementary Table S1 from Genetic Susceptibility to Nonalcoholic Fatty Liver Disease and Risk for Pancreatic Cancer: Mendelian Randomization
Supplementary Table S1 from Genetic Susceptibility to Nonalcoholic Fatty Liver Disease and Risk for Pancreatic Cancer: Mendelian Randomization Open
Supplementary Table S1 shows results of univariate analysis for 77 chronically elevated serum alanine aminotransferase (cALT)-defined nonalcoholic fatty liver disease SNPs in the Pancreatic Cancer Cohort Consortium (PanScan) data
View article: Supplementary Table S10 from Genetic Susceptibility to Nonalcoholic Fatty Liver Disease and Risk for Pancreatic Cancer: Mendelian Randomization
Supplementary Table S10 from Genetic Susceptibility to Nonalcoholic Fatty Liver Disease and Risk for Pancreatic Cancer: Mendelian Randomization Open
Supplementary Table S10 shows descriptive Statistics for PanC4 sample
View article: Supplementary Table S5 from Genetic Susceptibility to Nonalcoholic Fatty Liver Disease and Risk for Pancreatic Cancer: Mendelian Randomization
Supplementary Table S5 from Genetic Susceptibility to Nonalcoholic Fatty Liver Disease and Risk for Pancreatic Cancer: Mendelian Randomization Open
Supplementary Table S5 shows results of univariate analysis for 77 chronically elevated serum alanine aminotransferase (cALT)-defined nonalcoholic fatty liver disease in the Pancreatic Cancer Case-Control Consortium (PanC4) data
View article: Supplementary Table S9 from Genetic Susceptibility to Nonalcoholic Fatty Liver Disease and Risk for Pancreatic Cancer: Mendelian Randomization
Supplementary Table S9 from Genetic Susceptibility to Nonalcoholic Fatty Liver Disease and Risk for Pancreatic Cancer: Mendelian Randomization Open
Supplementary Table S9 shows descriptive Statistics for PanScan sample
View article: Data from SNPs at <i>SMG7</i> Associated with Time from Biochemical Recurrence to Prostate Cancer Death
Data from SNPs at <i>SMG7</i> Associated with Time from Biochemical Recurrence to Prostate Cancer Death Open
Background:A previous genome-wide association study identified several loci with genetic variants associated with prostate cancer survival time in two cohorts from Sweden. Whether these variants have an effect in other populations or if th…
View article: An interneuronal CRH and CRHBP circuit stabilizes birdsong performance
An interneuronal CRH and CRHBP circuit stabilizes birdsong performance Open
The performance of skilled behaviors requires a balance between consistency and adaptability. Although the neural mechanisms that regulate this balance have been extensively studied at systems and physiological levels, relatively little is…
View article: Association between KCNC1 gene polymorphism and blood lipid levels in determining the efficacy of high-intensity interval training
Association between KCNC1 gene polymorphism and blood lipid levels in determining the efficacy of high-intensity interval training Open
Objective: The potassium voltage-gated channel subfamily C member 1 (KCNC1) gene plays a crucial role in both neural excitability and lipid metabolism. However, the impact of its genetic polymorphisms on individual blood lipid levels and t…
View article: An interneuronal CRH and CRHBP circuit stabilizes birdsong performance
An interneuronal CRH and CRHBP circuit stabilizes birdsong performance Open
The performance of skilled behaviors requires a balance between consistency and adaptability. Although the neural mechanisms that regulate this balance have been extensively studied at systems and physiological levels, relatively little is…
View article: Supplementary Figure S1 from Genetic Susceptibility to Nonalcoholic Fatty Liver Disease and Risk for Pancreatic Cancer: Mendelian Randomization
Supplementary Figure S1 from Genetic Susceptibility to Nonalcoholic Fatty Liver Disease and Risk for Pancreatic Cancer: Mendelian Randomization Open
Supplementary Figure S1 shows forest plot for minimally adjusted model for the PanScan sample.
View article: Supplementary Table S2 from Genetic Susceptibility to Nonalcoholic Fatty Liver Disease and Risk for Pancreatic Cancer: Mendelian Randomization
Supplementary Table S2 from Genetic Susceptibility to Nonalcoholic Fatty Liver Disease and Risk for Pancreatic Cancer: Mendelian Randomization Open
Supplementary Table S2 shows results of univariate analysis for 22 imaging-defined nonalcoholic fatty liver disease SNPs in the PanScan sample
View article: Data from B-Cell NHL Subtype Risk Associated with Autoimmune Conditions and PRS
Data from B-Cell NHL Subtype Risk Associated with Autoimmune Conditions and PRS Open
Background:A previous International Lymphoma Epidemiology (InterLymph) Consortium evaluation of joint associations between five immune gene variants and autoimmune conditions reported interactions between B-cell response-mediated autoimmun…
View article: Data from Breast Cancer Risk in Women from Ghana Carrying Rare Germline Pathogenic Mutations
Data from Breast Cancer Risk in Women from Ghana Carrying Rare Germline Pathogenic Mutations Open
Background:Risk estimates for women carrying germline mutations in breast cancer susceptibility genes are mainly based on studies of European ancestry women.Methods:We investigated associations between pathogenic variants (PV) in 34 genes …
View article: Reframing Modern Human Origins: A Spatiotemporal Admixture Network Model
Reframing Modern Human Origins: A Spatiotemporal Admixture Network Model Open
The narrative of modern human origins has historically been dominated by models emphasizing simple divergence and replacement. However, accumulating genetic and archaeological evidence increasingly points towards a more complex, reticulate…
View article: Reframing Modern Human Origins: A Spatiotemporal Admixture Network Model
Reframing Modern Human Origins: A Spatiotemporal Admixture Network Model Open
The narrative of modern human origins has historically been dominated by models emphasizing simple divergence and replacement. However, accumulating genetic and archaeological evidence increasingly points towards a more complex, reticulate…
View article: Accelerating Genetic Gains in Cowpea through Rapid-Cycle Genomic Selection for Nutrient-Use Efficiency
Accelerating Genetic Gains in Cowpea through Rapid-Cycle Genomic Selection for Nutrient-Use Efficiency Open
Cowpea (Vigna unguiculata L. Walp.) serves as a critical protein source and soil fertility enhancer in sub-Saharan African smallholder systems, yet poor nutrient-use efficiency (NUE) under low-input conditions constrains productivity. Gene…
View article: Data from Evaluating the Potential of Polygenic Risk Score to Improve Colorectal Cancer Screening
Data from Evaluating the Potential of Polygenic Risk Score to Improve Colorectal Cancer Screening Open
Background:Colorectal cancer has high incidence and associated mortality worldwide. Screening programs are recommended for men and women over 50. Intermediate screens such as fecal immunochemical testing (FIT) select patients for colonosco…
View article: Data from Beyond GWAS of Colorectal Cancer: Evidence of Interaction with Alcohol Consumption and Putative Causal Variant for the 10q24.2 Region
Data from Beyond GWAS of Colorectal Cancer: Evidence of Interaction with Alcohol Consumption and Putative Causal Variant for the 10q24.2 Region Open
Background:Currently known associations between common genetic variants and colorectal cancer explain less than half of its heritability of 25%. As alcohol consumption has a J-shape association with colorectal cancer risk, nondrinking and …
View article: Data from Genetic Regulation of DNA Methylation Yields Novel Discoveries in GWAS of Colorectal Cancer
Data from Genetic Regulation of DNA Methylation Yields Novel Discoveries in GWAS of Colorectal Cancer Open
Background:Colorectal cancer has a strong epigenetic component that is accompanied by frequent DNA methylation (DNAm) alterations in addition to heritable genetic risk. It is of interest to understand the interrelationship of germline gene…
View article: Supplementary Table S8 from Genetic Susceptibility to Nonalcoholic Fatty Liver Disease and Risk for Pancreatic Cancer: Mendelian Randomization
Supplementary Table S8 from Genetic Susceptibility to Nonalcoholic Fatty Liver Disease and Risk for Pancreatic Cancer: Mendelian Randomization Open
Supplementary Table S8 shows results of univariate analysis for 17 imaging and biopsy validated SNPs in the PanC4 sample
View article: Supplementary Table 1 from Genetic Predictors for Fecal Propionate and Butyrate-Producing Microbiome Pathway Are Not Associated with Colorectal Cancer Risk: A Mendelian Randomization Analysis
Supplementary Table 1 from Genetic Predictors for Fecal Propionate and Butyrate-Producing Microbiome Pathway Are Not Associated with Colorectal Cancer Risk: A Mendelian Randomization Analysis Open
Supplementary Table 1 shows the power calculation for the associations of PWY-5022 and propionate with CRC risk.
View article: Supplementary Table S6 from Genetic Susceptibility to Nonalcoholic Fatty Liver Disease and Risk for Pancreatic Cancer: Mendelian Randomization
Supplementary Table S6 from Genetic Susceptibility to Nonalcoholic Fatty Liver Disease and Risk for Pancreatic Cancer: Mendelian Randomization Open
Supplementary Table S6 shows results of univariate analysis for 22 imaging defined nonalcoholic fatty liver disease SNPs in the PanC4 sample
View article: Supplementary Table S3 from Genetic Susceptibility to Nonalcoholic Fatty Liver Disease and Risk for Pancreatic Cancer: Mendelian Randomization
Supplementary Table S3 from Genetic Susceptibility to Nonalcoholic Fatty Liver Disease and Risk for Pancreatic Cancer: Mendelian Randomization Open
Supplementary Table S3 shows results of univariate analysis for 36 biopsy-confirmed nonalcoholic fatty liver disease SNPs in the PanScan sample
View article: Data from Genetic Predictors for Fecal Propionate and Butyrate-Producing Microbiome Pathway Are Not Associated with Colorectal Cancer Risk: A Mendelian Randomization Analysis
Data from Genetic Predictors for Fecal Propionate and Butyrate-Producing Microbiome Pathway Are Not Associated with Colorectal Cancer Risk: A Mendelian Randomization Analysis Open
Background:Mechanistic data indicate the benefit of short-chain fatty acids (SCFA) produced by gut microbial fermentation of fiber on colorectal cancer, but direct epidemiologic evidence is limited. A recent study identified SNPs for two S…
View article: Supplementary Figure 3 from Folate Intake and Ovarian Cancer Risk among Women with Endometriosis: A Case–Control Study from the Ovarian Cancer Association Consortium
Supplementary Figure 3 from Folate Intake and Ovarian Cancer Risk among Women with Endometriosis: A Case–Control Study from the Ovarian Cancer Association Consortium Open
Supplementary Figure 3 shows scatter plots with the genetic association with folate on the x-axis and the genetic association with ovarian cancer on the y-axis, for (A) women with and (B) without endometriosis. The regression line for the …
View article: Supplementary Data from Genetic Analysis in African American Children Supports Ancestry-Specific Neuroblastoma Susceptibility
Supplementary Data from Genetic Analysis in African American Children Supports Ancestry-Specific Neuroblastoma Susceptibility Open
Supplementary Data from Genetic Analysis in African American Children Supports Ancestry-Specific Neuroblastoma Susceptibility
View article: Supplementary Figure S2 from Genetic Susceptibility to Nonalcoholic Fatty Liver Disease and Risk for Pancreatic Cancer: Mendelian Randomization
Supplementary Figure S2 from Genetic Susceptibility to Nonalcoholic Fatty Liver Disease and Risk for Pancreatic Cancer: Mendelian Randomization Open
Supplementary Figure S2 shows forest plot for minimally adjusted model for PanC4 sample
View article: Supplementary Materials and Methods from Inference on the Genetic Architecture of Breast Cancer Risk
Supplementary Materials and Methods from Inference on the Genetic Architecture of Breast Cancer Risk Open
Supplementary Material 1 shows mathematical corroboration of the main inference in the paper. Supplementary Material 2 shows the derivation of conditional probability of carrying a specific allele given the co-twin’s allele. Supplementary …