Systemic reaction
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Drug-induced hypersensitivity syndrome/drug reaction with eosinophilia and systemic symptoms (DIHS/DRESS): 11 years retrospective study in Thailand Open
DRESS is associated with severe morbidity and mortality. Phenytoin, nevirapine, allopurinol, and cotrimoxazole were the major causes. Allopurinol-induced DRESS had the longest onset time, and was associated with higher eosinophilia and inc…
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Systemic allergic dermatitis caused by sesquiterpene lactones Open
Summary Patients with C ompositae sensitization are routinely warned against the ingestion of vegetables, spices, teas and herbal remedies from this family of plants. The evidence for the occurrence of systemic allergic dermatitis caused b…
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Drug reaction with eosinophilia and systemic symptoms (DRESS) in children. Open
Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) is a severe reaction to drugs. Incidence of DRESS in children is not well known and the mortality rate seems to be lower than 10%. Anticonvulsants are the main drugs involved bo…
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Drug reaction with eosinophilia and systemic symptoms (DRESS syndrome) Open
SUMMARY Objective: To review the hypersensitivity reaction to drugs known as drug reaction with eosinophilia and systemic symptoms (DRESS syndrome), based on a case report. We also intend to discuss the difficulty and importance of disease…
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Risk factors for systemic reactions in typical cold urticaria: Results from the COLD‐CE study Open
Background Cold urticaria (ColdU), that is, the occurrence of wheals or angioedema in response to cold exposure, is classified into typical and atypical forms. The diagnosis of typical ColdU relies on whealing in response to local cold sti…
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Systemic allergic reactions induced by labile plant‐food allergens: Seeking potential cofactors. A multicenter study Open
Background Heat‐and‐pepsin‐sensitive plant food allergens (PR‐10 and profilin) sometimes cause systemic reaction. Objective To detect the risk factors for systemic reactions induced by labile food allergens. Methods A retrospective multice…
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Management of Adult Patients With Drug Reaction With Eosinophilia and Systemic Symptoms Open
Importance Drug reaction with eosinophilia and systemic symptoms (DRESS) is a rare but potentially fatal drug hypersensitivity reaction. To our knowledge, there is no international consensus on its severity assessment and treatment. Object…
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Drug-related relapses in drug reaction with eosinophilia and systemic symptoms (DRESS) Open
Background A drug reaction with eosinophilia and systemic symptoms (DRESS) is a severe T cell mediated hypersensitivity reaction. Relapses of symptoms in the recovery phase are frequent and linked to the reduction of the corticosteroid tre…
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Two cases with HSS/DRESS syndrome developing after prosthetic joint surgery: does vancomycin-laden bone cement play a role in this syndrome? Open
We report two cases of hypersensitivity syndrome/drug reaction with eosinophilia and systemic symptoms (HSS/DRESS) syndrome following systemic and local (via antibiotic laden bone cement (ALBC)) exposures to vancomycin. Both cases develope…
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Safety Threshold Considerations for Sunscreen Systemic Exposure: A Simulation Study Open
Sunscreens are regulated as over‐the‐counter drugs in the United States. Some sunscreen ingredients are absorbed into the systemic circulation, which raises concerns about the safety of these drugs. There is limited information on the syst…
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Safety of allergen‐specific immunotherapy in children Open
Allergic respiratory diseases, such as asthma and allergic rhinitis, are global health issues and have had an increasing prevalence in the last decades. Allergen‐specific immunotherapy (AIT) is the only curative treatment for allergic rhin…
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The prevalence and significance of anti-PM/Scl antibodies in systemic sclerosis Open
Anti-PM/Scl antibodies are fairly common in patients with systemic sclerosis. In SSc, anti-PM/Scl antibodies are frequently associated with myalgia or myositis, hand joint contractures and an overlap syndrome.
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Novel targeted inhibition of the IL-5 axis for drug reaction with eosinophilia and systemic symptoms syndrome Open
Background The drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome represents a severe hypersensitivity reaction. Up-to-date treatment is based on withdrawal of medication, supportive care, and immunosuppression using hi…
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Role of Systemic Inflammatory Reaction in Female Genital Organ Malignancies – State of the Art Open
Systemic inflammatory reaction (SIR) is an unfavorable prognostic factor in many malignancies and has a role in all stages of the neoplastic process: initiation, promotion, and disease progression. Analysis of SIR can be performed by asses…
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Risk Factors for Vancomycin Drug Reaction With Eosinophilia and Systemic Symptoms Syndrome Open
This case-control study uses single-institution data to explore risk factors associated with vancomycin drug reaction with eosinophilia and systemic systems (DRESS) syndrome.
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Venom allergy, risk factors for systemic reactions and the knowledge levels among Turkish beekeepers Open
Similar to previous studies, we found that the systemic response to the bee sting in beekeepers was higher compared to normal population. Considering the occupational exposure to bee venom and thus higher risk, the awareness of venom aller…
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A Wolf in Sheep's Clothing: Systemic Immune Activation Post Immunotherapy Open
Introduction Immune checkpoint inhibitors (ICIs) are increasingly a standard of care for many cancers; these agents can result in immune-related adverse events (irAEs) including fever, which is common but can rarely be associated with syst…
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The combined administration of systemic and topical tranexamic acid for total hip arthroplasty: Is it better than systemic? Open
Obective The aim of this study was to evaluate the effect of combined intravenous and topical use of tranexamic acid (TXA) on total blood loss and transfusion rate in total hip arthroplasty. Methods This prospective randomized study includ…
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Implication of Tityus apiacas (Lourenco, 2002) in scorpion envenomations in the Southern Amazon border, Brazil Open
Herein, four cases of scorpion stings caused by Tityus apiacas recorded from the municipality of Apuí, in the southern region of the Brazilian Amazon, are described. Patients showed systemic clinical manifestations, described as unusual, i…
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Autoantibodies in Systemic Lupus Erythematosus, on Black African Subject, in Abidjan Open
Aim: To determine the clinical and immunological characteristics of patients with systemic erythematosus lupus in Abidjan. Patients and Method: We studied 117 patients' files with systemic lupus erythematosus aged 12 to 73 years old, who f…
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Systemic hypersensitivity reaction to Omnipaque radiocontrast medium: a case of mini‐<span>DRESS</span> Open
Key Clinical Message Drug reaction with eosinophilia and systemic symptoms ( DRESS ) is a delayed drug reaction defined by physical signs and laboratory parameters. Mini‐ DRESS is a new entity, in cases that display some but not all featur…
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Use of sIgE/T-IgE in Predicting Systemic Reactions Open
Occupational exposure is the most common cause in honeybee venom allergy induced systemic reactions. The use of sIgE/T-IgE results is a useful diagnostic parameter in determining honeybee venom allergy.
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Evaluation of serum IgE in peach-allergic patients with systemic reaction by using recombinant Pru p 7 (gibberellin-regulated protein) Open
We found that prPru p 7 exhibited reactivity in ELISA comparable to that of nPru p 7 for the diagnosis of peach allergy with systemic reaction.
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Spontaneous improvement of laryngeal sarcoidosis resistant to systemic corticosteroid administration Open
We report herein a case of laryngeal sarcoidosis that was refractory to systemic corticosteroids, but that improved spontaneously. A 49-year-old woman complained of dysphagia and hoarseness with accompanying edematous swellings of both ary…
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Higher risk of allergies at 4–6 years of age after systemic antibiotics in the first week of life Open
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A single centre retrospective study of systemic reactions to subcutaneous immunotherapy Open
Background Subcutaneous immunotherapy (SCIT) is the standard approach for treating patients with sensitizations to aeroallergens. However, immunotherapy can trigger severe systemic reactions if delivered inappropriately or to high risk pat…
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Large local reaction to Hymenoptera stings: Sound studies are needed to change a shared concept Open
The natural history of large local reactions to Hymenoptera stings allowed to estimate the risk to develop a systemic reaction after an initial large local reaction in about 4% of patients. A recently published study claimed that such risk…
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Allergic reactions after vaccination: translating guidelines into clinical practice Open
Background. Ultra-rush (UR) are induction protocols used in venom immunotherapy (VIT). Objectives: To evaluate the adverse reactions during a 210-minutes UR and determine possible risk factors. Methods: Retrospective study of 129 patients …
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Worldwide surveys on anaphylaxis to sublingual immunotherapy with house dust mite tablets are urgently needed Open
In the 1980s, a global number of 72 fatalities were reported in the UK and the USA following the application of subcutaneous immunotherapy (SCIT). This resulted in a significant limitation of SCIT use and in the search of other routes of a…
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Health-related quality of life in children and adolescents after systemic sting reaction Open
The gender, treatment duration and stage of anaphylactic reaction influenced level of anxiety. The level of feeling of safety was related to the place of living.